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Severe COVID-19 patients exhibit an ILC2 NKG2D^(+) population in their impaired ILC compartment

Cellular & Molecular Immunology 2021年第2期18卷 484-486页

作者： Alejandra Gomez-Cadena Laurie Spehner Marie Kroemer Myriam ben.khelil Kevin Bouiller Grégory Verdeil Sara Trabanelli Christophe Borg Romain Loyon Camilla Jandus Department of Pathology and Immunology University of GenevaGenevaSwitzerlandand Ludwig Institute for Cancer ResearchLausanneSwitzerland University of Bourgogne Franche-Comté INSERMEFS BFCUMR1098RIGHT Interactions Greffon-Hôte-Tumeur/Ingénierie Cellulaire et GéniqueF-25000BesançonFrance Department of Pharmacy University Hospital of BesançonF-25000BesançonFrance Department of Infectious Disease University Hospital of BesançonF-25000BesançonFrance UMR-CNRS 6249 Chrono-Environment UniversitéBourgogne Franche-ComtéF-25000BesançonFrance Department of Oncology UNIL-CHUVUniversity of Lausanne1066EpalingesSwitzerland Department of Medical Oncology University Hospital of BesançonF-25000BesançonFrance

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is responsible for the current COVID-19 disease *** some patients,the symptoms are mild,and a fraction of SARS-CoV-2-infected individuals develop severe illness with a high fatality rate due to lung damage and acute respiratory distress syndrome.1 Innate lymphoid cells(ILCs)are a recently identified type of effector immune cells that rapidly sense environmental stimuli and participate in early immune responses by promptly secreting large amounts of cytokines.2 The ILC2 subpopulation was shown to mediate Type 2 responses and to recruit eosinophils during viral lung infections upon the release of alarmins(e.g.,IL-33)by damaged epithelial cells.3,4,5 ILC2s were also shown to participate in the termination of inflammatory responses and tissue repair by amphiregulin *** addition,ILC2s are critical in the early phases of allergic lung inflammation,including that induced by the protease allergen papain.6 Based on the essential function of the papain-like protease PLpro in regulating SARS-CoV-27(Fig.1a)and the severe lung damage caused by this virus,we sought to investigate the potential involvement of ILC2s in immune responses to COVID-19.

关键词： impaired patients acute

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Monitoring the variation of soil quality with sewage sludge application rates in absence of rhizosphere effect

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International Soil and Water Conservation Research 2020年第3期8卷 245-252页

作者： Rahma Inès Zoghlami Helmi Hamdi Sonia Mokni-Tlili Sarra Hechmi Mohamed Naceur khelil Nadhira ben Aissa Mohamed Moussa Habib Bousnina Saoussen benzarti Naceur Jedidi Arid Regions Institute University of GabèsMèdenine4119Tunisia Water Research and Technology Center University of CarthageP.O.Box 273Soliman8020Tunisia Center for Sustainable Development College of Arts and SciencesQatar UniversityP.O.Box 2713DohaQatar National Institute for Research in Rural Engineering Water and ForestryP.O.Box 10Ariana2080Tunisia National Institute of Agronomy 43 Av.Charles NicolleTunis1082Tunisia College of Agriculture at Mograne University of Carthage1121MograneTunisia

Agricultural soils in semi-arid regions have frequently been degraded due to adverse climatic conditions,organic matter depletion,and poor farming *** enhance soil quality,this study examines the reuse of sewage sludge(SS)as an available source of organic matter in a typical Mediterranean sandy-loam ***,we studied the cumulative effect of two annual applications of 40,80 and 120 tons of sludge per ha on soil quality in absence of *** dose-dependent improvement of organic matter content was the most significant event that reflected sludge application rates,and consequently influenced other soil ***,soil structural stability increased by 13.3%,28.8%and 59.4%for treatments SS-40,SS-80 and SS-120 respectively as compared to unamended *** stability improvement was also confirmed by the dose-dependent variation of other edaphic factors including calcium content,the microbial quotient as well as Welt and C:N *** param-eters are involved in cementing soil aggregates by cation bridging,the formation of microbial mucilage,and clay-humic *** magnetic susceptibility(SMS)was measured in situ as a possible rapid tool to evaluate soil *** showed significant correlation with sludge dose and stability amelioration testifying to the aggregation role that can play Al2O3 and particularly Fe2O3 minerals added by the hematite-rich ***,analytical results and field observations revealed no trends of soil salinization or acidification by excessive sludge *** avoiding the rhizosphere effect,outcomes could reflect the resilience and intrinsic capacity of the soil to cope with excessive sludge loads.

