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Cumulative human impacts in the Bering strait Region

Ecosystem Health and sustainability 2017年第8期3卷 1-14页

作者： Jamie C.Afflerbach Dan Yocum benjamin s.halpern National Center for Ecological Analysis and synthesis University of CaliforniaSanta BarbaraCAUSA Bren school of Environmental science and Management University of CaliforniaSanta BarbaraCAUSA Department of Life sciences Imperial College LondonAscotUK

Introduction:Human impacts on Arctic marine ecosystems are increasing in extent and intensity as sea ice shrinks and utilization of marine resources *** effects of climate change are being felt across the arctic while stressors such as commercial fishing and shipping continue to grow as the Arctic becomes more *** these emerging changes,there is need for an assessment of the current cumulative impact of human activities to better anticipate and manage for a changing *** human impacts(CHI)assessments have been widely applied around the world in a variety of ecosystem types but have yet to incorporate temporal dynamics of individual *** dynamics are funda-mental to Arctic ***:Here,we present the first CHI assessment of an Arctic ecosystem to incorporate sea ice as a habitat and assess impact seasonality,using the Bering strait Region(BsR)as a case *** find that cumulative impacts differ seasonally,with lower impacts in winter and higher impacts in summer *** portions of the BsR have significantly different impacts within each season when compared to a mean annual cumulative impact *** impacts also have great spatial variability,with Russian waters between 2.38 and 3.63 times as impacted as Us ***:This assessment of seasonal and spatial cumulative impacts provides an under-standing of the current reality in the BsR and can be used to support development and evaluation of future management scenarios that address expected impacts from climate change and increasing interest in the Arctic.

关键词： Arctic marine ecosystems cumulative human impacts Bering strait sea ice limate change

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Principles for managing marine ecosystems prone to tipping points

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Ecosystem Health and sustainability 2015年第5期1卷 15-32页

作者： Kimberly A.selkoe Thorsten Blenckner Margaret R.Caldwell Larry B.Crowder Ashley L.Erickson Timothy E.Essington James A.Estes Rod M.Fujita benjamin s.halpern Mary E.Hunsicker Carrie V.Kappel Ryan P.Kelly John N.Kittinger Phillip s.Levin John M.Lynham Megan E.Mach Rebecca G.Martone Lindley A.Mease Anne Ksalomon Jameal F.samhouri Courtney scarborough Adrian C.stier Crow White Joy Zedler National Center for Ecological Analysis and synthesis 735 State StreetSuite 300Santa BarbaraCalifornia 93101 USA Hawaii Institute of Marine Biology University of HawaiiKaneoheHawaii 96744 USA stockholm Resilience Centre Stockholm UniversityKra¨ftriket 2B10691 StockholmSweden Center for Ocean solutions Stanford Woods Institute for the EnvironmentStanford University473 Via Ortega Room 193StanfordCalifornia 94305 USA school of Aquatic and Fishery sciences University of WashingtonSeattleWashington 98195 USA Department of Ecology and Evolutionary Biology 100 Shaffer RoadUniversity of CaliforniaSanta CruzCalifornia 95060 USA Environmental Defense Fund 123 Mission Street28th FloorSan FranciscoCalifornia 94105 USA Bren school of Environmental science and Management University of CaliforniaSanta BarbaraCalifornia 93106 USA Imperial College London Silwood Park CampusBuckhurst RoadAscot SL57PY United Kingdom school of Marine and Environmental Affairs University of Washington3707 Brooklyn Avenue NESeattleWashington 98105-6715 USA Conservation International Betty and Gordon Moore Center for Science and Oceans7192 Kalaniana‘ole HighwaySuite G230HonoluluHawaii 96825 USA Conservation Biology Division Northwest Fisheries Science CenterNational Marine Fisheries ServiceNational Oceanic and Atmospheric Administration2725 Montlake Boulevard EastSeattleWashington 98112 USA Department of Economics University of Hawaii at ManoaHonoluluHawaii 96822 USA school of Resource and Environmental Management Simon Fraser UniversityBurnabyBritish Columbia V5A1S6 Canada Department of Biological sciences California Polytechnic State UniversitySan Luis ObispoCalifornia 93407 USA Botany Department University of WisconsinMadisonWisconsin 53706 USA

As climatic changes and human uses intensify,resource managers and other decision makers are taking actions to either avoid or respond to ecosystem tipping points,or dramatic shifts in structure and function that are often costly and hard to *** indicates that explicitly addressing tipping points leads to improved management *** on theory and examples from marine systems,we distill a set of seven principles to guide effective management in ecosystems with tipping points,derived from the best available *** principles are based on observations that tipping points(1)are possible everywhere,(2)are associated with intense and/or multifaceted human use,(3)may be preceded by changes in earlywarning indicators,(4)may redistribute benefits among stakeholders,(5)affect the relative costs of action and inaction,(6)suggest biologically informed management targets,and(7)often require an adaptive response to *** suggest that early action to preserve system resilience is likely more practical,affordable,and effective than late action to halt or reverse a tipping *** articulate a conceptual approach to management focused on linking management targets to thresholds,tracking early-warning signals of ecosystem instability,and stepping up investment in monitoring and mitigation as the likelihood of dramatic ecosystem change *** approach can simplify and economize management by allowing decision makers to capitalize on the increasing value of precise information about threshold relationships when a system is closer to tipping or by ensuring that restoration effort is sufficient to tip a system into the desired regime.

