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现代生物医学进展 2017年第15期17卷 I0004-I0004页

作者： benjamin Descours, Gaël Petitjean, Raoul Raffel Monsef Benkirane José-Luis López-Zaragoza, Timothée Bruel, Christine Lacabaratz, Yves levy, Olivier Schwartz Jean Daniel Lelievre José-Luis López-Zaragoza, Christine Lacabaratz, Yves levy Jean Daniel Lelievre José-Luis López-Zaragoza, Christine Lacabaratz, Yves levy Jean Daniel Lelievre Timothée Bruel Olivier Schwartz Christina Psomas Jacques Reynes Institut de Génétique Humaine Laboratoire de Virologie Moléculaire UMR9002 CNRS Université de Montpellier Montpellier France Vaccine Research Institute Université Paris-Est Faculté de Médecine INSERM U955 and Assistance Publique-Hôpitaux de Paris Groupe Henri-Mondor Albert-Chenevier Service d’Immunologie Clinique Créteil France Inserm U955 Equipe 16 Créteil France AP-HP Hôpital Henri-Mondor Albert-Chenevier Service d’Immunologie Clinique et Maladies Infectieuses 94000 Créteil France Institut Pasteur Virus and Immunity Unit URA CNRS 3015 Paris France Département Maladies Infectieuses et Tropicales Hôpital Universitaire Montpellier France

《自然》杂志近日发表了法国研究人员的一项最新成果：他们通过实验室研究发现，潜藏艾滋病病毒（HIV）的T细胞表面特定表达着一种名叫CD32a的蛋白，这种蛋白在未感染HIV的T细胞中却没有被检测出来。这意味着，CD32a蛋白可以作为一种生... 详细信息

《自然》杂志近日发表了法国研究人员的一项最新成果：他们通过实验室研究发现，潜藏艾滋病病毒（HIV）的T细胞表面特定表达着一种名叫CD32a的蛋白，这种蛋白在未感染HIV的T细胞中却没有被检测出来。这意味着，CD32a蛋白可以作为一种生物靶标，用来开发出针对”隐身”状态HIV的全新药物。

关键词：艾滋病病毒 a蛋白《自然》杂志研究人员细胞表面 HIV 实验室 T细胞

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父母高血压与其非高血压后代的动脉僵硬度的关系

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中华高血压杂志 2016年第8期24卷 757-757页

作者：刘莉叶鹏 Andersson C Quiroz R Enserro D Larson MG Hamburg NM Vita JA levy D benjamin EJ Mitchell GF Vasan RS

高动脉僵硬度似乎参与高血压的发病。该研究旨在验证患高血压父母其后代在临床表现为高血压之前,就体现出较高的动脉僵硬度,毕竟高血压具有遗传性。方法：纳入Framingham心脏研究第三代队列中的1564名非高血压者（平均年龄38岁,55%为女... 详细信息

高动脉僵硬度似乎参与高血压的发病。该研究旨在验证患高血压父母其后代在临床表现为高血压之前,就体现出较高的动脉僵硬度,毕竟高血压具有遗传性。方法：纳入Framingham心脏研究第三代队列中的1564名非高血压者（平均年龄38岁,55%为女性,其父母是Framingham后代研究受试者）,比较动脉张力测量值。结果：最终分别纳入父母均无高血压（对照组）（468人）、父母其中一人患高血压（715人）、父母均患高血压的受试者（381人）进行研究。

关键词：动脉僵硬度动脉张力平均动脉压脉搏波传导速度第三代波振幅影响因素

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Antibiotic Prescribing Patterns and Prevalence of Surgical Site Infections in Caesarean Section Deliveries at Two Tertiary Hospitals in Lusaka, Zambia

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Pharmacology & Pharmacy 2022年第8期13卷 313-330页

作者： Maisa Kasanga Misheck Chileshe Steward Mudenda Raphael Mukosha Maika Kasanga Victor Daka Tobela Mudenda Maureen Chisembele John Musuku benjamin Bisesa Solochi Jian Wu College of Public Health Zhengzhou University Zhengzhou China Department of Pathology and Microbiology University Teaching Hospitals Lusaka Zambia Mary Begg Health Services Ndola Zambia Department of Pharmacy School of Health Sciences University of Zambia Lusaka Zambia Department of Disease Control School of Veterinary Medicine University of Zambia Lusaka Zambia Laboratory Department Levy Mwanawasa University Teaching Hospital Lusaka Zambia Department of Pharmacy University Teaching Hospitals Lusaka Zambia Department of Public Health Michael Chilufya Sata School of Medicine Copperbelt University Ndola Zambia Department of Pathology Ndola Teaching Hospital Ndola Zambia Department of Obstetrics and Gynaecology University of Zambia-School of Medicine Lusaka Zambia Women and Newborn Hospital University Teaching Hospitals Lusaka Zambia levy Mwanawasa University Teaching Hospital Lusaka Zambia

