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Early anticoagulation in patients with stroke and atrial fibrillation is associated with fewer ischaemic lesions at 1 month: the ATTUNE study

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Stroke & Vascular Neurology 2024年第1期9卷 30-37,I0034页

作者： Angelos Sharobeam Longting Lin Christina Lam Carlos Garcia-Esperon Yash Gawarikar Ronak Patel matthew Lee-Archer Andrew Wong michael Roizman Amanda Gilligan Andrew Lee Kee meng Tan Susan Day Christopher Levi Stephen m Davis mark Parsons bernard Yan melbourne Brain Centre at Royal melbourne Hospital ParkvilleVictoriaAustralia University of New South Wales South Western Sydney Clinical School LiverpoolNew South WalesAustralia Department of Neurology John Hunter HospitalNewcastleNew South WalesAustralia Department of Neurology Calvary Public HospitalCanberraAustralian Capital TerritoryAustralia Department of Neurology Northern Hospital EppingEppingVictoriaAustralia Department of Neurology Royal Brisbane and Women's HospitalHerstonQueenslandAustralia The University of Queensland School of medicine HerstonQueenslandAustralia Neurosciences Clinical Institute Epworth HealthcareRichmondVirginiaAustralia Department of Neurology Austin HealthUniversity of MelbourneHeidelbergVictoriaAustralia Flinders University College of medicine and Public Health AdelaideSouth AustraliaAustralia Department of Neurology Gold Coast University HospitalSouthportQueenslandAustralia The University of Sydney Northern Clinical School St LeonardsNew South WalesAustralia Department of Neurology and Neurophysiology Liverpool HospitalLiverpoolNew South WalesAustralia

Background The optimal time to commence anticoagulation in patients with atrial fibrillation(AF)after ischaemic stroke or transient ischaemic attack(TIA)is unclear,with guidelines differing in recommendations.A limitation of previous studies is the focus on clinically overt stroke,rather than radiologically obvious diffusion-weighted imaging ischaemic *** aimed to quantify silent ischaemic lesions and haemorrhages on mRI at 1month in patients commenced on early(mic lesions and more haemorrhages in the early anticoagulant group at 1-month *** A prospective multicentre,observational cohort study was performed at 11 Australian stroke *** and mRI data were collected at baseline and follow-up,with blinded imaging assessment performed by two *** of commencement of anticoagulation was at the discretion of the treating stroke *** We recruited 276 patients of whom 208 met the eligibility *** average age was 74.2 years(SD±10.63),and 79(38%)patients were *** National Institute of Health Stroke Scale score was 5(IQR 1–12).median baseline ischaemic lesion volume was 5mL(IQR 2–17).There were a greater number of new ischaemic lesions on follow-up mRI in patients commenced on anticoagulation≥4days after index event(17%vs 8%,p=0.04),but no difference in haemorrhage rates(22%vs 32%,p=0.10).Baseline ischaemic lesion volume of≤5mL was less likely to have a new haemorrhage at 1month(p=0.02).There was no difference in haemorrhage rates in patients with an initial ischaemic lesion volume of>5mL,regardless of anticoagulation *** Commencing anticoagulationmic lesions at 1month in AF *** is no increased rate of haemorrhage with early *** results suggest that early anticoagulation after mild-to-moderate acute ischaemic stroke associated w

关键词： patients lesions ischaemic

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Investigation of Groundwater Quality with Borehole Depth in the Basin Granitoids of the Ashanti Region of Ghana

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Journal of Water Resource and Protection 2024年第5期16卷 381-394页

作者： bernard Ofosu Augustine Kofi Asante Festus Anane mensah Umar-Farouk Usman Naa Korkoi Ayeh Geotechnical and materials Engineering Division CSIR-Building and Road Research Institute Kumasi Ghana

