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Sedimentary dynamics and depositional model for mud accumulation in deep lake basins:A case study in the Upper Triassic Chang-7 Member, Ordos Basin, northern China

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Journal of Palaeogeography 2024年第4期13卷 775-792页

作者： Wei yu Feng Wang Jing-chun Tian Jiao Wang benjamin Kneller Tian Yang Wei-Zhen Chen College of Petroleum Engineering Shandong Institute of Petroleum and Chemical Technology Key Laboratory of Deep-time Geography and Environment Reconstruction and Applications of Ministry of Natural Resources Chengdu University of Technology Institute of Sedimentary Geology Chengdu University of Technology University of Aberdeen School of Geoscience

Shales in deep lake basins have become the main focus of continental shale oil and gas exploration. In order to highlight the sedimentary dynamics of mud deposition in deep lake basins, a combination of core observation, thin section examination, X-ray diffraction, and QEMSCAN(quantitative evaluation of minerals by scanning electron microscopy) was used to analyze the depositional characteristics of mudrocks in the Chang-7 Member from the Yanchang Formation(Upper Triassic) in Ordos Basin, and to establish a depositional model for mud accumulation in deep lake basins. This study recognizes four mudrock lithofacies in the Chang-7 Member:(1) the laminated silt-bearing mudstone, which generally develops a binary composition of“silt-clay” or a ternary composition of “silt-clay-organic matter”;(2) the graded mudstone, mainly composed of dark gray and gray-black mudstone sandwiched by silt-bearing mudstone;(3) the massive mudstone, internally showing a uniform distribution of quartz, clay, and carbonate minerals, with also a small amount of organic detritus; and(4) the laminated shale, which is generally composed of clay laminae, and organic laminae of the former two. Sediment supply, topographic slope, and flood intensity combine to control the evolution of gravity flows and the transport and deposition of the mudrock in the Chang-7 Member. The influence of orogeny provides terrain gradient, water depth, abundant sediments at source areas, and triggering mechanism for the formation of gravity flows. Floods triggered by wetting events provide the impetus for sediment transport. Mud deposition in the Chang-7 Member was mainly related to the transport and sedimentation of mud by hyperpycnal flows and rapid sedimentation by buoyant plume flocculation. A comprehensive evolutionary model for shale accumulation in the deep lake basin is established by integrating various triggering mechanisms and mud transport sedimentary processes.

关键词： Mudrock Sedimentary dynamics mechanism Depositional model Chang-7 Member Depression lake basin

Chemoprevention of gastric cancer: current status

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Chinese Medical Journal 2003年第1期116卷 5-10页

作者： Harry Hua-Xiang Xia benjamin chun-yu wong shiu-kum lam Department of Medicine Department of MedicineDepartment of Medicine The University of Hong Kong Queen Mary Hospital Hong Kong SAR ChinaThe University of Hong Kong Queen Mary Hospital Hong Kong SAR ChinaThe University of Hong Kong Queen Mary Hospital Hong Kong SAR China

The development of gastric cancer is a multi-factor process. In addition to genetic factors, environmental factors including smoking, low gastric acidity, excessive intake of salt or salty food and low consumption of fresh fruits and vegetables all contribute to the development of gastric cancer. Of particular interest, epidemiological and experimental studies have demonstrated that Helicobacter pylori (H. pylori) infection is causally linked to gastric cancer. Most studies using micronutrient supplementation have failed to demonstrate any preventive effect against the development of gastric cancer. The use of non-steroidal anti-inflammatory drugs has been consistently observed to protect against the development of gastric cancer. Recently, eradication of H. pylori infection by a chemopreventative approach is being studied in a number of trials. Studies using precancerous lesions as an end point of the treatment have produced conflicting and mostly negative results. Trials using cancer as an end point are being cautiously carried out in high-risk populations, and will provide the definitive answer to this important question. In the end, vaccination may be proven to be the optimal strategy in human for the management of H. pylori infection and prevention of gastric cancer.

