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Bone marrow-derived mesenchymal stem cell transplantation attenuates overexpression of inflammatory mediators in rat brain after cardiopulmonary resuscitation

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Neural Regeneration Research 2020年第2期15卷 324-331页

作者： Qing-Ming Lin Xia-Hong Tang Shi-Rong Lin Ben-Dun Chen Feng chen Institute of Fujian Emergency Medicine Clinical College of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFujian Provincial Emergency CenterFuzhouFujian ProvinceChina

Emerging evidence suggests that bone marrow-derived mesenchymal stem cell transplantation improves neurological function after cardiac arrest and cardiopulmonary resuscitation;however, the precise mechanisms remain unclear. This study aimed to investigate the effect of bone marrow-derived mesenchymal stem cell treatment on expression profiles of multiple cytokines in the brain after cardiac arrest and cardiopulmonary resuscitation. Cardiac arrest was induced in rats by asphyxia and cardiopulmonary resuscitation was initiated 6 minutes after cardiac arrest. One hour after successful cardiopulmonary resuscitation, rats were injected with either phosphate-buffered saline(control) or 1 × 10~6 bone marrow-derived mesenchymal stem cells via the tail vein. Serum S100 B levels were measured by enzyme-linked immunosorbent assay and neurological deficit scores were evaluated to assess brain damage at 3 days after cardiopulmonary resuscitation. Serum S100 B levels were remarkably decreased and neurological deficit scores were obviously improved in the mesenchymal stem cell group compared with the phosphate-buffered saline group. Brains were isolated from the rats and expression levels of 90 proteins were determined using a RayBio Rat Antibody Array, to investigate the cytokine profiles. Brain levels of the inflammatory mediators tumor necrosis factor-α, interferon-γ, macrophage inflammatory protein-1α, macrophage inflammatory protein-2, macrophage inflammatory protein-3α, macrophage-derived chemokine, and matrix metalloproteinase-2 were decreased ≥ 1.5-fold, while levels of the anti-inflammatory factor interleukin-10 were increased ≥ 1.5-fold in the mesenchymal stem cell group compared with the control group. Donor mesenchymal stem cells were detected by immunofluorescence to determine their distribution in the damaged brain, and were primarily observed in the cerebral cortex. These results indicate that bone marrow-derived mesenchymal stem cell transplantation attenuates brain damage induced by cardiac arrest and cardiopul

关键词： antibody array asphyxia brain damage cardiac arrest cardiopulmonary resuscitation global cerebral ischemia inflammatory mediator mesenchymal stem cell neurological deficit score S100B

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Dynamic expression of Slit1–3 and Robo1–2 in the mouse peripheral nervous system after injury

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Neural Regeneration Research 2020年第5期15卷 948-958页

作者： Bing chen Lauren Carr Xin-Peng dun Department of Neurology The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical UniversityHuai’anJiangsu ProvinceChina Plymouth University Peninsula Schools of Medicine and Dentistry PlymouthUK The Co-innovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina

The Slit family of axon guidance cues act as repulsive molecules for precise axon pathfinding and neuronal migration during nervous system development through interactions with specific Robo receptors.Although we previously reported that Slit1–3 and their receptors Robo1 and Robo2 are highly expressed in the adult mouse peripheral nervous system,how this expression changes after injury has not been well studied.Herein,we constructed a peripheral nerve injury mouse model by transecting the right sciatic nerve.At 14 days after injury,quantitative real-time polymerase chain reaction was used to detect mRNA expression of Slit1–3 and Robo1–2 in L4–5 spinal cord and dorsal root ganglia,as well as the sciatic nerve.Immunohistochemical analysis was performed to examine Slit1–3,Robo1–2,neurofilament heavy chain,F4/80,and vimentin in L4–5 spinal cord,L4 dorsal root ganglia,and the sciatic nerve.Co-expression of Slit1–3 and Robo1–2 in L4 dorsal root ganglia was detected by in situ hybridization.In addition,Slit1–3 and Robo1–2 protein expression in L4–5 spinal cord,L4 dorsal root ganglia,and sciatic nerve were detected by western blot assay.The results showed no significant changes of Slit1–3 or Robo1–2 mRNA expression in the spinal cord within 14 days after injury.In the dorsal root ganglion,Slit1–3 and Robo1–2 mRNA expression were initially downregulated within 4 days after injury;however,Robo1–2 mRNA expression returned to the control level,while Slit1–3 mRNA expression remained upregulated during regeneration from 4–14 days after injury.In the sciatic nerve,Slit1–3 and their receptors Robo1–2 were all expressed in the proximal nerve stump;however,Slit1,Slit2,and Robo2 were barely detectable in the nerve bridge and distal nerve stump within 14 days after injury.Slit3 was highly ex-pressed in macrophages surrounding the nerve bridge and slightly downregulated in the distal nerve stump within 14 days after injury.Robo1 was upregulated in vimentin-positive cells and migrating Schwann cells inside the nerve bridge.Robo1 was a

