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Schizophrenia and comorbid sleep disorders

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Neuroimmunology and Neuroinflammation 2016年第1期3卷 225-227页

作者： Maurits van den Noort Heike Staudte benoît Perriard Sujung Yeo Sabina Lim Peggy Bosch Research Group of Pain and Neuroscience Kyung Hee UniversitySeoul 130-701South Korea Brussels Institute for Applied Linguistics Vrije Universiteit Brussel1050 BrusselsBelgium Psychiatric Research Institute LVR-Klinik Bedburg-Hau47511 Bedburg-HauGermany Neurology Unit Laboratory for Cognitive and Neurological SciencesDepartment of MedicineFaculty of ScienceUniversity of Fribourg1700 FribourgSwitzerland Department of Acupuncture and Meridian of Oriental Medicine Sang Ji UniversityWonju 26339South Korea Centre for Cognition Donders Institute for BrainCognition and BehaviourRadboud University Nijmegen6500 GL NijmegenGelderlandthe Netherlands.

Schizophrenia is a severe psychiatric disorder that has a worldwide prevalence of 0.5%^([1])and poses a high cost to society.^([2])the disorder is characterized by positive symptoms,such as hallucinations and delusions,^([3])negative symptoms,such as impaired emotional functioning and behavioral disruptions(*** affect,difficulty in starting activities and completing them,etc.),^([4])and cognitive symptoms,such as deficits in executive functioning,impaired working memory,and attention problems.

关键词： impaired Schizophrenia morbid

theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia

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Bone Research 2022年第1期10卷 137-149页

作者： Ludovic Martin Nabil Kaci Catherine benoist-Lasselin Marine Mondoloni Suzanne Decaudaveine Valentin Estibals Maxence Cornille Léa Loisay Justine Flipo benoît Demuynck Maria de la Luz Cádiz-Gurrea Florent Barbault Salvador Fernández-Arroyo Laurent Schibler Antonio Segura-Carretero Emilie Dambroise Laurence Legeai-Mallet Universitéde Paris Imagine InstituteLaboratory of Molecular and Physiopathological Bases of OsteochondrodysplasiaINSERM UMR 1163F‑75015ParisFrance Inovarion ParisFrance Department of Analytical Chemistry University of GranadaGranadaSpain Research and Development of Functional Food Centre(CIDAF) GranadaSpain Universitéde Paris ITODYSCNRSUMR 708615 rue J-A de BaïfParisFrance Biomedical Research Unit Medicine and Surgery DepartmentRovira i Virgili UniversityTarragonaSpain ALLICE Maison Nationale des EleveursParisFrance

A gain-of-function mutation in the fibroblast growth factor receptor 3 gene(FGFR3)results in achondroplasia(ACH),the most frequent form of *** activation of FGFR3 impairs bone formation and elongation and many signal transduction *** of new and relevant compounds targeting the FGFR3 signaling pathway is of broad importance for the treatment of ACH,and natural plant compounds are prime drug candidate ***,we found that the phenolic compound(-)-epicatechin,isolated from theobroma cacao,effectively inhibited FGFR3’s downstream signaling *** analysis in an Fgfr3 mouse model showed that ciliary mRNA expression was modified and influenced significantly by the Indian hedgehog and PKA pathways.(-)-Epicatechin is able to rescue mRNA expression impairments that control both the structural organization of the primary cilium and ciliogenesis-related *** femurs isolated from a mouse model(Fgfr3^(Y367C/+))of ACH,we showed that(-)-epicatechin eliminated bone growth impairment during 6 days of ex vivo *** vivo,we confirmed that daily subcutaneous injections of(-)-epicatechin to Fgfr3^(Y367C/+) mice increased bone elongation and rescued the primary cilium defects observed in *** modification to the primary cilia promoted the typical columnar arrangement of flat proliferative chondrocytes and thus enhanced bone *** results of the present proof-of-principle study support(-)-epicatechin as a potential drug for the treatment of ACH.

关键词： inhibited arrangement eliminated

贝鲁特486 MINA EL HOSN大厦

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建筑创作 2012年第4期 110-117页

作者： beno■t Jallon Umberto Napotitano LAN

此项目设计的出发点是基于对贝鲁特市的整体解读,即：将贝鲁特市设想为一个包含故事、背景、建筑作品与情境的连续层,在该连续层里每一座建筑都是这个城市独特风景的组成部分,都是一个强有力的词汇的具体体现;将此项目设计为一个界面,... 详细信息

此项目设计的出发点是基于对贝鲁特市的整体解读,即：将贝鲁特市设想为一个包含故事、背景、建筑作品与情境的连续层,在该连续层里每一座建筑都是这个城市独特风景的组成部分,都是一个强有力的词汇的具体体现;将此项目设计为一个界面,一个编织新关系并赋予其对于历史、现在与未来的新憧憬的方法。项目位于码头区和Soldiere街区附近,其特点是高层建筑整齐地排列在由贝鲁特国际学院延伸出来的一条绿色带上。

关键词： EL 大厦项目设计建筑作品组成部分高层建筑码头区街区

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精细结构常数新突破

新发现 2021年第8期 40-43页

作者： benoît Rey 王隽(编译) 不详

精细结构常数是一个神奇的数。它以分数的形式呈现,无单位、无量纲;分子为1.分母略大于137。它不仅维持着原子的凝聚力,确保分子化学键的稳定性,还控制着光与物质的相互作用。简言之,精细结构常数影响着方方面面。它可以表征电磁力的强... 详细信息

