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Congophilic fibrils in the glomeruli with polyclonal immunoglobulin gamma staining-another cause for diagnostic overlap:A case report

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World Journal of Clinical Cases 2024年第17期12卷 3200-3205页

作者： Maria bernadette Che-Ying Chow Lucas Bushrow Irmeen Siddiqui April Chiu Mirza Hamirani Anjali A Satoskar Department of Pathology The Ohio State University Medical CenterColumbusOH 43210United States Department of Pathology North District HospitalSheung ShuiHong KongChina Department of Laboratory Medicine and Pathology Mayo ClinicRochesterMN 55905United States Department of Internal Medicine S.Joseph's HospitalParkersburgWV 26101United States

BACKGROUND Glomerulopathy with fibrillary deposits is not uncommon in routine nephropathology practice,with amyloidosis and fibrillary glomerulonephritis being the two most frequently encountered *** amyloid heavy and light chain(AHL)is relatively uncommon and its biopsy diagnosis is usually limited to cases that show strong equivalent staining for a single immunoglobulin(Ig)heavy chain and a single light chain,further supported by mass spectrometry(MS)and serum studies for monoclonal *** polyclonal light chain staining can pose a *** SUMMARY Herein we present a challenging case of renal AHL with polyclonal and polytypic Ig gamma(IgG)staining pattern by *** patient is a 62-yearold Caucasian male who presented to an outside institution with a serum creatinine of up to 8.1 mg/dL and nephrotic range *** the finding of a polyclonal and polytypic staining pattern on immunofluorescence,ultrastructural study of the renal biopsy demonstrated the presence of fibrils with a mean diameter of 10 *** red was positive while DNAJB9 was *** suggested a diagnosis of amyloid AHL type with IgG and lambda,but kappa light chains were also present supporting the immunofluorescence staining *** immunofixation studies demonstrated IgG lambda monoclonal *** patient was started on *** chronic renal injury however was quite advanced and he ended up needing dialysis shortly *** Tissue diagnosis of AHL amyloid can be *** confirmation using other available diagnostic techniques is recommended in such cases.

关键词： Heavy and light chain amyloid Fibrillary glomerulonephritis DNAJB9 Serum immunofixation Protein electrophoresis Mass spectrometry Congo red Case report

Comparative Study of Gut Microbiota in Breast Cancer Patients versus Controls in Abidjan, Côte d’Ivoire

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Advances in Microbiology 2024年第9期14卷 405-415页

作者： M’Bengue Gbonon Valérie Gnahore Djeda Franck Kouadio Kouamé Assohoun Stanislas Coulibaly Safiatou Diplo Flore bernadette Sekongo Mamadou Osseni Akandji Afran Sidje Arlette N’Guessan Jean-David Dosso Mireille Molecular Genetics Platform Institut Pasteur de Cte dIvoire Abidjan Cte dIvoire Laboratory of Biology and Health UFR Biosciences Flix Houphout Boigny University Abidjan Cte dIvoire Department of Environment and Health Institut Pasteur de Cte dIvoire Abidjan Cte dIvoire Bioinformatics & Computational Biology Group National Computing Center of Cte dIvoire Flix Houphout Boigny University Bingerville Cte dIvoire National Blood Transfusion Center Abidjan Cte dIvoire Oncology Department Treichville University Hospital Abidjan Cte dIvoire

Context: The gut microbiota represents a complex ecosystem encompassing all unicellular microorganisms residing in the digestive tract, primarily bacteria, fungi, archaea, and even viruses. The relationship between the host and the microbiota is symbiotic: bacteria benefit from a stable environment, while the host gains numerous capabilities in terms of digestion, metabolism, nutrition, and immunity. However, numerous studies suggest that the gut microbiota plays a crucial role in various non-communicable diseases, including obesity, chronic inflammatory bowel diseases, allergic and immune disorders, behavioral disorders, and even certain cancers. The objective of our study was to characterize the gut microbiota of a group of breast cancer patients by comparing it to that of control subjects in Côte d’Ivoire, using a metagenomic approach. Method: A case-control study was conducted from May 2020 to September 2023. A total of 85 women (39 cases and 46 controls) were recruited, and stool samples were collected from both breast cancer patients and healthy women. Among these, ten (10) samples from patients and ten (10) samples from healthy women were randomly selected for the study of the gut microbiota. The gut microbiota was characterized by sequencing the V4 region of 16S rRNA using metagenomic NGS technology, and bioinformatic analysis was performed using the mothur pipeline. Results: In women with breast cancer, we observed a reduction in the relative abundance of the phyla Firmicutes and Bacteroidetes, as well as an increase in the phyla Actinobacteria and Verrucomicrobia. Additionally, their microbiota exhibited lower Chao1 and Sobs diversities compared to the control women (p < 0.05). Molecular variance analysis (AMOVA) revealed a significant difference between the case and control groups (p < 0.001). This study has highlighted a significant difference in the relative abundance of major phyla within the gut microbiota of cases compared to healthy controls. It wil

