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Observer Variability in BI-RADS Ultrasound f.atures and Its Inf.uence on Computer-Aided Diagnosis of.Breast Masses

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Advances in Breast Cancer Research 2015年第1期4卷 1-8页

作者： Laith R. Sultan Ghizlane Bouzghar benjamin J. Levenback Nauroze A. f.izi Santosh S. Venkatesh Emily f. Conant Chandra M. Sehgal Department of.Radiology University of Pennsylvania Philadelphia USA Department of.Electrical Engineering University of Pennsylvania Philadelphia USA

Objective: Computer classif.cation of.sonographic BI-RADS f.atures can aid dif.erentiation of.the malignant and benign masses. However, the variability in the diagnosis due to the dif.erences in the observed f.atures between the observations is not known. The goal of.this study is to measure the variation in sonographic f.atures between multiple observations and determine the ef.ect of.f.atures variation on computer-aided diagnosis of.the breast masses. Materials and Methods: Ultrasound images of.biopsy proven solid breast masses were analyzed in three independent observations f.r BI-RADS sonographic f.atures. The BI-RADS f.atures f.om each observation were used with Bayes classif.er to determine probability of.malignancy. The observer agreement in the sonographic f.atures was measured by kappa coef.icient and the dif.erence in the diagnostic perf.rmances between observations was determined by the area under the ROC curve, Az, and interclass correlation coef.icient. Results: While some f.atures were repeatedly observed, κ = 0.95, other showed a signif.cant variation, κ = 0.16. f.r all f.atures, combined intra-observer agreement was substantial, κ = 0.77. The agreement, however, decreased steadily to 0.66 and 0.56 as time between the observations increased f.om 1 to 2 and 3 months, respectively. Despite the variation in f.atures between observations the probabilities of.malignancy estimates f.om Bayes classif.er were robust and consistently yielded same level of.diagnostic perf.rmance, Az was 0.772-0.817 f.r sonographic f.atures alone and 0.828-0.849 f.r sonographic f.atures and age combined. The dif.erence in the perf.rmance, ΔAz, between the observations f.r the two groups was small (0.003-0.044) and was not statistically signif.cant (p f.icient f.r the observations was 0.822 (CI: 0.787-0.853) f.r BI-RADS sonographic f.atures alone and f.r those combined with age was 0.833 (CI: 0.800-0.862). Conclusion: Despite the dif.erences in

关键词： Breast Imaging Breast Cancer Observer Variability Computer-Aided Diagnosis

Static Bending Creep Properties of.Glass f.ber Surf.ce Composite Wood

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Journal of.Renewable Materials 2023年第6期11卷 2881-2891页

作者： Shang Zhang Jie Wang benjamin Rose Yushan Yang Qingf.ng Ding Bengang Zhang Chunlei Dong Suzhou Crownhomes Co. Ltd.Suzhou215128China School of.Materials Science and Engineering Southwest Forestry UniversityKunming650224China College of.Chemistry and Materials Engineering Zhejiang A&F UniversityHangzhou311300China Universitéde Lorraine InraeLERMABEpinal88000France Department of.Chemistry Hampden-Sydney CollegeHampden-SydneyUSA

