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Gut region-specific TNFR expression:TNFR2 is more affected than TNFR1 in duodenal myenteric ganglia of diabetic rats

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World Journal of Diabetes 2023年第1期14卷 48-61页

作者： bence p.l barta Benita Onhausz Afnan Al Doghmi Zita Szalai János Balázs Mária Bagyánszki Nikolett Bódi Department of physiology Anatomy and NeuroscienceUniversity of SzegedSzeged 6726Hungary

BACKGROUND Cytokines are essential in autoimmune inflammatory processes that accompany type 1 *** necrosis factor alpha plays a key role among others in modulating enteric neuroinflammation,however,it has a dual role in cell degeneration or survival depending on different *** general,TNFR1 is believed to trigger apoptosis,while TNFR2 promotes cell *** importance of the neuronal microenvironment has been recently highlighted in gut region-specific diabetic enteric neuropathy,however,the expression and alterations of different TNFRs in the gastrointestinal tract has not been *** To investigate the TNFR1 and TNFR2 expression in myenteric ganglia and their environment in different intestinal segments of diabetic *** Ten weeks after the onset of hyperglycemia,gut segments were taken from the duodenum,ileum and colon of streptozotocin-induced(60 mg/body weight kg i.p.)diabetic(n=17),insulin-treated diabetic(n=15)and sex-and age-matched control(n=15)*** plexus whole-mount preparations were prepared from different gut regions for TNFR1/HuCD or TNFR2/HuCD double-labeling fluorescent ***1 and TNFR2 expression was evaluated by post-embedding immunogold electron microscopy on ultrathin sections of myenteric *** levels were measured by enzyme-linked immunosorbent assay in muscle/myenteric plexus-containing(MUSClE-Mp)tissue homogenates from different gut segments and experimental *** A distinct region-dependent TNFRs expression was detected in *** density of TNFR1-labeling gold particles was lowest,while TNFR2 density was highest in duodenal ganglia and a decreased TNFRs expression from proximal to distal segments was observed in MUSClE-Mp *** diabetics,the TNFR2 density was only significantly altered in the duodenum with decrease in the ganglia(0.32±0.02 vs 0.45±0.04,ple no significant changes in TNFR1 density was *** diabetic MUSClE-Mp h

关键词： Tumor necrosis factor alpha receptors Myenteric ganglia Enteric neurons Neuronal environment Diabetes Insulin

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World Journal of Diabetes 2021年第5期12卷 658-672页

作者： Nikolett Bódi Diána Mezei payal Chakraborty Zita Szalai bence p.l barta János Balázs Zsolt Rázga Edit Hermesz Mária Bagyánszki Department of physiology Anatomy and NeuroscienceFaculty of Science and InformaticsUniversity of SzegedSzeged 6726Hungary Department of Biochemistry and Molecular Biology Faculty of Science and InformaticsUniversity of SzegedSzeged 6726Hungary Department of pathology Faculty of MedicineUniversity of SzegedSzeged 6720Hungary

BACKGROUND The importance of the neuronal microenvironment has been recently highlighted in gut region-specific diabetic enteric neuropathy. Regionally distinct thickening of endothelial basement membrane(BM) of intestinal cap.llaries sup.lying the myenteric ganglia coincide with neuronal damage in different intestinal segments. Accelerated synthesis of matrix molecules and reduced degradation of matrix components may also contribute to the imbalance of extracellular matrix dynamics resulting in BM thickening. Among the matrix degrading proteinases, matrix metalloproteinase 9(MMp9) and its tissue inhibitor(TIMp1) are essential in regulating extracellular matrix *** To evaluate the intestinal segment-specific effects of diabetes and insulin replacement on ganglionic BM thickness, MMp9 and TIMp1 *** Ten weeks after the onset of hyperglycaemia gut segments were taken from the duodenum and ileum of streptozotocin-induced diabetic, insulin-treated diabetic and sex-and age-matched control rats. The thickness of BM surrounding myenteric ganglia was measured by electron microscopic morphometry. Wholemount preparations of myenteric plexus were prepared from the different gut regions for MMp9/TIMp1 double-labelling fluorescent immunohistochemistry. post-embedding immunogold electron microscopy was ap.lied on ultrathin sections to evaluate the MMp9 and TIMp1 expression in myenteric ganglia and their microenvironment from different gut segments and conditions. The MMp9 and TIMp1 messenger ribonucleic acid(m RNA) level was measured by quantitative p.lymerase chain *** Ten weeks after the onset of hyperglycaemia, the ganglionic BM was significantly thickened in the diabetic ileum, while it remained intact in the duodenum. The immediate insulin treatment prevented the diabetes-related thickening of the BM surrounding the ileal myenteric ganglia. Quantification of particle density showed an increasing tendency for MMp9 and a decreasing tenden

