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Sulindac sulfide selectively increases sensitivity of ABCC1 expressing tumor cells to doxorubicin and glutathione depletion

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The Journal of Biomedical Research 2016年第2期30卷 120-133页

作者： Jason d.Whitt Adam B.Keeton bernard d.Gary Larry A.Sklar Kamlesh Sodani Zhe-Sheng Chen Gary A.Piazza department of Biochemistry University of Mississippi Medical Center Cancer Institute Jackson MS 39216 USA drug discovery Research Center Mitchell Cancer Institute University of South Alabama Mobile AL 36604 USA AdT Pharmaceuticals Inc. Orange Beach AL 36561 USA department of Pathology The University of New Mexico Albuquerque NM87131 USA department of Pharmaceutical Sciences St. John's University New York NY 11439 USA

ATP-binding cassette（ABC） transporters ABCC1（MRP1）,ABCB1（P-gp）,and ABCG2（BCRP） contribute to chemotherapy *** primary goals of this study were to characterize the efficacy and mechanism of the nonsteroidal anti-inflammatory drug（NSAId）,sulindac sulfide,to reverse ABCC1 mediated resistance to chemotherapeutic drugs and to determine if sulindac sulfide can influence sensitivity to chemotherapeutic drugs independently of drug *** assays were performed to measure resistance of ABC-expressing cell lines to doxorubicin and other chemotherapeutic *** were tested for the ability to restore sensitivity to resistance selected tumor cell lines,as well as a large panel of standard tumor cell *** experiments characterized the mechanism by which sulindac sulfide inhibits ABCC1 substrate and co-substrate（GSH） transport in isolated membrane vesicles and intact *** reversal of multi-drug resistance（MdR）,decreased efflux of doxorubicin,and fluorescent substrates were demonstrated by sulindac sulfide and a related NSAId,indomethacin,in resistance selected and engineered cell lines expressing ABCC 1,but not ABCB 1 or *** sulfide also inhibited transport of leukotriene C_4 into membrane *** sulfide enhanced the sensitivity to doxorubicin in 24 of 47 tumor cell lines,including all melanoma lines tested（7-7）.Sulindac sulfide also decreased intracellular GSH in ABCC1 expressing cells,while the glutathione synthesis inhibitor,BSO,selectively increased sensitivity to sulindac sulfide induced *** sulfide potently and selectively reverses ABCC1-mediated MdR at clinically achievable ***1 expressing tumors may be highly sensitive to the direct cytotoxicity of sulindac sulfide,and in combination with chemotherapeutic drugs that induce oxidative stress.

关键词： multi-drug resistance doxorubicin sulindac MRP1 glutathione

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从废橡胶中得到高价值工程材料

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橡胶参考资料 1996年第4期26卷 23-28页

作者： bernard d.Bauman 貟晓东

前言废轮胎是一个重要的问题。作为一种消费以后的垃圾,废轮胎几乎没有使用价值,大多数被埋于地下。众所周知经过一段时间以后,埋于地下的整个轮胎就会漂浮到地表面上来,破坏近代大地的层状结构。无用的没有埋于地下的轮胎就被堆集在废... 详细信息

前言废轮胎是一个重要的问题。作为一种消费以后的垃圾,废轮胎几乎没有使用价值,大多数被埋于地下。众所周知经过一段时间以后,埋于地下的整个轮胎就会漂浮到地表面上来,破坏近代大地的层状结构。无用的没有埋于地下的轮胎就被堆集在废轮胎堆里,它们频繁地起火,轮胎燃烧很难被扑灭,并制造大量的空气、土地和水污染。

关键词：橡胶废物处理工程材料

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Measurement of the wavelength modulation indices with selective reflection spectroscopy

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Chinese Optics Letters 2003年第7期1卷 426-428页

作者：肖连团赵建明尹王保赵延霆 bernard Journet 贾锁堂 State Key Lab of Quantum Optics and Quantum devices Department of Electronics & Information Technology Shanxi University Taiyuan 030006 SATIE Lab Ecole Normale Superieure de Cachan 61 Avenue du President Wilson 94230 Cachan France State Key Lab of Quantum Optics and Quantum devices Department of Electronics & Information Technology Shanxi University Taiyuan 030006 SATJE Lab EcoJe Normale Superieure de Cachan 61 Avenue du President Wilson 94230 Cachan France

