检索结果-南通市图书馆

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

意大利地震:科学依随政治

国际地震动态 2011年第12期32卷 4-4页

作者： benedetto de vivo 李平恩（译）左玉玲（校） University of Naples Federico Ⅱ Naples Italy 中国地震局地球物理研究所

John E Vidale的报道中指出（见本期第3页译文：“意大利地震：批评者的逻辑值得商榷”——编者注），有关2009年4月袭击拉奎拉的6．3级地震的过失杀人案是不公正的。

关键词：意大利地震政治科学逻辑值杀人案

Three-dimensional models:from cell culture to Patient-derived Organoid and its application to future liposarcoma research

在线全文

学校读者我要写书评

暂无评论

Oncology Research 2025年第1期33卷 1-13页

作者： SAYUMI TAHARA SYDNEY RENTSCH FERNANDA COSTAS CASAL de FARIA PATRICIA SARCHET ROMA KARNA FEdeRICA CALORE RAPHAEL E.POLLOCK department of Surgery Division of Surgical OncologyThe James Comprehensive Cancer CenterThe Ohio State University Wexner Medical CenterColumbusOH 43210USA department of Cancer Biology and Genetics The James Comprehensive Cancer CenterThe Ohio State University Wexner Medical CenterColumbusOH 43210USA

Liposarcoma is one of the most common soft tissue sarcomas,however,its occurrence rate is still rare compared to other *** to its rarity,in vitro experiments are an essential approach to elucidate liposarcoma *** cell culture-based research(2D cell culture)is still playing a pivotal role,while several shortcomings have been recently under *** vivo,mouse models are usually adopted for pre-clinical analyses with expectations to overcome the issues of 2D cell ***,they do not fully recapitulate human dedifferentiated liposarcoma(DDLPS)***,three-dimensional(3D)culture systems have been the recent research focus in the cell biology field with the expectation to overcome at the same time the disadvantages of 2D cell culture and in vivo animal models and fill in the gap between *** the liposarcoma rarity,we believe that 3D cell culture techniques,including 3D cell cultures/co-cultures,and Patient-derived tumor Organoids(PDOs),represent a promising approach to facilitate liposarcoma investigation and elucidate its molecular mechanisms and effective therapy *** this review,we first provide a general overview of 3D cell cultures compared to 2D cell *** then focus on one of the recent 3D cell culture applications,Patient-derived Organoids(PDOs),summarizing and discussing several PDO ***,we discuss the current and future applications of PDOs to sarcoma,particularly in the field of liposarcoma.

关键词： Cell culture Liposarcoma Patient-derived Organoid(PDO) Spheroid Three-dimensional(3D)cell culture

Optical coherence tomography in detection of dysplasia and cancer of the gastrointestinal tract and bilio-pancreatic ductal system

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2008年第42期14卷 6444-6452页

作者： Pier Alberto Testoni benedetto Mangiavillano Division of Gastroenterology and Gastrointestinal Endoscopy Vita-Salute San Raffaele University Scientific Institute San Raffaele Hospital Milan 20132 Italy

Optical coherence tomography(OCT) is an optical imaging modality that performs high-resolution,cross-sectional,subsurface tomographic imaging of the microstructure of *** physical principle of OCT is similar to that of B-mode ultrasound imaging,except that it uses infrared light waves rather than acoustic *** in vivo resolution is 10-25 times better(about 10 μm) than with high-frequency ultrasound imaging,but the depth of penetration is limited to 1-3 mm,depending upon tissue structure,depth of focus of the probe used,and pressure applied to the tissue *** the last decade,OCT technology has evolved from an experimental laboratory tool to a new diagnostic imaging modality with a wide spectrum of clinical applications in medical practice,including the gastrointestinal(GI) tract and pancreatic-biliary ductal *** imaging from the GI tract can be done in humans by using narrow-diameter,catheter-based probes that can be inserted through the accessory channel of either a conventional front-view endoscope,for investigating the epithelial structure of the GI tract,or a side-view endoscope,inside a standard transparent ERCP catheter,for investigating the pancreatico-biliary ductal *** and the esophago-gastric junction has been the most widely investigated organ so far;more recently,also duodenum,colon and pancreatico-biliary ductal system have been extensively *** imaging of the gastro-intestinal wall structure is characterized by a multiple-layer architecture that permits an accurate evaluation of the mucosa,lamina propria,muscularis mucosae,andpart of the *** technique may be,therefore,used to identify pre-neoplastic conditions of the GI tract,such as Barrett's epithelium and dysplasia,and evaluate the depth of penetration of early-stage neoplastic *** imaging of the pancreatic and biliary ductal system could improve the diagnostic accuracy for ductal epithelial changes and the differential diagnosis be

