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年龄20~30岁人群冠状动脉钙化预测:冠状动脉钙化研究

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中华高血压杂志 2020年第5期28卷 444-444页

作者：周卫(译) 叶鹏(校) Oseia Ad Uddin SMI dzayea O Achirica MC dardari ZA Obisesan OH Kianoush S Mirbolouk M Orimoloye OA Shaw L Rumberger JA berman d Rozanski A Miedema Md Budoff MJ Vasan RS Nasir K Blaha MJ 不详

该文旨在研究早期冠状动脉钙化(coronary artery calcium,CAC)的相关危险因素,以及CAC在20~30岁成年人中的潜在临床研究价值。方法:纳入CAC研究中基线年龄20~30岁的患者(n=373)作为研究对象,该研究为大型多中心队列研究,研究对象为年龄... 详细信息

该文旨在研究早期冠状动脉钙化(coronary artery calcium,CAC)的相关危险因素,以及CAC在20~30岁成年人中的潜在临床研究价值。方法:纳入CAC研究中基线年龄20~30岁的患者(n=373)作为研究对象,该研究为大型多中心队列研究,研究对象为年龄≥18岁无动脉粥样硬化性心血管病(atherosclerotic cardiovascular disease,ASCVd)的患者,应用CAC评分进行临床风险分层。

关键词：冠状动脉钙化动脉粥样硬化性心血管病风险分层 artery 基线年龄相关危险因素临床研究价值

冠状动脉钙化筛查对于无症状吸烟者和非吸烟者的预后价值比较

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世界核心医学期刊文摘（心脏病学分册） 2006年第9期2卷 26-26页

作者： Shaw L.J. Raggi P. Callister T.Q. berman d.S. 刘文秀 Cedars-Sinai Medical Center Taper Building8700 Beverly BoulevardLos AngelesCA 90048United States

Aims: To determine the extent and prognostic significance of coronary artery c alcium in asymptomatic smokers and nonsmokers. Population data are available on the prognostic impact of smoking on atherosclerotic imaging measurements of the carotid and peripheral arteries. Limited data are available on the impact of cig arette smoking on the prognostic value of coronary calcium. Methods and results: A referred patient registry of 10 377 asymptomatic individuals(40%were current smokers) was followed for death from all-causes at 5 years. Univariable and mu ltivariable Cox proportional hazard models were calculated to estimate time to a ll-cause mortality. Cumulative 5-year survival was 96.9 and 98.4%for smokers when compared with non-smokers(Pd Cox proportional hazards survival analysis, survival for non-smokers ranged from 99.7 to 89.6%w ith calcium score of 0-10 and >1000(Pd surv ival rates ranging from 99.5 to 81.4%for calcium score of 0-10 to >1000(Pdditive relationship between age and calcium that was exacerbate d with smoking, resulting in higher relative risk ratios for older smokers with coronary calcium(P1000 was associated with a relative risk ratio that was elevated 8.9-fold(P=0.029). Thus, resulting in an expected reduction in life expectancy of 4.8 years for sm okers400(Pdentifying a h igh-risk cohort of asymptomatic smokers and non-smokers. Young smokers with hi gh-risk calcium scores have a four-to nine-fold increased risk of dying when compared with similarly aged non-smokers. When prospectively applied, evidence of a high-risk calcium score may be useful in educating patients as to their ex pected

关键词：冠状动脉钙化无症状吸烟者非吸烟者预后价值 Cox比例风险模型外周动脉粥样硬化 5年生存率查对

Key factors in developing the trinitrobenzene sulfonic acid-induced post-inflammatory irritable bowel syndrome model in rats

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World Journal of Gastroenterology 2012年第20期18卷 2481-2492页

作者： Hong-Yan Qin Hai-Tao Xiao Justin CY Wu Brian M berman Joseph JY Sung Zhao-Xiang Bian School of Chinese Medicine Hong Kong Baptist University Hong Kong 999077 China Faculty of Medicine The Chinese University of Hong Kong.Hong Kong 999077 China Center for Integrative Medicine University of Maryland School of Medicine Baltimore MD 21201 United States

