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Characteristics of intracranial plaque in patients with non-cardioembolic stroke and intracranial large vessel occlusion

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Stroke & Vascular Neurology 2023年第5期8卷 387-398,I0015,I0016页

作者： Dan Wang Zi-yang Shang Yu Cui ben-qiang yang George Ntaios Hui-Sheng Chen Department of Neurology General Hospital of Northern Theatre CommandShenyangLiaoningChina Radiology General Hospital of Northern Theatre CommandShenyangLiaoningChina Department of Medicine University of ThessalyLarissaGreece

Objective To determine the characteristics of intracranial plaque proximal to large vessel occlusion(LVO)in stroke patients without major-risk cardioembolic source using 3.0 T high-resolution MRI(HR-MRI).Methods We retrospectively enrolled eligible patients from January 2015 to July *** multidimensional parameters of plaque such as remodelling index(RI),plaque burden(PB),percentage lipid-rich necrotic core(%LRNC),presence of discontinuity of plaque surface(DPS),fibrous cap rupture,intraplaque haemorrhage and complicated plaque were evaluated by *** Among 279 stroke patients,intracranial plaque proximal to LVO was more prevalent in the ipsilateral versus contralateral side to stroke(75.6%vs 58.8%,p<0.001).The larger PB(p<0.001),RI(p<0.001)and%LRNC(p=0.001),the higher prevalence of DPS(61.1%vs 50.6%,p=0.041)and complicated plaque(63.0%vs 50.6%,p=0.016)were observed in the plaque ipsilateral versus contralateral to *** analysis showed that RI and PB were positively associated with an ischaemic stroke(RI:crude OR:1.303,95%CI 1.072 to 1.584,p=0.008;PB:crude OR:1.677,95%CI 1.381 to 2.037,p<0.001).In subgroup with<50%stenotic plaque,the greater PB,RI,%LRNC and the presence of complicated plaque were more closely related to stroke,which was not evident in subgroup with≥50%stenotic *** This is the first study to report the characteristics of intracranial plaque proximal to LVO in non-cardioembolic *** provides potential evidence to support different aetiological roles of<50%stenotic vs≥50%stenotic intracranial plaque in this population.

关键词： patients intracranial occlusion

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Rollback reconstruction for TDC enhanced perfusion imaging

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Nuclear Science and Techniques 2021年第8期32卷 23-33页

作者： Jia-Shun Liu Yi-Kun Zhang Hui Tang Li-Bo Zhang ben-qiang yang Ying Yan Li-Min Luo yang Chen Laboratory of Image Science and Technology Southeast UniversityNanjing 210096China Department of Radiology General Hospital of the Northern Theater of the Chinese People’s Liberation ArmyShenyang 110016China Department of Radiotherapy General Hospital of the Northern Theater of the Chinese People’s Liberation ArmyShenyang 110016China Centre de Recherche en Information Biomedicale SinoFrancais(LIA CRIBs) 35000 RennesFrance

Tomographic perfusion imaging is a significant imaging modality for stroke ***,the low rotational speed of the C-arm(6–8 s per circle)is a challenge for applying perfusion imaging in C-arm cone beam computed tomography(CBCT).Traditional reconstruction methods cannot remove the artifacts caused by the slow rotational speed or acquire enough sample points to restore the time density curve(TDC).This paper presents a dynamic rollback reconstruction method for *** proposed method can improve the temporal resolution by increasing the sample points used for calculating the *** with existing techniques,the algorithm allows slow-rotating scanners to be used for perfusion imaging *** the experiments,the proposed method was compared with other dynamic reconstruction algorithms based on standard reconstruction and the temporal interpolation *** presented algorithm could improve the temporal resolution without increasing the X-ray exposure time or contrast agent.

