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Open Journal of Obstetrics and Gynecology 2020年第1期10卷 25-40页

作者： Babacar Biaye Jacque Raiga Moussa Diallo Reda Jafer Abdoul Aziz Diouf bernard benoit Bruno Carbone Gynecological and Obstetric Clinic of Aristide Hospital Le Dantec of Dakar Dakar Senegal

The diagnosis and management of ovarian cystic tumor is sometimes difficult. In this manuscript, we wish to summarize this issue by showing three cases. Ultrasound and Color Doppler are very useful to diagnose the presence of this tumor but also to distinguish between benign and malignant. Pelvic MRI is also a strong tool and is sometimes mandatory. HE4 and CA125 are often useful as a serum diagnostic marker of malignancy, but not always so. Recently, laparoscopic management has gained popularity;however, great caution should be exercised during laparoscopic operative procedures, as this may lead to intraperitoneal malignant cell spreading/proliferation when the tumor is malignant. During the surgery of malignant tumor, irrespective of laparoscopic or laparotomic, intraperitoneal rupture should be avoided. Since the final diagnosis must be made by histological examination, the patient must always be informed of this possibility.

关键词： Ovarian Cyst Tumor Diagnosis Management Prognosis

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新一代的HD live的卫星会

中国产前诊断杂志（电子版） 2015年第2期7卷 20-20页

作者： bernard benoit 摩纳哥格蕾丝王妃医院妇产超声科

搭建于煊光平台的煊影成像(HD live with Silhouette)融合了轮廓渲染模式,结合透视剪影,及光源的位置调节,可以更好展示皮肤的表面光泽,提高了渲染模式的图像分辨率,增加真实感,更好的组织边界识别。在早孕期,有利于观察胎儿内部的无回... 详细信息

搭建于煊光平台的煊影成像(HD live with Silhouette)融合了轮廓渲染模式,结合透视剪影,及光源的位置调节,可以更好展示皮肤的表面光泽,提高了渲染模式的图像分辨率,增加真实感,更好的组织边界识别。在早孕期,有利于观察胎儿内部的无回声结构,如脑室、积水、胃泡及膀胱等,方便显示遮盖的组织结构,如胎盘后的胎儿、多胎的结构,结合魔术剪(magicut),方便渲染图像处理后的剪辑和分析。

关键词：边界识别图像分辨率早孕期胃泡 HD live 组织结构深度信息同步实时灌注状态内血管

Spatio-Temporal evolutive Data Infrastructure: a Spatial Data Infrastructure for managing data flows of Territorial Statistical Information

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International Journal of Digital Earth 2017年第3期10卷 257-283页

作者： Camille bernard Marlène Villanova-Oliver Jérôme Gensel benoit Le Rubrus Univ.Grenoble Alpes CNRSLIGGrenobleFrance

The observation of demographical,economical or environmental indicators over time through maps is *** enables analysing territories and helps stakeholders to take ***,the understanding of Territorial Statistical Information(TSI)is compromised unless comprehensive description of both the statistical methodology used and the spatial and temporal references are ***,in this paper,we stress the importance of metadata descriptions and of their quality that helps assessing data ***,time-series of such TSI are *** enable analysing a territory over a long period of time and likewise judging the effectiveness of *** light of these observations,we present Spatio-Temporal evolutive Data Infrastructure(STeDI)an innovative Spatial Data Infrastructure(SDI)that enriches the description of a Digital Earth,providing a virtual representation of territories and of their evolution through statistics and *** aims at managing a whole dataflow of multi-dimensional,multi-scale and multi-temporal TSI,from their acquisition to their dissemination to scientists and *** content of this SDI evolves autonomously thanks to automated processes and to a Web platform that help improving the quality of datasets uploaded by ***,STeDI allows visualizing up-to-date time-series reflecting the human activities on a given *** helps policy-makers in their decision-making process.

关键词： Spatial Data Infrastructure Territorial Statistical Information metadata data quality INSPIRE

Effect of transcutaneous electroacupuncture at Neiguan(PC 6) on refractory vomiting in patients in intensive care unit

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Journal of Traditional Chinese Medicine 2017年第4期37卷 554-557页

作者： benoit Bataille Carine Chan-Shun Bastian Nucci bernard Verdoux Michel Mora Pierre Cocquet Stein Silva Department of Intensive Care Medicine Narbonne HospitalNarbonne F-11100France Centre Hospitalier de Narbonne Service de Réanimation PolyvalenteNarbonne F-11100France Department of Anesthesiology and Critical Care Medicine Purpan University HospitalToulouse F-31059France Department of Intensive Care Vledicine Narbonne HospitalNarbonne F-11 1 00France

