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BOUNDARY INTEGRAL EQUATIONS FOR ISOTROPIC LINEAR ELASTICITY

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Journal of Computational Mathematics 2022年第6期40卷 835-864页

作者： benjamin Stamm Shuyang Xiang Department of Mathematics RWTH Aachen UniversityAachenGermany

This articles first investigates boundary integral operators for the three-dimensional isotropic linear elasticity of a biphasic model with piecewise constant Lam´e coefficients in the form of a bounded domain of arbitrary shape surrounded by a background *** the simple case of a spherical inclusion,the vector spherical harmonics consist of eigenfunctions of the single and double layer boundary operators and we provide their ***,in the case of many spherical inclusions with isotropic materials,each with its own set of Lam´e parameters,we propose an integral equation and a subsequent Galerkin discretization using the vector spherical harmonics and apply the discretization to several numerical test cases.

关键词： Isotropic elasticity Boundary integral equation Spherical inclusions Vector spherical harmonics Layer potentials

New developments in immunotherapy for lymphoma

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Cancer Biology & Medicine 2018年第3期15卷 189-209页

作者： benjamin Heyman Yiping Yang Division of Hematologic Malignancies and Cellular Therapy Department of Medicine Department of Immunology Duke University

The development of immunotherapies for lymphoma has undergone a revolutionary evolution over the past decades. Since the advent of rituximab as the first successful immunotherapy for B-cell non-Hodgkin lymphoma over two decades ago, a plethora of new immunotherapeutic approaches to treat lymphoma has ensued. Four of the most exciting classes of immunotherapies include:chimeric antigen receptor T-cells, bispecific antibodies, immune checkpoint inhibitors, and vaccines. However, with addition of these novel therapies the appropriate timing of treatment, optimal patient population, duration of therapy, toxicity, and cost must be considered. In this review, we describe the most-promising immunotherapeutic approaches for the treatment of lymphoma in clinical development, specifically focusing on clinical trials performed to date and strategies for improvement.

关键词： CAR-T cells immune checkpoint blockade bispecific antibodies

Automatic object annotation in streamed and remotely explored large 3D reconstructions

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Computational Visual Media 2021年第1期7卷 71-86页

作者： benjamin Holler Annette Mossel Hannes Kaufmann Institute of Visual Computing and Human-Centered Technology Vienna University of TechnologyFavoritenstraβe 9-11/193/06A-1040 ViennaAustria

We introduce a novel framework for 3 D scene reconstruction with simultaneous object annotation,using a pre-trained 2 D convolutional neural network(CNN),incremental data streaming,and remote exploration,with a virtual reality *** enables versatile integration of any 2 D box detection or segmentation *** integrate new approaches to(i)asynchronously perform dense 3 D-reconstruction and object annotation at interactive frame rates,(ii)efficiently optimize CNN results in terms of object prediction and spatial accuracy,and(iii)generate computationally-efficient colliders in large triangulated3 D-reconstructions at run-time for 3 D scene *** method is novel in combining CNNs with long and varying inference time with live 3 D-reconstruction from RGB-D camera *** further propose a lightweight data structure to store the 3 D-reconstruction data and object annotations to enable fast incremental data transmission for real-time exploration with a remote client,which has not been presented *** framework achieves update rates of 22 fps(SSD Mobile Net)and 19 fps(Mask RCNN)for indoor environments up to 800 m^(3).We evaluated the accuracy of 3 D-object *** work provides a versatile foundation for semantic scene understanding of large streamed3 D-reconstructions,while being independent from the CNN’s processing *** code is available for non-commercial use.

