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Chinese Chemical Letters 2025年第2期36卷 323-327页

作者： Du Liu Yuyan Li Hankun Zhang benhua wang Chaoyi Yao Minhuan Lan Zhanhong Yang Xiangzhi Song College of Chemistry & Chemical Engineering Central South University

Photodynamic therapy(PDT) presents a promising avenue in cancer treatment. Erlotinib, an FDAapproved anticancer drug targeting epidermal growth factor receptor(EGFR), has shown effectiveness in normalizing tumor vasculature across various tumors, thereby promoting tumor oxygenation and facilitating PDT. In this work, erlotinib was conjugated with a near-infrared(NIR) photosensitizer,benzo[a]phenoselenazinium, yielding three EGFR-targeted PDT agents(NBSe-n C-Er). These newly synthesized photosensitizers demonstrate specificity in binding to EGFR, thereby enhancing their accumulation in cancer cells and tumors, and consequently improving the efficiency of both PDT and ***, the NIR fluorescence emitted by the photosensitizer allows for imaging-guided therapy, offering a non-invasive means of monitoring treatment progress. The distinctive properties of the three-inone photosensitizer render it an ideal candidate for precise tumor treatment, overcoming the limitations of conventional therapies.

关键词： Benzo[a]phenoselenazinium Chemotherapy Fluorescence imaging Photodynamic therapy Photosensitizer

A ratiometric merocyanine-based fluorescent probe for detecting hydrazine in living cells and zebra fish

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Chinese Chemical Letters 2020年第6期31卷 1508-1510页

作者： Jinliang Han Xiuxiu Yue Jingpei wang Yun Zhang benhua wang Xiangzhi Song College of Chemistry&Chemical Engineering Central South UniversityChangsha 410083China Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety Changsha 410083China

We developed a merocyanine-based fluorescent probe,NEPB,for tracing hydrazine(N2 H4)in a ratiometric manner with large Stokes shifts and long emission *** fluorescence color of probe NEPB changed from green to yellow upon addition of *** NEPB displayed high selectivity and sensitivity to hydrazine in solution,and could ratiometrically monitor N2 H4 in living cells and zebrafish with low cytotoxicity.

关键词： Fluorescent probe Hydrazine Merocyanine Ratiometric Cell imaging

Coumarin-based two-photon AIE fluorophores: Photophysical properties and biological application

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Chinese Chemical Letters 2023年第4期34卷 231-235页

作者： Yitong Yang Hao Zhong benhua wang Xiaojie Ren Xiangzhi Song College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China Department of Chemistry and Center of Super-Diamond and Advanced Films(COSDAF) City University of Hong KongHong Kong 999077China

Based on the coumarin skeleton, we deliberately designed two groups of fluorophores, termed as CoumR and Naph-Coum-R, using the diphenylamino group as the electron donor, which displayed longwavelength emissions(red spectral region), large Stokes shift(up to 204 nm), superior AIE performance,and large two-photon absorbance cross-sections(as high as 365 GM). The electron-withdrawing substituents at the 3-position of these dyes could induce a significant red-shift in their emission *** imaging experiments demonstrated the capability of these dyes as two-photon fluorophores for specifically staining lipid droplets in living cells.

关键词： Fluorescent dyes AIE Two-photon Large Stokes shifts Lipid droplets

A"donor–acceptor"structured semiconductor polymer for near infrared fluorescence imaging guided photodynamic therapy

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Journal of Innovative Optical Health Sciences 2022年第4期15卷 75-85页

作者： Baoling Li Ting Xu Xiaosha wang Shaojing Zhao benhua wang Lihui Jiang Xiangzhi Song Minhuan Lan Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety College of Chemistry and Chemical Engineering Central South University Changsha 410083 P.R.China State Key Laboratory of Luminescent Materials and Devices South China University of Technology Guangzhou 510640 P.R.China

Near infrared(NIR)fluorescence imaging guided photodynamic therapy(PDT)is a technique which has been developed in many clinical trials due to its advantage of real-time optical monitoring,specific spatiotemporal selectivity,and minimal *** this,photosensitizers with NIR fluorescence emission and high^(1)O_(2)generation quantum yield are highly ***,we designed and synthesized a"donor-acceptor"(D-A)structured semiconductor polymer(SP),which was then wrapped with an amphiphilic compound(Pluronic■F127)to prepare water-soluble nanoparticles(F-SP NPs).The obtained F-SP NPs exhibit good water solubility,excellent particle size stability,strong absorbance at deep red region,and strong NIR fluorescent emission *** maximal mass extinction coe±cient and fluorescence quantum yield of these F-SPs were calculated to be 21.7 L/(g·cm)and 6.5%,***,the^(1)O_(2)quantum yield of 89%for F-SP NPs has been achieved under 635 nm laser irradiation,which is higher than Methylene Blue,Ce6,and *** outstanding properties of these F-SP NPs originate from their unique D-A molecular *** work should help guide the design of novel semiconductor polymer for NIR fluorescent imaging guided PDT applications.