关键词： Type 1 diabetes Diabetic enteric neuropathy Neuronal microenvironment Basement membrane Matrix metalloproteinase 9 Tissue inhibitor of metalloproteinase 1

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Enabling Technologies for Autonomous Robotic Systems in Manufacturing

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Transactions of Nanjing University of Aeronautics and Astronautics 2024年第4期41卷 403-431页

作者： ERDŐS Gábor ABAI Kristóf BEREGI Richárd CSEMpESZ János CSERTEG Tamás GODÓGábor HAJÓS Mátyás HÁY Borbála HORVÁTH Dániel HORVÁTH Gergely JUNIKIÁdám KEMÉNY Zsolt KOVÁCS András NACSA János pANITI Imre pEDONE Gianfranco TAKÁCS Emma TIpARY bence ZAHORÁN lászló VÁNCZA József Institute for Computer Science and Control Hungarian Research Network(HUN-REN SZTAKI)BudapestHungary Department of Manufacturing Science and Technology Budapest University of Technology and Economics(BME)BudapestHungary EpIC Innolabs Nonprofit ltd. BudapestHungary Eötvös loránd University(ElTE) BudapestHungary

Research of autonomous manufacturing systems is motivated both by the new technical possibilities of cyber-physical systems and by the practical needs of the *** operation in semi-structured industrial environments can now be supported by advanced sensor technologies,digital twins,artificial intelligence and novel communication *** enable real-time monitoring of production processes,situation recognition and prediction,automated and adaptive(re)planning,teamwork and performance improvement by *** paper summarizes the main requirements towards autonomous industrial robotics and suggests a generic workflow for realizing such *** case studies will be presented from recent practice at HUN-REN SZTAKI in a broad range of domains such as assembly,welding,grinding,picking and placing,and *** various solutions have in common that they use a generic digital twin concept as their *** making general recommendations for realizing autonomous robotic solutions in the industry,open issues for future research will be discussed.

关键词： industrial robotics autonomy digital twin enabling technology

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Niche differentiation among facultative filter feeders: Insights from invasive ponto-Caspian mysids

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Current Zoology 2024年第4期70卷 513-521页

作者： péter Borza Varsha Rani Csaba F.Vada Institute of Aquatic Ecology Centre for Ecological ResearchKarolina ut 29.1113 BudapestHungary Doctoral School of Biology Institute of BiologyEotvos Lorand UniversityPazmany Péter sétany 1/C1117 BudapestHungary

The degree of dietary specialization has a fundamental impact on the ecological function and interactions of suspension *** niche differentiation by food particle size is common among obligate suspension feeders,its role is not evident in facultative *** this study,we aimed at providing new insights on the matter by focusing on sympatric mysid *** mysids use different mechanisms for raptorial and filter-feeding,they represent a more adequate model system than for example,the more extensively studied *** made morpholog-ical measurements on the 4 coexisting invasive ponto-Caspian mysid species to determine the areas and mesh sizes of their *** also quantified their clearance rates on the microalga Cryptomonas *** a laboratory experiment to reveal how morphological differences manifest in their overall filtering *** found relatively small but consistent differences in the primary filter area among the species,indicating that morphological constraints due to the enclosed position of the setae might limit the possibility for *** primary filter mesh sizes were small in all 4 species(0.69-2.73μm)with moderate but consistent intraspecific differences,suggesting that the benefit of being able to capture small particles might outweigh the pressure for *** observed clearance rates were in accordance with the morphological characteristics of the species,highlighting that auxiliary filters(present in one of the species,limnomysis benedeni)are needed to increase filtering capacity *** study confirmed that food particle size can contribute to the niche differentiation of facultative filter feeders,but also indicated that they can tolerate a higher overlap than obligate *** observed differences were related to the habitat preferences and predatory potentials of the species,suggesting that complementarity among the different niche axes might further facilitate theircoexistence.

