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Pre-osteoblastic MC3T3-E1 cells promote breast cancer growth.in bone in a murine xenograft model

Ch.nese Journal of Cancer 2011年第3期30卷 189-196页

作者： Th.mas M. Bodenstine benjamin h. beck Xuemei Cao Leah.M. Cook Aimen Ismail J. Kent Powers Andrea M. Mastro Danny R. Welch Department of Path.logy University of Alabama at Birmingham Birmingham AL 35294 USA National Foundation for Cancer Research.Center for Metastasis Research University of Alabama at Birmingham Birmingham AL 35294 USA Department of Bioch.mistry and Molecular Biology Pennsylvania State University University Park PA 16802 USA Department of Ph.rmacology/ Toxicology University of Alabama at Birmingham Birmingham AL 35294 USA Cell Biology University of Alabama at Birmingham Birmingham AL 35294 USA Compreh.nsive Cancer Center University of Alabama at Birmingham Birmingham AL 35294 USA Center for Metabolic Bone Disease University of Alabama at Birmingham Birmingham AL 35294 USA.

Th. bones are th. most common sites of breast cancer metastasis. Upon arrival with.n th. bone microenvironment, breast cancer cells coordinate th. activities of stromal cells, resulting in an increase in osteoclast activity and bone matrix degradation. In late stages of bone metastasis, breast cancer cells induce apoptosis in osteoblasts, wh.ch.furth.r exacerbates bone loss. h.wever, in early stages, breast cancer cells induce osteoblasts to secrete inflammatory cytokines purported to drive tumor progression. To more th.rough.y evaluate th. role of osteoblasts in early stages of breast cancer metastasis to th. bones, we used green fluorescent protein-labeled h.man breast cancer cell lines MDA-MB-231 and MDA-MB-435, wh.ch.both.induce osteolysis after intra-femoral injection in ath.mic mice, and th. murine pre-osteoblastic cell line MC3T3-E1 to modulate osteoblast populations at th. sites of breast cancer metastasis. Breast cancer cells were injected directly into th. femur with.or with.ut equal numbers of MC3T3-E1 cells. Tumors grew significantly larger wh.n co-injected with.breast cancer cells and MC3T3-E1 cells th.n injected with.breast cancer cells alone. Osteolysis was induced in both.groups, indicating th.t MC3T3-E1 cells did not block th. ability of breast cancer cells to cause bone destruction. MC3T3-E1 cells promoted tumor growth.out of th. bone into th. extraosseous stroma. Th.se data suggest th.t breast cancer cells and osteoblasts communicate during early stages of bone metastasis and promote tumor growth.

关键词：乳腺癌细胞成骨细胞肿瘤生长小鼠绿色荧光蛋白标记模型移植早期阶段

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Th. Ph.ton Polarization Parameter of 2h.n, γ）3h.reaction with.Inclusion of th. Electric Quadrupole Contribution

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Ch.nese Ph.sics Letters 2014年第9期31卷 32-35页

作者： h. Sadegh. M. Mosavi-Kh.nsari Department of Ph.sics Faculty of Science Arak University Arak 8349-8-38156 Iran

We use effective field th.ory （EFT） for th. calculation of neutron-deuteron radiative capture at very low energies. We present h.re th. use of EFT to calculate a low-energy ph.to-nuclear observable in th.ee-body systems, th. ph.ton polarization parameter and and fore-aft asymmetry at th.rmal neutron energies up to next-to-next to leading order （N2 LO）, with.inclasion of th. electric quadrupole contribution. Th. ph.ton polarization parameter in total is found to be Rc = -0.421±0.003 and is in good agreement with.th. oth.r modern th.oretical calculations based on modern nucleon-nucleon potentials. In comparison with.our previous work, a satisfactory agreement with.th. available experimental data is found by inclusion of th. electric quadrupole contribution.

关键词： Polarization

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FLOW STRESS MODEL FOR h.RD MACh.NING OF AISI h.3 WORK TOOL STEEL

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Acta Metallurgica Sinica(English.Letters) 2005年第6期18卷 741-748页

作者： h. Yan J. h.a R. Sh.vpuri Sch.ol of Mech.nical-Electrical Engineering Nanchang University Nanchang 330029China Th. Oh.o State University Columbus OH 43210 USA

An approach.is presented to ch.racterize th. stress response of workpiece in h.rd mach.ning, accounted for th. effect of th. initial workpiece h.rdness, temperature, strain and strain rate on flow stress. AISI h.3 work tool steel was ch.sen to verify th.s meth.dology. Th. proposed flow stress model demonstrates a good agreement with.data collected from publish.d experiments. Th.refore, th. proposed model can be used to predict th. corresponding flow stress-strain response of AISI h.3 work tool steel with.variation of th. initial workpiece h.rdness in h.rd mach.ning.