关键词： Sandy loam soil Urban sewage sludge Structural stability Soil degradation Aggregation Magnetic susceptibility

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Asian Pacific Journal of Tropical Biomedicine 2016年第8期6卷 720-726页

作者： Amina Hoceini Nihel Klouche khelil Ilhem ben-Yelles Amine Mesli Sara Ziouani Lotfi Ghellai Nadia Aissaoui Fatima Nas Mounia Arab Laboratory of Applied Microbiology in Food Biomedical and Environment Department of Biology Faculty of Nature and Life University of Tlemcen Laboratory of Experimental Surgery Dental Surgery Department Faculty of Medicine University of Tlemcen Laboratory of Applied Molecular Biology and Immunology Department of Biology University of Tlemcen

Objective: To compare oral hygiene practices, education and social background, food intake and oral malodor of Algerian adults suffering from dental caries with normal controls, and to determine and compare the bacterial composition of the supragingival plaques from the above-mentioned ***: Participants completed a questionnaire and were clinically examined for dental caries using decayed, missing and filled teeth index according to the criteria laid down by the World Health Organization. Supragingival plaque samples were collected from 50 caries-free adults(CF) and 50 caries-active adults(CA). Standard procedures of culture and identification of aerobic and anaerobic bacteria were used. Data were analyzed using Chi-square ***: A total of 117 bacterial strains were isolated from supragingival plaques in CF group subjects, 76(64.96%) of them belonged to 9 aerobic genera, and 41(35.04%) to 9anaerobic genera(P < 0.05). While in the second group, 199 strains were isolated, 119(59.80%) of the strains belonged to 10 aerobic genera and 80(40.20%) to 10 anaerobic bacteria(P < 0.05). Streptococcus mutans, Enterococcus faecium, Aerococcus viridans,Actinomyces meyeri, Lactobacillus acidophilus and Eubacterium limosum showed a significantly higher prevalence in the CA group(P < 0.05). The findings revealed that CA group had a high sugar intake(80%). A significantly higher frequency of tooth brushing(P < 0.000) and a significantly less self-reported oral malodor(P < 0.000) and tooth pain(P < 0.000) were found in CF group, while there was no association of socioeconomic levels and intake of meal snacks with dental ***: This study confirms the association of some aciduric bacteria with caries formation, and a direct association of sugar intake and cultural level with dental ***, oral hygiene practices minimize the prevalence of tooth decay.

关键词： Supragingival plaque Caries-free Caries-active Bacterial composition Algerian adults Cultural level Food intake

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The Infectious Tricuspid Endocarditis in ICU： Clinical Features, Management and Outcome

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Journal of Pharmacy and Pharmacology 2017年第11期5卷 827-833页

作者： A. Jamoussi T. Merhebene K ben Ismail S. Ayed A ben Jazia ben.khelil M. Besbes Medical Intensive Care Unit Abderrahmen Mami Hospital Ariana 2080 Tunisia Faculty of Medicine of Tunis University of Tunis El Manar 1007 Tunisia

Objectives： Infectious tricuspid endocarditis is known to simply require antibiotherapy and to have good prognosis in most cases. Few studies focused on severe episodes managed in ICU. We aimed to describe clinical and microbiological features, and fmal outcome of infectious tricuspid endocarditis managed in ICU. Methods： From 1 January 2009 to 31 August 2017, all patients hospitalized in intensive care unit with infectious tricuspid endocarditis were enrolled. Key findings： We collected 15 episodes of infectious tricuspid endocarditis. Median age was of 39 years. Risk factors were： intravenous drug users （n = 10）, pace maker （n = 1）, vascular device （n = 2）, none （n = 2）. Median SAPS II, APACHE II and SOFA on admission were 21, 10 and 2 respectively. Organ failures on admission were： acute respiratory failure （n = 10）, sepsis （n = 7）, coma （n = 1） and acute kidney injury （n = 8）. The most frequent causative pathogen was Staphylococcus Aureus. Antibiotherapy failure happened in 10 patients from whom 8 underwent cardiac surgery （53.3%）. Most frequent complications were acute kidney injury （n = 14） and withdrawal syndrom. Infectious tricuspid endocarditis relapse on bioprosthesis occurred within 2 intravenous drug users after hospital discharge. Overall in-hospital mortality was 40%. Conclusions： Infectious tricuspid endocarditis in ICU is fitted with poor prognosis and high need to cardiac surgery. Special care should be provided to intravenous drug users to prevent relapse.

关键词： Infectious endocarditis tricuspid valve intensive care unit intravenous drug users staphylococcus aureus complications surgery endocarditis recurrence withdrawal syndrome.

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