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Nuance of inward rectifying potassium(Kir)channel dysfunctions in neurodegenerative diseases

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Neural Regeneration Research 2024年第6期19卷 1195-1196页

作者： benjamin Garland Linlin Ma Griffith Institute for Drug Discovery&School of Environment and Science Griffith UniversityNathanBrisbaneQLDAustralia

Neurodegenerative disorders are highly prevalent and diverse in *** manifestation largely depends on the cell types involved,with aberrant inflammatory episodes progressively inducing a constellation of phenotypes that are classified into specific diseases based on their neuropathological *** two most prevalent neurodegenerative diseases worldwide,Alzheimer’s disease(AD)and Parkinson’s disease(PD),for example,share notable similarities,yet they differ in terms of the specific cell types lost within the central nervous system(CNS).The significant and progressive loss of cortical and certain subcortical neurons in various regions is a major defining trait of *** contrast,the specific loss of dopaminergic neurons(DA)within the substantial nigra pars compacta(SNpc)is sufficient to cause motor symptoms associated with *** devastating condition arising from neurodegeneration within the CNS,amyotrophic lateral sclerosis(ALS),results in the progressive death of upper and lower motor *** degeneration originates in oligodendrocytes,whose defective myelination abilities lead to the denervation of the anterior horn,aggravating motor neuron death.

关键词： diseases degenerative degeneration

Modeling tuberous sclerosis complex with human induced pluripotent stem cells

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World Journal of Pediatrics 2024年第3期20卷 208-218页

作者： Weibo Niu benjamin Siciliano Zhexing Wen Department of Psychiatry and Behavioral Sciences Emory University School of MedicineWhitehead Research Building 447615 Michael StreetAtlantaGA 30322USA The Graduate Program in Molecular and Systems Pharmacology Laney Graduate SchoolEmory UniversityAtlanta.GA 30322.USA Department of Cell Biology Emory University School of MedicineWhitehead Research Building 447615 Michael StreetAtlantaGA30322USA Department of Neurology Emory University School of MedicineWhitehead Research Building 447.615 Michael StreetAtlantaGA 30322USA

Background Tuberous sclerosis complex(TSC)is an autosomal dominant genetic disorder with a birth incidence of I:6000 in the United States that is characterized by the growth of non-cancerous tumors in multiple organ systems including the brain,kidneys,lungs,and ***,TSCis also associated with signicant neurological manifestations including epilepsy TSC-associated neuropsychiatric disorders,intellectual disabilities,and autism spectrum *** in the TSCI or TSC2 genes are well-established causes of TSC,which lead to TSC1/TSC2 deficiency in organs and hyper-activation of the mammalian target of rapamycin signaling *** models have been widely used to study the effect of TSCl/2 genes on the development and function of the *** considerable progress in understanding the molecular mechanisms underlying TSC in animal models,a human-specific model is urgently needed to investigate the effects of TSCl/2 mutations that are unique to human *** sources Literature reviews and research articles were published in PubMed-indexed *** Human-induced pluripotent stem cells(iPSCs),which capture risk alleles that are identical to their donors and have the capacity to differentiate into virtually any cell type in the human body,pave the way for the empirical study of previously inaccessible biological systems such as the developing human *** In this review,we present an overview of the recent progress in modeling TSC with human iPSC models,the existing limitations,and potential directions for future research.

关键词： Induced pluripotent stem cells Three-dimensional cultures Tuberous sclerosis complex Two-dimensional cultures

A nerve-like self-healable conductive wire

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National Science Review 2024年第6期11卷 89-90页

作者： Xuemei Fu benjamin C.K.Tee Department of Materials Science and Engineering National University of Singapore Institute for Health Innovation and Technology National University of Singapore

In wearables and robotics, it is often required to deploy electronic devices at different spatially distributed locations for multi-functionality [1–3]. Thus, conductive wires for efficient interconnection of various electronic devices are ***, in practical applications, the frequent motion of wearers and robots will result in high-strain deformations of these wires, which could cause irreparable damage.

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Effect of thermo-mechanical conditions during constrained friction processing on the particle refinement of AM50 Mg-alloy phases

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Journal of Magnesium and Alloys 2024年第6期12卷 2298-2311页

作者： Camila Caroline de Castro AndréMartins Neves benjamin Klusemann Helmholtz-Zentrum Hereon Institute of Material and Process DesignSolid-State Materials Processing21502 GeesthachtGermany Helmholtz-Zentrum Hereon Institute of Hydrogen TechnologySystem Design for Mobility21502 GeesthachtGermany Helmut Schmidt University/University of the German Federal Armed Forces Hamburg Department of Mechanical and Civil Engineering22043 HamburgGermany Leuphana University Lüneburg Institute for Production Technology and Systems21335 LüneburgGermany