关键词： dense 3D reconstruction object detection CNN distributed virtual reality

Bacteriological Profile of Infections Encountered in a Pneumology Service in a Moderate-Income Country [Pneumology Department of CHU Cocody (Côte d’Ivoire)]

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Open Journal of Respiratory Diseases 2024年第1期14卷 1-11页

作者： Brou Jean Marcel Ahui Alitonde Eudoxie Djegbeton Alima Kone Marc-Olivier Koffi Kouame Clarisse Elogne Mobio Nancy Hermine benjamin Kouraogo Erick Akouatia Constante Virginie Brou-Gode Kigninlman Horo Boko Alexandre Kouassi Ngoran Koffi Pneumology Service Teaching Hospital of Cocody Abidjan C&#244te d’Ivoire Medical School of Abidjan University Félix Houphou&#235t Boigny Abidjan C&#244te d’Ivoire Pasteur Institute of Cô te d’Ivoire Abidjan C&#244te d’Ivoire

Introduction: Infections represent a real public health problem aggravating the morbidity and mortality of hospitalized patients. Methods: This was a retrospective study with descriptive purposes over a period of 05 years, in the Pneumology Department of the University Hospital of Cocody. Results: The average age in our population was 42 years. We observed a male predo- minance of 64.5%, with a sex ratio of 1.8. Medical history was dominated by HIV infection (23.5%), followed by tuberculosis (15.6%). Concerning lifestyle, smoking was found in 38% of cases. Symptoms progressed chronically in 80% of cases. An infectious syndrome was found in 75% of cases. Microbial culture was positive in 42% of cases. Pseudomonas aeruginosa and Klebsiella pneumoniae were encountered in 26.4% of cases each, followed by Echerichia coli in 10.4% of cases. Klebsiella pneumoniae in the first three years topped the list, but gradually. Pseudomonas aeruginosa maintained its leadership over the last three years. Pseudomonas aeruginosa isolates expressed a resistance rate of 9.8% to ceftazidime and 8.1% to imipenem;to aztreonam (36%), ticarcillin (33.3%) and levofloxacin. These strains were susceptible to fosfomycin (100%), mero- penem (96.6%) and amikacin (96%). For isolated strains of Entero- bacteria- ceae, resistance was observed about ticarcillin (83.3%) and amoxicillin clavula- nic acid (71.2%). Streptococcaceae showed resistance to tetracycline (69.2%) and erythromycin (50%). Over the years there has been an increase in re- sistance to amoxicillin-clavulanic acid ceftriaxone. The death rate was 14%. Conclusion: The bacterial profile of infections is dominated by germs respon- sible for nosocomial infection with significant mortality.

关键词： Bacterial Pleural Pneumonia Nosocomial Infection Sub-Saharan Africa Antibiotic Therapy

Dracunculiasis eradication-Finishing the job before surprises arise

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Asian Pacific Journal of Tropical Medicine 2012年第7期5卷 505-510页

作者： benjamin Jelle Visser Academic Medical Centre University of AmsterdamMeibergdreef 91105AZAmsterdamThe Netherlands

Dracunculiasis(Guinea worm disease) is a preventable waterborne parasitic disease that affects the poorest people living in remote rural areas in sub-Saharan African countries,who do not have access to safe drinking *** Guinea Worm Eradication Program,a 25-year old campaign to rid the world of Guinea Worm disease has now reached its final stage accelerating to zero cases in all endemic *** the 19th and 20th centuries,dracunculiasis was common in much of Southern Asia and the African *** overall number of cases has been reduced tremendously by≥99%,from the 3.32 million cases estimated to have occurred in 1986 in Africa to only I 797 cases reported in 2010 reported in only five countries(Sudan,Mali,Ethiopia,Chad and Ghana) and Asia free of the *** achievement is unique in its kind - the only previously eradicated disease is smallpox,a viral infection for which vaccination was possible - and it has been achieved through primary community-based prevention and health education *** efforts need to be taken in two countries,South Sudan(comprising 94%or I 698 out of 1 797 of the cases reported world-wide in 2010) and Mali because of frequent movements of nomads in a vast area inside and outside Mali’s *** factors favourable to dracunculiasis eradication are available including adequate financial resources,community and political support and high levels of *** there is no reason that this disabling parasitic disease cannot be eradicated soon before surprises arise such as new civil conflicts in currently endemic countries.

