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面向单分子检测的纳米孔传感特异性增强技术

物理学报 2024年第10期73卷 1-19页

作者：潘钦杰赵灿东陈琪何毓辉缪向水华中科技大学集成电路学院信息存储材料及器件研究所武汉430074 江城实验室武汉430205

目前,基于纳米孔的传感器已经成为了分析生物标志物的重要工具,包括但不限于核酸,蛋白质以及其他在生命活动中发挥重要作用的分子.作为一种创新的单分子检测技术,纳米孔传感本身并不具有特异性,通过表面官能化以及分子探针技术可以提升... 详细信息

目前,基于纳米孔的传感器已经成为了分析生物标志物的重要工具,包括但不限于核酸,蛋白质以及其他在生命活动中发挥重要作用的分子.作为一种创新的单分子检测技术,纳米孔传感本身并不具有特异性,通过表面官能化以及分子探针技术可以提升纳米孔传感对样本中的目标生物标志物的响应灵敏度.本文首先介绍了纳米孔传感的原理、分类,然后讨论了纳米孔表面改性的方法以及近年来纳米孔传感中待测分子特异性增强技术的发展和应用,特异性增强技术主要包含表面官能化以及分子探针两种形式,其中表面官能化以官能化分子类别分类,分子探针以载体形式分类.最后,本文总结了纳米孔传感仍然存在的若干挑战,并对纳米孔未来发展提出了若干建议.

关键词：纳米孔特异性分子探针官能化

信息环境、上市公司增量信息披露与资本市场定价效率——基于MD&A文本相似度的研究

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南开管理评论 2024年第5期27卷 30-39页

作者：宋昕倍陈莹逯东程杰重庆工商大学会计学院西南财经大学会计学院

本文基于2007—2020年中国沪深两市A股上市公司的样本,采用文本分析方法,以当期年报中管理层讨论与分析(MD&A)文本与上一期MD&A文本的相似度衡量上市公司增量信息披露水平,深入考察了上市公司增量信息披露与资本市场定价效率的关系。研... 详细信息

本文基于2007—2020年中国沪深两市A股上市公司的样本,采用文本分析方法,以当期年报中管理层讨论与分析(MD&A)文本与上一期MD&A文本的相似度衡量上市公司增量信息披露水平,深入考察了上市公司增量信息披露与资本市场定价效率的关系。研究发现,公司披露的MD&A文本相似度越高,即增量信息披露越少,公司的股价同步性越高,股价崩盘风险也越大。进一步研究发现,当公司披露的MD&A可读性较低、新媒体运用较少、审计质量较低、媒体报道较少,即内外部信息环境较差时,MD&A文本相似度提高公司股价同步性与股价崩盘风险的作用加剧。本文的研究对如何提高上市公司信息披露水平,改善信息环境,进而促进资本市场的良好运行提供了新的经验证据。

关键词：信息环境文本相似度股价同步性股价崩盘风险

Characterization of humoral immune responses against SARS-CoV-2 accessory proteins in infected patients and mouse model

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Virologica Sinica 2024年第3期39卷 414-421页

