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Liposomes functionalized with acidic lipids rescue Aβ-induced toxicity in murine neuroblastoma cells

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Liposomes functionalized with acidic lipids rescue Aβ-induc...

临床前期检测阿尔茨海默病与痴呆:基于人群的队列研究

2011全国老年痴呆与衰老相关疾病学术会议第三届山东省神经内科医师（学术）论坛

作者： Erika Bereczki Francesca Re Massimo E.Masserini bengt winblad Department of Neurobiology Care Sciences and Society Novum Floor 5 Karolinska Institutet Alzheimer Disease Research Center(KIARDC) Karolinska Institutet SE-141-86 Stockholm Sweden Department of Experimental Medicine University of Milano Bicocca 20052 Monza Italy

The loss of synapses and neurons in Alzheimer s disease(AD) is thought to be at least partly induced by toxic species formed by the amyloid beta(Aβ),therefore,therapeutics aimed at reducing Aβtoxicity could be of clinical use for treatment of *** are suitable vehicles for therapeutic agents and imaging probes and,a promising way of targeting the various Aβ*** tested liposomes functionalized with phosphatidic acid,cardiolipin or GM1 ganglioside previously shown to have high Aβbinding *** Aβ-induced toxicity in mouse neuroblastoma cell lines,combined with administration of cell viability modulating agents,we observed that functionalized liposomes rescued cell viability to different *** detected also rescue of the imbalance of GSK-3βand PP2A activity,and reduction in tau ***,these liposomes appear particularly suitable for implementing further therapeutic strategies of AD(Funded by the FP7:CP-IP 212043-2-NAD and the Karolinska Foundation).

关键词： Alzheimer s disease Liposome Amyloid beta Tau phosphorylation

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英国医学杂志(中文版) 2003年第3期6卷 190-191页

作者： Katie Palmer ,Lars Bckman ,bengt winblad ,Laura Fratiglioni ,孟晓梅

目的:对于用简单三步法检测普通人群中临床前期阿尔茨海默病与痴呆进行评价。设计:进行为期3年基于人群的队列研究。地点:瑞典斯得哥尔摩Kungsholmen地区。参与者:1435名年龄75～95岁非痴呆者。

关键词：阿尔茨海默病临床前期记忆方面队列研究

Effect of Shape and Placement of Twisted Pin Fins in a Rectangular Channel on Thermo-Hydraulic Performance

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Journal of Thermal Science 2024年第5期33卷 1773-1793页

作者： LI Yong ZHANG Jin ZHANG Yingchun ZHANG Jiajie MA Suxia SUNDEN bengt XIE Gongnan College of Electrical and Power Engineering Taiyuan University of TechnologyTaiyuan 030024China Key Laboratory of Cleaner Intelligent Control on Coal&Electricity Ministry of EducationTaiyuan 030024China Shanxi Provincial Key Laboratory of High Efficiency Heat Storage and Low Carbon Heat Supply Taiyuan 030008China School of Energy and Power Engineering North University of ChinaTaiyuan 030051China Department of Energy Sciences Lund UniversityP.O.Box 118Lund SE 22100Sweden School of Marine Science and Technology Northwestern Polytechnical UniversityXi'an 710072China

To enhance the thermo-hydraulic performance of cooling channels,this investigation examines the influence of distinct cross-sectional shapes(i.e.,triangular,rectangular,and hexagonal)of twisted pin fins and their arrangements in straight and cross *** ambient air cooling test platform was established to numerically and experimentally investigate the flow and heat transfer characteristics of 360°twisted pin fins at Re=*** findings reveal that straight rows exhibit higher Nu values than cross rows for triangular and rectangular twisted pin fins,and Nu increases with *** contrast,for hexagonal twisted pin fins,only straight rows at Re=19000 exhibit superior overall thermal performance compared to cross ***,the heat transfer performance of the cooling channel with hexagonal twisted fins surpasses both triangular and rectangular configurations,especially at high Reynolds numbers(Re=22800).Although the heat transfer coefficient of the cooling channel with hexagonal twisted fins is significantly enhanced by 132.71%compared to the flat channel,it also exhibits the highest thermal resistance and relative friction among the three types of twisted fins,the maximum of which are 2.14 and ***,the hydrothermal performance factor(HTPF)of the cooling channels with different types of twisted pin fins depends on the Reynolds number and arrangement *** Re=15200,the highest HTPF achieved for the cross-row hexagonal twisted pin fins is 0.99.