关键词： critical transition ecosystem-based management marine spatial planning nonlinear relationships restoration ecology stakeholder engagement

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Nuance of inward rectifying potassium(Kir)channel dysfunctions in neurodegenerative diseases

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Neural Regeneration Research 2024年第6期19卷 1195-1196页

作者： benjamin Garland Linlin Ma Griffith Institute for Drug Discovery&school of Environment and science Griffith UniversityNathanBrisbaneQLDAustralia

Neurodegenerative disorders are highly prevalent and diverse in *** manifestation largely depends on the cell types involved,with aberrant inflammatory episodes progressively inducing a constellation of phenotypes that are classified into specific diseases based on their neuropathological *** two most prevalent neurodegenerative diseases worldwide,Alzheimer’s disease(AD)and Parkinson’s disease(PD),for example,share notable similarities,yet they differ in terms of the specific cell types lost within the central nervous system(CNs).The significant and progressive loss of cortical and certain subcortical neurons in various regions is a major defining trait of *** contrast,the specific loss of dopaminergic neurons(DA)within the substantial nigra pars compacta(sNpc)is sufficient to cause motor symptoms associated with *** devastating condition arising from neurodegeneration within the CNs,amyotrophic lateral sclerosis(ALs),results in the progressive death of upper and lower motor *** degeneration originates in oligodendrocytes,whose defective myelination abilities lead to the denervation of the anterior horn,aggravating motor neuron death.

关键词： diseases degenerative degeneration

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Generation of meaningful synthetic sensor data—Evaluated with a reliable transferability methodology

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Energy and AI 2024年第1期15卷 248-264页

作者： Michael Meiser benjamin Duppe Ingo Zinnikus Deutsches Forschungszentrum für künstliche Intelligenz(DFKI) Stuhlsatzenhausweg 3Saarbrücken66123SaarlandGermany

As households are equipped with smart meters,supervised Machine Learning(ML)models and especially Non-Intrusive Load Monitoring(NILM)disaggregation algorithms are becoming increasingly *** be robust,these models require a large amount of data,which is difficult to ***,the generation of meaningful synthetic data is becoming more *** use a simulation framework to generate multiple datasets using different techniques and evaluate their quality statistically by measuring the performance of NILM models for *** demonstrate that the method of data generation is crucial to train ML models in a meaningful *** experiments conducted reveal that adding noise to the synthetic smart meter data is essential to train robust NILM models for *** best results are obtained when this noise is derived from unknown appliances for which no ground truth data is *** we observed that NILM models can provide unstable results,we develop a reliable evaluation methodology,based on Cochran’s sample ***,we compare the quality of the generated synthetic data with real data and observe that multiple NILM models trained on synthetic data perform significantly better than those trained on real data.

关键词： smart home synthetic sensor data Energy data Transfer learning Evaluation methodology Machine learning Neural networks NILM seq2point WindowGRU DAE seq2seq RNN

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A 63-Year-Old Male with D-Transposition of the Great Arteries Who Had an Early Form of the Arterial switch Operation

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Congenital Heart Disease 2024年第1期19卷 65-68页

作者： Michael A.Rebolledo Jane s.Yao Jason N.Johnson Umar s.Boston benjamin R.Waller III Division of Pediatric Cardiology Department of PediatricsThe University of Tennessee Health Science CenterThe Heart InstituteLe Bonheur Children’s HospitalMemphisUSA College of Medicine The University of Tennessee Health ScienceMemphisUSA Division of Pediatric Cardiothoracic surgery Department of SurgeryThe University of Tennessee Health Science CenterHeart InstituteLe Bonheur Children’s HospitalMemphisUSA

We describe a 63-year-old male who appears to have undergone an early form of the arterial switch operation for D-transposition of the great arteries performed in the *** review the clinical and imaging data that support our *** had a diagnostic cardiac catheterization which demonstrated severe pulmonary hypertension responsive to epoprostenol and *** case may represent one example of the experimental surgical work done prior to *** Jatene’s description of theﬁrst successful arterial switch performed in 1975.