AIM:To investigate the key factors in developing the trinitrobenzene sulfonic acid(TNBS)-induced postinflammatory irritable bowel syndrome(PI-IBS)model in rats. METHOdS:TNBS was administered to rats at the following conditions:(1)with different doses(20,10,5 mg/0.8 mL per rat);(2)with same dose in different concentrations(20 mg/rat,25,50 mg/mL);(3)in different ethanol percentage(25%,50%);and(4)at depth either 4 cm or 8 cm from *** 5 d and 4 wk after TNBS administration,inflammation severity and inflammation resolution were *** 4 and 8 wk after TNBS application,visceral hyperalgesia and enterochromaffin(EC)cell hyperplasia were assayed by abdominal withdrawal reflex test,silver staining and capillary electrophoresis. RESULTS:Our results showed that:(1)TNBS induced dose-dependent acute inflammation and inflammation *** 5 d post TNBS,the pathological score and myeloperoxidase(MPO)activity in all TNBS treated rats were significantly elevated compared to that of the control(9.48±1.86,8.18±0.67,5.78± 0.77 vs 0,and 3.55±1.11,1.80±0.82,0.97±0.08 unit/mg vs 0.14±0.01 unit/mg,Pd median dose TNBS-treated rats were still significantly higher than that of the control(1.52±0.38 and 0.80±0.35 vs 0,Pdministration position affected the persistence of visceral *** 4 wk post TNBS,abdominal withdrawal reflex (AWR)threshold pressure in all TNBS-treated groups were decreased compared to that of the control(21.52 ±1.73 and 27.10±1.94 mmHg vs 34.44±1.89 mmHg,Pd pressure in 8 cm administration group was still significantly decreased(23.33±1.33 mmHg vs 36.79±2.29 mmHg,Pd the TNBS-induced inflammation severity and visceral *** TNBS-25%ethanol-treated group,the pathological score and MPO activity were significantly lowered compared to that of the TNBS-50%ethanoltreated group,while AWR thres

关键词： Post-inflammatory Irritable bowel syndrome Rat model Trinitrobenzene sulfonic acid Key factors

Control of autoimmune arthritis by herbal extracts and their bioactive components

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Asian Journal of Pharmaceutical Sciences 2016年第2期11卷 301-307页

作者： Shivaprasad H.Venkatesha Brian Astry Siddaraju M.Nanjundaiah Hong R.Kim Rajesh Rajaiah Yinghua Yang Li Tong Hua Yu Brian M.berman Kamal d.Moudgil department of Microbiology and Immunology University of Maryland School of MedicineBaltimoreMD 21201United States Southern Medical University GuangzhouChina Center for Integrative Medicine University of Maryland School of MedicineBaltimoreMD 21201United States division of Rheumatology Department of MedicineUniversity of Maryland School of MedicineBaltimoreMD 21201United States

Autoimmune diseases such as rheumatoid arthritis (RA) cause significant morbidity and loss of productivity. Many potent conventionally used drugs are available for these diseases, but their prolonged use is accompanied by severe adverse effects besides a high ***, there is an unmet need for effective but less expensive medications for RA and other autoimmune diseases. Natural plant products belonging to the traditional systems of medicine, such as the traditional Chinese medicine and Indian Ayurvedic medicine, offer a vast and promising resource in this regard. However, herbal medicinal products are often poorly characterized for their composition as well as mechanisms of action. We review here the results of our systematically performed studies aimed at defining the anti-arthritic activity of three herbal extracts, namely, modified Huo-luo-xiao-ling dan (HLXL), Celastrus aculeatus Merr., and polyphenolic fraction of green tea (Camellia sinensis), as well as a purifiedcompound Celastrol, a bioactive component of Celastrus. Specifically, we examined the effects of these herbal products on the immunological, biochemical and molecular biological effector pathways in autoimmune arthritis. We have also reviewed here related studies on these herbal products by other investigators. Taken together, we suggest further testing of these herbal products in RA patients.

关键词： drug discovery Herbal medicine Immune response Traditional Chinese medicine Natural products Rheumatoid arthritis

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全新版新世纪走遍美国·学习指导 3

2008年

作者： Michael berman Janet Battiste

本书主要目的是帮助学生提高口语交际能力。每个单元都根据相应剧集的剧情设计了多种双人、小组和全班活动。

ISBN: (纸本)9787301143797

本书主要目的是帮助学生提高口语交际能力。每个单元都根据相应剧集的剧情设计了多种双人、小组和全班活动。

关键词：英语自学参考资料

来源：畅想之星图书光盘版（南... 评论

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全新版新世纪走遍美国·学习指导 1

Clinical laboratory and imaging evidence for effectiveness of agarose-agarose macrobeads containing stem-like cells derived from a mouse renal adenocarcinoma cell population (RMBs) in treatment-resistant, advanced metastatic colorectal cancer:Evaluation of

