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Evaluation of Alpha-case in Titanium Castings

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Journal of Materials Science & Technology 2008年第1期24卷 70-74页

作者： Si-Young Sung Bong-Jae choi beom-Suck Han Han-dun Oh Young-Jig Kim Materials & Processing Engineering Center R&D Division Korea Automotive Technology InstituteChonanChungnamKorea Department of Advanced Materials Engineering Sungkyunkwan University SuwonKorea Department of Materials Science Hanseo University Seosan 352-820Korea

The alpha-case formation reactions between Ti and investment molds （Al-2O-3,ZrSiO-4,ZrO-2,CaO stabilized ZrO-2） were evaluated in a plasma arc melting *** of thermodynamic approaches,there were distinct alpha-case *** reaction products were characterized by electron probe micro-analysis and transmission electron ***α-case generation between Ti and Al-2O-3 mold was not able to be explained by the conventionalα-case formation mechanism,which is known to be formed by the interstitials,especially oxygen dissolved from mold ***,from our experimental results and thermodynamic calculations,it was confirmed that theα-case is formed not only by an interstitial element but also by substitutional metallic elements dissolved from mold *** newly establishedα-case formation mechanism will surely lead to a variety of significant applications of theα-case controlled Ti casting.

关键词： Titanium Casting Alpha-case Net-shape

A novel cytokine consisting of the p40 and EBI3 subunits suppresses experimental autoimmune arthritis via reciprocal regulation of Th17 and Treg cells

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Cellular & Molecular Immunology 2022年第1期19卷 79-91页

作者： Seon-Yeong Lee Su-Jin Moon Young-Mee Moon Hyeon-beom Seo Jun-Geol Ryu A Ram Lee Chae Rim Lee Da-Som Kim Yang-Mi Her Jeong Won choi Seung-Ki Kwok Sung-Hwan Park Mi-La Cho The Rheumatism Research Center The Catholic University of KoreaSeoulSouth Korea Division of Rheumatology Department of Internal MedicineSeoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoulSouth Korea Department of Biomedicine&Health Sciences College of MedicineThe Catholic University of KoreaSeoulSouth Korea Department of Medical Lifescience College of MedicineThe Catholic University of KoreaSeoulSouth Korea These author contributed equally:Seon-Yeong Lee Su-Jin MoonYoung-Mee Moon

OBJECTIVE:The interleukin(IL)-12 cytokine family is closely related to the development of T helper cells,which are responsible for autoimmune disease enhancement or ***-12 family members are generally heterodimers and share threeα-subunits(p35,p19,and p28)and twoβ-subunits(p40 and EBI3).However,aβ-sheet p40 homodimer has been shown to exist and antagonize IL-12 and IL-23 signaling ***,we assumed the existence of a p40-EBI3 heterodimer in nature and sought to investigate its role in immune ***:The presence of the p40-EBI3 heterodimer was confirmed by ELISA,immunoprecipitation,and western blotting.A p40-EBI3 vector and p40-EBI3-Fc protein were synthesized to confirm the immunological role of this protein in mice with collageninduced arthritis(CIA).The anti-inflammatory effects of p40-EBI3 were analyzed with regard to clinical,histological,and immune cell-regulating features in mice with ***:Clinical arthritis scores and the expression levels of proinflammatory cytokines(e.g.,IL-17,IL-1β,IL-6,and TNF-α)were significantly attenuated in p40-EBI3-overexpressing and p40-EBI3-Fc-treated mice with CIA compared to vehicle-treated mice with *** joint damage and vessel formation-related gene expression were also reduced by p40-EBI3 heterodimer *** vitro,the p40-EBI3-Fc protein significantly suppressed the differentiation of Th17 cells and reciprocally induced CD4+CD25+Foxp3+(regulatory T)cells.p40-EBI3 also inhibited osteoclast formation in a concentrationdependent ***:In this study,p40-EBI3 ameliorated proinflammatory conditions both in vivo and in *** propose that p40-EBI3 is a novel anti-inflammatory cytokine involved in suppressing the immune response through the expansion of Treg cells and suppression of Th17 cells and osteoclastogenesis.