The dependence of groundwater quality on borehole depth is usually debatable in groundwater studies, especially in complex geological formations where aquifer characteristics vary spatially with depth. This study therefore seeks to investigate the relationship between borehole depth and groundwater quality across the granitoid aquifers within the Birimian Supergroup in the Ashanti Region. Physicochemical analysis records of groundwater quality data were collected from 23 boreholes of public and private institutions in the Ashanti Region of Ghana, and the parametric values of iron, fluoride, total hardness, pH, nitrate, and nitrite were used to study the groundwater quality-depth relationship. The results showed that the depth-to-groundwater quality indicated a marginal increase in water quality in the range of 30 to 50 m, which is mathematically represented by the low-value correlation coefficient (r2 = 0.026). A relatively significant increase occurs in the depth range of 50 to 80 m, which is given by a correlation coefficient of r2 = 0.298. The mean percent parameter compatibility was 74%, 82%, 89%, and 97% at 50, 60, 70, and 80 m depths, respectively. The variations in groundwater quality per depth ratio ranged from 1.48, 1.37, 1.27, and 1.21 for 50, 60, 70, and 80 m depth, respectively. The recommended minimum borehole depth for excellent groundwater quality is suggested with a compatibility per meter depth ratio of 1.37. This results in a range between 50 and 70 m as the most desirable drilling depth for excellent groundwater quality within the granitoids of the Birimian Supergroup of the Ashanti Region in Ghana.

关键词： Groundwater Quality Borehole Depth Birimian Supergroup Granitoid Aquifers Ashanti Region

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伦理学与SARS:多伦多的教训

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英国医学杂志中文版 2004年第4期7卷 243-246页

作者： Peter A Singer Solomon R Benatar mark Bernstein Abdallah S Daar bernard m dickens Susan K macRae Ross E G Upshur Linda Wright Randi Zlotnik Shaul 肖月 University of Torobto Joint Centre for Bioethics 88 College St TorontoCanadaM5G 1L4Sun Life financialchair and director Department of Public Health Sciences University Of Toronto visiting professor Division of Neurosurgery University of Toronto professor University of Toronto Joint Centre for Bioethics 88 College StTorontoCanada M5G 1L4 directorprogramme in applied ethics and biotechnology Faculty of Law University of Toronto University of Toronto Joint Centre for Bioethics 88 College St TorontoCanada M5G 1L4 deputy director Faculty of Law University of Toronto University of Toronto Joint Centre for Bioethics 88 College StTorontoCanadaM5G 1L4 bioethicist University of Toronto Joint Centre for Bioethics 88 College StTorontoCanadaM5G 1L4bioethicist

SARS的流行说明传染病在世界范围内流行是件多么容易的事,为了更好地应对下一次流行病,我们不仅要解决医学方面的问题,也同样需要解决伦理学方面的问题。

关键词：伦理学 SARS 多伦多严重急性呼吸综合征个人隐私权

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Prevalence of Work-Aggravated Asthma among Bakery Workers in Abidjan (Cote d’Ivoire)

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Health 2024年第3期16卷 204-217页

作者： Loukou Leandre Konan Esme marie Laure Essis Brou michel Kouassi marius Kedote Julius Fobil William Yavo Ossey bernard Yapo Issaka Tiembre National Institute of Public Health Abidjan Cote d’Ivoire Interuniversity Doctoral Program Cotonou Benin medical Sciences Training and Research Unit Department of Public Health and Biostatistics Felix Houphouet Boigny University Abidjan C&#244te d’Ivoire Global Environmental Occupational Health (GEOHealth) Accra Ghana UFR of Pharmaceutical and Biological Sciences Department of Public Health Felix Houphou&#235t Boigny University Abidjan Cote d’Ivoire Nangui Abrogoua University Abidjan C&#244te d’Ivoire National Institute of Public Hygiene Abidjan C&#244te d’Ivoire

Introduction: Work-aggravated asthma is pre-existing or concomitant asthma whose symptoms are aggravated by the work environment. The aim of this study was to determine the prevalence of this pathology and its associated factors among bakery workers in Abidjan. materials and methods: This descriptive and analytical cross-sectional study was conducted over a period of four (4) months from 18 December 2019 to 18 April 2020. Two questionnaires were used, one on employees and the other on the indoor environment of bakeries. In addition, a spirometry test was performed on all bakery workers. Statistical analysis was performed using stata 15.1 software. Results: A total of 599 bakery employees, including bakers (59.73%), sales assistants/ cashiers (23.52%), cleaners (6.34%) and administrative staff (10.18%), were investigated. The mean age was 30.8 ± 8 years, with a sex ratio (m/F) = 2.2. Asthma symptoms were found in 95 (15.86%) employees, of whom 74 (77.9%) had work-related asthma and 11 (14.9%) had asthma aggravated by work. The factors associated with work-aggravated asthma were personal or family history of allergy or atopy [ORa = 3.75;CI95%: 1.56 - 8.93;p = 0.003], exposure to dust [ORa = 5.01;CI95%: 1.43 - 7.50;p = 0.011] and humidity level (60% - 70%) [ORa = 1.80;CI 95%: 0.99 - 3.28;p = 0.05]. Conclusion: Work-aggravated asthma is a reality in bakeries in Abidjan, with an estimated prevalence of 14.9%. Two of the three factors associated with this condition suggest a link with indoor air pollution. Combating air pollution in these establishments must therefore be a priority for the relevant authorities, in order to provide employees with a working environment that protects their health.

