检索结果-南通市图书馆

Gut region-specific TNFR expression:TNFR2 is more affected than TNFR1 in duodenal myenteric ganglia of diabetic rats

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2023年第1期14卷 48-61页

作者： bence Pál Barta Benita Onhausz Afnan AL Doghmi Zita Szalai János Balázs Mária Bagyánszki Nikolett Bódi Department of Physiology Anatomy and NeuroscienceUniversity of SzegedSzeged 6726Hungary

BACKGROUND Cytokines are essential in autoimmune inflammatory processes that accompany type 1 *** necrosis factor alpha plays a key role among others in modulating enteric neuroinflammation,however,it has a dual role in cell degeneration or survival depending on different *** general,TNFR1 is believed to trigger apoptosis,while TNFR2 promotes cell *** importance of the neuronal microenvironment has been recently highlighted in gut region-specific diabetic enteric neuropathy,however,the expression and alterations of different TNFRs in the gastrointestinal tract has not been *** To investigate the TNFR1 and TNFR2 expression in myenteric ganglia and their environment in different intestinal segments of diabetic *** Ten weeks after the onset of hyperglycemia,gut segments were taken from the duodenum,ileum and colon of streptozotocin-induced(60 mg/body weight kg i.p.)diabetic(n=17),insulin-treated diabetic(n=15)and sex-and age-matched control(n=15)*** plexus whole-mount preparations were prepared from different gut regions for TNFR1/HuCD or TNFR2/HuCD double-labeling fluorescent ***1 and TNFR2 expression was evaluated by post-embedding immunogold electron microscopy on ultrathin sections of myenteric *** levels were measured by enzyme-linked immunosorbent assay in muscle/myenteric plexus-containing(MUSCLE-MP)tissue homogenates from different gut segments and experimental *** A distinct region-dependent TNFRs expression was detected in *** density of TNFR1-labeling gold particles was lowest,while TNFR2 density was highest in duodenal ganglia and a decreased TNFRs expression from proximal to distal segments was observed in MUSCLE-MP *** diabetics,the TNFR2 density was only significantly altered in the duodenum with decrease in the ganglia(0.32±0.02 vs 0.45±0.04,P<0.05),while no significant changes in TNFR1 density was *** diabetic MUSCLE-MP h

关键词： Tumor necrosis factor alpha receptors Myenteric ganglia Enteric neurons Neuronal environment Diabetes Insulin

Shop-Floor Controller Based on RT-Middleware Technology

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Mechanics Engineering and Automation 2013年第11期3卷 685-693页

作者： Ferenc Tajti Geza Szayer bence Kovacs Peter Korondi Department of Mechatronics Optics and Engineering Informatics Budapest Univ. of Technology and Economics Budapest 1111 Hungary MTA-ELTE Comparative Ethology Research Group Budapest 1111 Hungary

Nowadays the flexible configuration of manufacturing cells becomes to an important requirement especially at small and medium sized companies. This method can make the production fast and effective at small series or frequent manufacturing changes. The shop-floor control method, presented in this paper, offers a solution for the facing problem of fast and easy reconfiguration. The hardware of the controller designed modular with software components for online configuration. This solution allows sensor integration on different levels for every part of the manufacturing cell. With unified programming language and the machine specific controllers （post-processing） the cells can be defined easily by different types of human-machine interaction. The shop-floor control architecture is implemented and validated on an Adept SCARA （selective compliance assembly robot arm） robot. The robot is driven by standalone, low-level, interchangeable, software and hardware components.

关键词： Robot controller RT-middleware CNC (computer numerical control) SCARA.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2021年第5期12卷 658-672页

作者： Nikolett Bódi Diána Mezei Payal Chakraborty Zita Szalai bence Pál Barta János Balázs Zsolt Rázga Edit Hermesz Mária Bagyánszki Department of Physiology Anatomy and NeuroscienceFaculty of Science and InformaticsUniversity of SzegedSzeged 6726Hungary Department of Biochemistry and Molecular Biology Faculty of Science and InformaticsUniversity of SzegedSzeged 6726Hungary Department of Pathology Faculty of MedicineUniversity of SzegedSzeged 6720Hungary