作者： Yuming Li Yanhong Tang Xiaoqian Wang Airu Zhu dongdong Liu Yiyun He Hu Guo jie Zheng Xinzhuo Liu Fengyu Chi Yanqun Wang Zhen Zhuang Zhaoyong Zhang donglan Liu Zhao chen Fang Li Wei Ran Kuai Yu dong Wang Liyan Wen Jianfen Zhuo Yanjun Zhang Yin Xi Jingxian Zhao Jincun Zhao Jing Sun School of Public Health Shandong First Medical University&Shandong Academy of Medical SciencesJi'nan250117China Key Laboratory of Emerging Infectious Diseases in Universities of Shandong Shandong First Medical University&Shandong Academy of Medical SciencesJi'nan250117China State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseNational Center for Respiratory MedicineGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong510182China Hunan Provincial People's Hospital The First Affiliated Hospital of Hunan Normal UniversityHunan Normal UniversityChangsha410005China Guangzhou National Laboratory GuangzhouGuangdong510005China Shanghai Institute for Advanced Immunochemical Studies School of Life Science and TechnologyShanghai Tech UniversityShanghai201210China Institute for Hepatology National Clinical Research Center for Infectious DiseaseShenzhen Third People's HospitalThe Second Affiliated HospitalSchool of MedicineSouthern University of Science and TechnologyShenzhen518005China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the causative agent of COVID-19,encodes several accessory proteins that have been shown to play crucial roles in regulating the innate immune ***,their expressions in infected cells and immunogenicity in infected humans and mice are still not fully *** study utilized various techniques such as luciferase immunoprecipitation system(LIPS),immunofluorescence assay(IFA),and western blot(WB)to detect accessory protein-specific antibodies in sera of COVID-19 *** antibodies to proteins 3a,3b,7b,8 and 9c can be detected by LIPS,but only protein 3a antibody was detected by IFA or *** against proteins 3a and 7b were only detected in ICU patients,which may serve as a marker for predicting disease ***,we investigated the expression of accessory proteins in SARS-CoV-2-infected cells and identified the expressions of proteins 3a,6,7a,8,and *** also analyzed their ability to induce antibodies in immunized mice and found that only proteins 3a,6,7a,8,9b and 9c were able to induce measurable antibody productions,but these antibodies lacked neutralizing activities and did not protect mice from SARS-CoV-2 *** findings validate the expression of SARS-CoV-2 accessory proteins and elucidate their humoral immune response,providing a basis for protein detection assays and their role in pathogenesis.

关键词： SARS-CoV-2 Accessory protein Humoral immune responses COVID-19 Mouse model

Central nervous system efficacy of aumolertinib versus gefitinib in patients with untreated,EGFR-mutated,advanced non-small cell lung cancer:data froma randomized phase III trial(AENEAS)

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Cancer Communications 2024年第9期44卷 1005-1017页

作者： Shun Lu Xiaorong dong Hong Jian Jianhua chen Gongyan chen Yuping Sun Yinghua Ji ZipingWang Jianhua Shi Junguo Lu Shaoshui chen dongqing Lv Guojun Zhang Chunling Liu Juan Li Xinmin Yu Zhong Lin Zhuang Yu ZhehaiWang Jiuwei Cui Xingxiang Xu Jian Fang Jifeng Feng Zhi Xu RuiMa jie Hu Nong Yang Xiangdong Zhou XiaohongWu chengping Hu Zhihong Zhang You Lu Yanping Hu Liyan Jiang Qiming wang Renhua Guo Jianying Zhou Baolan Li Chunhong Hu Wancheng Tong Helong Zhang LinMa Yuan chen Zhijun jie Yu Yao Longzhen Zhang jieWeng Weidong Li Jianping Xiong Xianwei Ye Jianchun Duan Haihua Yang Meili Sun HongyingWei JiaweiWei Zheyu Zhang QiongWu Department of Medical Oncology Shanghai Chest Hospital Shanghai JiaoTong UniversityShanghaiP.R.China Cancer Center Union Hospital Tongji Medical College Huazhong University of Science and TechnologyWuhanHubeiP.R.China Department of Medical Oncology-Chest Hunan Cancer Hospital&The Affiliated Cancer Hospital of Central South University Xiangya School of MedicineChangshaHunanP.R.China Thoracic OncologyMedicine HarbinMedical University Cancer HospitalHarbinHeilongjiangP.R.China Department of Oncology Jinan Central HospitalJinanShandongP.R.China Department of Oncology First Affiliated Hospital of Xinxiang Medical UniversityXinxiangHenanP.R.China Department of Chest Medicine Beijing Cancer HospitalBeijingP.R.China Department of Internal Medicine Linyi Cancer HospitalLinyiShandongP.R.China Department of Respiratory Medicine Nantong Tumor HospitalNantongJiangsuP.R.China Department of Oncology Binzhou Medical University HospitalBinzhouShandongP.R.China Breath Internal Medicine Taizhou Hospital of Zhejiang ProvinceLinhaiZhejiangP.R.China Department of Respiration The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenanP.R.China Department of Lung Internal Medicine Affiliated Tumor Hospital of Xinjiang Medical UniversityUrumqiXinjiangP.R.China Department of Thoracic Oncology Sichuan Cancer HospitalChengduSichuanP.R.China Thoracic Medical Oncology Cancer Hospital of the University of Chinese Academy of Sciences(Zhejiang Cancer Hospital)HangzhouZhejiangP.R.China Department of Thoracic Oncology The Fifth Subsidiary Sun Yat-sen University HospitalZhuhaiGuangdongP.R.China Department of Oncology The Affiliated Hospital of QingdaoUniversityQingdaoShandongP.R.China Department of Oncology Shandong Cancer HospitalJinanShandongP.R.China Department of Oncology The First BethuneHospital of Jilin UniversityChangchunJilinP.R.China Department of Respiration Northern Jiangsu People’s Hospital Affiliated to Yangzhou UniversityYangzhouJiangsuP.R.China Department of Internal

