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Comparative effectiveness of combined antiplatelet treatments in acute minor ischaemic stroke

Stroke & Vascular Neurology 2022年第1期7卷 13-21页

作者： Shina kim joon-Tae kim Ji Sung Lee beom joon kim Jong-Moo Park Kyusik Kang Soo Joo Lee Jae Guk kim Jae-Kwan Cha Dae-Hyun kim Tai Hwan Park Sang-Soon Park Kyung Bok Lee Jun Lee Keun-Sik Hong Yong-Jin Cho Hong-Kyun Park Byung-Chul Lee Kyung-Ho Yu Mi Sun Oh Dong-Eog kim Wi-Sun Ryu Jay Chol Choi Jee-Hyun Kwon Wook-Joo kim Dong-Ick Shin Sung-Il Sohn Jeong-Ho Hong Man-Seok Park Kang-Ho Choi Ki-Hyun Cho Juneyoung Lee Hee-joon Bae Department of Neurology Chonnam National University HospitalChonnam National University Medical SchoolGwangjuKorea Clinical Research Center Asan Institute for Life SciencesAsan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Department of Neurology Cerebrovascular CenterSeoul National University Bundang HospitalSeongnamKorea Department of Neurology Uijeongbu Eulji Medical CenterEulji University School of MedicineUijeongbu-siKorea Department of Neurology Nowon Eulji Medical CenterEulji UniversitySeoulKorea Department of Neurology Eulji University HospitalEulji UniversityDaejeonKorea Department of Neurology Dong-a UniversityBusanKorea Department of Neurology Seoul Medical CenterSeoulKorea Department of Neurology Soonchunhyang University HospitalSeoulKorea Department of Neurology Yeungnam University HospitalDaeguKorea Department of Neurology Inje University Ilsan Paik HospitalInje University College of MedicineGoyangKorea Department of Neurology Hallym University Sacred Heart HospitalAnyangKorea Department of Neurology Dongguk University Ilsan HospitalGoyangKorea Department of Neurology Jeju National University HospitalJeju National University School of MedicineJejuKorea Department of Neurology University of Ulsan College of MedicineUlsanKorea Department of Neurology Chungbuk National University HospitalCheongjuKorea Department of Neurology Keimyung University Dongsan Medical CenterDaeguKorea Department of Biostatistics Korea University College of MedicineSeoulKorea

Background No study has thoroughly compared the effectiveness of combined antiplatelet treatments(other than clopidogrel–aspirin)versus clopidogrel–aspirin or aspirin alone for early secondary prevention in acute ischaemic *** We identified patients with acute,minor,non-cardiogenic ischaemic stroke treated with aspirin alone,clopidogrel–aspirin or other combination *** scores considering the inverse probability of treatment weighting were used to adjust for baseline *** primary outcome was the composite of all strokes(ischaemic or haemorrhagic),myocardial infarction and all-cause mortality at 3 *** Among 12234 patients(male:61.9%;age:65.5±13 years)who met the eligibility criteria,aspirin,clopidogrel–aspirin and other combination treatments were administered in 52.2%,42.9%and 4.9%of patients,*** the crude analysis,the primary outcome event at 3 months occurred in 14.5%of the other combination group,14.4%of the aspirin group and 13.0%of the clopidogrel–aspirin *** the weighted Cox proportional hazards analysis,the 3-month primary outcome event occurred less frequently in the clopidogrel–aspirin group than in the other combination group(weighted HR:0.82(0.59–1.13)),while no association was found between the aspirin group(weighted HR:1.04(0.76–1.44))or other combination group and the 3-month primary *** Other combined antiplatelet treatment,compared with aspirin alone or clopidogrel–aspirin,was not associated with reduced risks of primary composite vascular events or recurrent stroke during the first 3 months after ***,the results suggest that other combination treatments,particularly the cilostazol-based combination,may not be effective alternatives for clopidogrel–aspirin to prevent early vascular events in patients with acute minor *** exploration in clinical trials will be needed.

