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Differences in the expression of hepatocyte growth factor in acute and chronic bowel inflammation—Implications for diagnosis?

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Advances in Bioscience and Biotechnology 2013年第8期4卷 33-42页

作者： Johanna Lonn Sravya Nakka Hans olsson Torbjorn bengtsson Sven Almer Fariba Nayeri The Institute for Protein Environment Affinity Surveys PEAS InstitutLinkopingSweden Division of Clinical Medicine School of Health and Medical SciencesOrebro UniversityOrebroSweden Department of Pathology Linkoping UniversityLinkopingSweden Division of Gastroenterology and Hepatology Karolinska InstitutetStockholmSweden Division of Gastroenterology and Hepatology Department of Clinical and Experimental MedicineLinkoping UniversityLinkopingSweden Department of Molecular and Clinical Medicine Division of Infectious DiseasesLinkoping UniversityLinkopingSweden

Background: Hepatocyte growth factor (HGF) acts as an acute phase protein with regenerative properties. HGF is produced systemically and locally during inflammation but exhibits decreased binding affinity to heparan sulphate proteoglycan (HSPG)/glycosaminoglycan during chronic inflammation. We previously observed a high faecal concentration and binding affinity of HGF to HSPG during acute gastroenteritis. High faecal concentrations of calprotectin and HGF have been reported in chronic inflammatory bowel disease (IBD). Methods: Stool samples from patients with ulcerative colitis in remission (n = 11) or exacerbation (n = 5), microscopic colitis (n = 11), colon cancer (n = 6), or acute gastroenteritis caused by Clostridium difficile (n = 20), as well as healthy controls (n = 7), were analysed for the presence of HGF by ELISA, surface plasmon resonance, SDS-PAGE, and Western blot. Then in two patients with ulcerative colitis exacerbation and C. difficile infection, the expression of HGF and calprotectin was studied in colonic biopsies. Results: The faecal concentration of HGF was significantly higher in patients with ulcerative colitis compared to the other groups. The binding affinity to dextran was lower in all groups compared to acute inflammation. HGF receptor binding was similar across groups. In a patient with concomitant C. difficile infection and distal ulcerative colitis, HGF was highly expressed in the part of the bowel unaffected by ulcerative colitis, but no expression was found at the site of chronic inflammation. In the patient with total colitis the biopsies showed low expression of HGF. The areas with chronic inflammation exhibited infiltrating calprotectin-stained neutrophils. Conclusion: HGF is produced locally during inflammation of the bowel. The HGF produced during acute inflammation or exacerbations of chronic inflammation by the unaffected area shows binding affinity to glucosaminoglycans. Measuring HGF binding in faeces and biopsies may be a too

关键词： Diarrhoea Ulcerative Colitis Dextran Sulphate HGF HSPG Calprotectin

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如何实施医疗质量控制

英国医学杂志中文版 2020年第7期23卷 373-375页

作者： Bryan Jones Emma Vaux Anna olsson Brown 邱艳(译) 任菁菁(校) The Health Foundation London Royal Berkshire NHS Foundation Trust Reading Department of Molecular and Clinical Pharmacology The Institute of Translational MedicineUniversity of Liverpool 浙江大学医学院附属第一医院

参与医疗质量控制可使临床医生获得和运用重要的专业能力7,例如处理复杂问题和人际沟通的能力1.对于临床实习生来说,这是一个可以提高照护水平、培养领导能力、演讲能力和时间管理能力,并与新单位的同事建立深厚友谊的机会9-11。对于资... 详细信息

参与医疗质量控制可使临床医生获得和运用重要的专业能力7,例如处理复杂问题和人际沟通的能力1.对于临床实习生来说,这是一个可以提高照护水平、培养领导能力、演讲能力和时间管理能力,并与新单位的同事建立深厚友谊的机会9-11。对于资深的临床医生来说,可以借此机会解决长期以来关心的问题,如医疗服务及卫生体系方面的问题,还可以加强自身的领导能力12。

关键词：医疗质量控制临床医生演讲能力临床实习生卫生体系人际沟通医疗服务时间管理能力

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人类皮下和网膜脂肪组织脂肪细胞因子的表达

江苏医药 2005年第12期31卷 914-916,I0001页

作者：李晓南陈荣华 Tommy olsson Olle Hernell 南京医科大学第二附属医院儿童保健中心 210011 南京医科大学儿科学研究所瑞典Ume大学公共卫生和医学系瑞典Ume大学医院临床医学儿科系

目的探讨脂肪细胞因子在成人皮下和网膜脂肪组织中的表达水平。方法应用即刻定量PCR方法测定16例成人皮下和网膜脂肪组织中瘦素、脂联素、肿瘤坏死因子α(TNF-α)和抵抗素的表达水平。结果正常体重组和超重组皮下脂肪组织瘦素mRNA水平... 详细信息