关键词： dorsal root ganglion nerve regeneration neural regeneration peripheral nerve Robo 1 Robo 2 sciatic nerve Slit1 Slit2 Slit3

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Bifunctional nanozyme activities of layered double hydroxide derived Co-A1-Ce mixed metal oxides for antibacterial application

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Journal of Oceanology and Limnology 2020年第4期38卷 1233-1245页

作者： chen Chao WANG Yi ZHANG dun CAS Key Laboratory of Marine Environmental Corrosion and Bio-fouling Institute of OceanologyChinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China Open Studio for Marine Corrosion and Protection Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China Center for Ocean Mega-Science Chinese Academy of SciencesQingdao 266071China

Marine biofouling is an expensive problem that needs evolved chemical or physical antifouling strategies.However,most of the current antifouling materials that would damage the environment through metal leaching and bacteria resistance are being halted.Nanozyme is one kind of environmental antifouling materials through generating reactive oxygen species(ROS).We prepared various contents of CeO2 that could uniform disperse compounding with Co3 O4 and CoAl2 O4 to form a stable Co-Al-Ce mixed metal oxide(MMO) by a layered double hydroxide derived method.We find that coupling with CeO2 can improve the peroxidase(POx) activity.When the molar ratio of Ce is 2.5% and the calcination temperature is 200℃,the POx activity of Co-Al-Ce MMO is the best caused by the good dispersion of catalytically active components and the high specific area(150.10±4.95 m2/g).This novel Co-Al-Ce MMO also exhibits an antibacterial mode of action Gram-negative bacteria in near-neutral pH solution through generating ROS(mainly ·O2-)in the presence of H2 O2.Ce containing MMO can be utilized as potential green marine antifouling material.

关键词： mixed metal oxide ceria enzyme mimic antibacterial marine biofouling

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Estimating Seismic Intensity Maps of the 2021 Mw 7.3 Madoi,Qinghai and Mw 6.1 Yangbi,Yunnan,China Earthquakes

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Journal of Earth Science 2022年第4期33卷 839-846页

作者： Wenkai chen dun Wang Can Zhang Qiang Yao Hongjun Si Lanzhou Institute of Seismology China Earthquake AdministrationLanzhou 730000China State Key Laboratory of Geological Processes and Mineral Resources School of Earth SciencesChina University of GeosciencesWuhan 430074China Seismological Research Institute Inc. Tokyo 113-0032Japan

This study focuses on rapidly determining seismic intensity maps of earthquakes because it offers fundamental information for effective emergency rescue and subsequent scientific research,and remains challenging to accurately determine seismic intensity map in regions with sparse instrumental observations.Here we applied a novel method that consisted of array technology(backprojection),ground-motion prediction equations,and site corrections,to estimate the seismic intensity maps of the 2021 Mw 7.3 Madoi,Qinghai and the Mw 6.1 Yangbi,Yunnan,China earthquakes.We used seismic data recorded at European stations to back-project the source processes of the 2021 Mw7.3 Madoi,Qinghai and the Mw 6.1 Yangbi,Yunnan,China earthquakes.The back-projected energy radiations were then used as subevents or used to define the fault geometry.Summing the contributions of each subevent or estimating the shortest distances from each site to the rupture fault,we obtained the ground motion(PGA and PGV)for each site under rock site conditions.The estimated ground motions were corrected at each site for local site amplification according to the Vs30 database.Our estimated seismic intensity maps and field reports showed high similarity,which further validated the effectiveness of the novel approach,and pushed the limit of earthquake size down to~M 6.Such efforts would substantially help in the fast and accurate evaluation of earthquake damage,and precise rescue efforts.