关键词： Rollback reconstruction CBCT Time resolution Time density curve

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Neoadjuvant nivolumab with or without platinum-doublet chemotherapy based on PD-L1 expression in resectable NSCLC(CTONG1804):a multicenter open-label phase II study

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Signal Transduction and Targeted Therapy 2024年第1期9卷 249-258页

作者： Si-yang Liu Song Dong Xue-Ning yang Ri-qiang Liao ben-Yuan Jiang Qun Wang Xiao-Song ben Gui-Bin Qiao Jun-Tao Lin Hong-Hong Yan Li-Xu Yan qiang Nie Hai-Yan Tu Bin-Chao Wang Jin-Ji yang Qing Zhou Hong-Rui Li Ke Liu Wendy Wu Si-yang Maggie Liu Wen-Zhao Zhong Yi-Long Wu Guangdong Lung Cancer Institute Guangdong Provincial Key Laboratory of Translational Medicine in Lung CancerGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina Department of Thoracic Surgery Zhongshan HospitalFudan UniversityShanghaiChina Department of Thoracic Surgery Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina Department of Pathology Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina Fujian Key Laboratory of Advanced Technology for Cancer Screening and Early Diagnosis FuzhouChina Berry Oncology Corporation FuzhouChina Chinese Thoracic Oncology Group(CTONG) GuangzhouChina Department of Hematology The First Affiliated HospitalJinan UniversityGuangzhouChina

This prospective multicenter phase II study evaluated the clinical efficacy of neoadjuvant nivolumab-exclusive(N)and nivolumab–chemotherapy(N/C)combinations based on PD-L1 *** patients exhibited resectable clinical stage IIA–IIIB(AJCC 8th edition)NSCLC without EGFR/ALK *** received either mono-nivolumab(N)or nivolumab+nabpaclitaxel+carboplatin(N/C)for three cycles based on PD-L1 *** primary endpoint was the major pathological response(MPR).Key secondary endpoints included the pathologic complete response(pCR),objective response rate(ORR),and event-free survival(EFS).Baseline PD-L1 expression and perioperative circulating tumor DNA(ctDNA)status were correlated with pCR and ***-two patients were enrolled,with 46 undergoing *** MPR was 50.0%(26/52),with 25.0%(13/52)achieving pCR,and 16.7%and 66.7%for patients with PD-L1≥50%in N and N/C groups,***(25.0%)patients experienced grade 3 or higher immune-related adverse events during neoadjuvant *** with post-neoadjuvant ctDNA negativity was more likely to have pCR(39.1%)compared with those remained positive(6.7%,odds ratio=6.14,95%CI 0.84-Inf,p=0.077).With a median follow-up of 25.1 months,the 18-month EFS rate was 64.8%(95%CI 51.9–81.0%).For patients with ctDNA–***+,the 18m-EFS rate was 93.8%vs 47.3%(HR,0.15;95%CI 0.04,0.94;p=0.005).Immunochemotherapy may serve as an optimal neoadjuvant treatment even for patients with PD-L1 expression≥50%.ctDNA negativity following neoadjuvant treatment and surgery could help identify superior pathological and survival benefits,which requires further confirmation in a prospective clinical trial(NCT04015778).

关键词： chemotherapy NSCLC treatment

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Unidirectional movement behavior of underwater bubbles on the wettability gradient mesh via asymmetrical bounce

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Science China Chemistry 2024年第8期67卷 2606-2613页

作者： Yuzhen Ning Zhihong Zhao Shuang ben qiang Li Cunming Yu Xudong Zhang Huawei Chen Kesong Liu Lei Jiang School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology School of ChemistryBeihang UniversityBeijing 100191China Research Institute of Aero-Engine Beihang UniversityBeijing 100191China School of Materials Science and Engineering Shenyang Ligong UniversityShenyang 110159China Tianmushan Laboratory Hangzhou 310023China The Analysis Testing CenterBeihang UniversityBeijing 100191China

The impact of underwater bubbles on solid surfaces with a gradient wettability is important for fundamental science and technological applications. Despite progress in the translational motion of underwater bubbles on asymmetric surface, a fundamental dynamic understanding of asymmetrical bounce behavior of the underwater bubble needs to be further ***, we investigate asymmetrical bounce of underwater bubbles after impacting the wettability gradient copper mesh *** bounce of the underwater bubble on the wettability gradient mesh(WGM) surface is composed by asymmetrical spread in the spread process and asymmetrical recoil in the recoil process, which induce the unidirectional movement ***, effective bubble-size manipulation can be easily implemented due to different volumes of bubbles remaining at different locations of WGM surface. We envision that this work will provide a new understanding of asymmetrical bounce behavior of the underwater bubble on the wettability gradient surface, and propose a novel and feasible strategy for constructing the underwater bubble manipulation system.