关键词： Work-Aggravated Asthma Occupational Asthma Work-Related Asthma Bakeries Abidjan Ivory Coast

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The influence of pressure waves in tidal gravity records

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Geodesy and Geodynamics 2023年第1期14卷 15-25页

作者： bernard Ducarme Catholic University of Louvain Georges Lemaître Centre for Earth and Climate Research(ELI)Louvain-la-NeuveBelgium

For the reduction of atmospheric effects,observed gravity has initially been corrected by using the computed barometric admittance k of the in situ measured pressure,expressed in nms-2/hPa units and estimated by least squares ***,the local pressure changes alone cannot account for the atmospheric mass attraction and loading when the coherent pressure field exceeds a specific size,i.e.,with increasing *** overcome this difficulty,it is necessary to compute the total atmospheric effect at each station using the global pressure ***,the direct subtraction of the total gravity effect,provided by the models of pressure correction,is not yet satisfactory for S2 and other tidal components,such as K2 and P1,which include solar heating pressure *** paper identifies the origin of the problem and presents strategies to obtain a satisfactory ***,we set up a difference vector between the tidal factors of m2 and S2 after correction of the pressure and ocean tides *** vector,hereafter denoted as RES,presents the advantage of being practically insensitive to calibration *** minimum discrepancy between the tidal parameters of m2 and S2 corresponds to the minimum of the RES vector norm *** we adopt the hybrid pressure correction method,separating the local and the global pressure contribution of the models and replacing the local contribution by the pressure measured at the station multiplied by an admittance *** tested this procedure on 8 stations from the IGETS superconducting gravimeters network(former GGP network).For stations at an altitude lower than 1000 m,the value of dopt is always smaller *** discrepancy between the tidal parameters of the m2 and S2 waves is always lower than0.05% on the amplitude factors and 0.025° on the *** these stations,a correlation exists between the altitude and the value *** results at the three Central European stations Conrad,Pecny and Vienna are

关键词： Atmospheric pressure waves Atmospheric pressure correction in tidal records Atmospheric pressure models ERA5 and mERRA-2

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Correlation-induced magnetism in substrate-supported 2D metal-organic frameworks

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npj Computational materials 2022年第1期8卷 2170-2179页

作者： bernard Field Agustin Schiffrin Nikhil V.medhekar School of Physics and Astronomy Monash UniversityClaytonVIC3800Australia ARC Centre of Excellence in Future Low-Energy Electronics Technologies Monash UniversityClaytonVIC3800Australia Department of materials Science and Engineering Monash UniversityClaytonVIC3800Australia

Two-dimensional(2D)metal-organic frameworks(mOFs)with a kagome lattice can exhibit strong electron-electron interactions,which can lead to tunable quantum phases including many exotic magnetic *** technological developments of 2D mOFs typically take advantage of substrates for growth,support,and electrical contacts,investigations often ignore substrates and their dramatic influence on electronic ***,we show how substrates alter the correlated magnetic phases in kagome mOFs using systematic density functional theory and mean-field Hubbard *** demonstrate that mOF-substrate coupling,mOF-substrate charge transfer,strain,and external electric fields are key variables,activating and deactivating magnetic phases in these *** we consider the example of kagome-arranged 9,10-dicyanoanthracene molecules coordinated with copper atoms,our findings should generalise to any 2D kagome *** work offers useful predictions for tunable interaction-induced magnetism in surface-supported 2D(metal-)organic materials,opening the door to solid-state electronic and spintronic technologies based on such systems.