2008年

作者： Michael berman Janet Battiste等

本书的主要目标是帮助学习者掌握听力理解的技艺,同时更透彻地理解《全新版新世纪走遍美国》剧集中的人物和故事线索。

ISBN: (纸本)9787301143773

本书的主要目标是帮助学习者掌握听力理解的技艺,同时更透彻地理解《全新版新世纪走遍美国》剧集中的人物和故事线索。

关键词：英语自学参考资料

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Chinese Journal of Cancer Research 2018年第1期30卷 72-83页

作者： Barry H.Smith Lawrence S.Gazda Thomas J.Fahey Angelica Nazarian Melissa A.Laramore Prithy Martis Zoe P.Andrada Joanne Thomas Tapan Parikh Sudipta Sureshbabu Nathaniel berman Allyson J.Ocean Richard d.Hall david J.Wolf The Rogosin Institute New York NY 10021 USA The Rogosin Institute-Xenia division Xenia OH 45385 USA New York Presbyterian-Weill Cornell Medical Center New York NY 10021 USA Bob Evans Farms Inc. New Albany OH 43054 USA

Objective： The complexity, heterogeneity and capacity of malignant neoplastic cells and tumors for rapid change and evolution suggest that living-cell-based biological-systems approaches to cancer treatment are merited. Testing this hypothesis, the tumor marker, metabolic activity, and overall survival（OS） responses, to the use of one such system, implantable macrobeads [RENCA macrobeads（RMBs）], in phase I and IIa clinical trials in advanced,treatment-resistant metastatic colorectal cancer（m CRC） are described ***： Forty-eight m CRC patients（30 females; 18 males）, who had failed all available, approved treatments,underwent RMB implantation（8 RMB/kg body weight） up to 4 times in phase I and phase IIa open-label ***, labs [tumor and inflammation markers, lactate dehydrogenase（LdH）] and positron emission tomography-computed tomography（PET-CT） imaging to measure number/volume and metabolic activity of the tumors were performed pre-and 3-month-post-implantation to evaluate safety and initial efficacy（as defined by biological responses）. PET-CT maximum standard uptake value（SUVmax）（baseline and d 90; SUVmax ≥2.5）, LdH,and carcinoembryonic antigen（CEA） and/or cancer antigen 19-9（CA 19-9） response（baseline, d 30 and/or d 60）were assessed and compared to ***： Responses after implantation were characterized by an at least 20% decrease in CEA and/or CA 19-9 in75% of patients. Fluorodeoxyglucose（FdG）-positive lesions（phase I, 39; 2 a, 82） were detected in 37/48 evaluable patients, with 35% stable volume and stable or decreased SUV（10） plus four with necrosis; 10, increased tumor volume, SUV. LdH levels remained stable and low in Responders（R）（d 0–60, 290.4–333.9）, but increased steadily in Non-responders（NR）（d 0–60, 382.8–1,278.5）（d 60, P=0.050）. Responders to RMBs, indicated by the changes in the above markers, correlated with OS（R mean OS=10.76 months; NR mean OS=4.9 months; P=0.0006）.Conclusions： The correlations of the tumor marker, tumor volume

关键词： Clinical trial systems-biology RENCA macrobeads metastatic colorectal cancer colon cancer

Approaching democracy / Larry berman, Bruce Allen Murphy. 5th ed.

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9070型和9071型自容式数字温盐深剖面系统

2007年

作者： Larry berman Bruce Allen Murphy.

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海洋科技资料 1974年第2期 29-34页

作者： (Bissett-berman Corporotion) 比塞特——伯曼公司

这是两个完全新式的数字式仪器,它们能测量作为深度函数的以下任意四种海洋参数:盐度、温度、电导率、声速或者溶解氧。这两个仪器是自容式的,由电池供电,数字资料记录于七通道增量式磁带记录器(8030型),适用于国际商用电子计算机。整... 详细信息

这是两个完全新式的数字式仪器,它们能测量作为深度函数的以下任意四种海洋参数:盐度、温度、电导率、声速或者溶解氧。这两个仪器是自容式的,由电池供电,数字资料记录于七通道增量式磁带记录器(8030型),适用于国际商用电子计算机。整个系统密封在一个单独的耐压壳体内。9070型和9071型实质上相同。9071型是轻型的,有一个铝合金外壳,盐度和温度测量精度较低,并且深度范围只达2000米。9071型不具备盐度压力效应的自动补偿,但它提供一个

关键词：滞后效应温度效应自容式非线性效应精度压力效应冲击波反应记录器记录仪磁带盘时间常数温盐