The wavelength modulation indices are measured based on harmonic amplitude ratio of 4famp/6famp (4famp and 6famp are the 4- and 6-th harmonic central peak amplitudes correspondingly) with the doppler-free selective reflection modulation spectroscopy. The experiments for the 6S1/2(F = 4) → 6P3/2(F' = 5) transition of cesium d2 line with 30-MHz linewidth were carried out. The 4f- and 6f-harmonic signals were detected with two digital lock-in amplifiers separately. The maximum error for modulation indices measurement was ±0.1 within the range of m from 3 to 6. The non-linear modulation behaviour of an external cavity diode laser induced by voltage tuning was studied with this method. The method for modulation indices measurement does not require a solid etalon as usual for measuring the wavelength modulation depth and the absorption linewidth correspondingly.

关键词： of as in on with Measurement of the wavelength modulation indices with selective reflection spectroscopy line form HFS

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含有表面改性聚合物粒子和纤维的聚氨酯

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橡胶参考资料 1993年第9期23卷 34-38页

作者： bernard d. Bauman 刘虹

1 前言在聚氨酯胶料中混入聚合物粒子和纤维可能是聚氨酯技术方面的一个重要进展。材料工程中的这一新技术使加工者能够制造出高物理性能和/或降低成本的成品。通过改变材料的性能/成本比率使聚氨酯比其它材料更有竞争力,从而大大地扩... 详细信息

1 前言在聚氨酯胶料中混入聚合物粒子和纤维可能是聚氨酯技术方面的一个重要进展。材料工程中的这一新技术使加工者能够制造出高物理性能和/或降低成本的成品。通过改变材料的性能/成本比率使聚氨酯比其它材料更有竞争力,从而大大地扩展了聚氨酯材料的市埸。

关键词：聚氨酯表面改性聚合物粒子纤维

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Barcelona clinic liver cancer nomogram and others staging/scoring systems in a French hepatocellular carcinoma cohort

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World Journal of Gastroenterology 2017年第14期23卷 2545-2555页

作者： Xavier Adhoute Guillaume Pénaranda Jean Luc Raoul Julien Edeline Jean-Frédéric Blanc bernard Pol Manuela Campanile HervéPerrierO livier Bayle Olivier Monnet Patrick Beaurain Cyril Muller Paul Castellani Yves Patrice Le Treut Jean Pierre Bronowicki Marc Bourlière department of Hepato-Gastroenterology Hopital Saint-Joseph Marseille Alpha Bio Laboratory Marseille department of Hepato-Gastroenterology and digestive Oncology Institut Paoli-Calmette Marseille department of Hepato-Gastroenterology and digestive Oncology Centre Eugène Marquis Rennes department of Hepato-Gastroenterology Centre Hospitalo-Universitaire Saint-AndréBordeaux department of Hepatobiliary Surgery Hopital Saint-Joseph Marseille department of Radiology Hopital Saint-Joseph Marseille department of Hepatobiliary Surgery Centre Hospitalo-Universitaire Timone Marseille department of Hepato-Gastroenterology Centre Hospitalo-Universitaire de Nancy INSERM U954 Universitéde LorraineCHU de NancyVandoeuvre les Nancy

AIM To compare the performances of the Barcelona clinic liver cancer(BCLC) nomogram and others systems(BCLC, HKLC, CLIP, NIACE) for survival prediction in a large hepatocellular carcinoma(HCC) French *** data were collected retrospectively from 01/2007 to 12/2013 in five French centers. Newly diagnosed HCC patients were analyzed. The discriminatory ability, homogeneity ability, prognostic stratification ability Akaike information criterion(AIC) and C-index were compared among scoring systems. RESULTS The cohort included 1102 patients, mostly men, median age 68 [60-74] years with cirrhosis(81%), child-Pugh A(73%), alcohol-related(41%), HCV-related(27%). HCC were multinodular(59%) and vascular invasion was present in 41% of cases. At time of HCC diagnosis BCLC stages were A(17%), B(16%), C(60%) and d(7%). First line HCC treatment was curative in 23.5%, palliative in 59.5%, BSC in 17% of our population. Median OS was 10.8 mo [4.9-28.0]. Each system distinguished different survival prognosis groups(P d the highest discriminatory ability, the highest C-index value. NIACE score had the lowest AIC value. The nomogram distinguished sixteen different prognosis groups. By classifying unifocal large HCC into tumor burden 1, the nomogram was less powerful. CONCLUSION In this French cohort, the BCLC nomogram and the NIACE score provided the best prognostic information, but the NIACE could even help treatment strategies.