Background:The initial randomized,double-blinded,actively controlled,phase III ANEAS study(NCT03849768)demonstrated that aumolertinib showed superior efficacy relative to gefitinib as first-line therapy in epidermal growth factor receptor(EGFR)-mutated advanced non-small cell lung cancer(NSCLC).Metastatic disease in the central nervous system(CNS)remains a challenge in the management of *** study aimed to compare the efficacy of aumolertinib versus gefitinib among patients with baseline CNS metastases in the ANEAS ***:Eligible patients were enrolled and randomly assigned in a 1:1 ratio to orally receive either aumolertinib or gefitinib in a double-blinded *** with asymptomatic,stable CNS metastases were ***-up imaging of the same modality as the initial CNS imaging was performed every 6 weeks for 15 months,then every *** responsewas assessed by a neuroradiological blinded,independent central review(neuroradiological-BICR).The primary endpoint for this subgroup analysis was CNS progression-free survival(PFS).Results:Of the 429 patients enrolled and randomized in the ANEAS study,106 patients were found to have CNS metastases(CNS Full Analysis Set,cFAS)at baseline by neuroradiological-BICR,and 60 of them had CNS target lesions(CNS Evaluable for Response,cEFR).Treatment with aumolertinib significantly prolonged median CNS PFS compared with gefitinib in both cFAS(29.0 vs.8.3 months;hazard ratio[HR]=0.31;95%confidence interval[CI],0.17-0.56;P<0.001)and cEFR(29.0 vs.8.3 months;HR=0.26;95%CI,0.11-0.57;P<0.001).The confirmed CNS overall response rate in cEFRwas 85.7%and 75.0%in patients treated with aumolertinib and gefitinib,*** risk analysis showed that the estimated probability of CNS progression without prior non-CNS progression or death was consistently lower with aumolertinib than with gefitinib in patients with and without CNSmetastases at *** new safety findings were ***:The

关键词： aumolertinib brain metastasis non-small cell lung cancer third-generation EGFR-TKI

Preliminary compact torus injection experiments on the Keda Torus eXperiment reversed field pinch

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Plasma Science and Technology 2024年第10期26卷 56-64页

作者： Tao LAN chen chen Chijin XIAO Weixing DING jie WU Wenzhe MAO Sen ZHANG Defeng KONG Shoubiao ZHANG Zhengwei WU Qilong dong Yongkang ZHOU Hangqi XU Jiaren WU Zian WEI Xiaohui WEN Hai WANG Chu ZHOU Adi LIU Hong LI Jinlin XIE Wandong LIU Ge ZHUANG Department of Plasma Physics and Fusion Engineering University of Science and Technology of ChinaHefei 230026People’s Republic of China Plasma Physics Laboratory University of SaskatchewanSaskatoon SK S7N 5E2Canada Institute of Plasma Physics Chinese Academy of SciencesHefei 230031People’s Republic of China