关键词： asymmetrical bounce unidirectional movement behavior gradient wettability

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Heterogeneously elevated branched-chain/aromatic amino acids among new-onset type-2 diabetes mellitus patients are potentially skewed diabetes predictors

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World Journal of Diabetes 2024年第1期15卷 53-71页

作者： Min Wang yang Ou Xiang-Lian Yuan Xiu-Fang Zhu ben Niu Zhuang Kang Bing Zhang Anwar Ahmed Guo-qiang Xing Heng Su School of Chemical Science and Technology Yunnan UniversityKunming 650091Yunnan ProvinceChina Department of Endocrinology The First People’s Hospital of Yunnan ProvinceKunming 650032Yunnan ProvinceChina Clinical Laboratory Nanchong Central Hospital&The Second Clinical Medical College of North Sichuan Medical UniversityNanchong 637000Sichuan ProvinceChina Department of Preventive Medicine and Biostatistics Uniformed Services University of the Health SciencesBethesdaMD 20814United States The Affiliated Hospital and Second Clinical Medical College North Sichuan Medical UniversityNanchong 637000Sichuan ProvinceChina Department of Research and Development Lotus *** LLCGaithersburgMD 20878United States

BACKGROUND The lack of specific predictors for type-2 diabetes mellitus(T2DM)severely impacts early intervention/prevention *** branched-chain amino acids(BCAAs:Isoleucine,leucine,valine)and aromatic amino acids(AAAs:Tyrosine,tryptophan,phenylalanine)show high sensitivity and specificity in predicting diabetes in animals and predict T2DM 10-19 years before T2DM onset in clinical ***,improvement is needed to support its clinical *** To evaluate the effects of body mass index(BMI)and sex on BCAAs/AAAs in new-onset T2DM individuals with varying body *** Ninety-seven new-onset T2DM patients(<12 mo)differing in BMI[normal weight(NW),n=33,BMI=22.23±1.60;overweight,n=42,BMI=25.9±1.07;obesity(OB),n=22,BMI=31.23±2.31]from the First People’s Hospital of Yunnan Province,Kunming,China,were ***-way and 2-way ANOVAs were conducted to determine the effects of BMI and sex on BCAAs/*** Fasting serum AAAs,BCAAs,glutamate,and alanine were greater and high-density lipoprotein(HDL)was lower(P<0.05,each)in OB-T2DM patients than in NW-T2DM patients,especially in male OB-T2DM ***,histidine,leucine,methionine,and lysine were greater in male patients than in female ***,histidine,alanine,glutamate,lysine,valine,methionine,leucine,isoleucine,tyrosine,phenylalanine,and tryptophan were significantly correlated with abdominal adiposity,body weight and BMI,whereas isoleucine,leucine and phenylalanine were negatively correlated with *** Heterogeneously elevated amino acids,especially BCAAs/AAAs,across new-onset T2DM patients in differing BMI categories revealed a potentially skewed prediction of T2DM *** higher BCAA/AAA levels in obese T2DM patients would support T2DM prediction in obese individuals,whereas the lower levels of BCAAs/AAAs in NW-T2DM individuals may underestimate T2DM risk in NW *** potentially skewed T2DM prediction should be considered when BCAAs/AAAs are to

关键词： Hyperaminoacidemia Branched-chain/aromatic amino acids New-onset type-2 diabetes Predictor Obesity Sex

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High-resolution mid-infrared single-photon upconversion ranging

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Photonics Research 2024年第6期12卷 1294-1302页

作者： SHUHONG JIANG KUN HUANG TINGTING YU JIANAN FANG ben SUN YAN LIANG qiang HAO E.WU MING YAN HEPING ZENG State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200062China Chongqing Key Laboratory of Precision Optics Chongqing Institute of East China Normal UniversityChongqing 401121China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuan 030006China School of Optical Electrical and Computer Engineering University of Shanghai for Science and TechnologyShanghai 200093China Shanghai Research Center for Quantum Sciences Shanghai 201315China Guangyang Bay Laboratory Chongqing Institute for Brain and IntelligenceChongqing 400064China