关键词： chemoprevention gastric cancer Helicobacter pylori

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Macrophage migration inhibitory factor stimulated by He/icobacter py/oriincreases proliferation of gastric epithelial cells

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World Journal of Gastroenterology 2005年第13期11卷 1946-1950页

作者： Harry Hua-Xiang Xia shiu kum lam Annie O.O.Chan Marie Chia Mi Lin Hsiang Fu Kung Keiji Ogura Douglas E.Berg benjamin chun-yu wong Department of Medicine Institute of Molecular Biology Department of Molecular Microbiology

AIM: Helicobacter pylori (H pylori) is associated with increased gastric inflammatory and epithelial expression of macrophage migration inhibitory factor (MIF) and gastric epithelial cell proliferation. This study aimed at determining whether H pylori directly stimulates release of MIF in monocytes, whether the cag pathogenicity island (PAI) is involved for this function, and whether MIF stimulated by H pylori increases gastric epithelial cell proliferation in vitro. METHODS: A cytotoxic wild-type H pylori strain (TN2), its three isogenic mutants (TN2Δcag,TN2ΔcagA and TN2ΔcagE) were co-cultured with cells of a human monocyte cell line, THP-1, for 24 h at different organism/ cell ratios. MIF in the supernatants was measured by an ELISA. Cells of a human gastric cancer cell line, MKN45, were then co-cultured with the supernatants, with and without monoclonal anti-MIF antibody for 24 h. The cells were further incubated for 12 h after addition of 3H-thymidine, and the levels of incorporation of 3H-thymidine were measured with a liquid scintillation counter. RESULTS: The wild-type strain and the isogenic mutants, TN2ΔcagA and TN2ΔcagE, increased MIF release at organism/cell ratios of 200/1 and 400/1, but not at the ratios of 50/1 and 100/1. However, the mutant TN2Δcag did not increase the release of MIF at any of the four ratios. 3H-thymidine readings for MKN-45 cells were significantly increased with supernatants derived from the wild-type strain and the mutants TN2ΔcagA and TN2ΔcagE, but not from the mutant TN2Δcag. Moreover, in the presence of monoclonal anti-MIF antibody, the stimulatory effects of the wild-type strain on cell proliferation disappeared. CONCLUSION: H pylori stimulates MIF release in monocytes, likely through its cag PAI, but not related to cagA or cagE. H pylori-stimulated monocyte culture supernatant increases gastric cell proliferation, which is blocked by anti-MIF antibody, suggesting that MIF plays an important role in H pylori-induced gastric ep

关键词： H pylori MIF PAI

幽门螺杆菌慢性感染诱导胃上皮细胞产生凋亡耐受

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中华医学杂志 2003年第1期83卷 42-45页

作者：何兴祥胡品津 benjamin chun yu wong shiu kum lam Harry Hua Xiang Xia 中山医科大学第一附属医院消化内科广州510080 DepartmentofMedicine TheUniversityofHongKongQueenMaryHospital

目的　建立幽门螺杆菌 (Hp)慢性感染胃上皮细胞模型 ,并分析Hp慢性感染与胃上皮细胞凋亡的关系。方法　用HpSS1与人非肿瘤性胃上皮细胞株GES 1共培养 16周 ,建立GES 1模型细胞 ,然后采用流式细胞术分析这种模型细胞对Hp和其它肠道细菌... 详细信息

目的　建立幽门螺杆菌 (Hp)慢性感染胃上皮细胞模型 ,并分析Hp慢性感染与胃上皮细胞凋亡的关系。方法　用HpSS1与人非肿瘤性胃上皮细胞株GES 1共培养 16周 ,建立GES 1模型细胞 ,然后采用流式细胞术分析这种模型细胞对Hp和其它肠道细菌以及抗肿瘤药物凋亡诱导剂的应答。结果　成功获得了Hp慢性感染胃上皮细胞模型 (GES 1模型细胞 )。这种模型细胞不仅对Hp诱导的凋亡耐受 ,而且对其他肠道细菌和一些凋亡诱导剂也是耐受的。结论　幽门螺杆菌慢性感染诱导胃上皮细胞产生凋亡耐受 ,由此可能增加了胃上皮细胞癌变的危险性。

关键词：胃上皮细胞细胞凋亡幽门螺杆菌感染胃癌

维普期刊数据库

Antralization at the edge of proximal gastric ulcers:Does Helicobacter pylori infection play a role?

