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Hypersensitivity to Aspirin as a Factor for Poor Control in Hereditary Angioedema

Journal of Biosciences and Medicines 2017年第3期5卷 39-54页

作者： Carlos Alberto Garcia-lopez Maria Eugenia Vargas-Camano Emmanuel Alcazar-Casarin Guillermo Quintana Mexiac Pablo Leon Gomez Mario Alberto Ynga-Durand benjamin lopez-velazquez Maria Isabel Castrejon-Vazquez Servicio Inmunologia Clinica y Alergia Centro Medico Nacional“20 de Noviembre”ISSSTEMexico CityMexico Laboratorio de Inmunidad de Mucosas Seccion de Investigacion y PosgradoEscuela Superior de MedicinaInstituto Politecnico NacionalMexico CityMexico

Background: Hereditary angioedema (HAE) is a primary immunodeficiency disorder characterized by C1 complement inhibitor deficiency and unregulated activation of complement. Aspirin hypersensitivity is related to an increase in the amount of leukotrienes with eosinophil and mast cell activation and increased levels of glandular kallikrein with upregulated local conversion of bradykinin. Both conditions can be present in the same patient. Objectives: We present five patients with HAE;they were all being treated in similar ways according to the therapeuthic options available in our institute (danazol). However, three of them had recurrent episodes of angioedema;in these cases, it was identified aspirin hypersensitivity as a cause of poor disease control. A review of the literature is included. Case Presentation: We present the cases of four females and one male (age range 21 - 58 years) with type I HAE. Subjects were all ISSSTE beneficiaries (state workers) treated at the National Medical Center “20 de Noviembre”. Aspirin hypersensitivity was identified in three patients. Elimination of NSAIDs along with dietary elimination of high salicylate-containing foods improved control of angioedema crisis (severe and/ or recurrent episodes). Discussion: Aspirin hypersensitivity was identified as a factor for poor control in our patients with HAE. Such cases improved with dietary elimination of high salicylate-containing foods and avoidance of NSAIDs. Conclusions: This is the first report of patients with HAE and aspirin hypersensitivity as a cause of poor control. We recommend a deliberate search of these comorbidities, especially in cases of poor disease control. Further studies are needed to continue the investigation on this topic.

关键词： Hereditary Angioedema Immunodeficiency Complement Salicylates

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Bulk lateral shearing interferometry for spatiotemporal study of time-varying ultrashort optical vortices

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Photonics Research 2022年第4期10卷 922-931页

作者： Miguel lopez-Ripa Inigo J.Sola benjamin Alonso Grupo de Aplicaciones del Laser y Fotonica(ALF) Departamento de Fisica AplicadaUniversidad de Salamanca37008 SalamancaSpain

The spatiotemporal measurement of ultrashort laser beams usually involves techniques with complex set-ups or limited by instabilities that are unable to accurately retrieve the frequency-resolved wavefront. Here, we solve these drawbacks by implementing a simple, compact, and ultra-stable spatiotemporal characterization technique based on bulk lateral shearing spectral interferometry using a birefringent uniaxial crystal. We apply it to retrieve complex spatiotemporal structures by characterizing ultrafast optical vortices with constant and time-varying orbital angular momentum. This technique can operate in all the transparency range of the anisotropic elements,enabling the characterization in different spectral ranges like infrared, visible, or ultraviolet.

关键词： ultrashort shearing interferometry

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Novel hybrid biocomposites for tendon grafts:The addition of silk to polydioxanone and poly(lactide-co-caprolactone)enhances material properties,in vitro and in vivo biocompatibility

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Bioactive Materials 2023年第7期25卷 291-306页

作者： Behzad Shiroud Heidari Emma Muiños lopez Emma Harrington Rui Ruan Peilin Chen Seyed Mohammad Davachi benjamin Allardyce Rangam Rajkhowa Rodney Dilley Froilán Granero-Moltó Elena M.De-Juan-Pardo Minghao Zheng Barry Doyle Harry Perkins Institute of Medical Research QEII Medical CentreNedlands and the UWA Centre for Medical ResearchThe University of Western AustraliaPerthAustralia School of Engineering The University of Western AustraliaPerthAustralia Australian Research Council Centre for Personalised Therapeutics Technologies Australia Cell Therapy Area Centro de Investigaci´on M´edica AplicadaIDISNAUniversidad de NavarraPamplonaSpain Centre for Orthopaedic Research Faculty of Health and Medical SciencesThe University of Western AustraliaPerthAustralia Department of Biology and Chemistry Texas A&M International UniversityLaredoTXUSA Institute for Frontier Materials Deakin UniversityGeelongVIC3216Australia Perron Institute for Neurological and Translational Science NedlandsWestern AustraliaAustralia

