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DNA damaging agent-induced autophagy produces a cytoprotective adenosine triphosphate surge in malignant glioma cells

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中国神经肿瘤杂志 2007年第4期5卷 250-250页

作者： Katayama M Kawaguchi T berger ms Pieper RO Department of Neurological Surgery Brain Tumor Research Center University of California San Francisco CA 94115-0875 USA.

Repeated operations for infiltrative low - grade gliomas without intervening therapy.

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中国神经肿瘤杂志 2003年第2期1卷 110-110页

作者： Schmidt MH berger ms Lamborn KR Aldape K McDermott MW Prados MD Chang SM Department of Neurological Surgery University of California at San FranciscoCaliforniaUSA.

OBJECT:Progression of infiltrative low-grade gliomas(LGGs)has been reported *** limitations ofsuch studies include diverse histological grading systems,intervening therapy,and the lack of histological confir-mation of malignant tumor *** aim of this study was to determine tumor progression in adult patientswith an initial diagnosis of infiltrative LGG who subsequently underwent a repeated operation,but no other inter-vening *** authors examined factors that may be associated with tumor progression.

关键词： were with in of Pro Repeated operations for infiltrative low grade gliomas without intervening therapy

复发性岛叶胶质细胞瘤再手术的围术期结局分析（英文）

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中华神经外科疾病研究杂志 2018年第6期 572-572页

作者： Morshed RA Young JS Han SJ Hervey-Jumper SL berger ms Department of Neurological Surgery University of CaliforniaSan FranciscoCalifornia Department of Neurological Surgery Oregon Health & Science University

Objective Greater extent of resection( EOR) improves overall survival and progression-free survival for patients with lowand high-grade glioma. While resection for newly diagnosed insular gliomas can be performed with minimal morbidity,perioperative morbidity is not clearly defined for patients undergoing a repeat resection for recurrent insular gliomas. In this study the authors report on tumor characteristics,tumor EOR,and functional outcomes in patients undergoing reoperation for recurrent insular glioma. Methods Adult patients with insular gliomas( WHO grades Ⅱ-Ⅳ) who underwent index resection followed by reoperation were identified through the University of California San Francisco Brain Tumor Center. Treatment history and functional outcomes were collected retrospectively from the electronic medical record. Pre-and postoperative tumor volumes were quantified using software with region-of-interest analysis based on FLAIR and T1-weighted postgadolinium sequences from pre-and postoperative MRI. Results Forty-four patients( 63. 6% male,36. 4% female) undergoing 49 reoperations for recurrent insular tumors were identified with a median follow-up of 741 days. Left-and right-sided tumors comprised 52. 3% and 47. 7% of the cohort,respectively. WHO grade Ⅱ,Ⅲ,and Ⅳ gliomas comprised 46. 9%,28. 6%,and 24. 5% of the cohort,respectively. Ninety-five percent( 95. 9%) of cases involved language and/or motor *** EOR of the insular component of grade Ⅱ,Ⅲ,and Ⅳ tumors were 82. 1%,75. 0%,and 94. 6%,respectively. EOR during reoperation was not impacted by berger-Sanai insular zone or tumor side. At the time of reoperation,44. 9% of tumors demonstrated malignant transformation to a higher WHO grade. Ninety-day postoperative assessment confirmed that 91. 5% of patients had no new postoperative deficit attributable to surgery. Of those with new deficits,3( 6. 4%) had a visual field cut and 1( 2. 1%) had hemiparesis( strength grade 1-2/5). The presence of a new postoperati

关键词： WHO

An efficient sensitivity analysis for energy performance of building envelope: A continuous derivative based approach

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Building Simulation 2021年第4期14卷 909-930页

作者： Ainagul Jumabekova Julien berger Aurélie Foucquier UMR 5271 CNRS LOCIEUniversity of Grenoble AlpesUniversity of Savoie Mont Blanc73000ChambéryFrance LaSIE La Rochelle UniversityCNRSUMR 735617000La RochelleFrance CEA LITENDTSINESUniversity of Grenoble AlpesF-38000GrenobleFrance

Within the framework of building energy assessment,this article proposes to use a derivative based sensitivity analysis of heat transfer models in a building ***,global and local,estimators are obtained at low computational cost,to evaluate the influence of the parameters on the model *** of these estimators values allows to reduce the number of model unknown parameters by excluding non-significant parameters.A comparison with variance and regression-based methods is carried out and the results highlight the satisfactory accuracy of the continuous-based ***,for the carried investigations the approach is 100 times faster compared to the variance-based methods.A case study applies the method to a real-world building *** sensitivity of the thermal loads to local or global variations of the wall thermal properties is ***,a case study of wall with window is analyzed.

关键词： heat transfer sensitivity analysis continuous derivative based approach parameter estimation problem DuFort-Frankel numerical scheme sensitivity coefficients

H2A Variants in Arabidopsis: Versatile Regulators of Genome Activity

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Plant Communications 2020年第1期1卷 82-94页

作者： Bingkun Lei Frederic berger Gregor Mendel Institute of Molecular Plant Biology Austrian Academy of SciencesVienna BioCenterDr.Bohr-Gasse 31030 ViennaAustria

The eukaryotic nucleosome prevents access to the *** evolving histone isoforms,also called histone variants,form diverse families that are enriched over distinct features of plant *** the diverse families of plant histone variants,H2A.Z exclusively marks *** we review recent research progress on the genome-wide distribution patterns and deposition of H2A.Z in plants as well as its association with histone modifications and roles in plant chromatin *** also discuss some hypotheses that explain the different findings about the roles of H2A.Z in plants.