关键词： properties materials material

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Enhancing laccase stability and activity for dyes decolorization using ZIF-8@mWCNT nanocomposite

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Chinese Journal of Chemical Engineering 2022年第8期35卷 66-75页

作者： Pascal Habimana Yanjun Jiang Jing Gao Jean bernard Ndayambaje Osama m.Darwesh Jean Pierre mwizerwa Xiaobing Zheng Li ma School of Chemical Engineering and Technology Hebei University of TechnologyTianjin 300130China University of Rwanda College of Science and Technology3900 KigaliRwanda Department of Agricultural microbiology National Research CentreCairo 12622Egypt College of mechatronics and Control Engineering Shenzhen UniversityShenzhen 518060China

The continuous use of chemical dyes in various industries,and their discharge into industrial effluents,results in severe problems to human life and water *** have the ability to decolorize dyes and toxic chemicals in industrial effluents as green *** possible industrial applications have been limited by poor reusability,low stability,and loss of free laccase *** this research,lac-case was immobilized on zeolitic imidazolate framework coated multi-walled carbon nanotubes(Laccase@ZIF-8@mWCNTs)via metal affinity adsorption to develop an easy separable and stable *** optimum reaction conditions for immobilized laccase are at a pH of 3.0 and a temperature of 60℃.The immobilized laccase was enhanced in storage and thermal *** results indicated that Laccase@ZIF-8@mWCNTs still maintained 68%of its original activity after 10 times of repeated *** importantly,the biocatalytic system was applied for decolorization of different dyes(20 mg·L^(-1))without a mediator,and up to 97.4%for Eriochrome black T and 95.6%Acid red 88 was achieved in 25 *** with these properties may be used in a variety of environmental and industrial applications.

关键词： metal-organic framework Zeolitic imidazolate framework Reusability and stability Immobilized laccase Dye decolorization

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1:5 0000 SCALE TOPOGRAPHIC mAPPING IN WEST CHINA USING SPOT 5 DATA

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测绘科学 2008年第S2期33卷 25-27,9页

作者： m.bernard

On the one hand,the successful launch of the SPOT 5 satellite in 2002 can be seen as a milestone for DEm extraction and mapping,because its payload includes HRS,a stereoscopic imaging instrument devoted to collection of large *** in panchromaticmode,the HRS instrument has two telescopes,one pointing forward and one aft of the *** is thus able to cover an area of 600 km×120 km in a single pass(ie 72000 km^2 stereoscopic strips).moreover,SPOT 5 is able to collect stereoscopic triplets,through a simultaneousactivation of HRG sensors in vertical mode,which will overcome the difficulty of terrain shadow in DEm *** the extremelyprecise ancillary metadata of SPOT 5 allows accurate geometric processing with sparse ground control *** SPOT 5 stereoscopicimagery becomes one of main satellite data sources for accurate DEm extraction and quickly mapping large *** current status and coverageof stereoscopic HRS imagery as well as the metadata of SPOT 5 will be briefly *** the second hand,about 2 million km^2 in west China never has been covered by 1:50000 scale topographic maps for several *** area contains the famous Qingzang plateau with average 5000m altitude and boundless Talimu basin *** this area withtraditional methods had unimaginable difficulties and was impossible to complete at *** the high technology advancing,especially thegreat progresses in geomatics,it is the time to start to map the area with new geo-information *** in 2006,China decided to initiatea large project,named 1:50000 scale topographic mapping of west China(*** China topographic mapping project),in order to getthe 1:50000 scale topographic maps(DEm,DOm and DLG)of that area within next 5 *** we know the weather is extremely atrociousand a lot of sites are out of reach in that area,mapping from aero-born and satellite remote sensing imagery with spares ground control pointswas determined to be the main so

关键词： mapping SPOT geometric modelling DEm accuracy

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Assessing the influence of digital technologies on antenatal care visits in Zimbabwe:insights from 2019 Zimbabwe multiple Indicator Cluster Survey

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Global Health Journal 2023年第3期7卷 167-174页

作者： Elliot mbunge Garikayi bernard Chemhaka Tafadzwa Dzinamarira Enos moyo Department of Computer Science Faculty of Science and EngineeringUniversity of EswatiniKwaluseniManziniM201Eswatini Department of Statistics and Demography Faculty of Social SciencesUniversity of EswatiniKwaluseniManziniM201Eswatini School of Health Systems and Public Health University of PretoriaPretoria 0028South Africa Schoolof Nursing and Public Health College of Health SciencesUniversity of KwaZulu-NatalDurban 3601South Africa

