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腹部摩法结合颈椎旋转定位扳法治疗痰湿阻络型椎动脉型颈椎病患者的疗效观察

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世界中西医结合杂志 2024年第3期19卷 550-555页

作者：许嘉犇刘士硕陈柏臻薛玉满黑龙江中医药大学黑龙江哈尔滨150040 黑龙江中医药大学附属第二医院黑龙江哈尔滨150001 黑龙江中医药大学附属第三医院黑龙江哈尔滨150001

目的探讨腹部摩法结合颈椎旋转定位扳法治疗椎动脉型颈椎病痰湿阻络证的效果。方法选取2022年1月—2022年12月期间黑龙江中医药大学附属第二医院收治的90例椎动脉型痰湿阻络证患者,采用随机数字表法分为腹摩组、扳法组、联合组,每组各3... 详细信息

目的探讨腹部摩法结合颈椎旋转定位扳法治疗椎动脉型颈椎病痰湿阻络证的效果。方法选取2022年1月—2022年12月期间黑龙江中医药大学附属第二医院收治的90例椎动脉型痰湿阻络证患者,采用随机数字表法分为腹摩组、扳法组、联合组,每组各30例。3组患者均给予西药与常规推拿治疗,在此基础上,腹摩组施以腹部摩法,扳法组施以颈椎旋转定位扳法,联合组给予腹部摩法+颈椎旋转定位扳法,3组患者均治疗2周。观察比较3组患者临床疗效、安全性以及治疗前后中医证候积分、眩晕症状评分(Evaluation scale for cervical vertigo,ESCV评分)、颈椎功能评分[颈椎功能障碍指数(Neck disability index,NDI)及日本骨科协会(Japanese orthopaedic association scores,JOA)]、椎-基底动脉血流动力学[平均血流速度(Velocitymean,Vm)、收缩期峰值血流速度(Velocity systolic,Vs)、舒张期末血流速度(Vend of diastolic velocity,Vd)、阻力指数(Resistance index,RI)、搏动指数(Pulsation index,PI)值]。结果治疗后联合组临床总有效率96.67%(29/30)高于腹摩组70.00%(21/30)与扳法组80.00%(24/30),差异有统计学意义(P0.05)。结论腹部摩法结合颈椎旋转定位扳法治疗椎动脉型颈椎病痰湿阻络证安全、有效,有利于改善颈椎功能,调节椎-基底动脉血流动力学,进而缓解眩晕症状。

关键词：椎动脉型颈椎病痰湿阻络证腹部摩法颈椎旋转定位扳法血流动力学

Curcumin Interferes with TGF-β1-Induced Fibrosis in NRK-49F Cells by Reversing ADAMTS18 Gene Methylation

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Chinese Journal of Integrative Medicine 2024年第7期30卷 600-607页

作者： XU ben ZHANG jia-en YE Lin YUAN Chang-wei Department of Urology Peking University First Hospital and Institute of UrologyPeking UniversityNational Urological Cancer CenterBeijing100034China

Objective To explore the molecular mechanism by which curcumin affects renal interstitial fibrosis(RIF)progression by regulating ADAM metallopeptidase with thrombospondin type 1 motif 18(ADAMTS18)*** NRK-49F cells RIF model were induced with transforming growth factorβ1(TGF-β1).Effects of different concentrations of curcumin(0,10,20,and 30μmol/L)on cell proliferation,cell cycle,cell apoptosis as well as cyclin D1 expression were analyzed by cell counting kit-8,flow cytometry and Western blot,***18 methylation levels were determined by methylation-specific polymerase chain ***18,fibronectin(FN),type I collagen(Col-I)and alpha-smooth muscle actin(α-SMA)mRNA and protein expressions were analyzed by real-time PCR(RT-PCR)and Western blot,***,cells were treated with 50 mmol/L 5-aza-2′-deoxycytidine(5-aza-dC,demethylation agent)for 72 *** of curcumin on extracellular matrix(ECM)deposition was evaluated by immunochemical staining and Western ***-49F cells were transfected with ADAMTS18 small interfering RNA and grouped into a normal control,ADAMTS18-knock-out(KO),and ADAMTS18-KO+30μmol/L curcumin groups,and whether curcumin can reverse the effect of ADAMTS18 knockdown on RIF was *** Compared with the control group,TGF-β1 significantly inhibited the proliferation of NRK-49F cells,blocked the G1/G0 phase,promoted cell apoptosis and inhibited cyclin D1 expression(P<0.01).Among the different concentrations of curcumin,30μmol/L curcumin significantly reversed these processes(P<0.01).Immunochemical staining and Western blot results showed that curcumin significantly inhibited the deposition of FN,Col-I andα-SMA(P<0.01).Curcumin and 5-zaz-dC had synergistic effects,promoting ADAMTS18 expression,removing ADAMTS18 methylation,and reducing ECM ***18 knockdown promoted ECM accumulation,and curcumin reversed this process(P<0.01).Conclusion TGF-β1-induced fibrosis in NRK-49F ***