OBJECTIVE: To observe the effect of transcutaneous electroacupuncture(TEA) at Neiguan(PC 6) on refractory vomiting in critically ill patients in intensive care(ICU) ***: Ten patients admitted in ICU and presenting vomiting refractory to one or more antiemetic drugs were prospectively included in the study. TEA was applied at acupoint of Neiguan(PC6) during 30 min with a neuromuscular transmission monitor(single-twitch stimulation with 1 Hz at a constant current of 10 m A). Nausea and Vomiting were evaluated at the following intervals: immediately after 30 min of TEA at Neiguan(PC 6),30 min-6h and 6-24 h. The presence of nausea and/or vomiting throughout the observational period was defined as the primary end ***: The presence of nausea or vomiting throughout the observational period was 10% at the end of TEA, 40% between 30 min and 6 h, and50% between 30 min and 24 h(P < 0.001, P = 0.01 and P = 0.03 vs pre-TEA, respectively). There were no complications or side effects related to ***: TEA at Neiguan(PC 6) seems effective in reducing refractory vomiting in the patients in ICU setting, even if larger trials are needed to define optimal modalities.

关键词： Electroacupuncture Point PC 6 (Neiguan) Nausea Vomiting Antiemetics

Matrix Assisted Laser Desorption Ionization Time of Flight(MALDI-TOF)-Mass Spectrometry and^(13)C-NMR-Identified New Compounds in Paraberlinia bifoliolata(Ekop-Beli)Bark Tannins

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Journal of Renewable Materials 2024年第3期12卷 553-568页

作者： Liliane Nga benoit Ndiwe Achille bernard Biwolé Antonio Pizzi Jean Jalin Eyinga Biwole Joseph Zobo Mfomo Laboratory of Forest Resources and Wood Valorization Training Unit in Engineering SciencesPost Graduate School of Fundamental and Applied SciencesUniversity of DoualaP.O.Box 1872DoualaCameroun Laboratory of Mechanics Training Unit in Engineering SciencesPost Graduate School of Fundamental and Applied SciencesUniversity of DoualaP.O.Box 2701DoualaCameroun Laboratory of Studies and Research on Wood Material(LERMAB) University of LorraineNancyFrance

Extracts of plant origin,particularly tannins,are attracting growing interest for the sustainable development of materials in the industrial *** discovery of new tannins is therefore *** aim of this work was to contribute to the understanding of the properties of Paraberlinia bifoliolata tannin by Matrix Assisted Laser Desorption Ionization Time of Flight Mass Spectroscopy MALDI-TOF/MS and Carbon 13 Nuclear Magnetic Resonance(13C NMR).The chemical composition of tannin extracted from Paraberlinia bifoliolata bark was determined,as was the mechanical strength of the resin hardened with Acacia nilotica *** by successive water extraction was 35%.MALDI-TOF/MS analysis revealed the presence of three new compounds in this tannin,previously unknown in this family of *** are 3-hydroxyproline acid,N-methyl-4-hydroxypipecolic acid and N-methyl-5-dihydroxypipecolic *** identification of the above molecules means that this tannin can be used for industrial applications,as a resin in the manufacture of particleboard and in the formulation of green corrosion *** information is reinforced by 13C NMR spectrometry,which indicates the presence of several polyflavonoid units,confirming the condensed nature of the *** analysis of the resin formed by the purified tannin of Paraberlinia bifoliolata to which a vegetal biohardener has been added provided a Modulus of Elasticity(MOE)value of 4840 MPa at 150℃,confirming its possible use as a binder resin in the manufacture of wood panels as well as for the formulation of a corrosion inhibitor.

关键词： Tannin Paraberlinia bifoliolata Central African wood species MALDI-TOF/MS 13C NMR bark extracts thermomechanical behaviour wood-binder

Very late transcatheter heart valve thrombosis

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World Journal of Cardiology 2017年第2期9卷 196-199页

作者： Etienne L Couture Serge Lepage Jean-bernard Masson benoit Daneault Division of Cardiology Centre Hospitalier Universitaire de Sherbrooke Division of Cardiology Centre Hospitalier Universitaire de Montréal

We describe a case of very late transcatheter heart valve(THV) thrombosis of a first-generation SAPIEN prosthesis(Edwards Lifesciences, Irvine, CA) implanted in a 64-yearold woman with severe symptomatic aortic stenosis. More than 54 mo after implantation, she presented with severe symptomatic prosthesis dysfunction(stenosis) which was successfully treated with oral anticoagulation. To our knowledge, this is the tardiest case of THV thrombosis ever reported. This case should increase clinical awareness for THV thrombosis even beyond the first two-year period following implantation.

