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Selective serotonin reuptake inhibitors and Alzheimer’s disease

Neural Regeneration Research 2020年第1期15卷 41-46页

作者： bernadette mdawar Elias Ghossoub Rita Khoury Department of Psychiatry American University of Beirut Medical CenterBeirutLebanon Department of Psychiatry and Behavioral Neuroscience Saint Louis University School of MedicineSt.LouisMOUSA

Given the failure to develop disease-modifying therapies for Alzheimer’s disease(AD),strategies aiming at preventing or delaying the onset of the disease are being *** the debate regarding whether depression is an etiological risk factor or a prodrome of AD rages on,a key determining factor may be the timing of depression onset in older *** is increasing evidence that untreated early-onset depression is a risk factor and that late-onset depression may be a catalyst of cognitive *** from animal studies have shown a beneficial impact of selective serotonin reuptake inhibitors on pathophysiological biomarkers of AD including amyloid burden,tau deposits and *** humans,studies focusing on subjects with a prior history of depression also showed a delay in the onset of AD in those treated with most selective serotonin reuptake ***,which has strong anticholinergic properties,was associated with increased mortality and mixed effects on amyloid and tau deposits in mice,as well as increased odds of developing AD in *** most of the data regarding selective serotonin reuptake inhibitors is promising,findings should be interpreted cautiously because of notable methodological heterogeneity between *** is thus a need to conduct large scale randomized controlled trials with long follow up periods to clarify the dose-effect relationship of specific serotonergic antidepressants on AD prevention.

关键词： Alzheimer’s disease amyloidogenesis animal models antidepressant depression onset delay prevention selective serotonin reuptake inhibitor SSRI

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