关键词： prevention treatment alone

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Nanomolar concentration of alpha-synuclein enhances dopaminergic neuronal survival via Akt pathway

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Neural Regeneration Research 2013年第35期8卷 3269-3274页

作者： Ji-Young kim beom Seok Jeon Han-joon kim Tae-beom Ahn Department of Neurology Inje University Seoul Paik Hospital Department of Neurology College of Medicine Seoul National University Hospital Department of Neurology Kyung Hee University Medical Center

Although alpha-synuclein is generally thought to have a pathological role in Parkinson＇s disease, accumulative evidence exists that alpha-synuclein has a neuroprotective effect. The aim of this study was to evaluate the effect of extracellular alpha-synuclein on dopaminergic cell survival. We assessed cell viability using the 3-（4,5-dimethyt-thiazol-2-yt）-2,5-diphenyltertazolium bromide （MTT） assay both in undifferentiated SH-SY5Y （SHSY） cells and neuronally-differentiated SH-SY5Y （ndSHSY） cells after 24 hour treatment with monomeric alpha-synuclein at various concentrations （0 [control], 50, 100 nmol/L, 1 IJmol/L）. To determine whether cell viability assessed by MTT assay was affected by cell proliferation, 5-bromo-2＇-deoxyuridine （BrdU） incorporation assay was per- formed. Level of both Akt and phosphorylated Akt was measured using western blot method in ndSHSY cells with or without 24 hour alpha-synuclein treatment. Cell viability was increased in ndSHSY cells at the nanomolar concentration of alpha-synuclein, but not in SHSY cells. Proportion of BrdU-positive ndSHSY cells was decreased in alpha-synuclein-treated group compared with control group. Level of phosphorylated Akt in alpha-synuclein-treated group was higher compared with the control group. Our study shows that extracellular alpha-synuclein at nanomolar concentra- tion benefits dopaminergic cell survival via Akt pathway.

关键词： neural regeneration alpha-synuclein neuronal survival nanomolar extracellular phosphorylatedAkt SH-SY5Y cell neuronal differentiation proliferation dopaminergic 5-bromo-2'-deoxyuridine grants-supported paper neuroregeneration

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High-performance solid-solution potassium-ion intercalation mechanism of multilayered turbostratic graphene nanosheets

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Journal of Energy Chemistry 2022年第4期31卷 814-823页

作者： Jiae Um Seung Uk Yoon Hoseong kim beom Sik Youn Hyoung-joon Jin Hyung-Kyu Lim Young Soo Yun Program in Environmental and Polymer Engineering Inha Universityncheon 22212 South Korea Department of Polymer Science and Engineering Inha UniversityIncheon 22212South Korea Division of Chemical Engineering and Bioengineering Kangwon National University Chuncheon Gangwon-do 24341 South Korea KU-KIST Graduate School of Converging Science and Technologyea University 145 Anam-roSeongbuk-guSoul02841 South Korea Department of Integrative Energy Engineering 145 Anam-roSongbuk-guKorea UniversitySeoul 02841 South Korea

The solid-solution reaction between an alkali cation and an active host material is known as a singlephase redox mechanism,and it is typically accompanied by a continuous voltage *** is distinct from the typical alkali cation intercalation reaction at an equivalent site of the active host material,which exhibits a voltage ***,we report an unusual solid-solution potassium-ion intercalation mechanism with a low-voltage plateau capacity on multilayered turbostratic graphene nanosheets(T-GNSs).Despite the disordered graphitic structure with a broad range of d-spacings(3.65–4.18À),the T-GNSs showed a reversible plateau capacity of~200 m A h g^(-1),which is higher than that of a well-ordered graphite nanoplate(~120 m A h g^(-1)).In addition,a sloping capacity of~220 m A h g^(-1)was delivered with the plateau capacity,and higher rate capabilities,better reversibility,and a more stable cycling performance were confirmed on the turbostratic ***-principles calculations suggest that the multitudinous lattice domains of the T-GNSs contain diverse intercalation sites with strong binding energies,which could be the origin of the high-performance solid-solution potassium-ion intercalation behavior when the turbostratic graphene stacks have a d-spacing smaller than that of equilibrium potassium–graphite intercalation compounds(5.35À).