Biopolymers play a critical role as scaffolds used in tendon and ligament(TL)*** advanced biopolymer materials have been proposed with optimised mechanical properties,biocompatibility,degradation,and processability,it is still challenging to find the right balance between these ***,we aim to develop novel hybrid biocomposites based on poly(p-dioxanone)(PDO),poly(lactide-co-caprolactone)(LCL)and silk to produce high-performance grafts suitable for TL tissue *** containing 1-15%of silk were studied through a range of characterisation *** then explored biocompatibility through in vitro and in vivo studies using a mouse *** found that adding up to 5%silk increases the tensile properties,degradation rate and miscibility between PDO and LCL phases without agglomeration of silk inside the ***,addition of silk increases surface roughness and *** vitro experiments show that the silk improved attachment of tendon-derived stem cells and proliferation over 72 h,while in vivo studies indicate that the silk can reduce the expression of pro-inflammatory cytokines after six weeks of ***,we selected a promising biocomposite and created a prototype TL graft based on extruded *** found that the tensile properties of both individual fibres and braided grafts could be suitable for anterior cruciate ligament(ACL)repair applications.

关键词： Biocomposite Tendon graft Silk Fibre extrusion Biodegradable scaffolds Anterior cruciate ligament

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Evaluation of curcumin and copper acetate against Salmonella Typhimurium infection,intestinal permeability,and cecal microbiota composition in broiler chickens

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Journal of Animal Science and Biotechnology 2021年第3期12卷 1019-1030页

作者： Anaisa ALeyva-Diaz Daniel Hernandez-Patlan Bruno Solis-Cruz Bishnu Adhikari Young Min Kwon Juan D.Latorre Xochitl Hernandez-Velasco benjamin Fuente-Martinez Billy M.Hargis Raquel lopez-Arellano Guillermo Tellez-Isaias Departamento de Medicina y Zootecnia de Aves Facultad de Medicina Veterinaria y ZootecniaUNAM04510 Ciudad de MexicoMexico Laboratorio 5:LEDEFAR Unidad de Investigacion MultidisciplinariaFacultad de Estudios Superiores(FES)CuautitlanUniversidad Nacional Autonoma de Mexico(UNAM)54714 Cuautitlan IzcalliMexico Department of Poultry Science Center of Excellence for Poultry ScienceUniversity of Arkansas1260 W.MaplePOSC 0-114FayettevilleAR 72704USA Centro de Ensenanza Investigacion y Extension en Produccion AvicolaFacultad de Medicina Veterinaria y ZootecniaUNAMCiudad de MexicoMexico

Background:Interest in the use of natural feed additives as an alternative to antimicrobials in the poultry industry has increased in recent years because of the risk of bacterial *** of the most studied groups are polyphenolic compounds,given their advantages over other types of additives and their easy potentiation of effects when complexes are formed with metal ***,the objective of the present study was to evaluate the impact of dietary supplementation of copper acetate(CA),curcumin(CR),and their combination(CA-CR)against Salmonella Typhimurium colonization,intestinal permeability,and cecal microbiota composition in broiler chickens through a laboratory Salmonella infection *** recovery was determined on day 10 post-challenge by isolating Salmonella in homogenates of the right cecal tonsil(12 chickens per group)on Xylose Lysine Tergitol-4(XLT-4)with novobiocin and nalidixic *** integrity was indirectly determined by the fluorometric measurement of fluorescein isothiocyanate dextran(FITC-d)in serum samples from blood obtained on d 10 *** ***,microbiota analysis was performed using the content of the left caecal tonsil of 5 chickens per group by sequencing V4 region of 16S rRNA ***:The results showed that in two independent studies,all experimental treatments were able to significantly reduce the *** colonization in cecal tonsils(CT,P<0.0001)compared to the positive control(PC)***,only CA-CR was the most effective treatment in reducing *** counts in both independent ***,the serum fluorescein isothiocyanate dextran(FITC-d)concentration in chickens treated with CR was significantly lower when compared to PC(P=0.0084),which is related to a decrease in intestinal permeability and therefore intestinal *** effect of dietary treatments in reducing Salmonella was further supported by the analysis of 16S rRNA gene sequences using Li

关键词： Broiler chickens Copper acetate Curcumin Intestinal permeability Microbiota composition Salmonella Typhimurium

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Enforced PGC-1α expression promotes CD8 T cell fitness, memory formation and antitumor immunity

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Cellular & Molecular Immunology 2021年第7期18卷 1761-1771页

