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Tactical planning:improving performance for information technology (IT) groups creating digital projects

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Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第11期11卷 927-930页

作者： Melanie d.myers Library Information Technology Carnegie Mellon University

Good planning and communication are crucial to the digitization *** originators of project proposals and donors who finance the work are often not technically *** may have vastly different expectations of the complexi... 详细信息

关键词：信息技术项目组成绩 IT 规划战术数字化进程项目建议书

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Spastin and alsin protein interactome analyses begin to reveal key canonical pathways and suggest novel druggable targets

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Neural Regeneration Research 2025年第3期20卷 725-739页

作者： benjamin R.Helmold Angela Ahrens Zachary Fitzgerald P.Hande Ozdinler department of Neurology Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Center for Molecular Innovation and drug discovery Center for Developmental TherapeuticsChemistry of Life Processes InstituteNorthwestern UniversityEvanstonILUSA Mesulam Center for Cognitive Neurology and Alzheimer’s disease Feinberg School of MedicineNorthwestern UniversityChicagoILUSA Feinberg School of Medicine Les Turner ALS Center at Northwestern UniversityChicagoILUSA

developing effective and long-term treatment strategies for rare and complex neurodegenerative diseases is challenging. One of the major roadblocks is the extensive heterogeneity among patients. This hinders understanding the underlying disease-causing mechanisms and building solutions that have implications for a broad spectrum of patients. One potential solution is to develop personalized medicine approaches based on strategies that target the most prevalent cellular events that are perturbed in patients. Especially in patients with a known genetic mutation, it may be possible to understand how these mutations contribute to problems that lead to neurodegeneration. Protein–protein interaction analyses offer great advantages for revealing how proteins interact, which cellular events are primarily involved in these interactions, and how they become affected when key genes are mutated in patients. This line of investigation also suggests novel druggable targets for patients with different mutations. Here, we focus on alsin and spastin, two proteins that are identified as “causative” for amyotrophic lateral sclerosis and hereditary spastic paraplegia, respectively, when mutated. Our review analyzes the protein interactome for alsin and spastin, the canonical pathways that are primarily important for each protein domain, as well as compounds that are either Food and drug Administration–approved or are in active clinical trials concerning the affected cellular pathways. This line of research begins to pave the way for personalized medicine approaches that are desperately needed for rare neurodegenerative diseases that are complex and heterogeneous.

关键词： ALS2 alsin amyotrophic lateral sclerosis hereditary spastic paraplegia neurodegenerative diseases personalized medicine precision medicine protein interactome protein-protein interactions SPAST spastin

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走向成熟：信息系统学科的演变

信息系统学报 2008年第2期 110-117页

作者： Michael d.myers 黄彦新西兰奥克兰大学清华大学

在信息系统学科研究文献中,已经存在很多关于信息系统学科领域研究现状的争论。其一,关于现实意义与理论严谨性的争论。一些学者认为信息系统的研究过于理论化而缺乏现实意义,另一些学者则认为理论研究上的进步本身就是一种积极的发展...

在信息系统学科研究文献中,已经存在很多关于信息系统学科领域研究现状的争论。其一,关于现实意义与理论严谨性的争论。一些学者认为信息系统的研究过于理论化而缺乏现实意义,另一些学者则认为理论研究上的进步本身就是一种积极的发展。其二,关于同一性和多样性的争论。一些学者认为信息系统研究应该紧紧围绕某些基本的概念,另一些学者则认为多样性其实是一笔宝贵资产。本文希望能够引入一个新的论题——信息系统学科目前的发展阶段。虽然信息系统学科相对较为年轻,但它现在正处于一个过渡阶段。信息系统学科将在这个阶段从成长期走向成熟期。

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84.糖尿病和肾

江西医药 1987年第2期 186-189页

作者： Bryan d.myers

发病率和患病率美国每年列入长期透析和肾移植计划的15,000例患者中,约25%是由于糖尿病而陷于末期肾衰竭的。糖尿病性肾小球病是引起肾衰竭的主要原因,这是一种复杂病变,伴有肾小球胶质成分的

关键词：糖尿病代谢病肾小球膜糖尿病性肾小球病结节性肾小球硬化蛋白尿尿成分异常

Reconstructing ancestral ranges in historical biogeography:properties and prospects

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Journal of Systematics and Evolution 2009年第5期47卷 369-382页

作者： Kristin S.LAMM benjamin d.REdELINGS Bioinformatics Research Center North Carolina State University

Recent years have witnessed a proliferation of quantitative methods for biogeographic *** particular,novel parametric approaches represent exciting new opportunities for the study of range ***,we review a selection of current methods for biogeographic analysis and discuss their respective *** methods include generalized parsimony approaches,weighted ancestral area analysis,dispersal-vicariance analysis,the dispersal-extinction-cladogenesis model and other maximum likelihood approaches,and Bayesian stochastic mapping of ancestral ranges,including a novel approach to inferring range evolution in the context of island *** of these methods were developed specifically for problems of ancestral range reconstruction,whereas others were designed for more general problems of character state reconstruction and subsequently applied to the study of ancestral *** for reconstructing ancestral history on a phylogenetic tree differ not only in the types of ancestral range states that are allowed,but also in the various historical events that may change the ancestral *** explore how the form of allowed ancestral ranges and allowed transitions can both affect the outcome of ancestral range ***,we mention some promising avenues for future work in the development of model-based approaches to biogeographic analysis.