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World Journal of Gastroenterology 2003年第6期9卷 1265-1269页

作者： Harry Hua-Xinag Xia shiu kum lam Wai Man wong Wayne Hsing Cheng Hu Kam Chuen Lai Sau Hing wong Suet Yi Leung Siu Tsan yuen Nicholas A.Wright benjamin chun-yu wong Department of Medicine The University of Hong KongHong Kong SARChina Department of Pathology The University of Hong KongHong Kong SARChina Histopathology Unit London Research InstituteCancer ResearchUK

AIM: To determine the prevalence of antralization at the edge of proximal gastric ulcers, and the effect ofH. pylori eradication on the mucosal appearances.METHODS: Biopsies were taken from the antrum, body and the ulcer edge of patients with benign proximal gastric ulcers before and one year after treatment. Gastric mucosa was classified as antral, transitional or body type.H. pylori positive patients receivedeither triple therapy, or omeprazole.RESULTS: Patients with index ulcers in the incisura, body or fundus (n=116) were analyzed. Antral-type mucosa was more prevalent at the ulcer edge inH. pylori-positive patients ***-negative patients (93% vs 60%, OR=8.95,95%CI: 2.47-32.4, P=0.001). At one year, there was a significant reduction in the prevalence of antralization (from 93 % to 61%, P=0.004) at the ulcer edge in patients with H. pyloribeing eradicated. However, there was no difference in the prevalence of antralization at the ulcer edge in those with persistent infection.CONCLUSION: H. pylori infection is associated with antralization at the edge of proximal gastric ulcers, which may be reversible in some patients after eradication of the infection.

关键词：胃溃疡幽门螺杆菌感染胃粘膜活组织检查

Hepatoma with cardiac metastasis: An advanced cancer requiring advanced treatment

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World Journal of Gastroenterology 2007年第25期13卷 3513-3516页

作者： yu-Sheng Lin Shih-Ming lung Feng-chun Tsai chun-Nan Yeh Tzu-Fang shiu Hsueh-Hua Wu Pyng-Jing Lin Pao-Hsien Chu Division of Cardiology Department of Internal MedicineChang Gung Memorial Hospital Chang Gung University Collegeof Medicine Taipei Taiwan China Department of Pathology Chang GungMemorial Children Hospital Chang Gung University College of Medicine Taipei Taiwan China Division of Thoracic and Cardiovascular Surgery Chang Gung University College of Medicine Taipei Taiwan China Department of Surgery Chang Gung Memorial Hospital Chang Gung University College of Medicine TaipeiTaiwan China

AIM: To investigate the clinical and pathologic fi ndings, and to discuss the pathophysiology of hepatocellular carcinoma with cardiac metastasis. METHODS: Eight hepatoma patients with cardiac metastasis, who were treated by surgical excision from 1993 to 2006, were retrospectively studied. Detailed clinical parameters were analyzed. RESULTS: Of those eight patients, two (25%) were women and six (75%) were men, with the mean age of 50 years (range, 40-70 years). The presentations included: asymptomatic (75%), heart failure (25%), and pulmonary embolism (12.5%). All lesions involved the right atrium, and extended to the lung (12.5%), inferior vena cava (25%), and left atrium (12.5%). The level of tumor marker, alpha-fetal protein, was not correlated with the severity of metastasis or disease prognosis. Moreover, the availably estimated doubling time was less than 3 mo. The pathological fi ndings included variablehemorrhage and necrosis. The survival time following surgery also varied from one month to more than 30 mo. CONCLUSION: Hepatoma metastasis to the heart was detected in all eight patients. This study demonstrates that surgery might help the outcome in such cases.

关键词： Hepatoma Cardiac metastasis, Alpha-fetalprotein

Preliminary Exploration on the Application of Saussure Sign Concept in Bio-Inspired Design: A Case of Tiantoushui Doll-Design

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World Journal of Engineering and Technology 2021年第3期9卷 548-554页

作者： yu-chun Yao shiu-Hua Wu Ai-Li Wang Graduate Program of Sustainable Tourism and Recreation Management National Taichung University of Education Taichung Department of Digital Media Design Hsiuping University of Science and Technology Taichung School of Art and Design Dalian Polytechnic University Dalian