关键词： Turbostratic graphite Graphene nanosheet Defective carbon Anode Potassium-ion batteries

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Role of milk carbohydrates in intestinal health of nursery pigs: a review

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Journal of Animal Science and Biotechnology 2022年第3期13卷 628-641页

作者： Ki beom Jang Sung Woo kim Department of Animal Science North Carolina State UniversityRaleighNC 27695USA

Intestinal health is essential for the resistance to enteric diseases and for nutrient digestion and absorption to support *** intestine of nursery pigs are immature and vulnerable to external challenges,which cause negative impacts on the structure and function of the *** nutritional interventions,the benefits of milk are significant for the intestinal health of *** coproducts have traditionally been used in starter feeds to improve the growth of nursery pigs,but their use is somewhat limited due to the high costs and potential risks of excessive lactose on the ***,understanding a proper feeding level of milk carbohydrates is an important start of the feeding *** nursery pigs,lactose is considered a highly digestible energy source compared with plant-based starch,whereas milk oligosaccharides are considered bioactive compounds modulating intestinal immunity and ***,milk carbohydrates,mainly composed of lactose and oligosaccharides,have essential roles in the intestinal development and functions of nursery *** proper feeding levels of lactose in starter feeds could be variable by weaning age,body weight,or genetic *** of lactose and milk oligosaccharides have been broadly studied in human health and animal ***,this review focuses on the mechanisms of lactose and milk oligosaccharides affecting intestinal maturation and functions through modulation of enterocyte proliferation,intestinal immunity,and intestinal microbiota of nursery pigs.

关键词： Intestinal health Lactose Milk carbohydrates Milk oligosaccharides Nursery pig

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Numerical Study on Air Turbines with Enhanced Techniques for OWC Wave Energy Conversion

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China Ocean Engineering 2017年第5期31卷 517-527页

作者： CUI Ying HYUN beom-Soo kim Kilwon Department of Ocean Engineering College of EngineeringOcean University of China Division of Naval Architecture and Ocean Engineering Korea Maritime and Ocean University

In recent years,the oscillating water column(OWC) wave energy converter,which can capture wave energy from the ocean,has been widely applied all over the *** the essential part of the OWC system,the impulse and Wells turbines are capable of converting the low pressure pneumatic energy into the mechanical shaft *** an enhanced technique,the design of endplate or ring attached to the blade tip is investigated numerically in this paper.3 D numerical models based on a CFD-software FLUENT 12.0 are established and validated by the corresponding experimental results from the reports of Setoguchi et al.(2004) and Takao et al.(2001).Then the flow fields and non-dimensional evaluating coefficients are calculated and analyzed under steady *** show that the efficiency of impulse turbine with ring can reach up to 0.49 when Ф=1,which is 4% higher than that in the cases for the endplate-type and the original *** the ring-type Wells turbine with fixed guide vanes shows the best performance with the maximal efficiency of 0.55,which is 22% higher than that of the original *** addition,the quasi-steady analysis is used to calculate the mean efficiency and output-work of a wave cycle under sinusoidal flow *** all together,this study provides support for structural optimization of impulse turbine and Wells turbine in the future.