关键词： earthquakes seismic intensity map back-projection ground-motion prediction equations

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Synchronous impact phenomenon of a high-dimension complex nonlinear dual-rotor system subjected to multi-frequency excitations

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Science China(Technological Sciences) 2023年第6期66卷 1757-1768页

作者： LIN RongZou HOU Lei dun ShiWei CAI YuFeng SUN ChuanZong chen YuShu School of Astronautics Harbin Institute of TechnologyHarbin 150001China Factory of Xiangyang Hang Tai Power Machinery Xiangyang 441000China School of Mechanical Engineering Shenyang University of TechnologyShenyang 110870China

The“synchronous impact”is a phenomenon that increases the dynamic load of the inter-shaft bearing,when the frequency of the aerodynamic excitation is close to the contact frequency of the inter-shaft bearing.This work addresses the“synchronous impact”phenomenon of an aero-engine.The 104 degree-of-freedom dynamical model of an aero-engine is established by the finite element method,in which the complex nonlinearity of the Hertzian contact force of the inter-shaft bearing with clearance is included,and the multi-frequency excitations such as the unbalanced excitations of the high-and low-pressure rotors and the aerodynamic excitation are considered.A harmonic balance method combined with the alternating frequency time-domain method(HB-AFT)is introduced to obtain periodic responses of the high-dimension complex nonlinear dual-rotor system.The results show that there emerges a peak value of the amplitude-frequency response for the contact frequency harmonic component of the outer ring of the inter-shaft bearing,when the aerodynamic excitation frequency is close to the contact frequency.In addition,the dynamic load of the inter-shaft bearing increases significantly.Moreover,the parametric analysis shows that the“synchronous impact”phenomenon is sensitive to the change of the speed ratio of the high-and low-pressure rotors.The dynamic load of inter-shaft bearing can be significantly reduced by changing the speed ratio by 1%.The results obtained in this paper not only provide more insight into the mechanism of the“synchronous impact”phenomenon but also demonstrate the HBAFT method as a potential semi-analytical tool to explore the high-dimension complex nonlinear system.

关键词： synchronous impact dual-rotor inter-shaft bearing HB-AFT multi-frequency excitations

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Early Report of the Source Characteristics,Ground Motions,and Casualty Estimates of the 2023 Mw 7.8 and 7.5 Turkey Earthquakes

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Journal of Earth Science 2023年第2期34卷 297-303页

作者： Wenkai chen Gang Rao Dengjie Kang Zhifan Wan dun Wang Lanzhou Institute of Seismology China Earthquake AdministrationLanzhou730000China School of Geoscience and Technology Southwest Petroleum UniversityChengdu610500China State Key Laboratory of Geological Processes and Mineral Resources School of Earth SciencesChina University of GeosciencesWuhan430074China

INTRODUCTION,At 01:17 UTC(04:17 on local time)on Feb.6,2023,a devastating earthquake with a moment magnitude(Mw)7.8 occurred in the Gaziantep,southern Turkey.The earthquake was located at 37.174°N and 37.032°E,with ... 详细信息

关键词： earthquake magnitude Earthquake

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Magnitude of the 23 January 2018 M7.9 Alaska Earthquake Estimated from Local Dense Seismic Records in Alaska

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Journal of Earth Science 2019年第5期30卷 1005-1009页

作者： chen Song Qiang Yao dun Wang Key Laboratory of Earthquake Geodesy Institute of Seismology China Earthquake Administration Wuhan 430071 China State Key Laboratory of Geological Processes and Mineral Resources School of Earth Sciences China University of Geosciences Wuhan 430074 China

We apply a novel method to estimate the magnitude of the 23 January 2018 M7.9 Alaska earthquake using seismic stations recorded at local to regional distances in Alaska, US. We determine the source duration from back-projection results derived from the Alaska stations in a relatively compact azimuth range. Then we calculate the maximum P-wave displacements recorded on a wide azimuth range at distances of 8 to 15 degrees. Combining the source duration and the maximum P-wave displacements, we obtain magnitudes of 7.86–8.03 for the 23 January 2018 earthquake in 3–5 min, very close to the Mw 7.9 determined by the USGS and GCMT. This example validates the new approach for determining magnitude of large earthquakes using local to regional stations, and its time efficiency that magnitudes of large earthquakes can be accurately estimated within in 3–5 min after origin time. Therefore, further application of this new method would help accurate estimation of size of earthquakes that occur offshore and might cause tsunami hazards.