关键词： Valve thrombosis Transcathether heart valve Transcatheter aortic valve replacement

Quantitative interactomic of CD40 in primary B cells

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hLife 2024年第2期2卷 88-93页

作者： Jeremy Argenty Emilie Maturin Mylene Camus Valentin Mellado Jeanne Perroteau benoit Pasquier Guillaume Voisinne Odile Burlet-Schiltz Lih-Ling Lin Anne Gonzalez de Peredo Romain Roncagalli bernard Malissen Centre d’Immunologie de Marseille-Luminy Aix Marseille UniversitéINSERMCNRSMarseilleFrance Centre d’Immunophénomique Aix Marseille UniversitéINSERMCNRS UMRMarseilleFrance Institut de Pharmacologie et de Biologie Structurale Département Biologie Structurale BiophysiqueProtéomique Génopole Toulouse Midi Pyrénées CNRS UMR 5089205 Route de NarbonneToulouse CedexFrance Checkpoint Immunology Immunology and Inflammation Therapeutic AreaSanofiVitryFrance Checkpoint Immunology Immunology and Inflammation Therapeutic AreaSanofiCambridgeUSA

INTRODUCTION Over the past few decades,antibody-based therapies have emerged as an additional tool to treat patients developing cancer and auto-immune *** natural properties of the developed antibodies may lead to agonist or blocking functions for the targeted ***,antibodies developed for clinical trials are extensively analyzed in vitro and in vivo for safety and efficacy,yet they are not routinely evaluated for their potential signaling effectiveness.

关键词： routine antibodies clinical

How Polydopamine Modulates Biological Responses to PTFE Prostheses

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Materials Sciences and Applications 2019年第5期10卷 377-392页

作者： Isabelle Talon Anne Schneider Eric Mathieu bernard Senger benoit Frisch Cendrine Seguin Vincent Ball Joseph Hemmerlé National Institute of Health and Medical Research INSERM UMR_S 1121 11 rue Humann Strasbourg France Pediatric surgery Department University Hospital of Strasbourg Avenue de Moliere Strasbourg France National Center of Scientific Research CNRS UMR_7199 UMR_7199 University of Pharmacy of Strasbourg 74 Route du Rhin-CS 60024 Illkirch Cedex France

Diaphragm repair after congenital diaphragmatic hernia is associated with hernia recurrence due to prosthesis failure. Expanded polytetrafluoroethylene (e-PTFE), a synthetic non-degradable biomaterial, is currently used for those diaphragmatic defect repairs. The drawback of e-PTFE is its poor wettability that leads to coating difficulties, bonding that could favor implant integration. However, polydopamine (PDA) can be deposited as well on organic as on inorganic substrates. Therefore, we assessed the biological responses of a clinically used e-PTFE biomaterial treated with PDA in two different manners: one impregnated with PDA and the other coated with a one side PDA film. Mechanical properties of the raw e-PTFE, the PDA soaked biomaterial and the PDA coated surface were characterized by colloidal probe atomic force microscopy. Behaviors of primary human fibroblasts and Wharton’s jelly stem cells were investigated by electron microscopy. Findings reveal that the mechanical properties at the microscopic scale are not modified by the PDA treatments. Cells spread onto both PDA functionalized substrates. In addition, microscopic observations disclose numerous focal cell contacts, evidencing cell attachment, and cytoplasmic projections particularly with the nanoscale PDA coating. Results clearly suggest that PDA in general but above all the PDA coating enhance cellular colonization of the implant material.

关键词： Biomaterials Expanded Polytetrafluoroethylene Polydopamine Functionalization Electron Microscopy

URB597对anandamide水解作用的抑制可以减少大鼠尼古丁渴求行为的再现—与大麻CB1受体拮抗剂利莫那班的比较研究

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中国药物依赖性杂志 2009年第4期18卷 346-348页

作者： benoit FORGET Kathy COEN bernard Le FOLL Translational Addiction Research Laboratory Centre for Addiction and Mental Health and University of Toronto

目的:吸烟在全世界引起了严重的健康问题,全球约5百万早产儿死于吸烟。此外,吸烟是一种以戒断后反复复吸为特点的慢性复发性疾病。尼古丁是烟草中导致人类成瘾的主要成分,可以使啮齿类动物形成持续的自身给药行为和条件性位置偏爱(CPP)... 详细信息