关键词： Gut Microbiota 16S Metagenomic Sequencing Breast Cancer Dysbiosis

Homogenization of Periodically Heterogeneous Thin Beams

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Chinese Annals of Mathematics,Series B 2018年第3期39卷 397-426页

作者： Georges GRISO bernadette MIARA Laboratoire J.-L.Lions-CNRS Bote courrier 187Universite Pierre et Marie Curie4 Place Jussieu75005 ParisFrance Universite Paris-Est 5 boulevard DescartesChamps-sur-Marne77454 Marne-la-Vallee Cedex2France

Consider an elastic thin three-dimensional body made of a periodic distribution of elastic *** both the thickness of the beam and the size of the heterogeneities tend simultaneously to zero the authors obtain three di... 详细信息

关键词： Bernoulli-Navier model Beam Korn's inequalities Dimensional reduction Homogenization

Aromatic,Medicinal Plants and Vulnerability of Traditional Herbal Knowledge in a Berber Community of the High Atlas Mountains of Morocco

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植物分类与资源学报 2014年第3期36卷 388-402页

作者： bernadette Montanari Centre for BioCultural Diversity University of Kent UK

This article compliments the S18 session( transmission of traditional ecological knowledge and conservation of medicinal plants) at the 13th International Congress of Ethnobiology( ISE) in Montpellier,France( May2012). The aim of the article is to provide an insight into the livelihoods of a Berber community,a village of the High Atlas Mountains of Morocco,of the local biodiversity and most importantly,the prevalent use of medicinal plants for primary health care. It seeks to demonstrate the value of traditional ecological and herbal knowledge for the subsistence of the community and emphasises the vital role that family and community connections play for the transmission of traditional herbal knowledge within the community.

关键词： Aromatic and medicinal plants Berber communities Erosion of traditional herbal knowledge Morocco

Selective serotonin reuptake inhibitors and Alzheimer’s disease

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Neural Regeneration Research 2020年第1期15卷 41-46页

作者： bernadette Mdawar Elias Ghossoub Rita Khoury Department of Psychiatry American University of Beirut Medical CenterBeirutLebanon Department of Psychiatry and Behavioral Neuroscience Saint Louis University School of MedicineSt.LouisMOUSA

Given the failure to develop disease-modifying therapies for Alzheimer’s disease(AD),strategies aiming at preventing or delaying the onset of the disease are being *** the debate regarding whether depression is an etiological risk factor or a prodrome of AD rages on,a key determining factor may be the timing of depression onset in older *** is increasing evidence that untreated early-onset depression is a risk factor and that late-onset depression may be a catalyst of cognitive *** from animal studies have shown a beneficial impact of selective serotonin reuptake inhibitors on pathophysiological biomarkers of AD including amyloid burden,tau deposits and *** humans,studies focusing on subjects with a prior history of depression also showed a delay in the onset of AD in those treated with most selective serotonin reuptake ***,which has strong anticholinergic properties,was associated with increased mortality and mixed effects on amyloid and tau deposits in mice,as well as increased odds of developing AD in *** most of the data regarding selective serotonin reuptake inhibitors is promising,findings should be interpreted cautiously because of notable methodological heterogeneity between *** is thus a need to conduct large scale randomized controlled trials with long follow up periods to clarify the dose-effect relationship of specific serotonergic antidepressants on AD prevention.

关键词： Alzheimer’s disease amyloidogenesis animal models antidepressant depression onset delay prevention selective serotonin reuptake inhibitor SSRI

Some Fuzzy Logic Based Methods to Deal with Sensorial Information

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Journal of Donghua University(English Edition) 2004年第3期21卷 5-8页

作者： bernadette Bouchon-Meunier CNRS-Université Pierre et Marie Curie LIP6 Pole IA 8 rue du Capitaine Scott75015 Paris France

Sensorial information is very difficult to elicit, to represent and to manage because of its complexity. Fuzzy logic provides an interesting means to deal with such information, since it allows us to represent imprecise, vague or incomplete descriptions, which are very common in the management of subjective information. Aggregation methods proposed by fuzzy logic are further useful to combine the characteristics of the various components of sensorial information.