关键词： twisted pin fin cross arrangement heat transfer pressure drop HTPF

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老年痴呆疫苗初获成功

科技创业 2012年第7期 118-118页

作者： bengt winblad

阿兹海默病疫苗CAD106在一期临床试验中表现良好，但尚需进一步的临床试验来证实其疗效。概述：阿兹海默病是一种极为常见的老年神经退行性疾病，或名老年痴呆，全世界有近2700万名患者。根据世界卫生组织的描述，老年痴呆是当下全球流... 详细信息

阿兹海默病疫苗CAD106在一期临床试验中表现良好，但尚需进一步的临床试验来证实其疗效。概述：阿兹海默病是一种极为常见的老年神经退行性疾病，或名老年痴呆，全世界有近2700万名患者。根据世界卫生组织的描述，老年痴呆是当下全球流行速度增长最快的疾病。目前，阿兹海默病无药可治，只有一些暂时性缓解症状的方法。

关键词：老年痴呆疫苗神经退行性疾病世界卫生组织临床试验流行速度暂时性

Neo-adjuvant radiotherapy in rectal cancer

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World Journal of Gastroenterology 2013年第46期19卷 8489-8501页

作者： bengt Glimelius Department of Radiology Oncology and Radiation Science Uppsala University

In rectal cancer treatment,attention has focused on the local primary tumour and the regional tumour cell deposits to diminish the risk of a loco-regional *** large randomized trials have also shown that combinations of surgery,radiotherapy and chemotherapy have markedly reduced the risk of a locoregional recurrence,but this has not yet had any major influence on overall *** best results have been achieved when the radiotherapy has been given *** radiotherapy improves loco-regional control even when surgery has been optimized to improve lateral clearance,i.e.,when a total mesorectal excision has been *** relative reduction is then 50%-70%.The value of radiotherapy has not been tested in combination with more extensive surgery including lateral lymph node clearance,as practised in some Asian *** details about how the radiotherapy is performed are still open for discussion,and practice varies between countries.A highly fractionated radiation schedule(5 Gy×5),proven efficacious in many trials,has gained much popularity in some countries,whereas a conventionally fractionated regimen(1.8-2.0 Gy×25-28),often combined with chemotherapy,is used in other *** additional therapy adds morbidity to the morbidity that surgery causes,and should therefore be administered only when the risk of loco-regional recurrence is sufficiently *** best integration of the weakest modality,to date the drugs(conventional cytotoxics and biologicals)is not known.A new generation of trials exploring the best sequence of treatments is ***,there is a great need to develop predictors of response,so that treatment can be further individualized and not solely based upon clinical factors and anatomic imaging.

关键词： Chemotherapy Chemoradiotherapy Local control Multidisciplinary Organ preservation Radio-therapy Randomized trials Rectal cancer

Investigation of Interacting Mechanism between Film Cooling and Internal Cooling Structures of Turbine Blade

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Journal of Thermal Science 2023年第1期32卷 330-350页

作者： ZHANG Guohua XIE Gongnan bengt Sundén School of Marine Science and Technology Northwestern Polytechnical UniversityXi'an 710072China School of Mechanical Engineering Northwestern Polytechnical UniversityXi'an 710072China Department of Energy Sciences Lund UniversityLund SE-22100Sweden Research&Development Institute of Northwestern Polytechnical University in Shenzhen Shenzhen 518057China