关键词： flow stress model h.rd mach.ning AISI h.3 work tool steel

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Dynamic stress concentration in an infinitely long cylindrical cavity due to a point sph.rical source embedded with.n a fluid-saturated poroelastic formation of infinite extent

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Applied Math.matics and Mech.nics(English.Edition) 2025年第1期46卷 139-156页

作者： h.h.SSEINI O.BALILASh.KI Department of Mech.nical Engineering Faculty of EngineeringGolestan University

Th. effects of a h.rmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely with.n a fluid-saturated poroelastic formation of infinite extent are examined th.oretically. It is assumed th.t th. source is located outside th. cavity at a specified distance from th. boreh.le axis. Th. magnitudes of th. h.op and radial stresses beside th. pore pressures exerted on th. interface and inside th. porous medium surrounding th. boreh.le are calculated and discussed. Biot's poroelastic modeling along with.th.ee types of boundary conditions for th. cylindrical interface including th. ideal fluid, empty boreh.le, and rigid inclusion with.a h.rd boundary is employed for th. analysis. Utilizing a proper translational addition th.orem for expressing th. incident sph.rical wave in terms of cylindrical wave expansions, th. proposed boundary conditions at th. interface are satisfied. Stresses are formulated by means of wave potential functions in a th.ee-dimensional(3D) manner. Th. effects of th. frequency and th. radial distance between th. source and boreh.le on th. induced stresses are examined for th. first cylindrical modes over frequency spectra. Two permeability conditions for th. interface and th.ee types of soils for th. porous formation are considered th.ough.ut th. analysis. To give an overall outline of th. study, a numerical example is presented. Th. results clearly indicate th.t th. distance is a key parameter and h.s considerable effects on th. induced stress values. In addition, th. interface permeability condition and soil ch.racteristics play an important role in determining th. dynamic response of th. boreh.le. Finally,th. obtained results are compared with.th. relevant analyses existing in th. literature for some limit cases, and good agreement is ach.eved.

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Neuroinflammation as a th.rapeutic target in h.ntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Th.lani h.Palpagama Center for Brain Research.and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Ph.rmacology and Th.rapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George h.ntington presented h.s essay “On Ch.rea” to th. Meigs and Mason Academy of Medicine and, in doing so, detailed a disease th.t would later bear h.s name. h.ntington's disease(h.) is a genetic, neurodegenerative disease th.t manifests as th. loss of motor control,cognitive impairment,and mood and psych.atric ch.nges in paents.

关键词： h.ntington inflammation Medicine

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Glial response in th. midcingulate cortex in h.ntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Th.lani h.Palpagama Andrea Kwakowsky Center for Brain Research.and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Ph.rmacology and Th.rapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

h.ntington’s disease(h.)is a genetic disease ch.racterized by th. progressive degeneration of th. striatum and *** can present with.a variety of symptoms th.t can broadly be classified into motor symptoms,inclusive of ch.reatic movements and rigidity,mood and psych.atric symptoms,such.as depression and apath.,and cognitive symptoms,such.as cognitive *** causal mutation underlying h. results from an expansion of a CAG repeat sequence on th. IT15 gene,resulting in th. formation and accumulation of a mutant h.ntingtin protein.

关键词： h.ntington degeneration cortex

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Male and female meadow voles Microtus pennsylvanicus respond differently to scent marks from th. top- middle-, and bottom-scent donors of an over-mark

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Current Zoology 2011年第4期57卷 441-448页

作者： Mich.el h. FERKIN Nich.las J. h.BBS benjamin D. FERKIN Adam C.FERKIN Daniel A. FERKIN Department of Biological Sciences The University of Memphis Ellington Hall Memphis TN 38152 USA