关键词： clearance rate coexistence filter area filtermesh size.

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Simulation of Blast and Fragment loading Using a Coupled Multi-Solver Approach

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Transactions of Tianjin University 2006年第B9期12卷 182-187页

作者： GERBER bence COWlER Malcolm BIRNBAUM Naury Century Dynamics ANSYS Inc1001 Galaxy WaySuite #325ConcordCA 94521USA

Simulating blast and fragment loading simultaneously in a single computation requires the combined use of multiple states of the art solvers. A pipe bomb is an example of simple improvised explosive device （IED） that consists of a piece of pipe filled with explosive material and capped at both ends. To simulate the explosion of a pipe bomb and the damage it causes, a coupled multisolver approach based upon finite element and finite volume methods is ap.lied. The numerical calculation presented demonstrates the ability of ANSYS AUTODYN to correctly simulate the threats of IEDs and provides insight into how the most significant physical phenomena affect the results.

关键词： finite element method finite volume method fluid/structure interaction blast impact fragmentation

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GO-DEX极早期火灾智能报警系统在发电厂和变电所中的应用

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今日自动化 2024年第3期 62-64页

作者：潘奔策许雅婧宋建浩国网温州供电公司浙江温州325000

对发电厂与变电所等场所来说,火灾事故的发生不仅会使居民的正常用电受到影响,还会造成严重的财产损失,威胁现场人员的生命安全。在这种情况下,相关人员需做好对火灾智能报警系统的应用,实现对电力生产及运输过程的实时监控,提高对火灾... 详细信息

对发电厂与变电所等场所来说,火灾事故的发生不仅会使居民的正常用电受到影响,还会造成严重的财产损失,威胁现场人员的生命安全。在这种情况下,相关人员需做好对火灾智能报警系统的应用,实现对电力生产及运输过程的实时监控,提高对火灾等事故的防范效果。文章对GO-DEX极早期火灾智能报警系统在发电厂和变电所中的应用进行了研究,基于实际情况提出了相应的应用措施,为发电厂及变电所的运行安全提供保障。

关键词：火灾智能报警系统火灾预防发电厂

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云型极早期火灾预警系统在配电网中的应用

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电力系统装备 2024年第6期 36-37,48页

作者：潘奔策黄瑞特赵小博国网温州供电公司浙江温州325000

火灾预警系统是保障配电网安全运行、减少风险发生的重要设施。现阶段,部分配电网建设采用的预警系统存在一定不足,无法在发生火灾时做到及时报警处理,增加了配电网运行中的安全风险。文章对云型极早期火灾预警系统在配电网中的应用进... 详细信息

火灾预警系统是保障配电网安全运行、减少风险发生的重要设施。现阶段,部分配电网建设采用的预警系统存在一定不足,无法在发生火灾时做到及时报警处理,增加了配电网运行中的安全风险。文章对云型极早期火灾预警系统在配电网中的应用进行研究,并分析了该系统的发展趋势,以期为相关工作人员提供参考。

关键词：火灾预警配电网应用

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自主机器人使能技术在制造业中的应用（英文）

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Transactions of Nanjing University of Aeronautics and Astronautics 2024年第4期 403-431页

作者： ERD?S Gábor ABAI Kristóf BEREGI Richárd CSEMpESZ János CSERTEG Tamás GODó Gábor HAJóS Mátyás HáY Borbála HORVáTH Dániel HORVáTH Gergely JUNIKI ádám KEMéNY Zsolt KOVáCS András NACSA János pANITI Imre pEDONE Gianfranco TAKáCS Emma TIpARY bence ZAHORáN lászló VáNCZA József 匈牙利研究网络计算机科学与控制研究所布达佩斯经济与技术大学制造科学与技术系 EpIC非盈利创新实验室厄特沃什·罗兰大学