Constrained Friction Processing(CFP)is a novel solid-state processing technique suitable for lightweight materials,such Mg-and *** technique enables grain size refinement to fine or even ultrafine *** this study,the effect of CFP on the microstructural refinement of AM50 rods is investigated in terms of particle size and morphology of the eutectic and secondary phases originally present in the base material,in particular the eutecticβ-Mg_(17)Al_(12)and Al-Mn *** that purpose,as-cast and solution heat-treated base material and processed samples were *** Al_(8)Mn_(5) intermetallic phase was identified as the main secondary phase present in all samples before and after the processing.A notorious refinement of these particles was observed,starting from particles with an average equivalent length of a few micrometers to around 560 nm after the *** refinement of the secondary phase refinement is attributed to a mechanism analogous to the attrition comminution,where the combination of temperature increase and shearing of the material enables the continuous breaking of the brittle intermetallic particles into smaller *** for the eutectic phase,the results indicate the presence of the partially divorcedβ-Mg_(17)Al_(12)particles exclusively in the as-cast base material,indicating that no further phase transformations regarding the eutectic phase,such as dynamic precipitation,occurred after the *** the case of the processed as-cast material analyzed after the CFP,the thermal energy generated during the processing led to temperature values above the solvus limit of the eutectic phase,which associated with the mechanical breakage of the particles,enabled the complete dissolution of this ***,CFP was successfully demonstrated to promote an extensive microstructure refinement in multiple aspects,in terms of grain sizes of theα-Mg phase and presence and morphology of the Al-Mn and eutecticβ-Mg_(17)Al_(12).

关键词： Constrained friction processing AM50 Refill friction stir spot welding Extrusion β-Mg_(17)Al_(12) Al-Mn phases

Analysis of synthetic parameters for coating aluminum powders with phenyltriethoxysilane coupling agent and their effects on powder flow behavior

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Particuology 2024年第7期90卷 412-417页

作者： Lillian M.Mawby Bellamarie Ludwig benjamin J.Lear Department of Chemistry The Pennsylvania State UniversityUniversity ParkPA16802USA Applied Research Laboratory The Pennsylvania State UniversityUniversity ParkPA16802USA

Though silanization of aluminum powder is currently used to improve its flow properties,for use as an alternative fuel source,there are a wide range of experimental parameters for the process and not all of them have been thoroughly *** this is complete,it is unknown if the process is optimized in terms of time,efficiency,and ***,we report on a study into the effects of changes in humidity,degree of agitation,reaction temperature,and curing time upon the deposition of phenyl triethoxysilane into 20μm(d50)aluminum *** confirm the deposition of the coating via diffuse reflectance infrared spectroscopy and x-ray photoelectron *** then characterize the coated particles using apparent density measurements and Carney flow *** analysis of variance,we find that,of the parameters explored,only changes in cure time and reaction temperature provide meaningful changes to the apparent density,while none of our parameters produced statistically significant changes in Carney flow ***,we conclude that,when optimizing silanization of aluminum particles,environmental control of humidity is unneeded and that the reaction can be run with minimal *** ability to largely ignore these parameters is a benefit to large-scale processing.

关键词： Aluminum powder Silane Fluidization Apparent density Carney flow

Generation of meaningful synthetic sensor data—Evaluated with a reliable transferability methodology

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Energy and AI 2024年第1期15卷 248-264页

作者： Michael Meiser benjamin Duppe Ingo Zinnikus Deutsches Forschungszentrum für künstliche Intelligenz(DFKI) Stuhlsatzenhausweg 3Saarbrücken66123SaarlandGermany

As households are equipped with smart meters,supervised Machine Learning(ML)models and especially Non-Intrusive Load Monitoring(NILM)disaggregation algorithms are becoming increasingly *** be robust,these models require a large amount of data,which is difficult to ***,the generation of meaningful synthetic data is becoming more *** use a simulation framework to generate multiple datasets using different techniques and evaluate their quality statistically by measuring the performance of NILM models for *** demonstrate that the method of data generation is crucial to train ML models in a meaningful *** experiments conducted reveal that adding noise to the synthetic smart meter data is essential to train robust NILM models for *** best results are obtained when this noise is derived from unknown appliances for which no ground truth data is *** we observed that NILM models can provide unstable results,we develop a reliable evaluation methodology,based on Cochran’s sample ***,we compare the quality of the generated synthetic data with real data and observe that multiple NILM models trained on synthetic data perform significantly better than those trained on real data.

