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保留十二指肠的胰头切除术治疗良性肿瘤、囊性肿瘤及神经内分泌瘤的系统分析

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中华外科杂志 2021年第7期59卷 608-617页

作者： Hans G.Beger benjamin mayer Yinmo Yang Bertram Poch c/o University of Ulm Albert-Einstein-Allee 2389081 UlmGermany Institute for Epidemiology and Medical Biometry University of UlmGermany Department of Surgery Peking University First HospitalBeijing 100034China Center for Oncologic Endocrine and Minimal Invasive SurgeryDonau-Klinikum Neu-UlmGermany

背景保留十二指肠的胰头切除术是替代胰十二指肠切除术治疗良性肿瘤、囊性肿瘤及神经内分泌瘤的可行之选。方法检索Pubmed、Embase及Cochrane数据库中保留十二指肠胰头切除术的研究结果。根据手术指征、围手术期并发症及微创应用等纳入1... 详细信息

背景保留十二指肠的胰头切除术是替代胰十二指肠切除术治疗良性肿瘤、囊性肿瘤及神经内分泌瘤的可行之选。方法检索Pubmed、Embase及Cochrane数据库中保留十二指肠胰头切除术的研究结果。根据手术指征、围手术期并发症及微创应用等纳入1994年1月至2021年3月的38项队列研究共702例患者的临床资料。结果共702例患者分别因良性肿瘤、癌前病变、囊性肿瘤、胰腺神经内分泌肿瘤、十二指肠乳头周围腺瘤等行保留十二指肠的胰头切除术。702例患者中,214例(30.5%)行保留十二指肠的部分胰头切除术,488例(69.5%)行保留十二指肠的全胰头切除术,后者中微创手术占17.3%。两种术式的术后早期严重并发症发生率(术后B及C级胰瘘、胆瘘、腹腔出血及腹腔脓肿)均2 cm的有或无功能的良性内分泌肿瘤外科治疗的首选术式。

关键词：胰腺肿瘤外科手术系统分析

Spastin and alsin protein interactome analyses begin to reveal key canonical pathways and suggest novel druggable targets

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Neural Regeneration Research 2025年第3期20卷 725-739页

作者： benjamin R.Helmold Angela Ahrens Zachary Fitzgerald P.Hande Ozdinler Department of Neurology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Center for Molecular Innovation and Drug Discovery Center for Developmental TherapeuticsChemistry of Life Processes InstituteNorthwestern UniversityEvanstonILUSA Mesulam Center for Cognitive Neurology and Alzheimer’s Disease Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Feinberg School of Medicine Les Turner ALS Center at Northwestern UniversityChicagoILUSA

Developing effective and long-term treatment strategies for rare and complex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among patients. This hinders understanding the underlying disease-causing mechanisms and building solutions that have implications for a broad spectrum of patients. One potential solution is to develop personalized medicine approaches based on strategies that target the most prevalent cellular events that are perturbed in patients. Especially in patients with a known genetic mutation, it may be possible to understand how these mutations contribute to problems that lead to neurodegeneration. Protein–protein interaction analyses offer great advantages for revealing how proteins interact, which cellular events are primarily involved in these interactions, and how they become affected when key genes are mutated in patients. This line of investigation also suggests novel druggable targets for patients with different mutations. Here, we focus on alsin and spastin, two proteins that are identified as “causative” for amyotrophic lateral sclerosis and hereditary spastic paraplegia, respectively, when mutated. Our review analyzes the protein interactome for alsin and spastin, the canonical pathways that are primarily important for each protein domain, as well as compounds that are either Food and Drug Administration–approved or are in active clinical trials concerning the affected cellular pathways. This line of research begins to pave the way for personalized medicine approaches that are desperately needed for rare neurodegenerative diseases that are complex and heterogeneous.

关键词： ALS2 alsin amyotrophic lateral sclerosis hereditary spastic paraplegia neurodegenerative diseases personalized medicine precision medicine protein interactome protein-protein interactions SPAST spastin

Experimental Study for Effect of Multi-Site Spark Ignition on Dedicated Hybrid Engine Performance under High Dilution Condition

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Journal of Thermal Science 2025年第1期34卷 254-267页

作者： YAN Bowen WATERS benjamin HAINES Andrew MCGHEE Mike HU Tiegang DENG Wei PU Yongxian MA Tianyu Powertrain Engineering R&D Center Chongqing Changan Automobile Co.Ltd. Changan UK R&D Centre Limited