关键词： allopatry ancestral range ancestral state reconstruction biogeography dispersal historical biogeogra-phy review speciation statistics vicariance.

Anthropomorphic Control of a dexterous Artificial Hand via Task dependent Temporally Synchronized Synergies

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Journal of Bionic Engineering 2014年第2期11卷 236-248页

作者： benjamin A. Kcnt John Lavery Erik d. Engeberg department of Mechanical Engineering University of Akron Akron OH 44325 USA department of Biomedical Engineering University of Akron Akron OH 44325 USA

despite the recent influx of increasingly dexterous prostheses, there remains a lack of sufficiently intuitive control methods to fully utilize this dexterity. As a solution to this problem, a control framework is proposed which allows the control of an arbitrary number of degrees of Freedom （dOF） through a single electromyogram （EMG） control input. Initially, the joint motions of nine test subjects were recorded while grasping and catching a cylinder. Inherent differences emerged depending upon whether the cylinder was grasped or caught. These data were used to form a distinct synergy for each task, described as the families of parametric functions of time that share a mutual time vector. These two Temporally Synchronized Synergies （TSS） were derived to reflect the task dependent control strategies adopted by the initial participants. These synergies were then mapped to a dexterous artificial hand that was subsequently controlled by two subjects with transradial amputations. The EMG signals from these subjects were used to replace the time vector shared by the synergies, enabling the subjects to perform both tasks with a dexterous artificial hand using only a single EMG input. After a ten minute training period, the subjects learned to use the dexterous artificial hand to grasp and catch the cylinder with 100.0% and 65.0% average success rates, respectively.

关键词： electromyogram dexterous hands grasp synergy prosthetics sliding mode control

Histone/protein deacetylase 3 dictates critical aspects of regulatory T cell development and function

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Cellular & Molecular Immunology 2016年第4期13卷 415-417页

作者： benjamin d. Singer Franco R. d'Alessio Johns Hopkins University division of Pulmonary and Critical Care Medicine Baltimore MD USA

Regulatory T cells （Tregs） comprise a subset of Cd4＋ T lymphocytes that holds promise as immunotherapy for inflammat- ory disease states including autoimmune disorders, solid organ allograft rejection, graft-versus-host disease, and acute inflam- matory conditions. However, limited availability of Treg numbers restricts their usefulness in cell transfer applications, particularly as patients may need multiple infusions for chronic diseases.

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Effects of temperature and SO_3 on re-emission of mercury from activated carbon under flue gas conditions

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Journal of Environmental Sciences 2019年第5期31卷 67-73页

作者： Michael Royko benjamin Galloway Noah d.Meeks Bihter Padak department of Chemical Engineering University of South Carolina Southern Company Services Inc.600 18th Street North

Mercury(Hg) is a toxic and bio-accumulating heavy metal that is predominantly released via the combustion of coal. due to its toxicity, the Environmental Protection Agency(EPA)has introduced Mercury and Air Toxics Standards(MATS) Rule regarding allowable Hg emissions. In order to reduce emissions, power plants have widely adopted activated carbon(AC) injection. AC injection has proven to be an effective method to reduce Hg emissions, but the re-emission of previously adsorbed Hg during unit operation, likely due to changing temperature or flue gas composition, could be problematic. This study specifically examined the effects of temperature and sulfur trioxide(SO3) concentration,by ramping temperature and SO3 concentration independently and simultaneously, on AC samples that are already exposed to flue gas and saturated in presence of Hg, sulfur dioxide(SO2) and nitric oxide(NO). Of these two suspected factors to cause re-emission,temperature had the greater impact and resulted in re-emission of both elemental and oxidized Hg with a greater fraction of oxidized Hg, which can be attributed to elemental Hg being more strongly bonded to the AC surface. Surprisingly, exposing the samples to increasing concentrations of SO3 had nearly no effect under the conditions examined in this study, possibly as a result of the samples being already saturated with sulfur prior to the SO3 ramp tests to simulate transient conditions in the plant.

关键词： Mercury re-emission Sulfur trioxide Activated carbon

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Taxonomic confusion of two tramp ant species： Iridomyrmex anceps and Ochetellus glaber are really species complexes

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Current Zoology 2011年第5期57卷 662-667页

作者： benjamin d. HOFFMANN Alan N. ANdERSEN Xiang ZHANG CSIRO Ecosystem Sciences Tropical Ecosystems Research Centre PMB 44 Winnellie NT 0822 Australia College of Plant Protection Fujian Agriculture and Forestry University Fuzhou Fujian 350002 China

Many invasive invertebrates belong to unresolved species complexes, and have a history of misidentification and in-appropriate management. Here we detail confusion surrounding the taxonomy and identification of two dolichoderine ant species, Iridomyrmex anceps Roger and OcheteUus glaber Mayr, which are commonly cited in the literature as having been spread widely by human commerce. We provide morphometric data and images strongly suggesting that these two ＂species＂ are instead com- plexes of species that are likely native to many regions where they are purportedly introduced. We take particular interest in the status of species referred to as L anceps and O. glaber in China, as this is the most northerly distribution of both genera. We con-clude by suggesting that many identifications of both species are likely to be unreliable, and we recommend against any manage- ment action aimed at controlling these species under the assumption that they are exotic [Current Zoology 57 （5）： 662-667, 2011].

关键词： Ant Exotic Invasive Invertebrate Management Tramp ant