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Tuberculosis Lymphadenitis in Northwest Ethiopia: Implications for Public Health

Open Journal of Medical Microbiology 2013年第1期3卷 18-24页

作者： Fantahun Biadglegne berhanu anagaw Belay anagaw Weghata Tesfaye Belay Tessema Ulrich Sack Arne C. Rodloff College of Medicine and Health Sciences University of Gondar Gondar Ethiopia Faculty of Medicine and Health Sciences Bahir Dar University Bahir Dar Ethiopia Faculty of Science Addis Ababa University Addis Ababa Ethiopia Institute of Clinical Immunology University Hospital University of Leipzig Leipzig Germany Institute of Medical Microbiology and Epidemiology of Infectious Diseases University Hospital University of Leipzig Leipzig Germany

Objective: In Ethiopia where there are limited diagnostic facilities, the actual burden of tuberculosis (TB) lymphadenitis is not well known. Therefore, we conducted this study to determine the proportion of TB lymphadenitis (TBL) in childhood and adults in Northwest Ethiopia. Materials and Methods: A prospective cross sectional study was conducted from April to May 2012. Fine needle aspiration cytology (FNAC) for cytological diagnosis of TBL was used. The diagnosis of TBL was established when cytological features from lymph node aspirates are strongly suggestive of TB. Descriptive and multivariate analysis was done using SPSS version 16. Results: Out of 1070 patients attending the cytological diagnosis in the study sites 437 (41%) were positive for TBL. Of the 437 registered TBL, 59 (13.5%) were pediatric patients and 378 (86.5%) were adults. There were more females than males with a male to female ratio of 0.8:1. The cervical region had the most common group of TBL with 321 (73.2%) patients. Most of all these patients 314 (75.3%), were matted with a majority of (250/314) being in the cervical region. Individuals who had contact history with TB patients (P = 0.046) were more likely to have TBL. Conclusions: In the studied region high prevalence of TBL was documented. Screening of TBL particularly for those who had contact with TB patients is recommended. Most patients in our study presented with matted lymph nodes, indicating that late arrival of patients to health institutions. Thus continuous and intensified public health strategies on health education and early referral system have to be done in order to link them to health institutions earlier than at present.

关键词： FNAC Epitheliod Cell Granulouma Caseous Necrosis TBL Northwest Ethiopia

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Antimicrobial susceptibility patterns of Streptococcus pneumoniae over 6 years at Gondar University Hospital, Northwest Ethiopia

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Asian Pacific Journal of Tropical Biomedicine 2013年第7期3卷 536-541页

作者： Belay anagaw Mucheye Gezachew Fantahun Biadgelgene berhanu anagaw Tariku Geleshe Birke Taddese Birhanu Getie Mengistu Endris Andargachew Mulu Chandrashekhar Unakal Department of Medical Microbiology School of Biomedical and Laboratory Sciences College of Medicine and Health Sciences University of GondarEthiopia Department of Microbiology Immunology and Parasitology College of Medicine and Health Sciences Bahir Dar UniversityBahir Dar Ethiopia Institute of Medical Microbiology and Epidemiology of Infectious Diseases Faculty of Medicine University of LeipzigGermany Science Faculty Addis Ababa UniversityAddis Ababa Ethiopia College of Medicine and Health Sciences University of Gondar Teaching Hospital Laboratory Bacteriology Section University of GondarEthiopia Institute of Virology Faculty of Medicine University of LeipzigGermany

Objective:To assess the magnitude and antimicrobial susceptibility patterns ofStreptococcus pneumoniaeisolates from various clinical ***:A record based on retrospectivestudy was conducted at Gondar University Teaching Hospital from September 2007 to January *** patients who visited Gondar University Hospital and provided clinical specimens(body fluids,discharge,swab and blood)for routine bacteriological culturing and antimicrobial susceptibilitytesting were taken for *** specimens were processed for bacterial culture accordingto the standard *** susceptibility test for isolated organisms was doneusing agar disk diffusion *** data were entered and analyzed using SPSS software version16 ***:One hundred and fifty threeStreptococcus pneumoniaewere isolated frompatients who visited Gondar University Teaching Hospital bacteriology laboratory for *** of the pneumococcal isolates were from inpatients[111(72.5%)],and 74(48.4%)were frombody *** of the total isolates,93(61%)were found to be resistant to at least one antibioticused for susceptibility *** eight(43.2%)of the isolates were multi-drug resistant(resistantto two or more drugs).The resistance rate noted for both ciprofloxacin 17(11.1%)and ceftriaxone15(9.8%)were ***:High proportions of the isolates tend to be increasinglyresistant to the commonly prescribed *** recommended drug of choice like ciprofloxacinand ceftriaxone were found to be less susceptible in the study *** on the findings,wetherefore recommend that antimicrobial agents should be inspected for acceptable activity beforethey are prescribed and administered *** study with a better design and surveyof antimicrobial susceptibility at large scale shoule be performed to draw advanced information.

关键词： Streptococcus pneumoniae Antimicrobial agents Susceptibility patterns Gondar Ethiopia

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