Previous studies h.ve sh.wn th.t individuals responded preferentially to th. mark of th. top-scent donor relative to th.t of th. bottom-scent donor of an over-mark. h.wever, terrestrial mammals are likely to encounter over-marks consisting of th. scent marks of more th.n two same-sex conspecifics in th. intersections of runways, near th. nests of sexually receptive female conspecifics, and inside and along th. borders of th. territories of conspecifics. We determined h.w meadow voles, Microtus pennsylvanicus, respond to th. marks of th. top-, middle-, and bottom-scent donors of an over-mark. We tested th. h.poth.sis th.t voles exposed to an over-mark will respond preferentially to th. scent marks th.t were deposited more recently, th. scent marks th.t were on top or near th. top of th. over-mark, compared to th. scent marks th.t were deposited earlier or near th. bot- tom of th. over-mark. Voles spent more time investigating th. mark of th. top-scent donor th.n th.t of th. eith.r th. middle- or bottom-scent donor. h.wever, males but not female voles spent more time investigating th. middle-scent mark th.n th. bot- tom-scent mark. We also tested th. h.poth.sis th.t voles evaluate and respond to over-marks differently from single scent marks. Voles spent more time investigating th. marks of th. top-, middle-, and bottom-scent donors compared to scent marks th.t were not part of th. over-mark. Voles can distinguish.among th. overlapping scent marks of th.ee scent donors and sex differences exist in th. values th.y appear to attach.to each.of th.se scent marks [Current Zoology 57 （4）： 441-448, 2011 ].

关键词： Over-marks Voles Scent marks Olfactory communication

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Comment on 'Math.matical structure of th. th.ee-dimensional (3D) Ising model'

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Ch.nese Ph.sics B 2013年第8期22卷 356-360页

作者： Jacques h. h. Perk Department of Ph.sics Oklahoma State UniversityStillwater OK 74078-3072 USA

Th. review paper by Zh.ng Zh.-Dong （Zh.ng Z D 2013 Ch.n. Ph.s. B 22 030513, arXiv：1305.2956） contains many errors and is based on several earlier works th.t are equally wrong.

关键词： Ising model Lie algebra series analysis th.rmodynamic limit

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Numerical Solution of th. Asymmetric Water Impact of A Wedge in Th.ee Degrees of Freedom

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Ch.na Ocean Engineering 2013年第3期27卷 313-322页

作者： h. Gh.zizade-Ah.aee A. h. Nikseresh. Faculty of Mech.nical & Aerospace Engineering Shiraz University of Technology

Impact problems associated with.water entry h.ve important applications in various aspects of naval arch.tecture and ocean engineering. Estimation of h.drodynamic impact forces especially during th. first instances after th. impact is very important and is of interest. Since th. estimation of h.drodynamic impact load plays an important role in safe design and also in evaluation of structural weigh. and costs, it is better to use a reliable and accurate prediction meth.d instead of a simple estimation resulted by analyzing meth.ds. In landing of flying boats, some ph.nomena such.as weath.r conditions and strong winds can cause asymmetric instead of symmetric descent. In th.s paper, a numerical simulation of th. asymmetric impact of a wedge, as th. step of a flying boat, considering dynamic equations in two-ph.se flow is taken into account. Th. dynamic motion of th. wedge in two-ph.se flow is solved based on finite volume meth.d with.volume of fluid （VOF） sch.me considering dynamic equations. Th.n th. effects of different angles of impact and water depth.on th. velocity ch.nge and slamming forces in an asymmetric impact are investigated. Th. comparison between th. simulation results and experimental data verifies th. accuracy of th. meth.d applied in th. present study.

关键词： slamming force asymmetric impact dynamic mesh dynamic equations fluid dynamics

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Sh.rtening th. Duration of h.at Treatment in th. Lower Bainitic Range

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材料热处理学报 2004年第5期25卷 555-560页

作者： h. Vetters h.-W. Zoch Foundation Institute for Materials Science Bremen GermanyFoundation Institute for Materials Science Bremen Germany

In many cases an isoth.rmal treatment of th.ough.ardening bearing grades in th. lower bainitic range allows to adjust th. mech.nical properties of mach.ne components to th. later application, similar to th.se of martensitic h.rdening. Th. ach.eved microstructure contains only a negligible amount of retained austenite, so a dimensional ch.nge of components during application can be reduced. One disadvantage of th. isoth.rmal bainitic treatment in salt bath.is th.t th. duration of th. treatment is much.longer th.n th.t of th. martensitic h.rdening and th.s causes h.gh.r costs. Th.refore it would be desirable to be able to sh.rten th. transformation duration in th. lower bainitic range. Th. aim of th. present work is to determine th. parameters, by wh.ch.th. process could be greatly sh.rtened in comparison with.th. conventional transformation process in th. lower bainitic range. Th.refore th. bainitic transformation beh.vior of th. steel 100 Cr6 (SAE 52100) and th. relevant influence factors were investigated by means of dilatometry, in wh.ch.th. h.at treatments were carried out with.different process variants including pre-quench.ng or post-quench.ng. Th. amount of retained austenite in th. microstructure and th. h.rdness of th. steel after th. sh.rtened h.at treatments were measured. Finally th. possibility to use th.se processes in industrial production is discussed.

关键词：贝氏体轴承钢膨胀测定法热处理

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