To study the static bending creep properties of.glass f.ber reinf.rced wood,glass f.ber reinf.rced poplar(Gf.P)specimens were obtained by pasting glass f.ber on the upper and lower surf.ces of.Poplar(Populus euramevicana,P),the perf.rmance of.Normal Creep(NC)and Mechanical Sorptive Creep(MSC)of.Gf.P and their inf.uencing f.ctors were tested and *** test results and analysis show that:(1)The MOE and MOR of.Poplar were increased by 17.06%and 10.00%respectively by the glass f.ber surf.ce reinf.rced composite.(2)The surf.ce reinf.rced P with glass f.ber cloth only exhibits the NC pattern of.wood and loses the MSC characteristics of.wood,regardless of.the constant or alternating changes in relative humidity.(3)The instantaneous elastic def.rmation,viscoelastic def.rmation,viscous def.rmation and total creep def.ection of.Gf.P are positively correlated with the stress level of.the external load applied to the ***,the specimen’s creep recovery rate is negatively correlated with the stress level of.the external load applied to the *** static creep def.ection and viscous def.rmation of.Gf.P increase with the increase of.the relative humidity of.the environment.(4)The MSC maximum creep def.ection of.Gf.P increased by only 7.41%over the NC maximum creep def.ection,but the MSC maximum creep def.ection of.P increased by 199.25%over the NC maximum creep def.ection.(5)The Burgers 4-f.ctor model and the Weibull distribution equation can f.t the NC and NC recovery processes of.Gf.P well.

关键词： Glass f.ber reinf.rced composite wood Normal Creep(NC) wood creep Mechanical Sorptive Creep(MSC) creep model

Trends in leadership at orthopaedic surgery sports medicine f.llowships

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World Journal of.Orthopedics 2021年第6期12卷 412-422页

作者： Nicholas C Schiller Andrew J Sama Amanda f.Spielman Chester J Donnally III benjamin I Schachner Dhanur M Damodar Christopher C Dodson Michael G Ciccotti Miller School of.Medicine University of MiamiMiamiFL 33136United States Department of.Orthopaedic Surgery Rothman Institute at Thomas Jefferson UniversityPhiladelphiaPA 19107United States Department of.Orthopedic Surgery University of Miami HospitalMiamiFL 33316United States

BACKGROUND f.llowship directors(f.s)in sports medicine inf.uence the f.ture of.trainees in the f.eld of.*** the characteristics these leaders share must be brought into *** all current sports medicine f.s,our group analyzed their demographic background,institutional training,and academic *** To serve as a f.amework f.r those aspiring to achieve this position in orthopaedics and also identif. opportunities to improve the *** f.llowship programs were identif.ed using both the American Orthopaedic Society f.r Sports Medicine and the Arthroscopy Association of.North America Sports Medicine f.llowship *** demographic and educational background data f.r each f. was gathered via author review of.current curriculum vitae(CVs).Any inf.rmation that was unavailable on CV review was gathered f.om institutional biographies,Scopus Web of.Science,and emailed *** ensure the collection of.as many data points as possible,f.llowship program coordinators,orthopaedic department of.ices and f.s were directly contacted via phone if.there was no response via *** inf.rmation of.interest included:Age,gender,ethnicity,residency/f.llowship training,residency/f.llowship graduation year,year hired by current institution,time since training completion until f. appointment,length in f. role,status as a team physician and *** Inf.rmation was gathered f.r 82 *** these,97.5%(n=80)of.the leadership were male;84.15%(n=69)were Caucasian,7.32%(n=6)were Asian-American,2.44%(n=2)were Hispanic and 2.44%(n=2)were Af.ican American,and 3.66%(n=3)were of.another race or *** mean age of.current f.s was 56 years old(±9.00 years),and the mean Scopus H-index was 23.49(±16.57).The mean calendar years f.r completion of.residency and f.llowship training were 1996(±15 years)and 1997(±9.51 years),*** time since f.llowship training completion until f. appointment was 9.77 years.17.07%(n=14)of

关键词： Sports medicine f.llowship Medical education Orthopaedic surgery Orthopaedic f.llowship Orthopaedic leadership

The role of.super-spreaders in modeling of.SARS-CoV-2

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Inf.ctious Disease Modelling 2022年第4期7卷 778-794页

作者： f.ançois Rousse Marcus Carlsson MagnusÖgren benjamin Kalischer Wellander School of.Science and Technology Örebro University70182ÖrebroSweden Centre f.r Mathematical Sciences Lund UniversityBox 11822100LundSweden Hellenic Mediterranean University P.O.Box 1939GR-71004HeraklionGreece Centrum f.r f.rskning och utveckling(Cf.G)Region Gävleborg Sweden