精细结构常数是一个神奇的数。它以分数的形式呈现,无单位、无量纲;分子为1.分母略大于137。它不仅维持着原子的凝聚力,确保分子化学键的稳定性,还控制着光与物质的相互作用。简言之,精细结构常数影响着方方面面。它可以表征电磁力的强度,因而使宇宙中的物质具有一定的结构。它的强度既足以令电子留在原子核周围,又正好能让原子与相邻原子组成分子。

关键词：精细结构常数原子组成电磁力化学键形式呈现凝聚力原子核分子

多场作用下盐穴储气库腔体稳定性的数值模拟研究

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石油科学通报 2023年第6期8卷 787-796页

作者：宫丹妮李景翠万继方庄晓谦 benoît Brouard 王琳琳中国石油大学(北京)安全与海洋工程学院北京102249 中国石油集团工程技术研究院有限公司北京102206 Brouard工程公司巴黎75003

针对盐岩储气库在多年运行下出现的体积收缩、损伤破坏等问题,以金坛盐岩储气库X腔为背景,根据声呐测腔数据建立真实三维几何模型并采用嵌套式双重网格划分,对应力场和温度场作用下储气库运行10年期间进行了数值模拟,并通过模拟结果分... 详细信息

针对盐岩储气库在多年运行下出现的体积收缩、损伤破坏等问题,以金坛盐岩储气库X腔为背景,根据声呐测腔数据建立真实三维几何模型并采用嵌套式双重网格划分,对应力场和温度场作用下储气库运行10年期间进行了数值模拟,并通过模拟结果分析了周期注采工况下不同运行年限盐腔体积变形及腔周损伤规律,预测储气库运营期间腔体稳定性薄弱区域。结果表明,与腔体上部相比,腔体中部平滑位置位移变形量较小;随着工作年限的不断增加,同一位置处腔壁位移变形量逐渐增加,但增加的速率逐渐减小;储气库在运营10年后体积收缩率达到7%左右,运营期中储气库体积收缩情况有逐年减缓的趋势;盐腔中部至顶板处的腔壁突出位置是储气库腔体稳定性的薄弱区域,在盐穴型储气库造腔设计中应避免该区域的产生。

关键词：多场耦合盐岩储气库周期性注采盐腔体积收缩稳定性评价

Psychological distress during the COVID-19 pandemic in France:a national assessment of at-risk populations

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General Psychiatry 2020年第6期33卷 400-405页

作者： Benjamin Chaix Guillaume Delamon Arthur Guillemasse benoit Brouard Jean-Emmanuel Bibault ENt Department Hopital Gui de ChauliacMontpellierFrance University Montpellier 1 MontpellierFrance Hopital Pite-Salpetriere WefightBrain&Spine InstituteParisFrance Department of Radiation Oncology Hopital Europeen Georges Pompidou CancerologieParisFrance

Background Lockdowns were implemented to limit the spread of *** distress(PD)and post-traumatic stress disorder have been reported after traumatic events,but the specific effect of the pandemic is not well *** the aim of this study was to assess PD in France,a country where C0VID-19 had such a dramatic impact that it required a country-wide *** We recruited patients in four groups of chatbot users followed for breast cancer,asthma,depression and *** used the Psychological Distress Inventory(PDI),a validated scale to measure PD during traumatic events,and correlated PD risk with patients*characteristics in order to better identify the ones who were the most at *** the study included 1771 participants.91.25%(n=1616)were female with a mean age of 32.8(13.71)years and 7.96%(n=141)were male with a mean age of 28.0(8.14)*** total,38.06%(n=674)of the respondents had psychological distress(PDI>14).An analysis of variance showed that unemployment and depression were significantly associated with a higher PDI *** using their smartphones or computers for more than 1 hour a day also had a higher PDI score(p=0.026).Conclusion Prevalence of PD in at-risk patients is *** patients are also at an increased risk of developing post-traumatic stress *** steps should be implemented to monitor and prevent PD through dedicated mental health policies if we want to limit the public health impact of COVID-19 in time.

关键词： distress steps limit

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“制造”超新星

新发现 2021年第8期 44-49页

作者： benoît Rey 王佳蕾不详

半世纪的努力换来了一秒钟的影像。这短暂的一秒改变了巨星的命运。在这一瞬间,恒星核心忽然坍缩,随之产生的一股骇人冲击波炸开了整个恒星,并将其物质抛撒至太空一这就是超新星,堪称宇宙中最剧烈的爆炸。

关键词：超新星坍缩恒星冲击波影像宇宙

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追捕中等质量黑洞

新发现 2021年第9期 42-46页

作者： benoît Rey 陈天涵(编译) 不详

在强大观测技术的帮助下,中等质量黑洞终于现身了。而天文学家对它们的大追捕才刚刚开始!潜伏在阴影中,隐蔽在星系最黑暗的角落,甚至躲过了人类望远镜的层层巡视:难以捕捉的中等质量黑洞是科学家最不了解的一类黑洞。

关键词：观测技术中等质量黑洞星系望远镜天文学家追捕

EXPERIMENtAL INVEStIGAtION OF tHE LEAKAGE BEHAVIOUR OF REINFORCED CONCREtE WALLS

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EXPERIMENTAL INVESTIGATION OF THE LEAKAGE BEHAVIOUR OF REINF...