关键词： histone H2A.Z transcription Arabidopsis histone variant histone modifications

Dual Control Strategy for Grid-tied Battery Energy Storage Systems to Comply with Emerging Grid Codes and Fault Ride Through Requirements

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Journal of Modern Power Systems and Clean Energy 2022年第4期10卷 977-988页

作者： Maxime berger Ilhan Kocar Evangelos Farantatos Aboutaleb Haddadi Department of Electrical Engineering Polytechnique MontréalMontréalCanada Electric Power Research Institute(EPRI) Palo AltoUSA

Battery energy storage systems(BESSs)need to comply with grid code and fault ride through(FRT)requirements during disturbances whether they are in charging or discharging *** literature has shown that constant charging current control of BESSs in charging mode can prevent BESSs from complying with emerging grid codes such as the German grid code under stringent unbalanced fault *** address this challenge,this paper proposes a new FRTactivated dual control strategy that consists of switching from constant battery current control to constant DC-link voltage control through a positive droop *** results show that the strategy ensures proper DC-link voltage and current management as well as adequate control of the positive-and negative-sequence active and reactive currents according to the grid code *** is also shown that the proposed FRT control strategy is tolerant to initial operating conditions of BESS plant,grid code requirements,and fault severity.

关键词： Battery energy storage system inverter-based resource fault ride through electromagnetic transient

SIBLINGs and SPARC families: Their emerging roles in pancreatic cancer

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World Journal of Gastroenterology 2014年第40期20卷 14747-14759页

作者： Ferda Kaleagasioglu Martin R berger Visiting Scientist at Toxicology and Chemotherapy Unit German Cancer Research Center D-69120 Heidelberg Germany Department of Pharmacology Faculty of Medicine University of Yeditepe 34755 Ata?ehir/?stanbul Turkey Toxicology and Chemotherapy Unit German Cancer Research Center D-69120 Heidelberg Germany

Pancreatic cancer has a considerably poor prognosis with a 5-year survival probability of less than 5% when all stages are combined. Pancreatic cancer is characterized by its dense stroma, which is involved in the critical interplay with the tumor cells throughout tumor progression and furthermore, creates a barrier restricting efficient penetration of therapeutics. Alterations in a large number of genes are reflected by a limited number of signaling pathways, which are potential targets. Understanding more about the molecular basis of this devastating cancer type regarding tumor microenvironment, distinct subpopulations of cells, epithelial-to-mesenchymal transition and inflammation will lead to the development of various targeted therapies for controlling tumor growth and metastasis. In this complex scenario of pancreatic cancer, especially members of the “small integrin binding ligand N-linked glycoproteins” (SIBLINGs) and “secreted protein acidic and rich in cysteine” (SPARC) families have emerged due to their prominent roles in properties including proliferation, differentiation, apoptosis, adhesion, migration, angiogenesis, wound repair and regulation of extracellular matrix remodeling. SIBLINGs consist of five members, which include osteopontin (OPN), bone sialoprotein, dentin matrix protein 1, dentin sialophosphoprotein and matrix extracellular phosphoglycoprotein. The SPARC family of modular extracellular proteins is comprised of SPARC/osteonectin (ON) and SPARC-like 1 (hevin); secreted modular calcium binding proteins; testicans and follistatin-like protein. In this review, we especially focus on OPN and ON, elaborating on their special and growing importance in pancreatic cancer diagnosis and prognosis.

关键词： Pancreatic cancer Microenvironment Signaling pathways Osteopontin Osteonectin Hevin Biomarker Therapeutic targeting

News from the IUGS Geoindicator Initiative

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Episodes 2004年第1期27卷 55-56页

作者： AntonyR.berger Co-DirectorlUGSGeoindicatorInitiative528ParadiseSt.VictoriaBCV9A5E2CANADA

As evidence for abrupt environmental change grows, the task of assessing the effects of rapid geological processes is becoming more important. Increasing interest in tracking and reporting landscape changes that take place within a normal human lifetime is, thus, not surprising. IUGS continues to emphasize the importance of tracking rapid geological change in State

关键词：环境变化地质学人类寿命资产估价

Large-signal modeling of three-phase dual active bridge converters for electromagnetic transient analysis in DC grids

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Journal of Modern Power Systems and Clean Energy 2019年第6期7卷 1684-1696页

作者： Maxime berger Ilhan KOCAR Handy FORTIN-BLANCHETTE Carl LAVERTU Polytechnique Montreal MontrealCanada Bombardier Transportation St-Bruno-de-MontarvilleCanada Ecole de Technologie Superieure MontrealCanada

The three-phase dual active bridge(3 p-DAB)converter is widely considered in next-generation DC grid *** for traditional AC grids,the successful integration of power electronic converters in DC grids requires accurate time-domain system-level *** demonstrated in the existing literature,the development and efficient implementation of large-signal models of 3 pDAB converters are not *** this paper,a generalized average model is developed,which enables system-level simulation of DC grids with 3 p-DAB converters in electromagnetic transient type(EMT-type)*** proposed model is rigorously compared with alternative modeling techniques:ideal-model,switching-function and state-space *** is concluded that the generalized average model provides an optimal solution when accuracy of transient response,reduction in computation time,and wideband response factors are considered.

关键词： Three-phase dual active bridge(3p-DAB) Generalized averaging Large-signal analysis Electromagnetic transient DC–DC conversion