关键词： Barcelona clinical liver cancer Hong kong liver cancer NIACE CLIP Hepatocellular carcinoma

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Evidence of SARS-CoV-2 infection in pets,captive non-human primates and farm animals in Central Africa

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Asian Pacific Journal of Tropical Medicine 2022年第5期15卷 232-235页

作者： Gael d.Maganga Barthelemy Ngoubangoye Jumafra P.Koumba Sonia Lekana-douki Ivan C.Moussadji Kinga Thierry A.Tsoumbou Antoine M.Mbeang Beyeme Telstar G.Ndong Mebaley Jean-bernard Lekana-douki Centre Interdisciplinaire de Recherches Medicales de Franceville(CIRMF) Unite Emergence des Maladies ViralesBP 769FrancevilleGabon Institut National Superieur d’Agronomie et de Biotechnologies(INSAB) Universite des Sciences et Techniques de Masuku(USTM)BP 941FrancevilleGabon Universite de Lyon Universite Lyon 1CNRSLaboratoire de Biometrie et Biologie evolutive UMR 555869622 VilleurbanneFrance LabEx ECOFECT Eco-evolutionary Dynamics of Infectious DiseasesUniversity of LyonLyonFrance

It has been reported that the host of SARS-CoV-2 can be extremely wide due to the conservation of angiotensin converting enzyme 2 in mammals[1].Several studies have reported natural or experimental infection with SARS-CoV-2 in pets,farm and captive wild animals[2-4].However,to the best of our knowledge,there was no published study assessing virus circulation among domestic or captive animals in Central,West and East *** this study,we assessed the presence and circulation of SARS-CoV-2 or other betacoronaviruses in pets,livestock and animals kept in captivity in conservation centers in Haut-Ogoouéprovince,southeastern Gabon.

关键词： Central southeastern Africa

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Large-scale mapping of the Ebola NP and GP proteins reveals multiple immunoprevalent and conserved Cd4 T-cell epitopes

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Cellular & Molecular Immunology 2021年第5期18卷 1323-1325页

作者： Yann Gallais Raphaël Sierocki Gautier Lhomme Coline Sivelle divor Kiseljak Florian Wurm Sami djoulah Ahmed Bouzidi Jérôme Kerzerho bernard Maillère département Médicament et Technologie pour la Santé SIMoSUniversitéParis-SaclayCEA-Saclay91191Gif surYvetteFrance Excellgene MontheySwitzerland Wiratech Europe Genopole91000EvryFrance Vaxeal holding SA VeveySwitzerland

Humankind faces regular outbreaks from emerging viruses,such as Ebola and the current SARS-CoV-2,or from viruses circulating at low levels in the wild animal *** to the suddenness of virus expansion,the lack of knowledge of immune determinants and correlates of protection severely limit the ability to address the *** in 1976,Ebola virus is part of the Filoviridae family and causes severe hemorrhagic fever with a mortality rate between 50%and 90%.From 2013 to 2020,more than 30,000 infections and 15,000 deaths have been reported *** antibody titers against Ebola virus GP are found in patients recovering from Ebola virus infection and correlate with protection in vaccination models.1 Both Cd8 and Cd4 T-cell responses also seem to participate in the control of Ebola virus infection in animals,and Cd4 T cells are necessary to induce resistance to Ebola virus challenge.

关键词： Ebola mortality hemorrhagic

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Innovative Solutions in Induction Heating for Better Energy Efficiency:Presentation of ISIS Project

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Journal of Iron and Steel Research International 2012年第S2期19卷 646-652页

作者： PAYA bernard GAGNOUd Annie MAUSSION Pascal ROEHR Philippe BREVILLE Thierry NEMER Maroun GOUPIL Christophe Coordinator of ISIS Project EDF R&DEco-Efficiency & Industrial Processes DptCentre des RenardieresF-77818 Morêt sur Loing CedexFrance SIMAP/EPM 1340Rue de la Piscine BP 75F-38402 Saint Martin d'Hères CedexFrance LAPLACE/COdIASE 2.Rue Charles CamichelBP 7122F-31071 Toulouse Cedex 7France FIVES CELES 89bisRue PrincipaleF-68610 LautenbachFrance ATYS CONSULTANTS ZA du pré ROBELIN358 route d'UriageF-38320 HerbeysFrance ARMINES/CEP ZI Les Glaizes5 rue Leon BlumF-91120 Palaiseau France CRISMAT ENSICAEN6Boulevard du Marechal JuinF-14050 CaenFrance