关键词： cytokine p40-EBI3 Rheumatoid arthritis Autoimmune disease regulatory T cell

Chondrogenesis of periodontal ligament stem cells by transforming growth factor-β3 and bone morphogenetic protein-6 in a normal healthy impacted third molar

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International Journal of Oral Science 2013年第1期5卷 7-13页

作者： Sunyoung choi Tae-Jun Cho soon-Keun Kwon Gene Lee Jaejin Cho Laboratory of Developmental Biology and Stem Cell Differentiation/Transplantation Department of Dental Regenerative BiotechnologySchool of DentistrySeoul National University Dental Research Institute School of DentistrySeoul National University Laboratory of Molecular Genetics School of DentistrySeoul National University

The periodontal ligament-derived mesenchymal stem cell is regarded as a source of adult stem cells due to its ***, the proof of chondrogenic potential of the cells is ***,we investigated the chondrogenic differentiation capacity of periodontal ligament derived mesenchymal stem cells induced by transforming growth factor(TGF)-p3 and bone morphogenetic protein(BMP)-*** isolation of periodontal ligament stem cells(PDLSCs) from human periodontal ligament,the cells were cultured in Dulbecco’s modified Eagle’s medium(DMEM) with 20%fetal bovine serum(FBS).A mechanical force initiated chondrogenic differentiation of the *** chondrogenic differentiation,10μg·LTGF-β3 or 100μg·LBMP-6 and the combination treating group for synergistic effect of the growth *** analyzed the PDLSCs by fluorescence-activated cell sorting and chondrogenesis were evaluated by glycosaminoglycans assay,histology,immunohistochemistry and genetic *** showed mesenchymal stem cell properties proved by FACS *** contents were increased 217%by TGF-β3 and 220%by BMP-6. The synergetic effect of TGF-β3 and BMP-6 were shown up to 281%compared to *** combination treatment increased Sox9, aggrecan and collagen II expression compared with not only controls,but also TGF-P3 or BMP-6 single treatment *** histological analysis also indicated the chondrogenic differentiation of PDLSCs in our *** results of the present study demonstrate the potential of the dental stem cell as a valuable cell source for chondrogenesis,which may be applicable for regeneration of cartilage and bone fracture in the field of cell therapy.

关键词： bone morphogenetic protein-6 chondrogenesis growth factor periodental ligament cell stem cell transforming growth factor-β3

Development of a skill assessment tool for the Korea operational oceanographic system

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Acta Oceanologica Sinica 2013年第9期32卷 74-81页

作者： CHO Kyoung-Ho choi Jin-Yong JEONG Sang-Hun choi Jung-Woon KWON Jae-Il PARK Kwang-soon Coastal Disaster Research Center Korea Institute of Ocean Science and Technology

A standard skill assessment （SA） tool was developed and implemented to evaluate the performance of op- erational forecast models in the Korea operational oceanographic system. The SA tool provided a robust way to assess model skill in the system by comparing predictions and observations, and involved the com- putation of multiple skill metrics including correlation and error skills. User- and system-based acceptance criteria of skill metrics were applied to determine whether predictions were acceptable for the system. To achieve this, the tool produced a time series comparison plot, a skill score table, and an advanced sum- marized diagram to effectively demonstrate the multiple skill scores. Moreover, the SA was conducted to evaluate both atmospheric and hydrodynamic forecast variables. For the atmospheric variables, acceptable error criteria were preferable to acceptable correlation criteria over short timescales, since the mean square error overwhelmed the observation variance. Conversely, for the hydrodynamic variables, acceptable root mean square percentage error （e.g., perms） criteria were preferable to acceptable error （e.g., erms） criteria owing to the spatially variable tidal intensity around the Korean Peninsula. Furthermore, the SA indicated that predetermined acceptance error criteria were appropriate to satisfy a target central frequency （fc） for which errors fell within the specified limits （i.e., the .fc equals 70%）.

