检索结果-南通市图书馆

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon j.Brown Rafael j.Yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Neo-adjuvant radiotherapy in rectal cancer

在线全文

学校读者我要写书评

暂无评论

World journal of Gastroenterology 2013年第46期19卷 8489-8501页

作者： bengt Glimelius Department of Radiology Oncology and Radiation Science Uppsala University

In rectal cancer treatment,attention has focused on the local primary tumour and the regional tumour cell deposits to diminish the risk of a loco-regional *** large randomized trials have also shown that combinations of surgery,radiotherapy and chemotherapy have markedly reduced the risk of a locoregional recurrence,but this has not yet had any major influence on overall *** best results have been achieved when the radiotherapy has been given *** radiotherapy improves loco-regional control even when surgery has been optimized to improve lateral clearance,i.e.,when a total mesorectal excision has been *** relative reduction is then 50%-70%.The value of radiotherapy has not been tested in combination with more extensive surgery including lateral lymph node clearance,as practised in some Asian *** details about how the radiotherapy is performed are still open for discussion,and practice varies between countries.A highly fractionated radiation schedule(5 Gy×5),proven efficacious in many trials,has gained much popularity in some countries,whereas a conventionally fractionated regimen(1.8-2.0 Gy×25-28),often combined with chemotherapy,is used in other *** additional therapy adds morbidity to the morbidity that surgery causes,and should therefore be administered only when the risk of loco-regional recurrence is sufficiently *** best integration of the weakest modality,to date the drugs(conventional cytotoxics and biologicals)is not known.A new generation of trials exploring the best sequence of treatments is ***,there is a great need to develop predictors of response,so that treatment can be further individualized and not solely based upon clinical factors and anatomic imaging.

关键词： Chemotherapy Chemoradiotherapy Local control Multidisciplinary Organ preservation Radio-therapy Randomized trials Rectal cancer

Mucosa-associated bacteria in two middle-aged women diagnosed with collagenous colitis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World journal of Gastroenterology 2012年第14期18卷 1628-1634页

作者： Rita j Gustafsson Bodil Ohlsson Cecilia Benoni bengt jeppsson Crister Olsson Department of Clinical Sciences Gastroenterology SectionSkne University HospitalLund University20502 MalmSweden Department of Surgery Skne University HospitalLund University20502 MalmSweden Food Technology Engineering and Nutrition Lund University22100 LundSweden

AIM:To characterize the colon microbiota in two women histologically diagnosed with collagenous colitis using a culture-independent ***:Biopsies were taken from the ascending colon and the total DNA was *** bacterial primers were used to amplify the bacterial 16S rRNA *** amplicons were then cloned into competent Escherichia coli *** clones were sequenced and identified by comparison to known ***:The clones could be divided into 44 different *** microbiota was dominated by Firmicutes and *** phylotypes werefound in both patients and constituted 47.5% of the total number of *** these,the most dominating were clones similar to Bacteroides cellulosilyticus,Bacteroides caccae,Bacteroides thetaiotaomicron,Bacteroides uniformis and Bacteroides dorei within *** similar to Faecalibacterium prausnitzii and Clostridium citroniae were also found in both ***:A predominance of potentially pathogenic Bacteroides spp.,and the presence of clones showing similarity to Clostridium clostridioforme were found but the overall colon microbiota showed similarities to a healthy *** for collagenous colitis other than an adverse bacterial flora must also be considered.

关键词： Microscopic colitis Collagenous colitis Lymphocytic colitis Colonic microbiota 16S rRNA sequencing

Women in visual neural regeneration research

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第2期20卷 489-490页

作者： Tonia S.Rex David j.Calkins Vanderbilt Eye Institute Vanderbilt University Medical CenterNashvilleTNUSA

The year 2024 marks the 60^(th)anniversary of Title IX and 25 years since the New York Times revealed bias against female faculty members at the Massachusetts Institute of *** take an opportunity here to examine the state of gender bias in a relatively new yet already prominent field,neural regeneration in the visual system,for which there is a well-defined context useful for this *** National Eye Institute(NEI)provided the first round of research funding for its Audacious Goals Initiative(AGI)on visual neural regeneration in 2013 and the last round in ***,we focus on this *** sources included PubMed,the National Science Foundation(NSF),the NEI,the Blue Ridge Institute for Medical Research and data from the major professional organization for eye and vision research,the Association for Research in Vision and Ophthalmology(ARVO).