关键词： OWC impulse turbine Wells turbine CFD endplate ring quasi-steady analysis

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Construction of random sheared fosmid library from Chinese cabbage and its use for Brassica rapa genome sequencing project

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Journal of Genetics and Genomics 2011年第1期38卷 47-53页

作者： Tae-Ho Park beom-Seok Park Jin-A kim joon Ki Hong Mina Jin Young-Joo Seol Jeong-Hwan Mun Genomics and Functional Bio-Material Division National Academy of Agricultural ScienceRural Development Administration The Department of Horticultural Science Daegu University

As a part of the Multinational Genome Sequencing Project of Brassica rapa, linkage group R9 and R3 were sequenced using a bacterial artificial chromosome （BAC） by BAC strategy. The current physical contigs are expected to cover approximately 90% euchromatins of both chromosomes. As the project progresses, BAC selection for sequence extension becomes more limited because BAC libraries are restriction enzyme-specific. To support the project, a random sheared fosmid library was constructed. The library consists of 97536 clones with average insert size of approximately 40 kb corresponding to seven genome equivalents, assuming a Chinese cabbage genome size of 550 Mb. The library was screened with primers designed at the end of sequences of nine points of scaffold gaps where BAC clones cannot be selected to extend the physical contigs. The selected positive clones were end-sequenced to check the overlap between the fosmid clones and the adjacent BAC clones. Nine fosmid clones were selected and fully sequenced. The sequences revealed two completed gap filling and seven sequence extensions, which can be used for further selection of BAC clones confirming that the fosmid library will facilitate the sequence completion of B. rapa.

关键词： Brassica rapa Chinese cabbage Fosmid library Genome sequencing Physical contig

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Sensing Characteristics of Polyaniline Sensor Coated with Porous Poly(vinylidenfluoride) Layer to Methanol Gas

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稀有金属材料与工程 2006年第A3期35卷 459-462页

作者： Cheol-beom Lim joon-Boo Yu Do-Yeon kim Sung-Ok Sohn Duk-Dong Lee Jeung-Soo Huh Department of Sensor and Display Engineering Kyungpook National UniversitySangyuk-Dong 1370BukguDeaguKorea Department of Materials Science & Metallurgy Kyungpook National UniversitySangyuk-Dong 1370BukguDeaguKorea Department of Electronic Engineering Kyungpook National UniversitySangyuk-Dong 1370BukguDeaguKorea Department of Sensor and Display Engineering Kyungpook National UniversitySangyuk-Dong 1370BukguDeaguKorea.Department of Materials Science & MetallurgyKyungpook National UniversitySangyuk-Dong 1370BukguDeaguKorea

Hydrophobic polymer [***(vinylidenfluoride)] layer was coated on polyaniline (PANi) sensor to reduce the problems of *** differences in sensitivity to methanol gas detection in various humidity condition between pure-PANi sensor and coated with poly(vinylidenfluoride) polymer (PVDF) (coated-PANi sensor) were *** the relation between the density of pore,which was coated on the layer of the PANi sensor,and sensitivity was *** fabricate the porous PVDF layer on PANi sensor,poly(vinylalcohol) (PVA),which is water-soluble polymer,was used. Coated-PANi sensor was less affected by humidity compared with pure-PANi *** higher density of pore on PVDF layer led to higher sensitivity.

关键词： polyaniline PVDF PVA methanol gas humidity

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Feasibility of wear reduction for soft nanostructured thin film through enhanced elastic recoverability and contact stress relief

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Friction 2023年第7期11卷 1292-1306页

作者： Kuk-Jin SEO Hyun-joon kim Dae-Eun kim Department of Mechanical Engineering Yonsei UniversitySeoul 03722Republic of Korea Department of Precision Mechanical Engineering Kyungpook National UniversitySangju 37224Republic of Korea Department of Advanced Science and Technology Convergence Kyungpook National UniversitySangju 37224Republic of Korea