BACKGROUND The importance of the neuronal microenvironment has been recently highlighted in gut region-specific diabetic enteric neuropathy. Regionally distinct thickening of endothelial basement membrane(BM) of intestinal capillaries supplying the myenteric ganglia coincide with neuronal damage in different intestinal segments. Accelerated synthesis of matrix molecules and reduced degradation of matrix components may also contribute to the imbalance of extracellular matrix dynamics resulting in BM thickening. Among the matrix degrading proteinases, matrix metalloproteinase 9(MMP9) and its tissue inhibitor(TIMP1) are essential in regulating extracellular matrix *** To evaluate the intestinal segment-specific effects of diabetes and insulin replacement on ganglionic BM thickness, MMP9 and TIMP1 *** Ten weeks after the onset of hyperglycaemia gut segments were taken from the duodenum and ileum of streptozotocin-induced diabetic, insulin-treated diabetic and sex-and age-matched control rats. The thickness of BM surrounding myenteric ganglia was measured by electron microscopic morphometry. Wholemount preparations of myenteric plexus were prepared from the different gut regions for MMP9/TIMP1 double-labelling fluorescent immunohistochemistry. Post-embedding immunogold electron microscopy was applied on ultrathin sections to evaluate the MMP9 and TIMP1 expression in myenteric ganglia and their microenvironment from different gut segments and conditions. The MMP9 and TIMP1 messenger ribonucleic acid(m RNA) level was measured by quantitative polymerase chain *** Ten weeks after the onset of hyperglycaemia, the ganglionic BM was significantly thickened in the diabetic ileum, while it remained intact in the duodenum. The immediate insulin treatment prevented the diabetes-related thickening of the BM surrounding the ileal myenteric ganglia. Quantification of particle density showed an increasing tendency for MMP9 and a decreasing tenden

关键词： Type 1 diabetes Diabetic enteric neuropathy Neuronal microenvironment Basement membrane Matrix metalloproteinase 9 Tissue inhibitor of metalloproteinase 1

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

高效领导力

2018年

作者： (美)布伦达·本斯(Brenda bence)

本书包含来自全球各地的领导力培训案例研究，可以帮助你：提升你的领导风度，打造出色的领导力品牌，远离自己是工作、时间或“系统”受害者的心态，利用强大的思想管理技巧停止这些破坏性行为，学习如何“向上管理”老板和“平级管理...

ISBN: (数字)9787516819289

本书包含来自全球各地的领导力培训案例研究，可以帮助你：提升你的领导风度，打造出色的领导力品牌，远离自己是工作、时间或“系统”受害者的心态，利用强大的思想管理技巧停止这些破坏性行为，学习如何“向上管理”老板和“平级管理”同事们，不吹嘘地宣传自己，帮助你获得知名度和你想要的职位。

关键词：

来源：汇雅图书（南通市图书馆... 评论

在线全文

汇雅图书（南通市图书馆）

学校读者我要写书评

暂无评论

三步打造你的个人品牌

作者： (美)布伦达·本斯(Brenda bence)

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

三步打造你的个人品牌

High-Resolution Sensors for the Operation and Control of a Novel Vacuum Evaporation Technology

作者： (美)布伦达·本斯(Brenda bence)

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

Journal of Environmental Science and Engineering(B) 2019年第1期8卷 1-6页

作者： bence Fazekas Krisztián Varga Bálint Péter Szabó Tamás Fráter Gábor Simoncsics PureAqua Environmental Engineering Company Ltd. Veszprém 8200 Hungary

Industrial liquid waste streams could be significantly reduced by evaporation. Using evaporation technologies, not only the amounts are reduced, but the opportunities of potential economic reuse of the solutes are also promoted. In the process developed by authors’ company, fast and efficient vaporization was achieved due to the high evaporation area and vacuum conditions. To investigate the details of the process, an experimental pilot equipment was constructed. The fine resolution monitoring of pressure and temperature conditions is essential in the system, which was implemented by a number of low response-time sensors. In this section of the research work, the developing and testing of the monitoring system customized for this aim was performed. Since the number of the sensors and the data rate is high, the control system was simplified (as possible), and instead of D/A converters author created a digital data management system. This system was capable of managing the 255 sensor’s signals simultaneously in one channel, which seemed to be sufficient for this task. The error statistics of authors’ system was excellent, even in industrial conditions.

关键词： Vacuum evaporation monitoring sensors data acquisition bit error

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

三步打造你的个人品牌

生物中心的生态社会主义理论及其动态均衡原则

作者： (美)布伦达·本斯(Brenda bence)

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

国外理论动态 2023年第6期 105-113页

作者：本斯·彼得·马洛桑周岳(译) 匈牙利布达佩斯国际商学院南开大学马克思主义学院

文章基于马克思主义视角,提出“生物中心的生态社会主义”的激进解放论。这是一种温和的生态中心主义理论和整体主义理论,可以被视为马克思解放理论的逻辑结果。在理论层面,它强调人类的解放永远离不开自然的解放,旨在赋予所有生物以基... 详细信息

文章基于马克思主义视角,提出“生物中心的生态社会主义”的激进解放论。这是一种温和的生态中心主义理论和整体主义理论,可以被视为马克思解放理论的逻辑结果。在理论层面,它强调人类的解放永远离不开自然的解放,旨在赋予所有生物以基本权利,并提醒人类切莫将非人类生物完全视为工具性手段。在实践层面,这一理论包含着“动态均衡”原则,目标在于最大化地激发所有生物的潜能。由此,“动态均衡”原则可以被细分为三个子原则:一是最大限度地提高生物多样性并发掘整个地球生态系统的潜能;二是最大限度地减少生物的痛苦;三是最大限度地发挥人类作为拥有自我意识的生物的潜能。

关键词：生物中心的生态社会主义生态马克思主义激进解放动态均衡环境伦理