关键词： Optical coherence tomography Barrett'sepithelium Dysplasia Adenocarcinoma Gastrointestinal tract Pancreatico-biliary ductal system

There is plenty of room at the top:generation of hot charge carriers and their applications in perovskite and other semiconductor-based optoelectronic devices

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2021年第9期10卷 1630-1657页

作者： Irfan Ahmed Lei Shi Hannu Pasanen Paola vivo Partha Maity Mohammad Hatamvand Yiqiang Zhan State Key Laboratory of ASIC and System Centre of Micro-Nano SystemSISTFudan University200433ShanghaiChina department of Physics Government Postgraduate College(Higher Education Department-HED)Khyber Pakhtunkhwa21300MansehraPakistan State Key Laboratory of Surface Physics Key Laboratory of Micro-and Nano-PhotonicsFudan University200433ShanghaiChina Faculty of Engineering and Natural Sciences Tampere UniversityFI-33014TampereFinland KAUST Solar Center Division of Physical Science and EngineeringKing Abdullah University of Science and Technology(KAUST)Thuwal23955-6900RiyadhKingdom of Saudi Arabia

Hot charge carriers(HC)are photoexcited electrons and holes that exist in nonequilibrium high-energy states of photoactive *** cooling time and rapid extraction are the current challenges for the development of future innovative HC-based optoelectronic devices,such as HC solar cells(HCSCs),hot energy transistors(HETs),HC photocatalytic reactors,and lasing *** on a thorough analysis of the basic mechanisms of HC generation,thermalization,and cooling dynamics,this review outlines the various possible strategies to delay the HC cooling as well as to speed up their *** materials with slow cooling behavior,including perovskites and other semiconductors,are thoroughly *** addition,the opportunities for the generation of plasmon-induced HC through surface plasmon resonance and their technological applications in hybrid nanostructures are discussed in *** judiciously designing the plasmonic nanostructures,the light coupling into the photoactive layer and its optical absorption can be greatly enhanced as well as the successful conversion of incident photons to HC with tunable energies can also be ***,the future outlook of HC in optoelectronics is highlighted which will provide great insight to the research community.

关键词： optoelectronic charge plenty

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-Yan Huang Yi-de Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li Hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

Physio-pathological roles of transglutaminase-catalyzed reactions

在线全文

学校读者我要写书评

暂无评论

World Journal of Biological Chemistry 2010年第5期1卷 181-187页

作者： Mariangela Ricotta Maura Iannuzzi Giulia de vivo Vittorio Gentile department of Biochemistry and Biophysics Medical SchoolSecond University of Naples

Transglutaminases(TGs) are a large family of related and ubiquitous enzymes that catalyze post-translational modifications of *** main activity of these enzymes is the cross-linking of a glutaminyl residue of a protein/peptide substrate to a lysyl residue of a protein/peptide *** addition to lysyl residues,other second nucleophilic co-substrates may include monoamines or polyamines(to form mono-or bi-substituted/crosslinked adducts) or-OH groups(to form ester linkages) .In the absence of co-substrates,the nucleophile may be water,resulting in the net deamidation of the glutaminyl *** TG enzymes are also capable of catalyzing other reactions important for cell *** distribution and the physiological roles of TG enzymes have been widely studied in numerous cell types and tissues and their roles in several diseases have begun to be identified."Tissue" TG(TG2) ,a member of the TG family of enzymes,has definitely been shown to be involved in the molecular mechanisms responsible for a very widespread human pathology:*** disease(CD) .TG activity has alsobeen hypothesized to be directly involved in the pathogenetic mechanisms responsible for several other human diseases,including neurodegenerative diseases,which are often associated with *** diseases,such as Alzheimer's disease,Parkinson's disease,supranuclear palsy,Huntington's disease and other recently identified polyglutamine diseases,are characterized,in part,by aberrant cerebral TG activity and by increased cross-linked proteins in affected *** this review,we discuss the physio-pathological role of TG-catalyzed reactions,with particular interest in the molecular mechanisms that could involve these enzymes in the physio-pathological processes responsible for human neurodegenerative diseases.

