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Chinese Chemical Letters 2024年第6期35卷 365-369页

作者： Xing Tian Di Wu Wanheng Wei Guifu Dai Zhanxian Li benhua wang Mingming Yu Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001China School of Life Sciences Zhengzhou UniversityZhengzhou 450001China Shenzhen Research Institute of Central South University Shenzhen 518057China

Abnormal accumulation and metabolism of lipid droplets can lead to a variety of diseases.Polarity,a key parameter of the microenvironment,is closely associated with many diseases and dysfunctions in the body.It is important to elucidate the relationship between the physiological activity of lipid droplets(LDs)and the polarity of the microenvironment.In this work,based on push-pull mechanism,a fluorescent probe(E)-3-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)-1-(2-hydroxyphenyl)prop-2-en-1-one(PPTH)with aggregation-induced emission(AIE)properties for the detection of polarity changes in cells was synthesized.PPTH not only visualize intracellular polarity fluctuation of iron death and inflammation but also distinguish between normal and fatty liver tissue.

关键词： Lipid droplets AIE Polarity Ferroptosis Fatty liver

Cisplatin-appended BODIPY for near infraredⅡfluorescent and photoacoustic imaging-guided synergistic phototherapy and chemotherapy of cancer

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Chinese Chemical Letters 2024年第3期35卷 352-357页

作者： Xuejian Xing E Pang Shaojing Zhao Tangna Pan Qiuxia Tan benhua wang Xiangzhi Song Minhuan Lan Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China

Combining phototherapy and chemotherapy has been considered a promising modality for cancer therapy due to their synergistic effect.Herein,we developed three D-π-A-structured boron dipyrromethenes(BODIPYs)(named as B-B,B-C,and B-C-Pt).Due to their enlargedπ-conjugated structure and high intramolecular charge transfer effect,the synthesized BODIPYs had photothermal conversion capability,and their absorption and fluorescence spectra were red-shifted.The cisplatin-appended BODIPY(B-C-Pt)exhibited good singlet oxygen(^1O_(2))generation ability and near infrared(NIR)absorption and fluorescence(λ_(Abs)=748 nm,λ_(Em)=947 nm).After being encapsulated by distearoyl phosphoethanolamine polyethyleneglycol 2000(DSPE-PEG-2000),which could inhibit the H-aggregation of B-C-Pt,the absorption and fluorescence of the obtained B-C-Pt nanoparticles(NPs)were red-shifted to 762 and 985 nm,respectively.The^1O_(2)quantum yield and photothermal conversion efficiency of the B-C-Pt NPs were 4.0%and 40.6%,respectively.Moreover,B-C-Pt NPs had chemotherapeutic efficacy due to the presence of cisplatin.In vitro and in vivo studies further demonstrated that B-C-Pt NPs had synergistic therapeutic efficacy.Together,B-C-Pt NPs could be employed in NIRⅡfluorescent and photoacoustic imaging-guided synergistic phototherapy and chemotherapy for cancer treatment.

关键词： Phototherapy Chemotherapy Cisplatin Bodipy NIRⅡfluorescent imaging

Coumarin-based two-photon AIE fluorophores: Photophysical properties and biological application

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Chinese Chemical Letters 2023年第4期34卷 231-235页

作者： Yitong Yang Hao Zhong benhua wang Xiaojie Ren Xiangzhi Song College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China Department of Chemistry and Center of Super-Diamond and Advanced Films(COSDAF) City University of Hong KongHong Kong 999077China

Based on the coumarin skeleton, we deliberately designed two groups of fluorophores, termed as CoumR and Naph-Coum-R, using the diphenylamino group as the electron donor, which displayed longwavelength emissions(red spectral region), large Stokes shift(up to 204 nm), superior AIE performance,and large two-photon absorbance cross-sections(as high as 365 GM). The electron-withdrawing substituents at the 3-position of these dyes could induce a significant red-shift in their emission spectra.Preliminary imaging experiments demonstrated the capability of these dyes as two-photon fluorophores for specifically staining lipid droplets in living cells.