关键词： Adult congenital heart disease arterial switch operation great vessel anomaly imaging(all modalities)

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Cost burden following esophagectomy:A single centre observational study

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World Journal of Gastrointestinal surgery 2024年第7期16卷 2255-2269页

作者： Vered Buchholz Dong Kyu Lee David s Liu Ahmad Aly stephen A Barnett Riley Hazard Peter Le benjamin Kioussis Vijayaragavan Muralidharan Laurence Weinberg Department of surgery Austin HealthMelbourne 3084VictoriaAustralia Department of Anesthesiology and Pain Medicine Dongguk University Ilsan HospitalSeoul 14566GoyangSouth Korea Department of surgery Austin HealthThe University of MelbourneMelbourne 3084VictoriaAustralia Department of Anesthesia Austin HealthMelbourne 3084VictoriaAustralia Department of Anesthesia Austin HospitalHeidelberg 3084VictoriaAustralia Department of Critical Care The University of MelbourneMelbourne 3084VictoriaAustralia

BACKGROUND Cost analyses of patients undergoing esophagectomy is valuable for identifying modifiable expenditure drivers to target and curtail costs while improving the quality of *** aimed to define the cost-complication relationship after esophagectomy and delineate the incremental contributions to *** To assess the relationship between the hospital costs and potential cost drivers post esophagectomy and investigate the relationship between the cost-driving variables(predicting variables)and hospital costs(dependent variable).METHODs In this retrospective single center study,the severity of complications was graded using the Clavien-Dindo(CD)classification *** esophagectomy complications were categorized and defined according to consensus *** costing data included the in-hospital costs of the index admission and any unplanned admission within 30 postoperative *** used correlation analysis to assess the relationship between key clinical variables and hospital costs(in United states dollars)to identify cost drivers.A mediation model was used to investigate the relationship between these variables and hospital *** A total of 110 patients underwent primary esophageal *** median admission cost was $47822.7(interquartile range:35670.2-68214.0).The total effects on costs were $13593.9(95%CI:10187.1-17000.8,Pse in CD severity grade,$4781(95%CI:3772.7-5789.3,Pse in the number of complications,and $42552.2(95%CI:8309-76795.4,P=0.015)if a key esophagectomy complication *** esophagectomy complications drove the costs directly by $11415.7(95%CI:992.5-21838.9,P=0.032).CONCLUsION The severity and number of complications,and the development of key esophagectomy complications significantly contributed to total hospital *** institutional initiatives and strategies are needed to enhance patient outcomes and minimize costs.

关键词： Anesthesia Esophagectomy Complications Cancer surgery

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Microbial electricity-driven anaerobic phenol degradation in bioelectrochemical systems

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Environmental science and Ecotechnology 2024年第1期17卷 40-47页

作者： shixiang Dai Falk Harnisch Micjel Chávez Morejòn Nina sophie Keller benjamin Korth Carsten Vogt Department of Environmental Microbiology Helmholtz Centre for Environmental Research GmbH-UFZLeipzigGermany Department of Isotope Biogeochemistry Helmholtz Centre for Environmental Research GmbH-UFZLeipzigGermany

Microbial electrochemical technologies have been extensively employed for phenol ***,previous research has yielded inconsistent results,leaving uncertainties regarding the feasibility of phenol degradation under strictly anaerobic conditions using anodes as sole terminal electron *** this study,we employed high-performance liquid chromatography and gas chromatography-mass spectrometry to investigate the anaerobic phenol degradation *** findings provide robust evidence for the purely anaerobic degradation of phenol,as we identified benzoic acid,4-hydroxybenzoic acid,glutaric acid,and other metabolites of this ***,no typical intermediates of the aerobic phenol degradation pathway were ***-chamber reactors(t0.4 V ***)exhibited a phenol removal rate of 3.5±0.2 mg L^(-1) d^(-1),while two-chamber reactors showed 3.6±0.1 and 2.6±0.9 mg L^(-1) d^(-1) at anode potentials of t0.4 and t 0.2 V,*** results also suggest that the reactor configuration certainly influenced the microbial community,presumably leading to different ratios of phenol consumers and microorganisms feeding on degradation products.

关键词： Microbial electroremediation Geobacter Extracellular electron transfer Anaerobic phenol degradation Microbial syntrophy

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Cost effectiveness of nonpharmacological prevention programs for diabetes:A systematic review of trial-based studies

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Chronic Diseases and Translational Medicine 2024年第1期10卷 12-21页

作者： Yongyi Xiong Zhaohua Huo samuel Y.s.Wong benjamin H.K.Yip Jockey Club school of Public Health and Primary Care Prince of Wales HospitalThe Chinese University of Hong KongShatinHong KongChina

