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Clinical study of metachronous multiple oral cancers.

中国口腔颌面外科杂志 2008年第B5期6卷 130-130页

作者： beng gwan teh Wataru Kobayashi Hisashi Sato Hiroto Kimura Department of OralUniversity Hospital 0368562 Japanand MaxillofacialHirosaki UniversitySurgery Hirosaki Hirosaki A omori

Purpose:To clinically study the background of metachronous multiple oral cancers encountered at the Department of Oral and Maxillofacial Surgery, Hirosaki University Hospital. Methods: A total of 9 patients with metachronous multiple oral cancers treated between 1996 and 2007 were included. Results: There were 3 males and 6 females, ranging from 66 to 79 years old with an average age of 71.2 years. The location of primary cancers were as follow: tongue, 2 cases (22.2%); mesopharyngeal, 3 cases (33.3%); and buccalmucosa, hard palate, upper and lower gingival, 1 case (11.1%) respectively. Eight cases were categorized as T1NOM0 and 1 case was termed as T2NOM0 in TNM classification. Four patients consumed alcohol while 3 were smokers. The average time elapsed between the detection of the first cancer and the appearance of the second was 63 months. Histologically, 6 were diagnosed as well differentiated squamous cell carcinomas, 1 was diagnosed as verrucous carcinoma and 2 were unknown. Conclusion:

关键词：口腔癌治疗方法临床研究颌鼻甲骨

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Concurrent chemoradiation with intra-arterial docetaxel-nedaplatin for advanced oral cancers

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中国口腔颌面外科杂志 2008年第B5期6卷 129-129页

作者： Wataru Kobayashi beng gwan teh Hirotaka Sakaki Hiroto Kimura Morio Nagahata Department of Oral and Maxillofacial Surgery Hirosaki University School of Medicine. 5-Zaifu-cho Hirosaki 036-8562 Japan Department of radiology Hirosaki University School of Medicine. 5-Zaifu-cho Hirosaki 036-8562 Japan

Purpose: To evaluate the effect and complication of concurrent chemoradiation with intra-arterial docetaxel-nedaplatin infusion。Methods: Fourteen patients with advanced oral cancers were treated between 2003 and 2007 at the Department of Oral and Maxillofacial Surgery, Hirosaki University Hospital。A total of 66Gy of external beam was irradiated for a period of seven weeks concurrent with two or three courses of intra-arterial infusion chemotherapy using a combination of docetaxel (40mg/mm2) and nedaplatin (80mg/mm2)。Treatment effect was evaluated by computed tomography (CT), magnetic resonance imaging (MRI) and positron emission tomography-CT (PET-CT)。Results: Thirteen out of fourteen patients (93%) were evaluated as complete response。The rate of gradeⅢtoⅣchemotoxicity was 93%。All patients developed reversible mucositis and dermatitis but the major adverse effects were leucopenia and alopecia。There has been no central nervous system complication related to the infusion technique。Two years survival rate was 72.9% with a median follow-up duration of 11 months。Conclusions: Intra-arterial docetaxel-nedaplatin infusion concurrent with radiotherapy is an effective treatment for advanced oral cancers but severe。complication is a problem that needs to be solved。

关键词：口腔癌动脉患者临床分析

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