关键词： Fluorescent dyes AIE Two-photon Large Stokes shifts Lipid droplets

A controllable self-localized imaging strategy capable of synchronous in situ tracking of local changes in intracellular bioactive small-molecules

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Science China Chemistry 2023年第8期66卷 2425-2434页

作者： Ke Li Shuai Xu benhua wang Shuangyan Huan Xiangzhi Song Lin Yuan Xiao-Bing Zhang State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha410082China College of Chemistry&Chemical Engineering Central South UniversityChangsha410083China School of Chemistry and Chemical Engineering University of JinanJinan250022China

In situ tracking and localization of ubiquitous bioactive small molecules(BSMs)within their native habitats is particularly challenging because of their low-molecular weight and widespread distribution properties.We report the proof of concept of a synchronous in situ imaging strategy,whereby the representative BSM amino-biothiols(ABs)mediate activation of the selflocalizable probe HYPQS,thereby releasing insoluble emissive precipitates to afford holistic distribution information of ABs.Notably,three organelle-targetable ABs inhibitors were innovatively fabricated for directed clearance of ABs in particular organelles,providing a powerful aid for HYPQS to achieve programmed in situ tracking of ABs in different organelles“on demand”.Biological transmission electron microscopy images confirmed that this probe released insoluble emissive precipitates at the reaction sites,which is of primary importance for achieving synchronous in situ tracking of BSMs.Furthermore,the probe HYPQS was successfully applied to monitor the dynamic changes in the endogenous ABs pool during diverse cell events.This strategy opens a promising avenue for investigating the undiscovered functional mechanism of local BSMs in relevant biological processes.

关键词： bioactive small-molecules in situ imaging fluorescent probes precipitated fluorophore imaging reagents

A"donor–acceptor"structured semiconductor polymer for near infrared fluorescence imaging guided photodynamic therapy

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Journal of Innovative Optical Health Sciences 2022年第4期15卷 75-85页

作者： Baoling Li Ting Xu Xiaosha wang Shaojing Zhao benhua wang Lihui Jiang Xiangzhi Song Minhuan Lan Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety College of Chemistry and Chemical Engineering Central South University Changsha 410083 P.R.China State Key Laboratory of Luminescent Materials and Devices South China University of Technology Guangzhou 510640 P.R.China

Near infrared(NIR)fluorescence imaging guided photodynamic therapy(PDT)is a technique which has been developed in many clinical trials due to its advantage of real-time optical monitoring,specific spatiotemporal selectivity,and minimal invasiveness.For this,photosensitizers with NIR fluorescence emission and high^(1)O_(2)generation quantum yield are highly desirable.Herein,we designed and synthesized a"donor-acceptor"(D-A)structured semiconductor polymer(SP),which was then wrapped with an amphiphilic compound(Pluronic■F127)to prepare water-soluble nanoparticles(F-SP NPs).The obtained F-SP NPs exhibit good water solubility,excellent particle size stability,strong absorbance at deep red region,and strong NIR fluorescent emission characteristics.The maximal mass extinction coe±cient and fluorescence quantum yield of these F-SPs were calculated to be 21.7 L/(g·cm)and 6.5%,respectively.Moreover,the^(1)O_(2)quantum yield of 89%for F-SP NPs has been achieved under 635 nm laser irradiation,which is higher than Methylene Blue,Ce6,and PpIX.The outstanding properties of these F-SP NPs originate from their unique D-A molecular characteristic.This work should help guide the design of novel semiconductor polymer for NIR fluorescent imaging guided PDT applications.