This paper presents three-dimensional numerical simulations with the established realizable k-εmodel to clarify the underlying and interacting mechanisms between the film cooling and the internal *** the one hand,the effects of three different internal cooling channels,i.e.,smooth channel,continuous ribbed channel,and truncated ribbed channel,on the film cooling effectiveness and the discharge coefficients are *** the other hand,the influences of three different film cooling holes,i.e.,cylindrical hole,two elliptical holes and two circular-to-elliptical holes,on the heat transfer performances and pressure loss of the internal cooling channel are ***,the suction effects of the film cooling holes are analyzed through setting up baselines with only internal cooling *** show that the placement of ribs in the internal channel has different influences on the film cooling effectiveness with respect to different hole shapes depending on the blowing *** discharge coefficient of the film hole can be improved by introducing ribs to the internal *** of film hole is helpful for enhancing the heat transfer performance and reducing the pressure loss of the internal ***,ribs instead of the suction effect of film hole play a major role to enhance the heat transfer performance in the internal cooling channel.

关键词： interacting mechanism film cooling effectiveness discharge coefficient heat transfer performance pressure drop

MAGNETIC FIELD EFFECT ON PHOTOPOLYMERIZATION OF STYRENE MICROEMULSION

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Chinese Journal of Polymer Science 1993年第1期11卷 1-7页

作者：陈用烈 Anders Hult bengt Ranby Institute of Polymer Science Zhongshan University Guangzhou Department of Polymer Technology The Royal Institute of Technology Stockholm Sweden

External magnetic field increases the photo-induced polymerization rate of styrene *** type of photoinitiator plays an important role. The photoinitiators, used are dimethoxyphenyl acetophenone(DMPA), 1-hydroxycyclohexyl phenylketone (Irgacure 184) and dimethylhydroxyacetophenone (Darocur 1173). No magnetic effect was observed by using dibenzylketone (DBK) as photoinitiator. The molecular weight of the polymer is slightly affected by magnetic field. The influence of temperature has also been investigated.

关键词： DMPA MAGNETIC FIELD EFFECT ON PHOTOPOLYMERIZATION OF STYRENE MICROEMULSION

Comparisons of Heat Transfer Enhancement of an Internal Blade Tip with Metal or Insulating Pins

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Advances in Applied Mathematics and Mechanics 2011年第3期3卷 297-309页

作者： Gongnan Xie bengt Sunden The Key Laboratory of Contemporary Design and Integrated Manufacturing Technology Northwestern Polytechnical UniversityXi’an 710072ShaanxiChina Division of Heat Transfer Lund UniversitySE-22100LundSweden

Cooling methods are needed for turbine blade tips to ensure a long durability and safe operation.A common way to cool a tip is to use serpentine passages with 180-deg turn under the blade tip-cap taking advantage of the threedimensional turning effect and impingement like *** internal convective cooling is therefore required to increase the blade tip *** the present study,augmented heat transfer of an internal blade tip with pin-fin arrays has been investigated numerically using a conjugate heat transfer *** computational domain includes the fluid region and the solid pins as well as the tip *** convective heat transfer between the fluid and pins,and heat conduction within pins and tip are simultaneously *** main objective of the present study is to observe the effect of the pin material on heat transfer enhancement of the pin-finned *** is found that due to the combination of turning,impingement and pin-fin crossflow,the heat transfer coefficient of a pin-finned tip is a factor of 2.9 higher than that of a smooth tip at the cost of an increased pressure drop by less than 10%.The usage of metal pins can reduce the tip temperature effectively and thereby remove the heat load from the ***,it is found that the tip heat transfer is enhanced even by using insulating pins having low thermal conductivity at low Reynolds *** comparisons of overall performances are also included.

关键词： Heat transfer enhancement tip-wall pins thermal conductivity weight

Gut microbiota and surgical disease

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Hepatobiliary Surgery and Nutrition 2018年第1期7卷 32-33页

作者： bengt Jeppsson Department of Surgery Lund UniversityLundSweden

Why should surgeons study gut microbiota and microbiome(totality of body's microorganisms and genomes)?There are at least three reasons.

关键词： surgical reasons surgeon