目的探讨脂肪细胞因子在成人皮下和网膜脂肪组织中的表达水平。方法应用即刻定量PCR方法测定16例成人皮下和网膜脂肪组织中瘦素、脂联素、肿瘤坏死因子α(TNF-α)和抵抗素的表达水平。结果正常体重组和超重组皮下脂肪组织瘦素mRNA水平均明显高于网膜组织(P<0.01);正常组网膜脂肪组织脂联素mRNA水平较皮下组织有升高趋势(P=0.07);TNF-α和抵抗素mRNA表达水平低下且无显著部位差异。无论皮下或网膜脂肪组织瘦素表达水平均与体重指数(BMI)成正相关(皮下:r=0.68,P<0.01;网膜:r=0.71,P<0.01)),而网膜脂肪组织脂联素表达与BMI呈明显负相关(r=-0.60,P<0.05)。结论基因编码的一些细胞因子在脂肪组织中的表达呈部位特征,肥胖时皮下和网膜脂肪组织瘦素过度表达,而内脏脂肪组织脂联素表达下调,这可能是肥胖相关的胰岛素抵抗发生的潜在危险因素。

关键词：细胞因子脂肪组织部位特异性体重指数

Maintenance and Condition-Based Maintenance

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International Journal of Plant Engineering and Management 2005年第3期10卷 160-170页

作者： DING Jin-hua WANG Xue-Jun ZHOU Rong LIN Min olsson Erland Department of Mechanical Engineering Dalian Institute of Light Industry Dalian 116034 P. R. China Department of Information Design and Product Development Maeilardalens University Box 325 Eskilstuna 63105 Sweden

The evolution of maintenance management is briefly introduced in this paper, from corrective maintenance to preventive maintenance. First, a range of condition monitoring and fault diagnosis techniques developed in different industries are surveyed; Second, many methods of condition monitoring are presented; Third, mathematical methods used in condition monitoring are given; Then the merits and shortcomings are discussed. Efficient maintenance policies are of fundamental importance in system engineering because of their fallbacks into the safety and economics of plant operation. Applying condition-based maintenance to a system can reduce the cost and extend the availability of facilities. With the advent of personal computers as fast and cost effective machines for data acquisition and processing of multiple signals some shortcomings mentioned in condition monitoring could be solved or reduced to some extent. These PCs can be a solution as a condition monitoring based maintenance system.

关键词： maintenance policy reliability condition-based monitoring

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沥滤化合物对煤中脱硫微生物生长的影响

矿业译丛 1990年第3期 54-59页

作者： olsson,G 曹作华

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药品安全监测——每个人应关注的问题

中国执业药师 2009年第6期6卷 45-46页

作者： Sten olsson WHO国际药品监测合作中心外部事务及传统医药司

药物警戒体系自二十世纪六十年代建立以来，越来越多地受到人们关注。沙利度胺灾难发生后，十个发达国家在WHO的领导下，认为有必要在药品监测方面开展国际合作，以防止类似的灾难再度发生。现在，对药品的潜在危险进行早期监测和信息... 详细信息

药物警戒体系自二十世纪六十年代建立以来，越来越多地受到人们关注。沙利度胺灾难发生后，十个发达国家在WHO的领导下，认为有必要在药品监测方面开展国际合作，以防止类似的灾难再度发生。现在，对药品的潜在危险进行早期监测和信息共享的重要性，已经在世界范围内得到认可。

关键词：药品监测安全监测药物警戒体系沙利度胺发达国家国际合作信息共享早期监测

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集成安全:有效保证安全性

电气时代 2009年第6期 58-60页

作者： Kristian olsson

安全是任何工厂的头等大事，人员伤亡更是令人无法接受。但是，安全的含义可能并不仅仅局限于对人员和设备实施必要的基本保护，如与安全相关事件的负面宣传可能会对相关企业造成极其深刻的影响，在某些情况下，甚至会影响到整个行业。... 详细信息

安全是任何工厂的头等大事，人员伤亡更是令人无法接受。但是，安全的含义可能并不仅仅局限于对人员和设备实施必要的基本保护，如与安全相关事件的负面宣传可能会对相关企业造成极其深刻的影响，在某些情况下，甚至会影响到整个行业。随着工艺复杂性的不断增加，工厂使用不同制造商提供的不同系统，这就给保证整体安全水平提出了挑战。ABB相信，未来的安全系统不再是一个附带系统，虽然在设计和供应方面与其他系统分开在不同的工厂或工艺过程进行，但理应成为其集成的一部分。

关键词：安全性集成安全系统工艺过程人员伤亡安全水平工厂复杂性

Integrative taxonomy of the Russet Bush Warbler Locustella mandelli complex reveals a new species from central China

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Chinese Birds 2015年第2期6卷 60-91页