A new compact torus injector(KTX-CTI)has been built for injection experiments on the Keda Torus eXperiment(KTX)reversed field pinch(RFP).The aim is to study the fundamental physics governing the compact torus(CT)central fueling *** experiments conducted under the sole influence of a 0.1 T toroidal magnetic field,the injected CT successfully penetrated the entire toroidal magnetic field,reaching the inner wall of the KTX vacuum *** reaching the inner wall,the CT diffused both radially outward and toroidally within the vessel at a discernible diffusion ***,the inherent helicity within the CT induced a modest KTX plasma current of 200 A,consistent with predictions based on helicity *** injection demonstrated the capability to initiate KTX discharges at low loop voltages,suggesting its potential as a pre-ionization and current startup *** RFP discharges featuring CT injection,the central plasma density was found to exceed the Greenwald density limit,with more peaked density profiles,indicating the predominant confinement of CT plasma within the core region of the KTX bulk plasma.

关键词： compact torus fueling reversed field pinch density limit

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用于创面修复的胶原基生物材料的研究进展

中华烧伤与创面修复杂志 2024年第1期40卷 90-95页

作者：董祖琴陈亚芳梁洁樊渝江四川大学国家生物医学材料工程技术研究中心四川大学生物医学工程学院成都610064

急性或慢性创面是常见的临床问题。胶原蛋白因具有来源丰富、生物相容性良好、免疫原性低以及可生物降解等诸多优点,被广泛用于创面修复的基础研究和临床治疗,具有广阔的临床应用前景。该文简要回顾胶原蛋白在创面愈合相关的不同生物学... 详细信息

急性或慢性创面是常见的临床问题。胶原蛋白因具有来源丰富、生物相容性良好、免疫原性低以及可生物降解等诸多优点,被广泛用于创面修复的基础研究和临床治疗,具有广阔的临床应用前景。该文简要回顾胶原蛋白在创面愈合相关的不同生物学过程中的作用,对胶原蛋白的来源进行了概述;此外,该文还总结了基于胶原蛋白的创面敷料在创面修复领域中的应用情况及最新研究进展。

关键词：胶原生物相容性材料组织支架重组胶原蛋白创面修复

氮添加对不同氮需求豆科植物幼苗根系形态性状和根叶养分含量的影响

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生态学杂志 2024年第5期43卷 1255-1262页

作者：董佳乐许涵解亚鑫陈洁李艳朋雷婕中国林业科学研究院热带林业研究所广州510520 南京林业大学南京210037

为揭示氮添加对不同氮需求豆科植物幼苗的影响,以海南热带雨林3种不同氮生境偏好的豆科植物——低氮需求的长脐红豆(Ormosia balansae)、中氮需求的荔枝叶红豆(Ormosia semicastrata ***)和高氮需求的猴耳环(Archidendron clypearia)幼... 详细信息

为揭示氮添加对不同氮需求豆科植物幼苗的影响,以海南热带雨林3种不同氮生境偏好的豆科植物——低氮需求的长脐红豆(Ormosia balansae)、中氮需求的荔枝叶红豆(Ormosia semicastrata ***)和高氮需求的猴耳环(Archidendron clypearia)幼苗为研究对象,设置5种氮添加水平(0、75、150、300和600 mg·kg^(-1))盆栽试验,观测它们根系形态性状与根叶器官养分含量的响应特征。结果表明:(1)氮添加水平的升高显著降低了低氮需求(长脐红豆)和中氮需求(荔枝叶红豆)豆科物种的总根长、总根表面积和根系干重,而对高氮需求(猴耳环)豆科物种的根系形态性状无影响。(2)相关性分析表明,在不同氮添加水平下,低氮需求的长脐红豆和中氮需求的荔枝叶红豆总根长、总根表面积、根系干重与根际土壤硝态氮、铵态氮浓度呈显著负相关。(3)氮添加仅对低氮和中氮需求豆科物种的根叶养分含量具有促进作用,而对高氮需求物种的根叶养分含量无显著影响。具体而言,氮添加显著增加了低氮需求的豆科物种(长脐红豆)叶片和根系的全氮含量,而对中氮需求的豆科物种(荔枝叶红豆)叶片和根系的氮、磷含量均有促进作用。综上所述,氮添加对豆科植物的影响因氮需求的不同以及氮添加水平而存在差异,一方面显著抑制低氮需求和中氮需求的豆科植物的根系形态性状的生长,促进了两者根叶氮、磷含量的增加,另一方面对高氮需求的豆科植物根系形态性状无影响,且仅促进了根系氮含量。未来关于氮沉降对豆科植物的化学计量特征以及群落动态变化的研究,有必要充分考虑豆科植物的自身不同特性。