关键词： skill assessment tool operational forecast system Korea operational oceanographic system

Removal of arsenate and arsenite from aqueous solution by waste cast iron

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Journal of Environmental Sciences 2012年第4期24卷 589-595页

作者： Nag-Choul choi Song-Bae Kim soon-Oh Kim Jae-Won Lee Jun-Boum Park Department of Rural Systems Engineering Seoul National UniversitySeoul 151-921Republic of Korea Department of Earth and Environmental Sciences and Research Institute of Natural Science Gyeongsang National UniversityJinju 660-701Republic of Korea JIU Corporation 154-3 Samsung-dongGangnam-guSeoul 135-879Republic of Korea Department of Civil and Environmental Engineering Seoul National UniversitySeoul 151-742Republic of Korea

The removal of As（III） and As（V） from aqueous solution was investigated using waste cast iron, which is a byproduct of the iron casting process in foundries. Two types of waste cast iron were used in the experiment： grind precipitate dust （GPD） and cast iron shot （CIS）. The X-ray diffraction analysis indicated the presence of Fe~ on GPD and CIS. Batch experiments were performed under different concentrations of As（III） and As（V） and at various initial pH levels. Results showed that waste cast iron was effective in the removal of arsenic. The adsorption isotherm study indicated that the Langmuir isotherm was better than the Freundlich isotherm at describing the experimental result. In the adsorption of both As（III） and As（V）, the adsorption capacity of GPD was greater than CIS, mainly due to the fact that GPD had higher surface area and weight percent of Fe than CIS. Results also indicated the removal of As（III） and As（V） by GPD and CIS was influenced by the initial solution pH, generally decreasing with increasing pH from 3.0 to 10.5. In addition, both GPD and CIS were more effective at the removal of As（III） than As（V） under given experimental conditions. This study demonstrates that waste cast iron has potential as a reactive material to treat wastewater and groundwater containing arsenic.

关键词： waste cast iron arsenic removal sorption batch experiment

Contact surface fatigue life for roller rack pinion system

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Journal of Central South University 2012年第12期19卷 3454-3459页

作者： KIM Chang-hyun choi Heung-soap KWON soon-man Department of Mechanical Design and Manufacturing Engineering Changwon National UniversityChangwon 641-773Korea Department of Mechano-Informatics and Design Engineering Hongik UniversitySejong 339-701Korea

A roller rack pinion(RRP)system,which consists of a rack-bar and a cam pinion,transforms a rotation motion into linear *** rack-bar has a series of roller train and meshes with the cam ***,the exact tooth profile of the cam pinion and the non-undercut condition to satisfy the required performance have been proposed with the introduction of the profile shift ***,the load stress factors are investigated under the variation of the shape design parameters to predict the gear surface fatigue limit which is strongly related to the gear noise and vibration at the contact *** results show that the pitting life can be extended significantly with the increase of the profile shift coefficient.

关键词：齿轮系统疲劳寿命齿条接触面直线运动旋转运动接触印痕齿轮噪声

Heating energy performance and part load ratio characteristics of boiler staging in an office building

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Frontiers in Energy 2019年第2期13卷 339-353页

作者： Da Young LEE Byeong Mo SEO Yeo beom YOON Sung Hyup HONG Jong Min choi Kwang Ho LEE Graduate School Hanbat National UniversityDaejeon 305-719South Korea College of Design North Carolina State University RaleighNC 27695-7701USA Department of Mechanical Engineering Hanbat National UniversityDaejeon 305-719South Korea Department of Architectural Engineering Hanbat National UniversityDaejeon 305-719South Korea

Commercial buildings account for significant portions of the total building energy in South Korea and thus a variety of research on the boiler operation related to heating energy in office buildings has been carried out thus far. However, most of the researches have been conducted on the boiler itself, i.e., the part load ratio characteristics and the corresponding gas energy consumption patterns are not analyzed in the existing studies. In this study, the part load ratio and the operating characteristics of gas boiler have been analyzed within an office building equipped with the conventional variable air volume system. In addition, the gas consumption among different boiler staging schemes has been comparatively analyzed. As a result, significant portions of total operating hours, heating load and energy consumption has been found to be in a part load ratio range of 0 through 40% and thus energy consumption is significantly affected by boiler efficiency at low part load conditions. This suggests that boiler operation at the part load is an important factor in commercial buildings. In addition, utilizing sequential boiler staging scheme can save a gas usage of about 7%. For annual heating energy saving, applying the sequential control boiler with a 3:7 proportion staging is considered to be the optimal control algorithm for maximum efficiency of boilers.