关键词： Donor-acceptor structure semiconducting polymer nanoparticles photodynamic therapy near infrared fluorescence imaging

A controllable self-localized imaging strategy capable of synchronous in situ tracking of local changes in intracellular bioactive small-molecules

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Science China Chemistry 2023年第8期66卷 2425-2434页

作者： Ke Li Shuai Xu benhua wang Shuangyan Huan Xiangzhi Song Lin Yuan Xiao-Bing Zhang State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha410082China College of Chemistry&Chemical Engineering Central South UniversityChangsha410083China School of Chemistry and Chemical Engineering University of JinanJinan250022China

In situ tracking and localization of ubiquitous bioactive small molecules(BSMs)within their native habitats is particularly challenging because of their low-molecular weight and widespread distribution *** report the proof of concept of a synchronous in situ imaging strategy,whereby the representative BSM amino-biothiols(ABs)mediate activation of the selflocalizable probe HYPQS,thereby releasing insoluble emissive precipitates to afford holistic distribution information of ***,three organelle-targetable ABs inhibitors were innovatively fabricated for directed clearance of ABs in particular organelles,providing a powerful aid for HYPQS to achieve programmed in situ tracking of ABs in different organelles“on demand”.Biological transmission electron microscopy images confirmed that this probe released insoluble emissive precipitates at the reaction sites,which is of primary importance for achieving synchronous in situ tracking of ***,the probe HYPQS was successfully applied to monitor the dynamic changes in the endogenous ABs pool during diverse cell *** strategy opens a promising avenue for investigating the undiscovered functional mechanism of local BSMs in relevant biological processes.

关键词： bioactive small-molecules in situ imaging fluorescent probes precipitated fluorophore imaging reagents

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Carbon dot-based fluorescent and colorimetric sensor for sensitive and selective visual detection of benzoyl peroxide

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Chinese Chemical Letters 2022年第3期33卷 1632-1636页

作者： Xiangcao Li Xuejian Xing Shaojing Zhao Shaohua Zhu benhua wang Minhuan Lan Xiangzhi Song Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China Shenzhen Research Institute of Central South University Shenzhen 518057China Hunan Norui Environmental Technology Co. Ltd.Changsha 410021China

Benzoyl peroxide(BPO) has been added in wheat flour because of its bleaching effect. However, the abnormal used BPO has caused increasing concern due to its strong oxidization capability which may have adverse effects on living organisms. Herein, we present a carbon dot(CD)-based fluorescent and colorimetric probe for visually, sensitively and selectively sensing BPO. The addition of BPO could quench the red fluorescence of CDs peaked at 622 and 677 nm, and decrease the absorbance at 613 nm, while increase the absorbance at 450 nm, resulting in a fluorescence turn-off and colorimetric spectral ***, the CDs had short response time of 10 min and high sensitivity towards BPO with a low limit of detection of 28 nmol/L. The applicability of the CDs in detecting BPO in wheat, noodle and starch samples was further demonstrated, and good recovery results were obtained.

关键词： Carbon dots Benzoyl peroxide Colorimetric Fluorescent probe Food safety

A lipid droplets-targetable fluorescent probe for polarity detection in cells of iron death,inflammation and fatty liver tissue

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Chinese Chemical Letters 2024年第6期35卷 365-369页

作者： Xing Tian Di Wu Wanheng Wei Guifu Dai Zhanxian Li benhua wang Mingming Yu Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001China School of Life Sciences Zhengzhou UniversityZhengzhou 450001China Shenzhen Research Institute of Central South University Shenzhen 518057China

Abnormal accumulation and metabolism of lipid droplets can lead to a variety of ***,a key parameter of the microenvironment,is closely associated with many diseases and dysfunctions in the *** is important to elucidate the relationship between the physiological activity of lipid droplets(LDs)and the polarity of the *** this work,based on push-pull mechanism,a fluorescent probe(E)-3-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)-1-(2-hydroxyphenyl)prop-2-en-1-one(PPTH)with aggregation-induced emission(AIE)properties for the detection of polarity changes in cells was *** not only visualize intracellular polarity fluctuation of iron death and inflammation but also distinguish between normal and fatty liver tissue.

