检索结果-南通市图书馆

Clinical imaging factors of excellent outcome after thrombolysis in large- vessel stroke: a THRACE subgroup analysis

引用

Stroke & Vascular Neurology 2021年第4期6卷 631-639页

作者： Nolwenn Riou-Comte benjamin gory Marc Soudant François Zhu Yu Xie Lisa Humbertjean Gioia Mione Catherine Oppenheim Francis Guillemin Serge Bracard Sébastien Richard on behalf of the THRACE investigators Department of Neurology-Stroke Unit CIC-P 1433INSERMU1116Universitéde LorraineNancy Regional University Hospital CenterNancyFrance Department of Diagnostic and Therapeutic Neuroradiology INSERM U1254IADIUniversitéde LorraineNancy Regional University Hospital CenterNancyFrance Clinical Investigation Centre-Clinical Epidemiology 1433 INSERMUniversitéde LorraineNancy Regional University Hospital CenterNancyFrance Department of Neuroradiology INSERM U894UniversitéParis-DescartesSainte-Anne HospitalParisFrance 不详

Background For patients with stroke with large-vessel occlusion(LVO),study of factors predicting response to intravenous thrombolysis(IVT)would allow identifying subgroups with high expected gain,and those for whom it could be considered as futile,and even *** patients included in the Mechanical Thrombectomy After Intravenous Alteplase vs Alteplase Alone After Stroke trial,we investigated clinical-imaging factors associated with optimal response to *** We included patients receiving IVT *** outcome was defined by a 3-month modified Rankin Scale(mRS)score≤***-imaging predictors were assessed on multivariate analysis after multiple *** predictive performance of the model was assessed with the *** Among 247 patients with LVO treated with IVT alone,77(31%)showed 3-month mRS≤*** of 3-month mRS≤1 were no medical history of hypertension(OR 2.43;95%CI 1.74 to 3.38;p=0.007);no current smoking(OR 2.76;95%CI 1.79 to 4.26;p=0.02);onset-to IVT time(OR 0.47 per hour increase;95%CI 0.23 to 0.78;p=0.003);diffusion-weighted imaging(DWI)volume(OR 0.78 per 10 mL increase;95%CI 0.68 to 0.89;p=0.0004);presence of susceptibility vessel sign(SVS)(OR 7.89;95%CI 1.65 to 37.78;p=0.01)and SVS length(OR 0.87 per mm increase;95%CI 0.80 to 0.94;p=0.001).The prediction models showed a C-statistic=0.79(95%CI 0.79 to 0.80).Conclusions In patients with stroke with anterior-circulation LVO treated with IVT alone,predictors of excellent outcome at 3 months were no medical history of hypertension or current smoking,reduced onset-to IVT time,small DWI volume,presence of SVS and short SVS *** predictive factors could help practitioners in decision-making for IVT implementation in reperfusion strategies,all the more for the drip and ship *** registration number NCT01062698.

关键词： thrombolysis Clinical assessed

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hemodynamics,inflammation,vascular remodeling,and the development and rupture of intracranial aneurysms:a review

引用

Neuroimmunology and Neuroinflammation 2015年第1期2卷 59-67页

作者： Francesco Signorelli benjamin gory Roberto Riva Paul-Emile Labeyrie Isabelle Pelissou-Guyotat Francis Turjman Service of Neurosurgery D Civil Hospitals of Lyon59Boulevard Pinel69500 Bron-LyonFrance Department of Experimental and Clinical Medicine University“Magna Graecia”of Catanzaro88100 CatanzaroItaly Service of Interventional Neuroradiology Civil Hospitals of Lyon59Boulevard Pinel69500 Bron-LyonFrance

The central nervous system is an immunologically active environment where several components of the immune and inflammatory response interact among them and with the constituents of nervous tissue and vasculature in a critically orchestrated manner,influencing physiologic and pathologic *** particular,inflammation takes a central role in the pathogenesis of intracranial aneurysms(IAs).The common pathway for aneurysm formation involves endothelial dysfunction and injury,a mounting inflammatory response,vascular smooth muscle cells(VSMCs)phenotypic modulation,extracellular matrix remodeling,and subsequent cell death and vessel wall *** conducted a literature review(1980-2014)by Medline and EMBASE databases using the searching terms“IA”and“cerebral aneurysm”and further search was performed to link the search terms with the following key words:inflammation,hemodynamic(s),remodeling,macrophages,neutrophils,lymphocytes,complement,VSMCs,mast cells,cytokines,and inflammatory *** aim of this review was to summarize the most recent and pertinent evidences regarding the articulated processes of aneurysms formation,growth,and *** of these processes may guide the diagnosis and treatment of these vascular malformations,the most common cause of subarachnoid hemorrhage,which prognosis remains dismal.

关键词： Inflammation hemodynamics vascular remodeling intracranial aneurysms

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：