Background and objective:To provide good health and well-being as established by the Sustainable Development Goal(SDG)3,access to digital technologies can act as conduits to achieve such progress in a *** guided by the World Health Organization,antenatal care(ANC)attendance is one of the measures promoted to curtail the global health burden of maternal and infant *** services are seldom utilized to their full potential in *** study explores if any of the women's digital technology characteristics were associated with antenatal care ***:The study analyzed population-based cross-sectional data with a subsample of 1932 women aged 15-49 years from the 2019 Zimbabwe multiple Indicator Cluster *** of associations with chi-square test,bivariate,and multivariate multinomial logistic regression analyses were used to examine the predictors of adequate(4-7)and optimal(≥8)ANC visits relative to undesirable(1-3)antenatal care visits among women who had given births 2 years before the ***:The results indicate that 64.5%(1246/1932)of the women attained adequate ANC while about 9.8%(189/1932)attained optimal *** a newspaper/magazine at least once a week(odds ratio[OR] 1.73,β'=0.551,t=2.030,P=0.043)and watching television at least once a week(OR 1.72,β=0.545,t=2.454,P=0.015),listening to the radio less than once a week(OR 1.28,β'=0.247,t=1.750,P=0.080),and owning a mobile phone(OR 1.48,β'=0.394,t=3.020,P=0.003)were positively associated with adequate *** ANC was significantly associated with women being able to read a newspaper at least once a week(OR 2.93,β'=1.074,t=3.120,P=0.002),listen to the radio less than 0nce a week(OR 2.07,p'=0.73,t=2.700,P=0.007)and have ownership of a mobile phone(OR 1.88,β'=0.631,t=2.620,P=0.009).Conclusion:Access to a newspaper,radio,television,and mobile phone were important predictors of a woman's ability to achieve her ANC *** to improve the knowledge of ANC pa

关键词： Digital technologies maternal and child health Africa Child mortality maternal mortality Prenatal care

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Approaches and tools for user-driven provenance and data quality information in spatial data infrastructures

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International Journal of Digital Earth 2023年第1期16卷 1510-1529页

作者： Julia Fischer Lukas Egli Juliane Groth Caterina Barrasso Steffen Ehrmann Heiko Figgemeier Christin Henzen Carsten meyer Ralph müller-Pfefferkorn Arne Rümmler michael Wagner Lars bernard Ralf Seppelt Department of Computational Landscape Ecology UFZ—Helmholtz Centre for Environmental ResearchLeipzigGermany macroecology and Society Group German Centre for Integrative Biodiversity Research(iDiv)Halle-Jena-LeipzigLeipzigGermany Chair of Geoinformatics Technische Universität DresdenDresdenGermany Institute of Biology Leipzig UniversityLeipzigGermany Institute of Geoscience&Geography Martin Luther University Halle-WittenbergHalle(Saale)Germany Center for Information Services and High Performance Computing Technische Universität DresdenDresdenGermany

Geospatial data are fundamental in most global-change and sustainability-related ***,readily accessible information on data quality and provenance is often missing or hardly accessible for users due to technical or perceptual barriers,for example,due to unstructured metadata information or missing *** an interdisciplinary process encompassing perspectives of data users,data producers,and software developers,we identified major needs to facilitate effectivefitness-for-use assessments by data users and developed approaches to address *** provided a stylized analysis of large-scale land use data to showcase selected *** support data users,interoperable quality and provenance information need to be meaningfully *** producers need efficient workflows and tools supporting them in creating high-quality,structured and detailed quality and provenance *** newly developed approaches to increase the availability of structured metadata synthesize new and existing tools to extract metadata or to generate provenance data during *** our approaches to improve interoperability and accessibility we present novel tools to support(i)the creation of curated and linked registers of data quality indicators and thematic terms,and(ii)linked visualization of data quality and provenance *** our approaches increases transparency,facilitatesfitness-for-use assessments,and ultimately improves research quality.

关键词： Dashboard earthsystem science fitness forpurpose ISO 19157 landuseandland cover data ontology

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