关键词： Donor-acceptor structure semiconducting polymer nanoparticles photodynamic therapy near infrared fluorescence imaging

Carbon dot-based fluorescent and colorimetric sensor for sensitive and selective visual detection of benzoyl peroxide

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Chinese Chemical Letters 2022年第3期33卷 1632-1636页

作者： Xiangcao Li Xuejian Xing Shaojing Zhao Shaohua Zhu benhua wang Minhuan Lan Xiangzhi Song Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China Shenzhen Research Institute of Central South University Shenzhen 518057China Hunan Norui Environmental Technology Co. Ltd.Changsha 410021China

Benzoyl peroxide(BPO) has been added in wheat flour because of its bleaching effect. However, the abnormal used BPO has caused increasing concern due to its strong oxidization capability which may have adverse effects on living organisms. Herein, we present a carbon dot(CD)-based fluorescent and colorimetric probe for visually, sensitively and selectively sensing BPO. The addition of BPO could quench the red fluorescence of CDs peaked at 622 and 677 nm, and decrease the absorbance at 613 nm, while increase the absorbance at 450 nm, resulting in a fluorescence turn-off and colorimetric spectral response.Moreover, the CDs had short response time of 10 min and high sensitivity towards BPO with a low limit of detection of 28 nmol/L. The applicability of the CDs in detecting BPO in wheat, noodle and starch samples was further demonstrated, and good recovery results were obtained.

关键词： Carbon dots Benzoyl peroxide Colorimetric Fluorescent probe Food safety

All-in-one phototheranostics based on BTP-4F-DMO nanoparticles for NIR-II fluorescence/photoacoustic dual-mode imaging and combinational therapy

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Chinese Chemical Letters 2023年第6期34卷 395-400页

作者： Ke Yang Bowen Yu Wei Liu Zequn Zhang Li Huang Shaojing Zhao benhua wang Jianing Yi Jun Yuan Yingping Zou Changwei Lin Xiangzhi Song Minhuan Lan Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China Department of Gastrointestinal Surgery The Third Xiangya Hospital of Central South UniversityChangsha 410013China Surgical Department of Breast and Thyroid Gland Hunan Provincial People’s HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 410083China

Various phototheranostics have recently been developed for phototherapy.Through proper molecular design,the photochemical and photophysical properties of these phototheranostics can be promoted.Herein,an acceptor-donor-acceptor(A-D-A)-structured dye,BTP-4F-DMO,was synthesized and prepared into water-soluble nanoparticles(NPs).The obtained BTP-4F-DMO NPs had strong absorption from650 nm to 850 nm and a fluorescence emission peak at~900 nm that tailed to~1100 nm.The NPs showed a superhigh photothermal conversion efficiency of 90.5%±5%and could simultaneously generate·OH and^(1)O_(2)with a^(1)O_(2)generation quantum yield of 4.6%under 808 nm laser irradiation.Due to these advanced properties,BTP-4F-DMO NPs can switch the role of autophagy from pro-survival to prodeath,thereby further promoting cancer cell death.These features make BTP-4F-DMO NPs a promising multifunctional phototheranostic agent for NIR-II fluorescence/photoacoustic dual-mode imaging-guided synergetic photodynamic/photothermal therapy.In general,this work provides a strategy for expanding the biomedical applications of organic A-D-A-structured phototheranostics.

关键词： Photodynamic therapy NIR-Ⅱfluorescence imaging Photothermal therapy Photoacoustic imaging Autophagy-induced death

A ratiometric merocyanine-based fluorescent probe for detecting hydrazine in living cells and zebra fish

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Chinese Chemical Letters 2020年第6期31卷 1508-1510页

作者： Jinliang Han Xiuxiu Yue Jingpei wang Yun Zhang benhua wang Xiangzhi Song College of Chemistry&Chemical Engineering Central South UniversityChangsha 410083China Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety Changsha 410083China

We developed a merocyanine-based fluorescent probe,NEPB,for tracing hydrazine(N2 H4)in a ratiometric manner with large Stokes shifts and long emission wavelength.The fluorescence color of probe NEPB changed from green to yellow upon addition of hydrazine.Probe NEPB displayed high selectivity and sensitivity to hydrazine in solution,and could ratiometrically monitor N2 H4 in living cells and zebrafish with low cytotoxicity.