In this study,a triple spark ignition scheme was first designed on a three-cylinder 1.5-L dedicated hybrid engine（DHE）.On this basis,the effect of different ignition modes on engine combustion and emission characteristics was studied,especially under high dilution *** results tested at 2000 r/min and 0.8 MPa BMEP（brake mean effective pressure） show that with highly increased in-cylinder flow intensity,using only passive prechamber（PPC） has a lower lean limit than that with single central spark plug（CSP）,thereby leading to slightly higher minimum fuel consumption and nitrogen oxides（NOx） *** side spark plugs（SSP）based on PPC can result in improved capability of lean limit extension and engine performance than ***,the improvement level is lower than that with triple spark plugs（TSP）.As the excess air ratio λincreases,the advantage of PPC and PPC with SSP in improving the combustion phasing compared with CSP gradually ***,the increasing tendency of their ignition delay and combustion duration is more *** added SSP based on PPC can effectively shorten the ignition delay of leaner mixture,but the combustion duration can be only slightly *** a result,under extremely lean condition,the advantage of PPC and PPC with SSP in terms of combustion characteristics over CSP becomes much *** contrast,the TSP ignition can achieve much shorter ignition delay and combustion duration simultaneously under this *** to the highest available dilution level,the TSP ignition achieves the lowest raw ***,it can also reduce the raw carbon monoxide（CO） and hydrocarbons（HC） emissions compared to CSP due to a more thorough combustion of the end gas *** on the excellent performance of TSP,the highest engine brake thermal efficiency（BTE） was further *** results show that with normal RON 92 fuel,the engine finally achieved 43.69% and 45.02% BTE under stochiometric mode with exhaust

关键词： dedicated hybrid engine high dilution condition NOx emissions passive prechamber thermal efficiency triple spark plug scheme

Concentrations of Potentially Toxic Elements in Groundwater and Surface Water in Ruashi and Annexe Municipalities of Lubumbashi City, Southeastern Democratic Republic of Congo

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Journal of Environmental Science and Engineering(A) 2025年第1期14卷 1-13页

作者： Bamba Bukengu Muhaya benjamin Busomoke Badarhi Department of Chemistry Faculty of ScienceUniversity of LubumbashiLubumbashi 1825Democratic Republic of Congo Department of Zootechnics Faculty of Veterinary MedicineUniversity of LubumbashiLubumbashi 1825Democratic Republic of Congo

Groundwater and surface water contamination by PTE(Potentially Toxic Elements)was assessed in Ruashi and Annexe municipalities of Lubumbashi *** of seventy water samples collected from six drilled wells,eight spade-sunk wells,one river and one spring in both municipalities in 2017 and 2018 were carried out by ICP-SF-MS(Inductively Coupled Plasma-Sector Field Mass Spectrometry).Twenty PTEs including aluminum,arsenic,barium,bismuth,cadmium,cesium,chromium,cobalt,copper,iron,lead,manganese,molybdenum,nickel,strontium,thallium,tungsten,uranium,vanadium and zinc were detected at various concentrations in each one of the *** samples had concentrations and mean concentrations of PTEs,such as aluminum,cadmium,copper,iron,lead,manganese,nickel and zinc,higher than the respective acceptable limits set for drinking water by the EU(European Union),the USEPA(United States Environmental Protection Agency),and the WHO(World Health Organization)*** PTEs being deleterious to human health even at very low concentrations,people who use the groundwater and surface water to meet their water needs in both Ruashi and Annexe municipalities are at risk.

关键词： Contamination groundwater PTEs spring stream Ruashi and Annexe municipalities Lubumbashi city.

Imaging tumor hypoxia:Blood-borne delivery of imaging agents is fundamentally different in hypoxia subtypes

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Journal of Innovative Optical Health Sciences 2014年第2期7卷 12-17页

作者： Peter Vaupel Armulf mayer Department of Radioncology and Radiotherapy University Medical Center 55131 MainzGermany

Dedicated to the memory of Professor Briton Chance on the ccasion of his 100th birthday(July24 th,2013),and remembering mary erciting discussions on the orygenation of breast cancer,ontumor hyporia in general and imaging of the orygenation status of malignant *** tissue subvolumes are a hallmark feat ure of solid malignant tumors,relevant for cancertherapy and patient outcome because they increase both the intrinsic aggressiveness of tumor cells and their resist ance to several commonly used anticancer *** mech-anisms leading to hypoxia are diverse,may coexist within the same tumor and are commonlygrouped according to the duration of their *** hypoxia is mainly caused by difusionlimitations resulting from enlarged intercapilary distances and adverse difusion geometriesand--to a lsser extent--by hypoxemia,compromised perfusion or long-lasting microregionalfow ***,acute hypoxia preferentilly results from transient disruptions in *** each of these features of the tumor microenvironment can contribute to a criticalreduction of oxy gen availability,the delivery of imaging agents(as well as nutrients and anti-cancer agents)may be compromised or remain unaffected,Thus,a critial appraisal of the ffectsof the various mechanisms leading to hypoxia with regard to the blood-bome delivery of imagingagents is necessary to judge their ability to correctly represent the hypoxic phenotype of solidmalignancies.