关键词： Sensorial information. Fuzzy logic Possibility theory.

Research on the Factors Influencing the Development of Cross-Border E-Commerce in South Africa-Based on the Analysis of the Wine Industry

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Research on the Factors Influencing the Development of Cross...

作者： bernadette Sibanda 浙江科技学院

学位级别：硕士

With the development of the communications industry and the internet more and more emerging countries have developed ***,with such changes in internet technology,cross-border e-commerce（CBEC）has started to advance as a new trade model,which plays a pivotal role in South Africa’s CBEC and export trade,to meet up with the developed *** the same time with the favorable situation with the traditional markets in Europe,South Africa’s wine industry is now seeking to export more of its products to *** shopping has been increasing vividly worldwide in the past *** Africa is no special *** research seeks to examine the key factors influencing CBEC development level in South Africa based on the analysis of the wine *** achieve this objective the study evaluated the relevant micro and macro factors influencing crossborder e-commerce development levels in South Africa using the factor analysis *** paper mainly uses the factor analysis method to analyze the relevant micro and macro *** macro factors use the PESTEL analysis *** analysis,also known as environmental analysis,is a method to investigate the external influence factors affecting the organization,including political,economic,social,technical,environmental,and legal *** study also incorporated micro factors specific to the South African wine *** study takes some of the 13 biggest wine exporters in South Africa as a sample,analyses the influence factors affecting the development level of cross-border e-commerce in the country,and puts forward some countermeasures and *** this paper,four main theories underpinning the study were examined and these include;trade facilitation,trade intermediary theory,transaction cost theory,and trade risk *** theories formed the basic theoretical analysis *** factor analysis was employed to analyze the micro and macro factors influencing the CBEC development level in Sout

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Delivery of acupuncture in clinical trials:Research acupuncturists’perspectives

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Journal of Integrative Medicine 2023年第4期21卷 315-319页

作者： Joyce K.Anastasi bernadette Capili Jessica Neumaier Londa Hackett Division of Special Studies in Symptom Management New York UniversityNew YorkNY 10010USA Heilbrunn Family Center for Research Nursing the Rockefeller UniversityNew YorkNY 10065USA

Delivery of acupuncture in the setting of a clinical trial is a unique practice that diverges significantly from the delivery of acupuncture in a real-world clinical setting. Research acupuncturists, particularly those trained in traditional Chinese medicine(TCM), are often required to set aside valued precepts of traditional care, including diagnosing imbalances, individualizing treatment, and forging a therapeutic relationship with patients. TCM-trained acupuncturists express mixed feelings about participating in clinical trials. Many are eager to play a vital role in the advancement of acupuncture science and appreciate the need for strict protocol adherence to minimize bias. However, the acupuncturist(s) may also have concerns about clinical trial methodology, including but not limited to the delivery of a control condition, e.g., sham acupuncture. Investigators should anticipate certain questions and even a level of resistance to the requirements of research among acupuncturists and be prepared to address them. This manuscript presents a brief review of the subjective experience of the research acupuncturist within the available scientific literature as it pertains to the delivery of active and sham clinical research protocols. Our goals are to better understand the perspectives of acupuncturists who may participate in clinical research, so that their concerns may be addressed in study design and methodology. To that end, we suggest the creation of a novel training program specifically for clinical trial acupuncturists, intended for qualified TCM-and Western-trained practitioners, that would help to standardize the research acupuncturist’s role and help to strengthen the design and execution of acupuncture studies.

关键词： Acupuncture Traditional Chinese medicine Clinical protocols Health knowledge,attitudes,practice Researcher-subject relationship Placebos

The human leucocyte differentiation antigens (HLDA) workshops: the evolv-ing role of antibodies in research, diagnosis and therapy

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Cell Research 2005年第9期 16-19页

作者： Heddy ZOLA,bernadette SWART Leucocyte Biology Laboratory Child Health Research Institute 72 King William Road North Adelaide 5006 Australia Leucocyte Biology Laboratory Child Health Research Institute 72 King William Road North Adelaide 5006 Australia

The 8th International Workshop on Human Leucocyte Differentiation Antigens (chaired by Zola H and managed by Swart B) was run over a 4-year period and culminated in a conference in December 2004. Here we review the achieve- ments of the HLDA Workshops and provide links to information on CD molecules and antibodies against them, including the 93 new CDs assigned in the 8th Workshop. We consider what remains to be achieved (including an estimate of the number of leucocyte surface molecules still to be discovered), and how the field can best move forward.

关键词： leucocyte differentiation antigens CD molecules cell markers.