作者： Nina Dumauthioz benjamin Tschumi Mathias Wenes Bastien Marti Haiping Wang Fabien Franco Wenhui Li Isabel Clopez-Mejia Lluis Fajas Ping-Chih Ho Alena Donda Pedro Romero Lianjun Zhang Translational Tumor Immunology Group Ludwig Cancer ResearchUniversity of LausanneEpalingesSwitzerland Department of Fundamental Oncology University of LausanneEpalingesSwitzerland Department of Fundamental Oncology University of LausanneEpalingesSwitzerland Ludwig Cancer Research Institute Lausanne BranchEpalingesSwitzerland Center for Systems Medicine Institute of Basic Medical SciencesChinese Academy of Medical Sciences and Peking Union Medical College100005BeijingChina Suzhou Institute of Systems Medicine SuzhouJiangsu215123China Center for Integrative Genomics University of LausanneLausanneSwitzerland

Memory CD8 T cells can provide long-term protection against tumors,which depends on their enhanced proliferative capacity,self-renewal and unique metabolic rewiring to sustain cellular ***,memory CD8 T cells engage oxidative phosphorylation and fatty acid oxidation to fulfill their metabolic *** contrast,tumor-infiltrating lymphocytes(TILs)display severe metabolic defects,which may underlie their functional ***,we show that overexpression of proliferator-activated receptor gamma coactivator 1-alpha(PGC-1α),the master regulator of mitochondrial biogenesis(MB),favors CD8 T cell central memory formation rather than resident memory ***-1α-overexpressing CD8 T cells persist and mediate more robust recall responses to bacterial infection or peptide ***,CD8 T cells with enhanced PGC-1αexpression provide stronger antitumor immunity in a mouse melanoma ***,TILs overexpressing PGC-1αmaintain higher mitochondrial activity and improved expansion when rechallenged in a tumor-free ***,our findings indicate that enforcing mitochondrial biogenesis promotes CD8 T cell memory formation,metabolic fitness,and antitumor immunity in vivo.

关键词： PGC-1α Mitochondria CD8 Memory Anti-tumor immunity

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Risk perception and knowledge of COVID-19 in patients with celiac disease

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World Journal of Gastroenterology 2021年第12期27卷 1213-1225页

作者： Jamie Zhen Juan Pablo Stefanolo María de la Paz Temprano Caroline L Seiler Alberto Caminero Enrique de-Madaria Miguel Montoro Huguet Vivas Santiago Sonia Isabel Niveloni Edgardo Gustavo Smecuol Luis Uzcanga Dominguez Elena Trucco Virginia lopez Carolina Olano Pasquale Mansueto Antonio Carroccio Peter H Green Donald Duerksen Andrew S Day Jason A Tye-Din Julio César Bai Carolina Ciacci Elena F Verdú benjamin Lebwohl M Ines Pinto-Sanchez Department of Medicine Farncombe Family Digestive Health Research InstituteMcMaster University Medical CenterHamilton Health SciencesHamilton L8S4K1ONCanada Department of Medicine Dr.C.Bonorino Udaondo Gastroenterology HospitalBuenos Aires 1264Argentina Department of Pancreatic Unit Hospital General Universitario de AlicanteAlicante 03010Spain Department of Medicine Instituto Aragonés de Ciencias de la Salud(IACS)Zaragoza 50009Spain Department of Medicine Hospital Universitario San Jorge.HuescaZaragoza 50004Spain Department of Gastroenterology Univ Hosp LeonGastroenterol UnitAltos de Nava S-NLeon 24071Spain Department of Medicine Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico DF 14080Mexico Department of Medicine Universidad de la RepublicMontevideo 11800Uruguay Department of Internal Medicine PROMISE DepartmentUniversity of PalermoPalermo 90127Italy Department of Internal Medicine V.Cervello HospitalPROMISE DepartmentUniversity of PalermoPalermo 90127Italy Celiac Disease Center Columbia University Medical CenterColumbia UnivCeliac Dis CtrDiv Digest and Liver DisNew YorkNY 10032United States Department of Medicine St Boniface Gen HospUniversity of ManitobaWinnipeg R2H 2A6Canada Department of Paediatrics University of Otago ChristchurchChristchurch 8041New Zealand Department of Gastroenterology Royal Melbourne HospitalImmunology DivisionWalter and Eliza Hall InstituteMelbourne 3052Australia Department of Medicine Surgery and DentryScuola Medica SalernitanaUniversity of SalernoCeliac Center at the University Hospital San Giovanni di Dio e Ruggi di AragonaSalerno 84131Italy Department of Medicine Farncombe Family Digestive Research InstituteMcMaster UniversityHamilton L8S4K1ONCanada The Celiac Disease Center Columbia UniversityNew YorkNY 10032United States