关键词：热带雨林豆科植物土壤无机氮根系形态性状养分状态

厌氧段光照策略对A/O模式下菌藻共生系统性能的影响

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中国环境科学 2024年第8期44卷 4336-4346页

作者：李冬公为敏李帅柴晨旭张杰北京工业大学水质科学与水环境恢复工程北京市重点实验室北京100124 哈尔滨工业大学城市水资源与水环境国家重点实验室黑龙江哈尔滨150090

设置4组以厌氧/好氧(A/O)模式运行的序批式反应器(SBR),其中R1厌氧段为8000lx的光照;R^(2)、R3和R4将厌氧段划分为A1和A_(2),A1段无光照,A_(2)段的光强分别为0、3000和5000lx,探究不同厌氧段光照策略对菌藻共生系统性能的影响.研究结果... 详细信息

设置4组以厌氧/好氧(A/O)模式运行的序批式反应器(SBR),其中R1厌氧段为8000lx的光照;R^(2)、R3和R4将厌氧段划分为A1和A_(2),A1段无光照,A_(2)段的光强分别为0、3000和5000lx,探究不同厌氧段光照策略对菌藻共生系统性能的影响.研究结果显示,在厌氧后期添加弱光照的R3和R4中可以快速富集微藻,这使其形成的菌藻共生颗粒结构致密,沉降性能良好,碳氮磷去除效果更佳,并且分泌出更多的胞外聚合物(EPS).其中R3除磷效果最好,总磷(TP)去除率达到95.87%.典型周期分析可知,弱光条件下厌氧末期的释磷量与叶绿素a(Chl-a)含量成正比,R3的厌氧释磷能力最强,其厌氧末磷浓度达到43.73mg/L,在A_(2)段形成的高磷环境能够刺激微藻生长,其Chl-a含量在运行后期达到6.13mg/gVSS.高通量测序显示,R3的原核生物中成功富集了以Candidatus_Accumulibacter为核心的聚磷菌(PAOs),丰度达到11.18%;真核生物中微藻的总丰度达到84.29%,其中Halochlorella丰度高达42.85%,说明在厌氧后期的高磷环境中添加弱光照(3000lx)能够在不影响PAOs生长的条件下同步富集微藻,形成了以微藻和PAOs为核心的共生颗粒,为污水深度处理提供技术支持.

关键词：菌藻共生颗粒污泥光照策略聚磷菌高通量测序

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营商环境、地方政府税收努力与企业税收遵从

广东财经大学学报 2024年第2期39卷 29-43页

作者：陶东杰陈政弘徐阳湖北经济学院财政与公共管理学院湖北武汉430205

营商环境优化能够改变政府与市场之间的博弈均衡,有助于政府提高最优税收努力水平,进而提升国家财政能力。构建“政府-企业”两部门Stackelberg博弈模型作为理论分析框架,利用我国行政审批制度改革作为地方政府优化营商环境的“准自然... 详细信息

营商环境优化能够改变政府与市场之间的博弈均衡,有助于政府提高最优税收努力水平,进而提升国家财政能力。构建“政府-企业”两部门Stackelberg博弈模型作为理论分析框架,利用我国行政审批制度改革作为地方政府优化营商环境的“准自然实验”,匹配中国工业企业数据库,对优化营商环境与地方财政能力之间的因果关系进行实证检验。研究发现:行政审批制度改革代表的营商环境优化有助于提升地方财政能力,表现为企业税收遵从的显著提升;在所得税由地税局管辖的企业、民营企业以及规模较小的企业,这种效应更加明显,从而证实了营商环境优化影响地方政府税收努力进而提高企业税收遵从的理论机制。研究结论对于从优化营商环境的路径提升国家财政能力提供了政策启示。

关键词：营商环境行政审批制度改革地方财政能力税收遵从