关键词： Dracunculiasis Guinea worm disease Eradication

Relative weak mixing is generic

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Science China Mathematics 2019年第1期62卷 69-72页

作者： Eli Glasner benjamin Weiss Department of Mathematics Tel Aviv University Institute of Mathematics The Hebrew University of Jerusalem

A classical result of Halmos asserts that among measure preserving transformations the weak mixing property is generic. We extend Halmos' result to the collection of ergolic extensions of a fixed, but arbitrary,aperiodic transformation T_0. We then use a result of Ornstein and Weiss to extend this relative theorem to the general(countable) amenable group.

关键词： relative weak mixing Rokhlin's lemma amenable groups

Mapping mutations in prostate cancer exomes

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Asian Journal of Andrology 2012年第6期14卷 801-802页

作者： benjamin Sunkel Qianben Wang Ohio State Biochemistry Graduate Program The Ohio State University College of Medicine Columbus OH 43210 USA Department of Molecular and Cellular Biochemistry and the Comprehensive Cancer Center The Ohio State University College of Medicine Columbus. OH 43210. USA

C omprehensive identification of driver mutations in prostate cancer can serve to enhance our understanding of the disease and expand the use of available treatment options. Two recent and comple- mentary studies from... 详细信息

关键词： MEDIATOR MED12 FOXA1 GENE

Novel insight into mechanisms of cholestatic liver injury

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World Journal of Gastroenterology 2012年第36期18卷 4985-4993页

作者： benjamin L Woolbright Hartmut Jaeschke Department of Pharmacology Toxicology and TherapeuticsUniversity of Kansas Medical CenterKansas CityKS 66160United States

Cholestasis results in a buildup of bile acids in serum and in *** studies into the mechanisms of cholestatic liver injury strongly implicated bile acidinduced apoptosis as the major cause of hepatocellular *** work has focused both on the role of bile acids in cell signaling as well as the role of sterile inflammation in the *** in modern analytical methodology have allowed for more accurate measuring of bile acid concentrations in serum,liver,and bile to very low levels of ***,toxic bile acid levels are seemingly far lower than previously *** initial hypothesis has been based largely upon the exposure of μmol/L concentrations of toxic bile acids and bile salts to primary hepatocytes in cell culture,the possibility that in vivo bile acid concentrations may be far lower than the observed in vitro toxicity has far reaching implications in the mechanism of *** review will focus on both how different bile acids and different bile acid concentrations can affect hepatocytes during cholestasis,and additionally provide insight into how these data support recent hypotheses that cholestatic liver injury may not occur through direct bile acid-induced apoptosis,but may involve largely inflammatory cell-mediated liver cell necrosis.

关键词： Bile acids Cholestasis Apoptosis Necro-sis Neutrophils Innate immunity Bile duct ligation

Underpad weight to estimate urine output in adult patients with urinary incontinence

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Journal of Geriatric Cardiology 2015年第2期12卷 189-190页

作者： benjamin T Galen Albert Einstein College of Medicine and Montefiore Medical Center Department of Internal Medicine Division of Hospital Medicine Suite 2-76 1825 East-chester Road Bronx NY 10461 USA.

To the Editor Monitoring urine output remains essential to the care of adult patients admitted to the hospital. In acute, decompen- sated heart failure, ongoing assessment of urine output is required to adjust diuretic dosing in keeping with current recommendations for hospitalized patients, In patients with acute kidney injury, assessment of urine output is essential for diagnosis and management. The diagnosis of circulatory shock is supported by renal hypoperfusion as measured by low urine output. Indwelling urinary cathe- ters are routinely used for the ＂strict＂ monitoring of urine output, which is an accepted indication.

关键词： Heart failure: Urinary catheters Urine output