BACKGROUND We recently demonstrated that the odds of contracting coronavirus disease 2019(COVID-19)in patients with celiac disease(CeD)is similar to that of the general ***,how patients with CeD perceive their COVID-19 risk may differ from their actual *** To investigate risk perceptions of contracting COVID-19 in patients with CeD and determine the factors that may influence their *** We distributed a survey throughout 10 countries between March and June 2020 and collected data on demographics,diet,COVID-19 testing,and risk perceptions of COVID-19 in patients with *** were recruited through various celiac associations,clinic visits,and social *** perception was assessed by asking individuals whether they believe patients with CeD are at an increased risk of contracting COVID-19 when compared to the general *** regression was used to determine the influencing factors associated with COVID-19 risk perception,such as age,sex,adherence to a gluten-free diet(GFD),and comorbidities such as cardiac conditions,respiratory conditions,and *** was presented as adjusted odds ratios(aORs)RESULTS A total of 10737 participants with CeD completed the *** them,6019(56.1%)patients with CeD perceived they were at a higher risk or were unsure if they were at a higher risk of contracting COVID-19 compared to the non-CeD population.A greater proportion of patients with CeD perceived an increased risk of contracting COVID-19 when compared to infections in general due to their CeD(56.1%vs 26.7%,P<0.0001).Consequently,34.8%reported taking extra COVID-19 precautions as a result of their *** of celiac associations were less likely to perceive an increased risk of COVID-19 when compared to non-members(49.5%vs 57.4%,P<0.0001).Older age(aOR:0.99;95%CI:0.99 to 0.99,P<0.001),male sex(aOR:0.84;95%CI:0.76 to 0.93,P=0.001),and strict adherence to a GFD(aOR:0.89;95%CI:0.82 to 0.96,P=0.007)were associated

关键词： Celiac disease Gluten Risk Infection Knowledge Perception Coronavirus COVID-19

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Tissue and regional expression patterns of dicistronic tRNA–mRNA transcripts in grapevine (Vitis vinifera) and their evolutionary co-appearance with vasculature in land plants

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Horticulture Research 2021年第1期8卷 1715-1729页

作者： Pastor Jullian Fabres Lakshay Anand Na Sai Stephen Pederson Fei Zheng Alexander A.Stewart benjamin Clements Edwin R.Lampugnani James Breen Matthew Gilliham Penny Tricker Carlos M.Rodriguez lopez Rakesh David School of Agriculture Food and WineUniversity of AdelaideAdelaideSAAustralia Environmental Epigenetics and Genetics Group Department of HorticultureCollege of AgricultureFood and EnvironmentUniversity of KentuckyLexingtonKYUSA ARC Centre of Excellence in Plant Energy Biology Waite Research Institute&School of AgricultureFood and WineUniversity of AdelaideAdelaideSAAustralia Bioinformatics Hub School of Biological SciencesUniversity of AdelaideAdelaideSAAustralia School of Biosciences University of MelbourneParkvilleVIC 3010Australia ARC Industrial Transformation Training Centre in Innovative Wine Production Waite Research Institute&School of AgricultureFood and WineUniversity of AdelaideAdelaideSAAustralia

Transfer RNAs(tRNA)are crucial adaptor molecules between messenger RNA(mRNA)and amino *** evidence in plants suggests that dicistronic tRNA-like structures also act as mobile signals for mRNA transcripts to move between distant ***-transcription is not a common feature in the plant nuclear genome and,in the few cases where polycistronic transcripts have been found,they include non-coding RNA species,such as small nucleolar RNAs and *** is not known,however,the extent to which dicistronic transcripts of tRNA and mRNAs are expressed in field-grown plants,or the factors contributing to their *** analysed tRNA–mRNA dicistronic transcripts in the major horticultural crop grapevine(Vitis vinifera)using a novel pipeline developed to identify dicistronic transcripts from high-throughput RNA-sequencing *** identified dicistronic tRNA–mRNA in leaf and berry samples from 22 commercial *** the 124 tRNA genes that were expressed in both tissues,18 tRNA were expressed forming part of 19 dicistronic tRNA–*** presence and abundance of dicistronic molecules was tissue and geographic sub-region *** leaves,the expression patterns of dicistronic tRNA–mRNAs significantly correlated with tRNA expression,suggesting that their transcriptional regulation might be *** also found evidence of syntenic genomic arrangements of tRNAs and protein-coding genes between grapevine and Arabidopsis thaliana,and widespread prevalence of dicistronic tRNA–mRNA transcripts among vascular land plants but no evidence of these transcripts in non-vascular *** suggests that the appearance of plant vasculature and tRNA–mRNA occurred concurrently during the evolution of land plants.

关键词： dic Vitis arrangement

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