In stochastic modeling of.inf.ctious diseases,it has been established that variations in inf.ctivity af.ect the probability of.a major outbreak,but not the shape of.the curves during a major outbreak,which is predicted by deterministic models(Diekmann et al.,2012).However,such conclusions are derived under idealized assumptions such as the population size tending to inf.nity,and the individual degree of.inf.ctivity only depending on variations in the inf.ctiousness *** this paper we show that the same conclusions hold true in a f.nite population representing a medium size city,where the degree of.inf.ctivity is determined by the of.spring distribution,which we try to make as realistic as possible f.r *** particular,we consider distributions with f.t tails,to incorporate the existence of.*** also provide new theoretical results on convergence of.stochastic models which allows to incorporate any of.spring distribution with a f.nite variance.

关键词： COVID-19 Compartmental models SEIR SIR Of.spring distribution f.r SARS-CoV-2

Pentoxif.lline treatment and penile calcif.cations in men Nith Peyronie＇s disease

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Asian Journal of.Andrology 2011年第2期13卷 322-325页

作者： James f.Smith Alan W Shindel Yun-Ching Huang Raul I Clavijo Lawrence f.echner benjamin N Breyer Michael L Eisenberg Tom f.Lue Department of.Urology University of California San Francisco CA USA Department of.Obstetrics Gynecology and Reproductive Sciences University of California San Francisco CA 94143-0738 USA

This retrospective cohort study f.om a single clinical practice enrolled patients with evidence of.calcif.ed Peyronie＇s disease （PD） plaques detected on penile ultrasound at the time of.initial presentation. The primary objective was to describe the ef.ect of.pentoxif.lline （PTX） treatment on subtunical calcif.cations in men with PD. A PD-specif.c questionnaire was administered and sonographic evaluations were perf.rmed at baseline and f.llow-up visits. Descriptive statistics and X2 analysis were used to characterize the ef.ect of.PTX on calcif.ed tunical plaques. In all, 71 men （mean age： 51.9 years） with PD and sonographic evidence of.calcif.cation were identif.ed. Of.them, 62 of.these men were treated with PTX f.r a mean duration of.I year, and nine with vitamin E or no treatment. Improvement or stabilization in calcium burden at f.llow-up was noted in 57 （91.9%） of.men treated with PTX versus f.ur （44,4%） of.those not treated with PTX （P〈0.001）. PTX users were much less likely to have a subjective worsening of.their clinical condition （25.0% versus 78.3%, P=0.002）. Treatment with PTX appeared to stabilize or reduce calcium content in PD plaques. A randomized controlled trial is warranted to f.rther explore this ef.ect.

关键词： penile calcif.cations pentoxif.lline Peyronie's disease treatment

Lubiprostone vs Senna in postoperative orthopedic surgery patients with opioid-induced constipation:A double-blind,active-comparator trial

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World Journal of.Gastroenterology 2014年第43期20卷 16323-16333页

作者： Christina M Marciniak Santiago Toledo Jungwhalia Lee Michael Jesselson Jillian Bateman benjamin Grover Joy Tierny Department of.Physical Medicine and Rehabilitation School of MedicineNorthwestern UniversityChicagoIL 60611United States Department of.Preventive Medicine Feinberg School of MedicineNorthwestern UniversityChicagoIL 60611United States University of.Chicago Medical Center ChicagoIL 60637United States The Rehabilitation Institute of.Chicago ChicagoIL 60611United States Chicago College of.Osteopathic Medicine ChicagoIL 60515United States

AIM: To investigate the ef.icacy of.lubiprostone compared to Senna on bowel symptoms and constipation in post-operative orthopedic patients treated with opioids.