Single-photon laser ranging has widespread applications in remote sensing and target ***,highly sensitive light detection and ranging(lidar)has long been restricted in the visible or near-infrared *** appealing quest is to extend the operation wavelength into the mid-infrared(MIR)region,which calls for an infrared photon-counting system at high detection sensitivity and precise temporal ***,we devise and demonstrate an MIR upconversion lidar based on nonlinear asynchronous optical ***,the infrared probe is interrogated in a nonlinear crystal by a train of pump pulses at a slightly different repetition rate,which favors temporal optical scanning at a picosecond timing resolution and a kilohertz refreshing rate ***,the cross-correlation upconversion trace is temporally stretched by a factor of 2×10^(4),which can thus be recorded by a low-bandwidth silicon *** combination with the time-correlated photon-counting technique,the achieved effective resolution is about two orders of magnitude better than the timing jitter of the detector itself,which facilitates a ranging precision of 4μm under a low detected flux of 8×10^(−5) photons per *** presented MIR time-of-flight range finder is featured with single-photon sensitivity and high positioning resolution,which would be particularly useful in infrared sensing and imaging in photon-starved scenarios.

关键词： resolution lidar repetition

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Fjord-Type AIEgens Based on Inherent Through-Space Conjugation

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CCS Chemistry 2024年第7期6卷 1739-1747页

作者： Ye-qiang Han Yuan Xie Jianyu Zhang Shiyu Tan Haoke Zhang ben Zhong Tang Jonathan L.Sessler Feihe Huang Stoddart Institute of Molecular Science Department of ChemistryZhejiang UniversityHangzhou 310058 Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials ZJU-Hangzhou Global Scientific and Technological Innovation CenterZhejiang UniversityHangzhou 311215 MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310058 Center for AIE Research College of Materials Science and EngineeringShenzhen UniversityShenzhen 518061 Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionThe Hong Kong University of Science and TechnologyKowloonHong Kong 999077 School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Guangzhou 518172 Department of Chemistry The University of Texas at AustinAustinTexas 78712-1224 Green Catalysis Center and College of Chemistry Zhengzhou UniversityZhengzhou 450001

Through-space conjugation(TSC)is a noncovalently electronic interaction that is emerging as a potential complement to through-bond conjugation(TBC)-based strategies for constructing luminescent ***,the design of efficient luminogens based on TSC is currently challenging due to a lack of established structure-property *** is particularly true in the case of luminogens displaying aggregation-induced emission(AIE)*** this work,three terphenyl derivatives were prepared,and their photophysical properties were systemically *** was found that relative to the corresponding m-and p-linked analogues,the electronic interaction of TBC is weakened while the strength of TSC is commensurately enhanced in the constitutional isomer containing an o-linked fjordtype *** this set of luminogens,the presence of a fjord-type arrangement promotes a transformation from aggregation-caused quenching to *** investigations involving congeneric quaterphenyl and pentphenyl isomers support the universality of the fjord-type unit as a framework for synthesizing AIE-active luminogens(AIEgens)with inherent *** work not only provides a novel set of AIEgens but also establishes the utility of TSC in controlling the photophysical properties of nonconventional and twisted luminogens.

关键词： fjord-type through-space conjugation through-bond conjugation aggregation-induced emission luminescence twisted conformation

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复杂载荷下复合材料螺栓连接预紧力松弛试验研究

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航空制造技术 2024年第9期67卷 98-105页

作者：魏嘉兵邹礼洋杨浩然贲强袁大鹏国营芜湖机械厂芜湖241000 南京航空航天大学南京210016

本研究基于疲劳试验机,自主设计了复杂载荷螺栓松动试验装置。在不同的试验参数下开展了复杂载荷作用下螺栓连接结构松弛行为试验,系统地研究振动幅值、载荷类型对复杂载荷下螺栓连接结构松弛行为的影响。通过获取螺栓连接的实时残余夹... 详细信息