The Energy Climate Package is the EU response to the Global Warming *** heating processes can contribute to the energy saving goal:20%saving within *** induction manufacturer already propose many efficient solutions at industrial *** improve induction devices for an always better energy efficiency, EdF R&d set up a French cooperative project called ISIS with a financial support of the French National Research *** objective is to promote induction heating as Best Available Technology(BAT)and to develop innovative solutions to increase its *** ISIS innovations concern the electroheat conversion of induction devices(auto-adaptive multi-coil power supply,low losses coils)and the recovering of fatally lost *** paper shows the mid-term results of this *** control algorithms were successfully tested on a 100 kW 3-coil power supply.A homogenization technique is proposed to model a multi-strand coil.A heat recovery test bench is build and equipped with a PFC control loop to fit with the production fluctuations.

关键词： induction heating energy efficiency multi-coil power supply multi-strand coil energy recovery PFC

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A Method to Predict Amino Acids at Proximity of Beta-Sheet Axes from Protein Sequences

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Applied Mathematics 2014年第1期5卷 79-89页

作者： Antonin Guilloux bernard Caudron Jean-Luc Jestin Analyse Algébrique Institut de Mathématique de Jussieu Université Pierre et Marie Curie Paris France Centre d’Informatique Pour la Biologie Institut Pasteur Paris France département de Virologie Institut Pasteur Paris France

A general and elementary protein folding step was described in a previous article. Energy conservation during this folding step yielded an equation with remarkable solutions over the field of rational numbers. Sets of sequences optimized for folding were derived. In this work, a geometrical analysis of protein beta-sheet backbone structures allows the definition of positions of topological interest. They correspond to amino acids’ alpha carbons located on a unique axis crossing all beta-sheet’s strands or at proximity of this axis defined here. These positions of topological interest are shown to be highly correlated with the absence of sequences optimized for folding. Applications in protein structure prediction for the quality assessment of structural models are envisioned.

关键词： Polypeptide Chain Protein Structure Topology Beta-Strand Folding Amino Acid Structure Prediction

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Predictive factors of survival in patients treated with definitive chemoradiotherapy for squamous cell esophageal carcinoma

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World Journal of Gastroenterology 2006年第26期12卷 4185-4190页

作者： Frédéric di Fiore Stéphane Lecleire Olivier Rigal Marie-Pierre Galais Emmanuel Ben Soussan Isabelle david bernard Paillot Jacques-Henri Jacob Pierre Michel digestive Oncology Unit Hepatogastroenterology department Rouen University HospitalFrance digestive Oncology unit Francois Baclesse Centre CaenFrance Radiotherapy department Henri Becquerel Centre RouenFrance

AIM： The aim of the study was to evaluate the predictive factors of survival in patients with locally advanced squamous cell esophageal carcinoma （LASCOC） treated with definitive chemoradiotherapy （CRT） regimen based on the 5FU/CddP combination. METHOdS： All patients with LASCOC treated with a definitive CRT using the 5FU/CddP combination between 1994 and 2000 were retrospectively included. Clinical complete response （CCR） to CRT was assessed by esophageal endoscopy and C-F-scan 2 mo after CRT completion. Prognostic factors of survival were assessed using univariate and multivariate analysis by the Cox regression model. RESULTS： A total of 116 patients were included in the study. A CCR to CRT was observed in 86/116 （74.1%）. The median survival was 20 mo （range 2-114） and the 5-year survival was 9.4%. Median survival of responder patients to CRT was 25 mo （range 3-114） as compared to 9 mo （range 2-81） in non-responder patients （P 〈 0.001）. In univariate analysis, survival was associated with CCR （P 〈 0.001）, WHO performance status 〈 2 （P = 0.01）, tumour length 〈 6 cm （P = 0.045） and weight loss 〈 10% was in limit of significance （P = 0.053）. In multivariate analysis, survival was dependant to CCR （P 〈 0.0001）, weight loss 〈 10% （P = 0.034） and WHO performance 〈 2 （P = 0.046）. CONCLUSION： Our results suggest that survival in patients with LASCOC b＇eated with definitive CRT was correlated to CCR, weight loss and WHO performance status.

关键词： definitive chemoradiotherapy Esophageal squamous cell carcinoma Predictive factors

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