自主制造系统的研究既受益于信息物理融合系统这一新技术的推动，也响应工业实际需求的号召。目前，先进的传感器技术、数字孪生、人工智能和新型通信技术可以支持半结构化工业环境中的自主操作，可实现对生产过程的实时监控、情况识别... 详细信息

自主制造系统的研究既受益于信息物理融合系统这一新技术的推动，也响应工业实际需求的号召。目前，先进的传感器技术、数字孪生、人工智能和新型通信技术可以支持半结构化工业环境中的自主操作，可实现对生产过程的实时监控、情况识别和预测、自动和自适应（重新）规划、团队合作，以及通过学习提高性能。本文总结了实现自主工业机器人技术的主要需求，提出了实现此类系统的通用工作流程，并介绍了HUN-REN SZTAKI最近在装配、焊接、打磨、拾取和放置以及机械加工等多个应用领域的广泛实践。这些解决方案的共同点是以通用的数字孪生概念为核心。最后，本文提出实现工业自主机器人解决方案的一般建议，并讨论了未来要研究的一些开放性问题。

关键词：工业机器人自动化数字孪生使能技术

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The archaeogenomic validation of Saint ladislaus'relic provides insights into theárpád dynasty's genealogy

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Journal of Genetics and Genomics 2023年第1期50卷 58-61页

作者： Gergely I.B.Varga lilla Alida Kristóf Kitti Maár luca Kis Oszkár Schütz Orsolya Váradi bence Kovács Alexandra Gînguță Balázs Tihanyi péter l.Nagy Zoltán Maróti Emil Nyerki Tibor Török Endre Neparáczki Department of Archaeogenetics Institute of Hungarian ResearchH-1014 BudapestHungary Doctoral School of History University of SzegedSzegedHungary Department of Genetics University of SzegedH-6726 SzegedHungary Department of Biological Anthrop.logy University of SzegedH-6726 SzegedHungary Department of Molecular Biology and Biotechnology Faculty of Biology and GeologyBabes-Bolyai University400006 Cluj-NapocaRomania praxis Genomics llC AtlantaUSA Department of pediatrics and pediatric Health Center University of SzegedH-6725 SzegedHungary

The house of Arp ad ruled Hungary for more than four centuries,establishing dynastical relationships with numerous European nobleand ruling houses,and giving many Catholic saints and blesseds to the Catholic *** were one of the significant dynasties of Medieval Europe(Krist o and Makk,1996).The knight-king Saint ladislaus I(c.1040-1095,reign:1077-1095)is one of the most outstanding kings of this *** addition to the hand relic(the Holy Right)of King Saint Stephanus I(c.975-1038,reign:1000/1001-1038),the skull relic in the Saint ladislaus’Herma(Fig.1A-1C)preserved in the Cathedral of Gy or,is one of the most important relics for Hungarians(Klaniczai,2000).

关键词： relic provides insights into the The archaeogenomic validation of Saint ladislaus d dynasty’s genealogy

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Shop-Floor Controller Based on RT-Middleware Technology

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Journal of Mechanics Engineering and Automation 2013年第11期3卷 685-693页

作者： Ferenc Tajti Geza Szayer bence Kovacs peter Korondi Department of Mechatronics Optics and Engineering Informatics Budapest Univ. of Technology and Economics Budapest 1111 Hungary MTA-ElTE Comparative Ethology Research Group Budapest 1111 Hungary

Nowadays the flexible configuration of manufacturing cells becomes to an important requirement especially at small and medium sized companies. This method can make the production fast and effective at small series or frequent manufacturing changes. The shop-floor control method, presented in this paper, offers a solution for the facing problem of fast and easy reconfiguration. The hardware of the controller designed modular with software components for online configuration. This solution allows sensor integration on different levels for every part of the manufacturing cell. With unified programming language and the machine specific controllers （post-processing） the cells can be defined easily by different types of human-machine interaction. The shop-floor control architecture is implemented and validated on an Adept SCARA （selective compliance assembly robot arm） robot. The robot is driven by standalone, low-level, interchangeable, software and hardware components.

关键词： Robot controller RT-middleware CNC (computer numerical control) SCARA.

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