Simply, shape bionics is to extract an image feature of natural objects, and most of the techniques for transforming and presenting are focused on metaphorical effects. In particular, the extraction process of metaphor design seems to be related to the concept of Saussure signs. Therefore, this research took the doll design of the Tiantoushui community in Changhua County, Taiwan as an example and attempted to use the Saussure concept to extract and evaluate the signs of bio-inspired design. The results showed that a total of three doll works symbolized respectively rice, guava, and pomelo implied the signification of local region by integrating the Saussure code image with the sign-image of the regional nature and transforming its content into “commodity design” and further transferring into “the product value of cultural and creative”. In addition, the specific extraction process included 1) Extraction of image—adjectives in creative products;2) Meaning space of image—adjec- tives in creative products;3) Extraction and determination of design elements of creative products, and 4) Combined the sensibility of creative products and design elements to derive design rules. After preliminary exploration of the extraction steps above, a concrete and efficient bio-inspired design process was proposed in this work. Besides, it was inferred that if further combined with the post-modern design style, it may not only simplify the design elements of creative products but also enhance the design connotations in the future.

关键词： Bio-Inspired Design Saussure Sign Concept Doll-Design Code-Image

Development,validation and comparison of multivariable risk scores for prediction of total stroke and stroke types in Chinese adults:a prospective study of 0.5 million adults

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Stroke & Vascular Neurology 2022年第4期7卷 328-336,I0023-I0045页

作者： Matthew chun Robert Clarke Tingting Zhu David Clifton Derrick A Bennett Yiping Chen yu Guo Pei Pei Jun Lv Canqing yu Ling Yang Liming Li Zhengming Chen benjamin J Cairns 无 Clinical Trial Service Unit and Epidemiological Studies Nuffield Department of Population HealthUniversity of OxfordOxfordUK Department of Engineering Science University of OxfordOxfordUK Department of Biomedical Engineering Oxford-Suzhou Centre for Advanced ResearchSuzhouChina Medical Research Council Health Research Unit Nuffield Department of Population HealthUniversity of OxfordOxfordUK CKB Project Department Fuwai Hospital Chinese Academy of Medical SciencesNational Center for Cardiovascular DiseasesBeijingChina CKB Project Department Chinese Academy of Medical SciencesBeijingChina Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijingChina Department of Epidemiology Peking University Center for Public Health and Epidemic Preparedness and ResponseBeijingChina On behalf of the China Kadoorie Biobank Collaborative Group

Background and purpose Low-income and middle-income countries have the greatest stroke burden,yet remain *** study compared the utility of Framingham versus novel risk scores for prediction of total stroke and stroke types in Chinese *** China Kadoorie Biobank(CKB)is a prospective study of 512726 adults,aged 30-79 years,recruited from 10 areas in China in *** 1 January 2018,43234 incident first stroke cases(36310 ischaemic stroke(IS);8865 haemorrhagic stroke(HS))were recorded in 503842 participants with no history of stroke at *** compared the predictive utility of the Framingham Stroke Risk Profile(FSRP)with novel CKB stroke risk scores and included recalibration,refitting,stratifying by study area and addition of other risk *** was assessed using area under the receiver operating characteristic curve(AUC)and calibration was assessed using Greenwood-Nam-D’Agostinoχ^(2) *** Incidence of total stroke varied fivefold by area in *** FSRP had good discrimination for total stroke(AUC(95%CI);men:0.78(0.77 to 0.79),women:0.77(95%CI 0.76 to 0.78)),but poor calibration(χ^(2);men:1,825,women:3,053),substantially underestimating absolute *** reducedχ^(2) by>80%,but did not improve *** the FSRP did not materially improve discrimination,but further improved *** by area improved discrimination(AUC;men:0.82(0.82 to 0.83);women:0.82(0.82 to 0.83)),but not *** other risk factors yielded modest,but statistically significant,improvements in the *** findings for IS and HS were similar to those for total *** The FSRP reliably differentiated Chinese adults with incident stroke,but substantially underestimated the absolute risks of *** local risk prediction equations that took account of differences in stroke incidence within China enhanced risk prediction of total stroke and major stroke pathological type

关键词： prediction income absolute

An Improvement on Observer-Based H∞ Control of Fuzzy Systems

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An Improvement on Observer-Based H∞ Control of Fuzzy System...