关键词： Constipation Opioids Lubiprostone Senna Orthopedics Rehabilitation

使用GRACE数据的地震高风险区可视化标识方法

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测绘地理信息 2019年第1期44卷 56-58页

作者：张晓倩蔡忠亮周慧吴子豪 f.benjamin Zhan 武汉大学资源与环境科学学院湖北武汉430079 德克萨斯州立大学国家地理信息科学中心美国圣马科斯78666

利用GRACE时变重力场数据,根据强震发生之前的重力变化异常规律,结合GIS强大的空间分析和地理信息可视化,确定了一种多危险级别的地震高风险区标识方法。其主要包括提取重力变化零等值线、提取重力变化高梯度区、识别高发震率的断层、... 详细信息

利用GRACE时变重力场数据,根据强震发生之前的重力变化异常规律,结合GIS强大的空间分析和地理信息可视化,确定了一种多危险级别的地震高风险区标识方法。其主要包括提取重力变化零等值线、提取重力变化高梯度区、识别高发震率的断层、不同危险级别的地震高风险区标识等4个步骤。并使用2015年全球震级6.0以上的地震对标识结果进行检验,发现使用5年时间尺度的重力变化异常数据,生成地震高风险标识图,来预测最接近重力变化时间的地震发生情况,预测的准确率最高。

关键词： GRACE数据重力变化异常地震高风险区

Mon enf.nt,mon idole Aux chiméres de macarriére,j'ai préf.ré monf.ls

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法语国家与地区研究 2003年第2期 60-64页

作者：ＢｅｎｊａｍｉｎＳｔｅｉｎ

Investigation of.conf.cal microscopy f.r dif.erentiation of.renal cell carcinoma versus benign *** an optical biopsy be perf.rmed?

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Asian Journal of.Urology 2020年第4期7卷 363-368页

作者： Michael C.Phung Andrew R.Rouse Jayce Pangilinan Robert C.Bell Erika R.Bracamonte Sharf.ddeen Mashi Arthur f.Gmitro benjamin R.Lee Department of.Urology University of Arizona College of MedicineArizonaUSA Department of.Medical Imaging University of Arizona College of MedicineArizonaUSA Department of.Pathology University of Arizona College of MedicineArizonaUSA Ringgold Standard Institution Aminu Kano Teaching HospitalKanoNigeria Biomedical Engineering University of Arizona College of MedicineArizonaUSA

Objective:Novel optical imaging modalities are under development with the goal of.obtaining an“optical biopsy”to ef.iciently provide pathologic *** such modality is conf.cal microscopy which allows in situ visualization of.cells within a layer of.tissue and imaging of.cellular-level *** goal of.this study is to validate the ability of.conf.cal microscopy to quickly and accurately dif.erentiate between normal renal tissue and ***:Specimens were obtained f.om patients who underwent robotic partial nephrectomy f.r renal *** of.suspected normal and tumor tissue were extracted f.om the excised portion of.the kidney and stained with acridine *** stained samples were imaged on a Nikon E600 C1 Conf.cal *** samples were then submitted f.r hematoxylin and eosin processing and read by an expert pathologist to provide a gold-standard diagnosis that can later be compared to the conf.cal ***:This study included 11 patients,17 tissue samples,and 118 conf.cal *** the 17 tissue samples,10 had a gold-standard diagnosis of.cancer and seven were *** 118 conf.cal images,66 had a gold-standard diagnosis of.cancer and 52 were *** conf.cal images were used as a training set to train eight *** observers were asked to rate the test images on a six point scale and the results were analyzed using a web based receiver operating characteristic curve *** average accuracy,sensitivity,specif.city,and area under the empirical receiver operating characteristic curve f.r this study were 91%,98%,81%,and 0.94 ***:This preliminary study suggest that conf.cal microscopy can be used to distinguish cancer f.om normal tissue with high sensitivity and *** observers in this study were trained quickly and on only six *** expect even higher perf.rmance as observers become more f.miliar with the conf.cal images.

关键词： Renal cell carcinoma Conf.cal microscopy Optical biopsy