关键词： rapid magnitude estimation back-projection real-time seismology tsunami warning geophysics

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On the Trends of Autonomous Unmanned Systems Research

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Engineering 2022年第5期8卷 20-23页

作者： ben M.chen Department of Mechanical and Automation Engineering The Chinese University of Hong KongHong Kong 999077China

In recent decades,academia and industry have put increasing attention and investment into the research and development of autonomous unmanned systems.An autonomous unmanned vehi-cle is a machine equipped with necessary data-processing units,sophisticated sensors,environment perception,automatic control,motion planning,task planning,mission management,and com-munication systems.

关键词： autonomous systems equipped

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Semi-global leader-following consensus-based formation flight of unmanned aerial vehicles

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Chinese Journal of Aeronautics 2022年第1期35卷 31-43页

作者： Panpan ZHOU ben M.chen Department of Mechanical ami Automation Engineering The Chinese University of Hong KongHong KongChina

In this paper,we investigate a formation control problem of multi-agent systems(specifically a group of unmanned aerial vehicles)based on a semi-global leader-following consensus approach with both the leader and the followers subject to input saturation.Utilizing the low gain feedback design technique,a distributed static control protocol and a distributed adaptive control protocol are constructed.The former solves the problem under an assumption that the communication network is undirected,and it depends on the global information of the graph.For the latter,we relax the undirected graph to directed graph.Moreover,an adaptive updating gain is designed to avoid using the global information of the communication network.It is shown that the consensus protocols can solve the semi-global leader-following consensus problem if the leader agent is globally reachable.The results are verified successfully by both simulation and real flight tests.

关键词： Consensus Formation flying Input saturation Low gain feedback Multi-agent systems Unmanned aerial vehicles

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Paleo-Earthquakes along the Zheduotang Fault,Xianshuihe Fault System,Eastern Tibet:Implications for Seismic Hazard Evaluation

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Journal of Earth Science 2022年第5期33卷 1233-1245页

作者： Guifan chen Mervin Bartholomew Demin Liu Kai Cao Minxuan Feng dun Wang School of Earth Sciences China University of GeosciencesWuhan 430074China Three Gorges Geotechnical Consultants Co. Ltd.Wuhan 430074China Department of Earth Sciences University of MemphisMemphisTN38152USA Xi’an Center of Geological Survey China Geological SurveyXi’an710054China

The Kangding City in eastern Tibet is at high risk due to frequent strong earthquakes along the Xianshuihe sinistral strike-slip fault bounding the Chuandian Block to the northeast.The knowledge of paleo-seismicity recurrence along this fault system is key to the evaluation of earthquake hazards in this region;thus,more accurate paleoseismic information are required.We examined the paleo-seismicity along the Zheduotang fault in the central segment of the Xianshuihe fault system by applying the field investigation,trenching,and Quaternary dating methods(e.g.,OSL and ^(14)C).Field observations found~8.5 m offset of stream by sinistral slip along the Zheduotang fault.We trenched the central fault zone of the Zheduotang fault and found that the colluvial wedges and five buried,discontinuous,A-soil horizons progressively have been offset in the shallow graben on the SW-side of the main fault indicative of the paleo-earthquakes.The dating results of OSL and ^(14)C,in line with existing data,enable us to establish the paleo-seismic history of the Zheduotang fault.It shows at least eight surface ruptures in the last 7500 years identified from displaced buried soils,colluvial wedges and terraces.Our study reveals~100 years minimum paleo-earthquake recurrence,suggesting potential large earthquakes in the Kangding area in the future.

关键词： Tibetan Plateau Xianshuihe fault system paleo-seismicity trench recurrence geophysics

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