关键词： Fluorescent probe Hydrazine Merocyanine Ratiometric Cell imaging

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山东省巨野县浅层地下水咸化特征及成因

济南大学学报（自然科学版） 2024年第3期38卷 257-266页

作者：冯国伟刘本华徐晶徐聪罗杰王琦济南大学水利与环境学院山东济南250022

为了深入了解浅层地下水的水化学特征及形成原因,在山东省巨野县采集20组浅层地下水样品,采用数理统计、Durov图、主成分分析、离子比值以及矿物饱和指数等方法,对地下水样检测结果进行统计分析,研究该地区地下水咸化特征及产生机制。... 详细信息

为了深入了解浅层地下水的水化学特征及形成原因,在山东省巨野县采集20组浅层地下水样品,采用数理统计、Durov图、主成分分析、离子比值以及矿物饱和指数等方法,对地下水样检测结果进行统计分析,研究该地区地下水咸化特征及产生机制。结果表明:研究区浅层地下水总体呈弱碱性,溶解性总固体的质量浓度为1680~14000 mg/L,地下水化学类型主要分为SO_(4)·Cl-Na·Mg、HCO_(3)·SO_(4)·Cl-Na·Ca·Mg、HCO_(3)·SO_(4)-Na·Mg以及HCO_(3)·SO_(4)·Cl-Na·Mg型;浅层地下水的咸化程度主要受蒸发浓缩作用影响,水中离子主要来自硅酸盐、岩盐矿物的溶解,钾盐、石膏、岩盐、硬石膏是溶解性总固体的主要来源,造成研究区地下水咸化的最主要矿物是钾盐、岩盐。

关键词：浅层地下水咸化溶解性总固体矿物饱和指数

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渤海湾盆地埕岛东部新近纪火山活动及其油气地质意义

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现代地质 2024年第2期38卷 312-321页

作者：张在振曾溅辉张本华王志伟刘金华于世娜武群虎王艳珍中国石油大学(北京)地球科学学院北京102249 中石化胜利油田分公司海洋采油厂山东东营257237 西南石油大学地球科学与技术学院四川成都610500

渤海湾盆地中部埕岛地区火山多期活动,对储层发育、油气运移及成藏等方面起到了一定的影响。目前研究主要集中在中生界火山岩储层上,对新近纪火山活动及油气成藏的影响认识不足,制约着埕岛东部油气的进一步勘探。本文综合区内应用测井... 详细信息

渤海湾盆地中部埕岛地区火山多期活动,对储层发育、油气运移及成藏等方面起到了一定的影响。目前研究主要集中在中生界火山岩储层上,对新近纪火山活动及油气成藏的影响认识不足,制约着埕岛东部油气的进一步勘探。本文综合区内应用测井、录井及地震资料,阐释了火山岩岩性、岩相及活动性等特征,并进一步探讨了火山活动对油气成藏过程的影响。研究区火山岩主要为灰黑色玄武岩,地震剖面上火山锥的形态较为清晰,平面上呈现串珠状或链状分布。结合地震相及钻井揭示岩电特征,将新近系底部火山岩岩相划分为火山通道相、爆发相、溢流相、火山沉积相和侵入相5种类型。火山活动始于新近纪早期,持续3~5 Ma即消亡,形成局部发育的角度不整合,并导致沉积环境由湖泊三角洲向辫状河的转变。研究区在火山活动和火山岩体作用下,重塑了油气输导及侧向遮挡条件,形成多种油气藏类型,与火山活动相关的岩性及火山岩体遮挡型油气藏是下一步勘探的重要方向。

关键词：渤海湾盆地埕岛油田新近纪火山活动油气成藏