关键词： Smart home Synthetic sensor data Energy data Transfer learning Evaluation methodology Machine learning Neural networks NILM Seq2point WindowGRU DAE Seq2seq RNN

Floating plants reduced methane fluxes from wetlands by creating a habitat conducive to methane oxidation

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Journal of Environmental Sciences 2024年第1期135卷 149-160页

作者： Fuwei Wang Songhe Zhang Xiuren Hu Xin Lv Min Liu Yu Ma benjamin Manirakiza Key Laboratory of Integrated Regulation and Resource Development on Shallow Lakes Ministry of EducationHohai UniversityNanjing 210098China College of Environment Hohai UniversityNanjing 210098China China Machinery International Engineering Desigh and Research Institute co. Ltd.East China Regional CenterNanjing 210008China

Wetlands are one of the important natural sources of atmospheric methane (CH_4),as an important part of wetlands,floating plants can be expected to affect methane ***,the effects of floating plants on methane release are *** this study,methane fluxes,physiochemical properties of the overlying water,methane oxidation potential and rhizospheric bacterial community were investigated in simulated wetlands with floating plants Eichhornia crassipes,Hydrocharis dubia,and Trapa *** found that ***,***,and *** plants could inhibit 84.31%-97.31%,4.98%-88.91%and 43.62%-92.51%of methane fluxes at interface of water-atmosphere compared to Control,*** fluxes were negatively related to nutrients concentration in water column but positively related to the aerenchyma proportions of roots,stems,and *** the same biomass,root of *** (36.44%) had the highest methane oxidation potential,followed by *** (12.99%) and *** (11.23%).Forty-five bacterial phyla in total were identified on roots of three plants and 7 bacterial genera (2.10%-3.33%) were known *** I methanotrophs accounted for 95.07%of total *** pmoA gene abundances ranged from 1.90×10^(16)to 2.30×10^(18)copies/g fresh weight of root *** of pmoA gene was significantly positively correlated with environmental *** (5.40%) and methanotrophy (3.75%) function were closely related to methane *** study highlights that floating plant restoration can purify water and promote carbon neutrality partially by reducing methane fluxes through methane oxidation in wetlands.

关键词： Floating plants Methane fluxes Aerenchyma Methanotrophs

Laser-induced plasma formation in water with up to 400 mJ double-pulse LIBS

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Plasma Science and Technology 2024年第1期26卷 93-100页

作者： Marion HENKEL Michelle SIEMENS Ralf METHLING benjamin EMDE Jörg HERMSDORF Steffen FRANKE Diego GONZALEZ Leibniz Institute for Plasma Science and Technology(INP) Felix-Hausdorff-Straße 2Greifswald 17489Germany Laser Zentrum Hannover e.V.(LZH) Hollerithallee 8Hannover 30419Germany

Double-pulse LIBS is a promising technique for deep-sea *** measurements in shallow water with up to 400 mJ each pulse were done to select laser parameters which promote optimized spectral line emission from plasma even at elevated pressures,where line broadening until loss of most of the spectral information can *** emission spectroscopy,using a Czerny-Turner spectrometer,has been applied to investigate the dependence of the emitted radiation on laser parameters and hydrostatic *** has been found,that higher laser pulse energies,especially with short pulse delay as required in high water pressure,can also have an adverse effect on the measured spectrum.

关键词： double-pulse LIBS underwater plasma formation emission spectrosocpy

CO_(2)capture costs of chemical looping combustion of biomass:A comparison of natural and synthetic oxygen carrier

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Journal of Energy Chemistry 2024年第5期92卷 296-310页

作者： benjamin Fleiß Juraj Priscak Martin Hammerschmid Josef Fuchs Stefan Müller Hermann Hofbauer Institute of Chemical Environmental and Bioscience EngineeringTU WienVienna1060 ViennaAustria BEST–Bioenergy and Sustainable Technologies GmbH Graz8010 StyriaAustria

Chemical looping combustion has the potential to be an efficient and low-cost technology capable of contributing to the reduction of the atmospheric concentration of CO_(2) in order to reach the 1.5/2°C goal and mitigate climate *** this process,a metal oxide is used as oxygen carrier in a dual fluidized bed to generate clean CO_(2) via combustion of *** commonly,natural ores or synthetic materials are used as oxygen carrier whereas both must meet special requirements for the conversion of solid *** oxygen carriers are characterized by higher reactivity at the expense of higher costs versus the lower-cost natural *** determine the viability of both possibilities,a techno-economic comparison of a synthetic material based on manganese,iron,and copper to the natural ore ilmenite was *** synthetic oxygen carrier was characterized and tested in a pilot plant,where high combustion efficiencies up to 98.4%and carbon capture rates up to 98.5%were *** techno-economic assessment resulted in CO_(2) capture costs of 75 and 40€/tCO_(2) for the synthetic and natural ore route respectively,whereas a sensitivity analysis showed the high impact of production costs and attrition rates of the synthetic *** synthetic oxygen carrier could break even with the natural ore in case of lower production costs and attrition rates,which could be reached by adapting the production process and recycling *** comparison to state-of-the-art technologies,it is demonstrated that both routes are viable and the capture cost of CO_(2) could be reduced by implementing the chemical looping combustion technology.

关键词： Chemical looping combustion BECCS Techno-economic assessment CO_(2)capture costs Oxygen carrier development Synthetic materials Ilmenite