关键词： Delivery of imaging agents tumor hypoxia hypoxia subty pes,chronic hypoxia acutehypoxia.

Can DyeCycling break the photobleaching limit in single-molecule FRET?

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Nano Research 2022年第11期15卷 9818-9830页

作者： benjamin Vermeer Sonja Schmid NanoDynamicsLab Laboratory of BiophysicsWageningen UniversityStippeneng 46708WE WageningenThe Netherlands

Biomolecular systems,such as proteins,crucially rely on dynamic processes at the *** biomolecular nanodynamics is therefore key to obtaining a mechanistic understanding of the energies and molecular driving forces that controlbiomolecular ***-molecule fluorescence resonance energy transfer(smFRET)is a powerful technique to observe inreal-time how a single biomolecule proceeds through its functional cycle involving a sequence of distinct structural ***,this technique is fundamentally limited by irreversible photobleaching,causing the untimely end of the experiment andthus,a narrow temporal bandwidth of≤3 orders of ***,we introduce“DyeCycling”,a measurement scheme withwhich we aim to break the photobleaching limit in *** introduce the concept of spontaneous dye replacement bysimulations,and as an experimental proof-of-concept,we demonstrate the intermittent observation of a single biomolecule forone hour with a time resolution of ***,DyeCycling can provide>100-fold more information per singlemolecule than conventional *** discuss the experimental implementation of DyeCycling,its current and fundamentallimitations,and specific biological use *** its general simplicity and versatility,DyeCycling has the potential torevolutionize the field of time-resolved smFRET,where it may serve to unravel a wealth of biomolecular dynamics by bridgingfrom milliseconds to the hour range.

关键词： biomolecular dynamics single-molecule fluorescence resonance energy transfer(smFRET) photobleaching conformational changes single-molecule kinetics

Clash of the Cytokine Titans： counter-regulation of interleukin-1 and type I interferon-mediated inflammatory responses

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Cellular & Molecular Immunology 2017年第1期14卷 22-35页

作者： Katrin D mayer-Barber Bo Yan Inflammation and Innate Immunity Unit Laboratory of Clinical Infectious Diseases National Institute of Allergy and Infectious Diseases National Institutes of Health. Bethesda. MD 20892. USA

Over the past decades the notion of ＇inflammation＇ has been extended beyond the original hallmarks of rubor （redness）, calor （heat）, tumor （swelling） and dolor （pain） described by Celsus. We have gained a more detailed understanding of the cellular players and molecular mediators of inflammation which is now being applied and extended to areas of biomedical research such as cancer, obesity, heart disease, metabolism, auto-inflammatory disorders, autoimmunity and infectious diseases. Innate cytokines are often central components of inflammatory responses. Here, we discuss how the type I interferon and interleukin-1 cytokine pathways represent distinct and specialized categories of inflammatory responses and how these key mediators of inflammation counter-regulate each other.

关键词： cytokines infection inflammation interleukin-1 tuberculosis type-1 interferons

Wahi, a discrete global grid gazetteer built using linked open data

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International Journal of Digital Earth 2017年第5期10卷 490-503页

作者： benjamin Adams Department of Computer Science Centre for eResearchThe University of AucklandAucklandNew Zealand

Discrete global grid systems have become an important component of Digital Earth ***,previously there has not existed an easy way to map between named places(toponyms)and the cells of a discrete global grid *** lack of such a tool has limited the opportunities to synthesize social place-based data with the more standard Earth and environmental science data currently being analyzed in Digital Earth *** paper introduces Wāhi,the first gazetteer to map entities from the GeoNames database to multiple discrete global grid systems.A gazetteer service is presented that exposes the grid system and the associated gazetteer data as Linked Data.A set of use cases for the discrete global grid gazetteer is discussed.

关键词： Discrete global grid gazetteer linked data place toponym Digital Earth

Integrating high levels of variable renewable energy into electric power systems

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Journal of Modern Power Systems and Clean Energy 2017年第6期5卷 831-837页

作者： benjamin KROPOSKI National Renewable Energy Laboratory GoldenCO 80401USA

As more variable renewable energy(VRE)such as wind and solar are integrated into electric power systems,technical challenges arise from the need to maintain the balance between load and generation at all *** paper examines the challenges with integrating ultrahigh levels of VRE into electric power system,reviews a range of solutions to these challenges,and provides a description of several examples of ultra-high VRE systems that are in operation today.

关键词： High penetration Variable renewable energy Grid operation Wind Solar