本研究基于疲劳试验机,自主设计了复杂载荷螺栓松动试验装置。在不同的试验参数下开展了复杂载荷作用下螺栓连接结构松弛行为试验,系统地研究振动幅值、载荷类型对复杂载荷下螺栓连接结构松弛行为的影响。通过获取螺栓连接的实时残余夹紧力和螺栓螺母相对旋转角度,并结合光学显微镜分析复合材料板表面损伤形貌,进一步揭示复合材料螺栓连接松动机理。主要结论如下:当载荷幅值越大,螺栓连接残余夹紧力下降的值越大,连接结构越容易发生松弛行为;轴向幅值增大会导致复合材料板孔周位置损伤加重,横向幅值增大则会导致复合材料板板面磨损加重;复杂载荷的载荷类型对连接结构松弛行为会产生明显影响,与静拉伸载荷相比,振动载荷对螺栓连接残余夹紧力的影响更大。

关键词：复杂载荷螺栓连接螺栓松弛复合材料夹紧力复合材料损伤

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短暂性脑缺血脑深部髓质静脉分布的SWI分析

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中国临床医学影像杂志 2016年第11期27卷 761-764,783页

作者：李虹易杨本强段阳刘文源常灿灿刘娜张连雪林森沈阳军区总医院放射诊断科辽宁沈阳110016

目的:应用磁敏感加权成像(SWI)技术研究短暂性脑缺血(TIA)脑内深部髓质静脉(DMV)的分布。方法:双盲回顾性分析118例TIA患者及32例正常志愿者的临床及脑部MR影像学资料。两位放射科医生共同判定图像质量、DMV对称性(对称定义为相同区域均... 详细信息

目的:应用磁敏感加权成像(SWI)技术研究短暂性脑缺血(TIA)脑内深部髓质静脉(DMV)的分布。方法:双盲回顾性分析118例TIA患者及32例正常志愿者的临床及脑部MR影像学资料。两位放射科医生共同判定图像质量、DMV对称性(对称定义为相同区域均有DMV显示,数量差0.05。对照组与TIA组DMV对称性四格表Fisher确切概率法P=0.004,P0.05)。结论 :TIA脑内DMV判定有很好一致性,DMV可不对称分布,其管径多小于和接近脑浅层静脉。

关键词：脑缺血发作短暂性磁共振成像

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Hemolysis attributed to high dose vitamin C:Two case reports

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World Journal of Clinical Cases 2024年第17期12卷 3168-3176页

作者： Shi-Wan Wang Xiao-Wei Zhang Jin-Xiu Qu Yi-Zhong Rao Shuai Lu Bing Wang Jia He Yuan Zhao ben-qiang Rao Center for Oncology Nutrition and Metabolism Beijing Shijitan HospitalCapital Medical University/Key Laboratory of Cancer FSMP for State Market RegulationBeijing 100038China

BACKGROUND High-dose vitamin C treatment(HVCT)can reduce the adverse effect of chemotherapy and enhance the effect of antitumor therapy,which has been considered one of the safest alternative ***,the severity of its adverse effects may have been *** most serious adverse effect is hemolysis,which may result in acute kidney injury or *** glucose-6-phosphate dehydrogenase(G6PD)deficiency is considered to be the main cause,the probability and pathological mechanism are not completely understood,leading to a lack of effective and standardized treatment *** SUMMARY Two patients with colorectal cancer developed hemolytic anemia after using 1 g/kg *** contrast to previous cases,the lowest hemoglobin level in the two cases was<50 g/L,which was lower than previously *** may be because Case 1 had chronic hepatitis B for many years,which caused abnormal liver reserve function,and Case 2 had grade II bone marrow *** patients improved and were discharged after blood replacement *** cases had the most severe degree of hemolysis but the best prognosis,suggesting that our treatment may be helpful for rescue of drug-induced *** is the first review of the literature on hemolysis caused by HVCT,and we found that all patients with G6PD deficiency developed hemolysis after *** G6PD deficiency should be considered as a contraindication to HVCT,and it is not recommended for patients with bone marrow suppression,moderate-tosevere anemia,hematopoietic abnormalities,or abnormal liver and kidney *** blood purification and steroid therapy may avoid acute kidney injury or death caused by HVCT-related hemolytic anemia.

关键词： Hemolysis Vitamin C Adverse effects Acute kidney injury Cancer Case report

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