Introduction: A caesarean section (CS) is one of the most frequently performed obstetric surgeries in the world and its use has increased dramatically in recent years. The number of caesarean section cases worldwide has been increasing each year, and the World Health Organization (WHO) reported an excess of 10% - 15% of CS procedures for all births. However, some women experience surgical site infections (SSIs) after undergoing CS delivery. This study investigated the prescribing patterns of antibiotics in CS deliveries and the prevalence of SSIs at two tertiary hospitals in Lusaka, Zambia. Materials and Methods: A retrospective cross-sectional study was conducted from January 2020 to December 2020 at the Women and Newborn University Teaching Hospital (UTH) and the levy Mwanawasa University Teaching Hospital, in Lusaka, Zambia. Results: Of a total of 838 women who delivered via CS, more than half were aged between 21 and 25 years (n = 461, 55.0%), 56.3% were from low-cost residential areas, and 57% had emergency CS delivery. The prevalence of SSIs was 6.0%, with the level of education (OR 0.377, 95% CI 0.150 - 0.946), type of caesarean section (OR 6.253, 95% CI 2.833 - 13.803), and oral antibiotics post-caesarean (OR 0.218, 95% CI 0.049 - 0.963). The duration of IV antibiotic treatment significantly predicted SSI (p Conclusion: This study found that the third-generation cephalosporin (cefotaxime) and triple combination therapy (benzylpenicillin, gentamicin, and metronidazole) were the most frequently prescribed antibiotics before and after CS. The level of education, type of CS, oral antibiotics post-CS, facility, and duration of administering IV antibiotics were all predictors of SSIs.

关键词： Antibiotic Prescribing Patterns Caesarean Section Post-Operative Antibiotics Prophylactic Antibiotics Surgical Site Infections

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Nitric Oxide Inhibits Apoptosis-Related Gene Expression Vias-Nitrosyiation in a Caspase-9 Dependent Fashion

Nitric Oxide Inhibits Apoptosis-Related Gene Expression Vias...

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第四届中国肿瘤学术大会暨第五届海峡两岸肿瘤学术会议

作者： James A.Radosevich benjamin J. Vesper Kim Elseth Brandon G.Bentz Kenneth W.Altman G. Kenneth Haines Center for Molecular Biology of Oral Diseases College of Dentistry University of Illinois at Chicago801 S.Paulina St.ChicagoIL60612USA Center for Molecular Biology of Oral Diseases College of Dentistry University of Illinois at Chicago801 S.Paulina St.ChicagoIL60612USA Center for Molecular Biology of Oral Diseases College of Dentistry University of Illinois at Chicago801 S.Paulina St.ChicagoIL60612USA Department of Surgery University of Utah 2000 Circle of Hope Dr.Salt Lake CityUT84112USA Department of Otolaryngology Head ＆ Neck Surgery Mt. Sinai School of Medicine One Gustave L. Levy PlaceNew YorkNYUSA Department of Pathology Northwestern University 303 E.Chicago Ave.ChicagoIL60611USA

＜正＞Background/Aims:Nitric Oxide （NO） and its interrelated redox species （collectively denoted as NOx） play a multi - faceted role in cancer progression. NOx production induces mutational events,and it has also been found to simultaneously inhibit apoptosis. In an effort to define the underlying mechanisms of apoptosis inhibition arising from nitric oxide exposure, we here develop a novel mouse model of lung adenocarcinoma. Methods: Four NOx donor compounds （DETA - NONOate, Spermine - NONOate, SNAP, and glyco - SNAP） were exposed to a novel murine lung adenocarcinoma cell line at increasing *** extent of NOx production was measured by the Griess reaction,spectrophotometrically,and via nitrotyrosine *** alkaline single- cell gel electrophoresis assay （the COMET assay） was used to measure DNA strand breaks （DSB’ s） and was correlated with cell viability. A fluorescence caspase activity assay was used to determine apoptosis and was correlated with apoptosis - related gene products using cDNA microarrays. Results:Kinetics,concentration,and mode of delivery all had an effect on NOx mediated DSB’s. At the highest concentration of NONOate donors, the DSB’ s correlated with cell death in a caspase - 9 dependent fashion. Caspase -9 activity appeared to be inhibited by thiol - based NOx donors, and since DTT reversed NO’s effect of apoptosis, inhibition is believed to have occurred via a S - nitrosylation pathway. This change in caspase activity was found to correlate with a number of transcriptional changes, suggesting that several key apoptosis steps are likely under transcriptional control via S - nitrosylation. Conclusions: The results of our murine model of lung cancer progression were found to parallel those previously reported in a human lung adenocarcinoma cell line. The model suggests that various apoptosis related gene products are likely regulated through S - nitrosylation in a caspase - 9 dependent manner. With this model in hand, we c

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