关键词： Transglutaminases Post-translational-modifications of proteins Celiac disease Neurodegenerative diseases Transglutaminase inhibitors

Confocal laser endomicroscopy in the “in vivo” histological diagnosis of the gastrointestinal tract

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第46期15卷 5770-5775页

作者： Giovanni D de Palma department of Surgery and Advanced Technologies Center of Excellence for Technical Innovation in SurgeryUniversity of Naples Federico ⅡSchool of Medicine

Recent technological advances in miniaturization have allowed for a confocal scanning microscope to be integrated into a conventional flexible endoscope,or into trans-endoscopic probes,a technique now known as confocal endomicroscopy or confocal laser *** newly-developed technology has enabled endoscopists to collect real-time in vivo histological images or "virtual biopsies" of the gastrointestinal mucosa during endoscopy,and has stimulated significant interest in the application of this technique in clinical *** review aims to evaluate the current data on the technical aspects and the utility of this new technology in clinical gastroenterology and its potential impact in the future,particularly in the screening or surveillance of gastrointestinal neoplasia.

关键词： Confocal microscopy Diagnostic imaging Gastrointestinal neoplasms Precancerous conditions Endoscopy Virtual histology

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

葡萄糖转运体缺陷综合征研究进展

中华儿科杂志 2004年第10期42卷 756-758页

作者：王东孙若鹏王霞杨如杨红 Pascual Juan M de vivo Darryl C department of Neurology Columbia UniversityNewYork10032USA 山东大学齐鲁医院小儿内科山东省日照市人民医院妇科 department

葡萄糖是哺乳动物细胞能量代谢的主要原料.它是一种极性分子,只能以主动转运和易化扩散的方式通过细胞膜.其跨膜转运由钠依赖性葡萄糖转运体(sodium depedent glucose transporter,SGLTs)和易化扩散的葡萄糖转运体(faciliated glucose t... 详细信息

葡萄糖是哺乳动物细胞能量代谢的主要原料.它是一种极性分子,只能以主动转运和易化扩散的方式通过细胞膜.其跨膜转运由钠依赖性葡萄糖转运体(sodium depedent glucose transporter,SGLTs)和易化扩散的葡萄糖转运体(faciliated glucose transporter,GLUTs)[1]两大家族来完成.

关键词：葡萄糖转运体亚型综合征家族研究进展易化能量代谢哺乳动物细胞跨膜转运细胞膜

孕三烯酮与达那唑作为宫腔镜术前用药的一项前瞩性随机评估

在线全文

学校读者我要写书评

暂无评论

世界核心医学期刊文摘（妇产科学分册） 2006年第8期2卷 35-36页

作者： Triolo O. de vivo A. benedetto V. 李跃萍 Policlinico Universitario G. Martino Dipartimento di Scienze Ginecologiche Ostetriche e Medicina Della Riproduzione Via Consolare Valeria Messina 98124 Italy Dr.

Objective: To compare danazol and gestrinone treatment as preoperative endometrial preparation for operative hysteroscopy. design: Prospective, randomized clinical study. Setting: University department of gynecological, obstetrical sciences and reproductive medicine. Patient(s): One hundred thirty-five patients with endouterine pathologies (endometrial polyps, submucous myoma, septate uterus). Intervention(s): Patients pretreated with gestrinone (n = 68) and with danazol (n = 67)- underwent operative hysteroscopy. Main Outcome Measure(s): Endometrial response to the medical pretreatment, side effects, procedure time, intraoperative bleeding, infusion volume, patient satisfaction. Result(s): Side effects were infrequent in both groups, though the patients’ personal satisfaction was in favor of gestrinone. The rate of endometrial response was higher for the gestrinone group (97.1% vs. 83.6% ). Operative time (mean ± SD) was 12 ± 1.8 and 15.2 ± 1.9 minutes for the gestrinone and danazol groups, respectively. The gestrinone group showed a lower incidence of moderate bleeding (3% vs. 22.4% ) and a lower infusion volume (2,100 ± 200 mL vs. 2,400 ± 250 mL). Regarding cervical dilatation time, no significant difference was found between the two groups (1.6 ± 0.3 minutes vs. 1.5 ± 0.4 minutes). Conclusion(s): Both treatments are good ways to prepare the endometrium for operative hysteroscopy. However, the data suggest that gestrinone pretreatment is preferable to danazol.

关键词：孕三烯酮达那唑腔镜术子宫内膜宫内膜息肉黏膜下肌瘤纵隔子宫随机临床研究输液量轻度出血