关键词： Lipid droplets AIE Polarity Ferroptosis Fatty liver

Cisplatin-appended BODIPY for near infraredⅡfluorescent and photoacoustic imaging-guided synergistic phototherapy and chemotherapy of cancer

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Chinese Chemical Letters 2024年第3期35卷 352-357页

作者： Xuejian Xing E Pang Shaojing Zhao Tangna Pan Qiuxia Tan benhua wang Xiangzhi Song Minhuan Lan Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety College of Chemistry and Chemical EngineeringCentral South UniversityChangsha 410083China

Combining phototherapy and chemotherapy has been considered a promising modality for cancer therapy due to their synergistic ***,we developed three D-π-A-structured boron dipyrromethenes(BODIPYs)(named as B-B,B-C,and B-C-Pt).Due to their enlargedπ-conjugated structure and high intramolecular charge transfer effect,the synthesized BODIPYs had photothermal conversion capability,and their absorption and fluorescence spectra were *** cisplatin-appended BODIPY(B-C-Pt)exhibited good singlet oxygen(^1O_(2))generation ability and near infrared(NIR)absorption and fluorescence(λ_(Abs)=748 nm,λ_(Em)=947 nm).After being encapsulated by distearoyl phosphoethanolamine polyethyleneglycol 2000(DSPE-PEG-2000),which could inhibit the H-aggregation of B-C-Pt,the absorption and fluorescence of the obtained B-C-Pt nanoparticles(NPs)were red-shifted to 762 and 985 nm,***^1O_(2)quantum yield and photothermal conversion efficiency of the B-C-Pt NPs were 4.0%and 40.6%,***,B-C-Pt NPs had chemotherapeutic efficacy due to the presence of *** vitro and in vivo studies further demonstrated that B-C-Pt NPs had synergistic therapeutic ***,B-C-Pt NPs could be employed in NIRⅡfluorescent and photoacoustic imaging-guided synergistic phototherapy and chemotherapy for cancer treatment.

关键词： Phototherapy Chemotherapy Cisplatin Bodipy NIRⅡfluorescent imaging

FRET-based two-photon benzo[a]phenothiazinium photosensitizer for fluorescence imaging-guided photodynamic therapy

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Chinese Chemical Letters 2024年第7期35卷 325-328页

作者： Yiling Li Zekun Gao Xiuxiu Yue Minhuan Lan Xiuli Zheng benhua wang Shuang Zhao Xiangzhi Song College of Chemistry&Chemical Engineering Central South UniversityChangsha 410083China Key Laboratory of Photochemical Conversion and Optoelectronic Materials and City U-CAS Joint Laboratory of Functional Materials and Devices Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Department of Dermatology Xiangya HospitalCentral South UniversityChangsha 410083China

To overcome the conflict between the long-wavelength excitation and high singlet oxygen quantum yield of photosensitizers,we conjugated a two-photon fluorophore,tetrahydroquinoxaline coumarin(TQ),and an efficient photodynamic therapeutic agent,benzo[a]phenothiazinium(NBS-NH_(2)),through a hexamethylene linker to build a two-photon photosensitizer,*** TQ-NBS,TQ served as an energy donor and NBS-NH_(2) acted as an energy acceptor;and TQ-NBS was a F?rster resonance energy transfer(FRET)cassette with a 92.8%*** large two-photon absorption cross-section of TQ allowed photosensitizer TQ-NBS to work in a 900 nm two-photon excitation(TPE)mode,which greatly benefited the deep tissue penetration in PDT ***,the excellent phototoxicity and near-infrared fluorescence of NBS-NH2was kept in TQ-NBS under a TPE mode via a FRET *** TQ-NBS exhibited a high phototoxic efficacy in living cells and tumor-bearing mice.

关键词： Photodynamic therapy Two-photon excitation FRET-based photosensitizer Singlet oxygen Near-infrared fluorescence

中学语文课堂教学的基本走向——基于各省级单位推荐优秀教学课例的分析

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课程．教材．教法 2024年第9期44卷 109-116页

作者：王本华人民教育出版社中学语文编辑室中国教育学会中学语文教学专业委员会北京100081

新课程改革大潮下,因应语文统编教材的使用,语文课堂教学方式正在发生着巨大变革。梳理各省级单位推荐的优秀课例,从新课程理念出发分析当前中学语文课堂教学的基本走向,可以看出:以文化人的价值追求,以任务为核心的教学设计,追求真实... 详细信息

新课程改革大潮下,因应语文统编教材的使用,语文课堂教学方式正在发生着巨大变革。梳理各省级单位推荐的优秀课例,从新课程理念出发分析当前中学语文课堂教学的基本走向,可以看出:以文化人的价值追求,以任务为核心的教学设计,追求真实的情境创设,在变革中坚守语文教学传统,指向积极的语言实践活动,等等,都成为语文课堂的新标识;同时也存在任务设计走形式、过于强调情境创设、不重视教材价值、忽略语文基本训练等问题。

关键词：中学语文课程改革课堂展示教学方式变革有效坚守传统