目的:吸烟在全世界引起了严重的健康问题,全球约5百万早产儿死于吸烟。此外,吸烟是一种以戒断后反复复吸为特点的慢性复发性疾病。尼古丁是烟草中导致人类成瘾的主要成分,可以使啮齿类动物形成持续的自身给药行为和条件性位置偏爱(CPP)。大量数据表明内源性大麻系统在尼古丁成瘾神经机制中有重要的作用。阻断CB1受体减少了尼古丁自身给药,线索诱导的尼古丁渴求的再现,以及尼古丁诱导的CPP。然而,最近的数据提示URB597通过抑制脂肪酸酰胺水解酶(fat acid amide hydrolase,FAAH)增强anandamide的传递,进而减少尼古丁关联行为,如尼古丁自身给药行为的获得和再现,尼古丁诱导大鼠CPP的表达和再现(Scherma et al.,2008)。CB1受体拮抗剂利莫他班对尼古丁自身给药累进比率(progressive ratio,PR),尼古丁点燃诱导的复吸,以及URB597对线索诱导尼古丁渴求再现的作用尚没有研究报道。本研究旨在填补这一空白。方法:大鼠在形成稳定的尼古丁累进自身给药行为后,观察利莫他班急性(0.3-3mg·kg-1,ip)或反复给药(1mg·kg-1,ip)对尼古丁转换点(breaking point)的作用。该测试完成后,所有的大鼠进行消退训练。我们比较了自身给药行为消退后URB597不可逆地选择性抑制FAAH和选择性CB1受体拮抗剂利莫他班两种干预对线索诱导的和尼古丁点燃(0.15mg·kg-1,sc)诱导的尼古丁复吸行为再现的作用。结果:利莫他班(0.3-3mg·kg-1)剂量依赖性的减少了尼古丁的转换点,1mg·kg-1的利莫他班的作用稳定。在尼古丁给药行为消退后,尼古丁点燃和尼古丁相关线索可以再现尼古丁自身给药行为。利莫他班(1mg·kg-1)和URB597(0.3 and 1mg·kg-1)显著减少了这种自身给药行为的再现。结论:本研究结果显示DB1受体的完整性是尼古丁自身给药行为动机所必需的,利莫他班可以稳定的减少这种行为。利莫他班阻断CB1受体或者通过抑制FAAH活性增强anandamide水平都减少了尼古丁渴求行为的再现。URB597的这些作用提示anadamide可能在尼古丁渴求中起抑制性的作用;这个假设还需要进一步研究介导尼古丁渴求的多种内源性大麻物质的功能。既然利莫他班在戒烟和复吸的使用上受精神副作用的限制,我们的结果提示更精确的靶相调节大麻系统可能可以预防戒烟者的复吸。

关键词： URB597 尼古丁渴求 CB1受体利莫那班

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加拿大局域多点通信系统现场测试

电视技术 2000年第4期24卷 23-26页

作者：吴奕彦姜有保 bernard Caron Alain Bergeron benoit Ledoux Pierre Bouchard Andre Kennedy Michele Guillet 通信研究中心信息产业部电子第三研究所北京743信箱100015

加拿大通信研究中心对一个２８ＧＨｚ的先导性局域多点通信系统的现场测试在一个５ｋｍ半径内的３９５个地点进行，以评估系统的可用性。可用性与地势、通道间隔和发射机／接收机天线高度有很大关系。另一个值得注意的一点是，对这... 详细信息

加拿大通信研究中心对一个２８ＧＨｚ的先导性局域多点通信系统的现场测试在一个５ｋｍ半径内的３９５个地点进行，以评估系统的可用性。可用性与地势、通道间隔和发射机／接收机天线高度有很大关系。另一个值得注意的一点是，对这两个单元，在预想的５ｋｍ半径之外的地点也有效。该试验的目的是要验证在不存在大的障碍的小范围内，下变换后的信号功率（ＳＰＡＤＳｉｇｎａｌＰｏｗｅｒＡｆｔｅｒＤｏｗｎｃｏｎｖｅｒｓｉｏｎ）没有大的变化。从结果可见，在一个区域内ＳＰＡＤ仅变化几个分贝，而且所有测试结果与假定在自由空间传播时计算的ＳＰＡＤ曲线非常吻合。还需要开展的研究包括：关于在不同气候和季节条件下的长时间可用性；为获得更好的频谱效率和可靠性的高级调制与信道编码；业务之间的干扰和高屋顶定向接收天线的安装。为获得较好的可靠性和／或较高的数据传输能力，ＣＲＣ现正评估不同的调制技术，也正计划对双向通信业务中需要的返回通道的有关问题进行研究。

关键词：局域多点通信系统现场测试系统评估