Trial-based economic value of prevention programs for diabetes is *** aimed to review the cost-effectiveness of nonpharmacological interventions to prevent type-2 diabetes mellitus(T2DM)for high-risk *** electronic databases were searched up to March *** assessing both the cost and health outcomes of nonpharmacological interventions for people at high-risk of T2DM were *** quality of the study was assessed by the Consolidated Health Economic Evaluation Reporting standards 2022 *** primary outcome for synthesis was incremental cost-effectiveness ratios(ICER)for quality-adjusted life years(QALYs),and costs were standardized in 2022 Us *** synthesis was performed,considering different types and delivery methods of *** studies included five based on the Us diabetes prevention program(DPP),six on non-DPP-based lifestyle interventions,four on health education,and one on screening plus lifestyle *** with usual care,lifestyle interventions showed higher potential of cost-effectiveness than educational *** lifestyle interventions,DPP-based programs were less cost-effective(median of ICERs:$27,077/QALY)than non-DPP-based programs(median of ICERs:$1395/QALY)from healthcare perspectives,but with larger decreases in diabetes ***,the cost-effectiveness of interventions was more possibly realized through the combination of different delivery *** interventions to prevent T2DM in high-risk populations are both cost-effective and feasible in various ***,economic evidence from low-and middle-income countries is still lacking,and interventions delivered by trained laypersons and combined with peer support sessions or mobile technologies could be potentially a cost-effective solution in such settings with limited resources.

关键词： economic evaluation nonpharmacological interventions pre-diabetes prevention

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structural Pattern Related to Gold Mineralization in the Essakane Area (Northern Burkina Faso, West African Craton)

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Open Journal of Geology 2024年第9期14卷 855-879页

作者： Marc Desire Valea benjamin sawadogo Kalidou Traoré Urbain Wenmenga Naba seta benjamin Allou Laboratoire Gosciences et Environnement (LaGE) Dpartement des Sciences de la Terre Universit Joseph Ki-Zerbo Ouagadougou Burkina Faso Essakane sarl IAMGOLD Corporation Ouagadougou Burkina Faso Laboratoire de Godynamique et de Cartographie Universit des Sciences des Techniques et des Technologies de Bamako Bamako Mali

The finite deformation structures recorded in the Essakane area, located in the northeast corner of Burkina Faso, highlight three major compressive deformation phases, successively named D1, D2, and D3. The D1 event phase, trending NE-sW, is characterised by P1 folds and s1 axial plane schistosity. The D2 phase trending NW-sE is characterised by folds P2, schistosity (s2) and shear (C) planes. And the D3 phase trending NNE-ssW to N-s is characterised by P3 folds, crenulation microfolds and s3 spaced schistosity. It has also been noted that gold mineralizations are mainly hosted in quartz, carbonate, pyrite, and arsenopyrite veins. structural interpretation indicates that these veins are organized into lenticular bodies that were formed during the first two deformation phases (D1 and D2). This suggests a strong structural control typical of orogenic gold concentrations.

关键词： Burkina Faso Essakane shear Zone Deformation Phases Orogenic Gold

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spastin and alsin protein interactome analyses begin to reveal key canonical pathways and suggest novel druggable targets

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Neural Regeneration Research 2025年第3期20卷 725-739页

作者： benjamin R.Helmold Angela Ahrens Zachary Fitzgerald P.Hande Ozdinler Department of Neurology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Center for Molecular Innovation and Drug Discovery Center for Developmental TherapeuticsChemistry of Life Processes InstituteNorthwestern UniversityEvanstonILUSA Mesulam Center for Cognitive Neurology and Alzheimer’s Disease Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Feinberg school of Medicine Les Turner ALS Center at Northwestern UniversityChicagoILUSA

Developing effective and long-term treatment strategies for rare and complex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among patients. This hinders understanding the underlying disease-causing mechanisms and building solutions that have implications for a broad spectrum of patients. One potential solution is to develop personalized medicine approaches based on strategies that target the most prevalent cellular events that are perturbed in patients. Especially in patients with a known genetic mutation, it may be possible to understand how these mutations contribute to problems that lead to neurodegeneration. Protein–protein interaction analyses offer great advantages for revealing how proteins interact, which cellular events are primarily involved in these interactions, and how they become affected when key genes are mutated in patients. This line of investigation also suggests novel druggable targets for patients with different mutations. Here, we focus on alsin and spastin, two proteins that are identified as “causative” for amyotrophic lateral sclerosis and hereditary spastic paraplegia, respectively, when mutated. Our review analyzes the protein interactome for alsin and spastin, the canonical pathways that are primarily important for each protein domain, as well as compounds that are either Food and Drug Administration–approved or are in active clinical trials concerning the affected cellular pathways. This line of research begins to pave the way for personalized medicine approaches that are desperately needed for rare neurodegenerative diseases that are complex and heterogeneous.

关键词： ALs2 alsin amyotrophic lateral sclerosis hereditary spastic paraplegia neurodegenerative diseases personalized medicine precision medicine protein interactome protein-protein interactions sPAsT spastin

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