关键词： EnergyPlus boiler part load ratio gas con-sumption office building boiler staging

Factors Affecting the Genetic Diagnostic Rate in Congenital Heart Disease

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Congenital Heart Disease 2022年第6期17卷 653-673页

作者： Jun Sung Park Go Hun Seo Yunha choi Soojin Hwang Minji Kang Hyo-Sang Do Young-Hwue Kim Jeong Jin Yu Ellen Ai-Rhan Kim Euiseok Jung Byong Sop Lee Jae Suk Baek beom Hee Lee Department of Pediatrics Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea 3 Billion Inc.SeoulKorea Genome Research Center for Birth Defects and Genetic Diseases Asan Institute for Life SciencesAsan Medical CenterSeoulKorea Division of Cardiology Department of PediatricsAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Division of Neonatology Department of PediatricsAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Medical Genetics Center Asan Medical Center Children’s HospitalUniversity of Ulsan College of MedicineSeoulKorea

Background: Over 400 genes contribute to the development of congenital heart disease (CHD). Additionally,multisystemic manifestations accompanying syndromic CHD pose a higher risk of genetic diseases. This studyinvestigated the diagnostic yield of whole-exome sequencing (WES) in patients with sporadic syndromic CHDand the phenotypic factors affecting the genetic diagnostic rate. Methods: Sixty-four patients with sporadic syndromicCHD aged 0.05), betweenthe groups with and without a diagnostic variant. However, patients with ≥3 extracardiac phenotypes had a significantlyhigher likelihood of having a diagnostic variant than those with ≤2 (38.3% vs. 5.9%, odds ratio = 9.93,95% confidence interval = 1.21–81.44, P = 0.013). Conclusions: The number of extracardiac phenotypes is importantin predicting the possibility of genetic diagnosis. Physicians will be able to select patients with a high probabilityof genetic diagnosis and provide appropriate genetic counseling based on the results of this study.

关键词： Heart defects congenital whole-exome sequencing genetic testing phenotype

Second to fourth digit ratio： a predictor of adult penile ength

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Asian Journal of Andrology 2011年第5期13卷 710-714页

作者： In Ho choi Khae Hawn Kim Han Jung Sang Jin Yoon Soo Woong Kim Tae beom Kim Department of Urology Gachon University Gil Hospital Incheon Korea Department of Urology Seoul National University College of Medicine Seoul Korea

The second to fourth digit ratio （2D：4D） has been proposed as a putative biomarker for prenatal testosterone and covaries with the sensitivity of the androgen receptor （AR）. Both prenatal testosterone and the AR play a central role in penile growth. In this study, we investigated the relationship between digit ratio and penile length. Korean men who were hospitalized for urological surgery at a single tertiary academic centre were examined in this study, and 144 men aged 20 years or older who gave informed consent were prospectively enrolled. Right-hand second- and fourth-digit lengths were measured by a single investigator prior to measurement of penile length. Under anaesthesia, flaccid and stretched penile lengths were measured by another investigator who did not measure nor have any the information regarding the digit lengths. Univariate and multivariate analysis using linear regression models showed that only height was a significant predictive factor for flaccid penile length （univariate analysis： r=0. 185, P=-0.026; multivariate analysis： r=-0.172, P=0.038） and that only digit ratio was a significant predictive factor for stretched penile length （univariate analysis： r=-0.216, P=0.009; multivariate analysis： r=-0.201, P=0.024; stretched penile length=-9.201 xdigit ratio ＋ 20.577）. Based on this evidence, we suggest that the digit ratio can predict adult penile size and that the effects of prenatal testosterone may in part explain the differences in adult penile length.

关键词： digit ratio flaccid penile length stretched penile length