作者： Per Alstrom Canwei Xia Pamela C Rasmussen Urban olsson Bo Dai Jian Zhao Paul J Leader Geoff J Carey Lu Dong Tianlong Cai Paul I Holt Hung Le Manh Gang Song Yang Liu Yanyun Zhang Fumin Lei Key Laboratory of Zoological Systematics and Evolution Institute of ZoologyChinese Academy of Sciences Swedish Species Information Centre Swedish University of Agricultural Sciences Ministry of Education Key Laboratory for Biodiversity and Ecological Engineering College of Life SciencesBeijing Normal University Department of Integrative Biology and MSU Museum Michigan State University Bird Group The Natural History Museum at Tring Department of Biology and Environmental Sciences Systematics and BiodiversityUniversity of Gothenburg College of Life Sciences Leshan Normal University State Key Laboratory of Biocontrol and College of Ecology and Evolution Sun Yat-sen University c/o AEC Ltd 121–127 Commercial CentrePalm SpringsYuen LongHong Kong College of Life Sciences University of Chinese Academy of Sciences Bracken Dean PendletonClitheroeLancashire BB7 1PTUK Institute of Ecology and Biological Resources Vietnam Academy of Science and Technology

Background: The Russet Bush Warbler Locustella(previously Bradypterus) mandelli complex occurs in mountains in the eastern Himalayas, southern China, Vietnam, the Philippines, and Indonesia. The taxonomy has been debated,with one(L. seebohmi) to four(L. seebohmi, L. mandelli, L. montis and L. timorensis) species having been ***: We used an integrative approach, incorporating analyses of morphology, vocalizations and a molecular marker, to re-evaluate species limits in the L. mandelli ***: We found that central Chinese L. mandelli differed from those from India through northern Southeast Asia to southeast China in plumage, morphometrics and song. All were easily classified by song, and(wing + culmen)/tail ratio overlapped only marginally. Both groups were reciprocally monophyletic in a mitochondrial cytochrome b(cytb) gene tree, with a mean divergence of 1.0 ± 0.2%. They were sympatric and mostly altitudinally segregated in the breeding season in southern Sichuan province. We found that the Mt Victoria(western Myanmar) population differed vocally from other L. mandelli, but no specimens are available. Taiwan Bush Warbler L. alishanensis was sister to the L. mandelli complex, with the most divergent song. Plumage, vocal and cytb evidence supported the distinctness of the south Vietnamese L. mandelli idonea. The Timor Bush Warbler L. timorensis, Javan Bush Warbler *** and Benguet Bush Warbler L. seebohmi differed distinctly in plumage, but among-population song variation in L. montis exceeded the differences between some populations of these taxa, and mean pairwise cytb divergences were only 0.5–0.9%. We also found that some L. montis populations differed ***: We conclude that the central Chinese population of Russet Bush Warbler represents a new species,which we describe herein, breeding at mid elevations in Sichuan, Shaanxi, Hubei, Hunan and Guizhou *** taxonomic status of the other allopatric populati

关键词： Bradypterus Cryptic species Locustella seebohmi Locustella mandelli Locustella montis Locustella timorensis Locustella alishanen

A Study of the Microbial Community at the Interface between Granite Bedrock and Soil Using a Culture-Independent and Culture-Dependent Approach

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Advances in Microbiology 2016年第3期6卷 233-245页

作者： Karen olsson-Francis Victoria K. Pearson Paul F. Schofield Anna Oliver Stephen Summers Department of Environment Earth and Ecosystems The Open University Walton Hall Milton Keynes UK Department of Physical Sciences The Open University Walton Hall Milton Keynes UK Department of Earth Sciences Natural History Museum Cromwell Road London UK NERC Centre for Ecology and Hydrology Benson Lane Crowmarsh Gifford Wallingford UK Department of Engineering and Innovation The Open University Walton Hall Milton Keynes UK

The dissolution of minerals plays an important role in the formation of soils and sediments. In nutrient limiting soils, minerals constitute a major reservoir of bio-essential cations. Of particular interest is granite as it is the major rock type of the continental land mass. Although certain bacteria have been shown to enhance weathering of granite-forming minerals, little is known about the dissolution of granite, at the whole rock scale, and the microbial community involved. In this study, both culture-independent and culture-dependent approaches were used to study the bacterial community at the interface between granite bedrock and nutrient limiting soil in Dartmoor National Park, United Kingdom. High throughput sequencing demonstrated that over 70% of the bacterial population consisted of the bacterial classes Bacilli, Beta-proteobacteria and Gamma-proteo-bacteria. Bacteria belonging to the genera Serratia, Pseudomonas, Bacillus, Paenibacillus, Chromo-bacterium and Burkholderia were isolated from the sample site. All of the isolates were able to grow in a minimal growth medium, which contained glucose and ammonium chloride, with granite as the sole source of bio-essential elements. Sixty six percent of the isolates significantly enhanced basalt dissolution (p < 0.05). Dissolution of Si, K, Ca and Mg correlated with production of oxalic acid and acidification. The results of this study suggest that microorganisms in nutrient limiting soils can enhance the rate of granite dissolution, which is an important part of the biogeochemical cycle.

关键词： Mineral Weathering Soil Community