关键词： neural visual Times

Generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael j.Lee Ryota L.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

Investigation of Interacting Mechanism between Film Cooling and Internal Cooling Structures of Turbine Blade

在线全文

学校读者我要写书评

暂无评论

journal of Thermal Science 2023年第1期32卷 330-350页

作者： ZHANG Guohua XIE Gongnan bengt Sundén School of Marine Science and Technology Northwestern Polytechnical UniversityXi'an 710072China School of Mechanical Engineering Northwestern Polytechnical UniversityXi'an 710072China Department of Energy Sciences Lund UniversityLund SE-22100Sweden Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China

This paper presents three-dimensional numerical simulations with the established realizable k-εmodel to clarify the underlying and interacting mechanisms between the film cooling and the internal *** the one hand,the effects of three different internal cooling channels,i.e.,smooth channel,continuous ribbed channel,and truncated ribbed channel,on the film cooling effectiveness and the discharge coefficients are *** the other hand,the influences of three different film cooling holes,i.e.,cylindrical hole,two elliptical holes and two circular-to-elliptical holes,on the heat transfer performances and pressure loss of the internal cooling channel are ***,the suction effects of the film cooling holes are analyzed through setting up baselines with only internal cooling *** show that the placement of ribs in the internal channel has different influences on the film cooling effectiveness with respect to different hole shapes depending on the blowing *** discharge coefficient of the film hole can be improved by introducing ribs to the internal *** of film hole is helpful for enhancing the heat transfer performance and reducing the pressure loss of the internal ***,ribs instead of the suction effect of film hole play a major role to enhance the heat transfer performance in the internal cooling channel.

关键词： interacting mechanism film cooling effectiveness discharge coefficient heat transfer performance pressure drop

MAGNETIC FIELD EFFECT ON PHOTOPOLYMERIZATION OF STYRENE MICROEMULSION

在线全文

学校读者我要写书评

暂无评论

Chinese journal of Polymer Science 1993年第1期11卷 1-7页

作者：陈用烈 Anders Hult bengt Ranby Institute of Polymer Science Zhongshan University Guangzhou Department of Polymer Technology The Royal Institute of Technology Stockholm Sweden

External magnetic field increases the photo-induced polymerization rate of styrene *** type of photoinitiator plays an important role. The photoinitiators, used are dimethoxyphenyl acetophenone(DMPA), 1-hydroxycyclohexyl phenylketone (Irgacure 184) and dimethylhydroxyacetophenone (Darocur 1173). No magnetic effect was observed by using dibenzylketone (DBK) as photoinitiator. The molecular weight of the polymer is slightly affected by magnetic field. The influence of temperature has also been investigated.

关键词： DMPA MAGNETIC FIELD EFFECT ON PHOTOPOLYMERIZATION OF STYRENE MICROEMULSION

Effects of Ribbed-Cavity Tip on the Blade Tip Aerothermal Performance in a High Pressure Turbine Stage

在线全文

学校读者我要写书评

暂无评论

journal of Thermal Science 2023年第2期32卷 800-811页

作者： DU Kun LI Huarong SUNDEN bengt LIU Cunliang School of Power and Energy Northwestern Polytechnical UniversityXi'an 710072China Yangtze River Delta Research Institute of NPU Northwestern Polytechnical UniversityTaicang 215400China Shaanxi Key Laboratory of Thermal Sciences in Aero-Engine System Northwestern Polytechnical UniversityXi'an 710129China NPU-KAI International joint Laboratory of Advanced Aero-Engine Thermal Structure Northwestern Polytechnical UniversityXi'an 710129China Division of Heat Transfer Department of Energy SciencesLund UniversityLund SE-22100Sweden

For unshrouded blade tip,the high-temperature gas flows through the tip clearance by force of the lateral pressure ***,the blade tip endures increasing thermal ***,the conventional blade tip treatment cannot continuously provide protection for the deteriorating service *** the present study,aerothermal characteristics of the squealer blade tip with staggered ribs,partial squealer rim and different partial squealer rim thickness were investigated to explore the influences of ribbed-cavity tip on the tip heat transfer,leakage flow and turbine stage *** numerical results indicate that the ribbed-cavity tips are beneficial for the reduction of the blade tip thermal load and leakage *** the present six blade tip designs,the minimal area-averaged heat transfer coefficient is obtained by the case with the staggered ribs and a deeper squealer rim,which is reduced by 31.41%relative to the squealer ***,the blade tip modification closer to leading edge or tip mid-chord region performs better than trailing edge in reducing the tip leakage flow.

关键词： gas turbine tip leakage flow numerical simulation blade tip configuration