This work shows that a soft,thin film comprising randomly aligned carbon nanotubes(CNTs)can reduce surface wear more effectively than a homogeneous thin film because of enhanced elastic recoverability and contact stress relief originating from its mesh *** investigate the wear characteristics of the mesh structure compared to those of the homogeneous thin film,multi-walled CNTs(MWCNTs)and diamond-like carbon(DLC)thin films were prepared to conduct nanoscale tribological experiments using the atomic force microscopy(AFM).The MWCNT thin film showed unmeasurably low wear compared with the DLC thin film under a certain range of normal *** demonstrate the wear reduction mechanism of the MWCNT thin film,its indentation and frictional behaviors were *** indentation behavior of the MWCNT thin film revealed repetitive elastic deformation with a wide strain range and a significantly lower elastic modulus than that of the DLC thin *** permanent deformation of the MWCNT thin film was observed through frictional experiments under relatively high normal load *** results are expected to provide insights into the design of highly wear-resistant surfaces using nanostructures.

关键词： carbon nanotube(CNT) thin film wear friction elastic recovery

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Uncertainty analysis of flow rate measurement for multiphase flow using CFD

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Acta Mechanica Sinica 2015年第5期31卷 698-707页

作者： joon-Hyung kim Uk-Hee Jung Sung kim joon-Yong Yoon Young-Seok Choi Department of Mechanical Design Engineering Hanyang University Thermal & Fluid System R&BD Group Korea Institute of Industrial Technology Energy System Engineering University of Science and Technology

The venturi meter has an advantage in its use,because it can measure flow without being much affected by the type of the measured fluid or flow ***,it has excellent versatility and is being widely applied in many *** flow of a liquid containing air is a representative example of a multiphase flow and exhibits complex flow *** particular,the greater the gas volume fraction（GVF）,the more inhomogeneous the flow *** a result,using a venturi meter to measure the rate of a flow that has a high GVF generates an *** this study,the cause of the error occurred in measuring the flow rate for the multiphase flow when using the venturi meter for analysis by *** ensure the reliability of this study,the accuracy of the multiphase flow models for numerical analysis was verified through comparison between the calculated results of numerical analysis and the experimental *** a result,the Grace model,which is a multiphase flow model established by an experiment with water and air,was confirmed to have the highest ***,the characteristics of the internal flow Held about the multiphase flow analysis result generated by applying the Grace model were analyzed to find the cause of the uncertainty occurring when measuring the flow rate of the multiphase flow using the venturi meter.A phase separation phenomenon occurred due to a density difference of water and air inside the venturi,and flow inhomogeneity happened according to the flow velocity difference of each *** was confirmed that this flow inhomogeneity increased as the GVF increased due to the uncertainty of the flow measurement.

关键词： Multiphase flow Measurement Numerical analysis Venturi meter Gas volume fraction(GVF) Uncertainty Multiphase flow model Grace model

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Hepatitis B virus mutations related to liver disease progression of Korean patients

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World Journal of Gastroenterology 2014年第2期20卷 460-467页

作者： Bum-joon kim Department of Biomedical Sciences Microbiology and ImmunologyLiver Research Instituteand Cancer Research InstituteCollege of MedicineSeoul National UniversitySeoul 110-799South Korea

Hepatitis B virus(HBV)infection is a global health problem and more than 350 million people worldwide are chronic carriers of the *** the recent dramatic decline in HBV chronic patients through successful programs of hepatitis B surface antigen vaccination,South Korea is still recognized as an endemic area of HBV *** infections in South Korea exhibit several distinct features in epidemiologic and clinical *** this review paper,we summarize the distinct HBV mutation patterns related to clinical severity and the molecular epidemiologic traits in Korean chronic patients based on previous ***,several lines of evidence,including our previous results,have led to the conclusion that a combination of the exclusive predominance of genotype C2,which is prone to mutations,the high prevalence of basal core promoter double mutations,and the presence of distinct immune responses against HBV proteins in the Korean population may generate the distinct HBV variants rarely or not encountered in other areas,which results in distinct clinical manifestations in Korean chronic *** may provide a novel insight into the relationships between clinical severity,HBV genotype distribution,and HBV naturally occurring variants.

关键词： Hepatitis B virus Mutation South Korea Hepatocellular carcinoma Genotype C2

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