关键词： renal fibrosis curcumin Chinese medicine ADAMTS18 methylation modification

Characterizing motion types of G-band bright points in the quiet Sun

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Research in Astronomy and Astrophysics 2015年第4期15卷 569-582页

作者： Yun-Fei Yang Hui-Xue Qu Kai-Fan Ji Song Feng Hui Deng jia-ben Lin Feng Wang Faculty of Information Engineering and Automation / Yunnan Key Laboratory of Computer Technology Application Kunming University of Science and Technology Key Laboratory of Solar Activity National Astronomical ObservatoriesChinese Academy of Sciences Key Laboratory of Modern Astronomy and Astrophysics Nanjing UniversityMinistry of Education Yunnan Observatories Chinese Academy of Sciences

We study the motion of G-band bright points （GBPs） in the quiet Sun to obtain the characteristics of different motion types. A high resolution image sequence taken with the Hinode/Solar Optical Telescope （SOT） is used, and GBPs are automat- ically tracked by segmenting 3D evolutional structures in a space-time cube. After putting the GBPs that do not move during their lifetimes aside, the non-stationary GBPs are categorized into three types based on an index of their motion type. Most GBPs that move in straight or nearly straight lines are categorized as a straight mo- tion type, a few moving in rotary paths into rotary motion, and the others fall into a motion type we called erratic. The mean horizontal velocities are 2.18±0.08 km s-1, 1.63±0.09km s^-1 and 1.33±0.07 km s^-1 for straight, erratic and rotary motion types, respectively. We find that a GBP drifts at a higher and constant velocity during its whole life if it moves in a straight line. However, it has a lower and variational velocity if it moves on a rotary path. The diffusive process is ballistic-, super- and sub-diffusion for straight, erratic and rotary motion types, respectively. The corresponding diffusion index （γ） and coefficients （K） are 2.13±0.09 and 850±37km^2 s^-1, 1.82±0.07 and 331 ±24 km^2 s^-1, and 0.73±0.19 and 13±9 km^2 s^-1. In terms of direction of motion, it is homogeneous and isotropic, and usually persists between neighboring frames, no matter what motion type a GBP is classified as.

关键词： techniques: image processing -- Sun: photosphere -- methods: dataanalysis -- methods: statistical

基于脂质组学的整合素αvβ6对结肠癌细胞的促癌机制研究

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中国现代普通外科进展 2024年第9期27卷 678-683页

作者：梁本甲付仰彬于金涛王军牛军周明良山东第一医科大学附属省立医院胃肠外科山东济南250021 淄博市张店区人民医院普外科山东淄博255020 山东大学齐鲁医院肝胆外科山东济南250012

目的:探讨整合素αvβ6对结肠癌细胞的脂质代谢的影响;确定用于诊断结肠癌的潜在代谢生物标志物。方法:利用基于液相色谱-质谱(LC-MS)的脂质组学分析研究αvβ6对结肠癌细胞系SW480代谢变化的影响。偏最小二乘判别分析模型在αvβ6过表... 详细信息

目的:探讨整合素αvβ6对结肠癌细胞的脂质代谢的影响;确定用于诊断结肠癌的潜在代谢生物标志物。方法:利用基于液相色谱-质谱(LC-MS)的脂质组学分析研究αvβ6对结肠癌细胞系SW480代谢变化的影响。偏最小二乘判别分析模型在αvβ6过表达或低表达的SW480中显示出不同的脂质特征。结果:在αvβ6过表达后,SW480细胞中共有252种脂质呈现出显著的差异,其中138种脂质出现上调、114种脂质出现下调。同时发现,甲基磷胆碱(MePC)、磷脂酰胆碱(PC)、磷酰乙醇胺(PE)和甘油三酯(TG)对αvβ6过表达的癌细胞具有良好的诊断潜力。结论:整合素αvβ6可能通过调节脂质代谢失调的途径,使癌细胞更具侵袭性和转移性。这些结果可能为αvβ6对结肠癌细胞作用的分子机制提供潜在的线索。

关键词：结肠肿瘤整合素 αvβ6 脂质组学脂质代谢

无固相弱凝胶射孔液在渤海油田大位移井完井中的应用

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广东石油化工学院学报 2024年第1期34卷 25-28页

作者：张艺耀李进余建生贾奔乔中山孙帅帅中海石油(中国)有限公司天津分公司天津300459

为了减少渤海油田完井作业过程中完井液的漏失,缩短返排时间,保障渤海油田大斜度、大位移井作业安全,降低压力亏空地层射孔作业卡枪的风险,此文分析了封堵机理及其特点,研发了无固相弱凝胶射孔液体系,并通过室内实验评价其剪切稀释、触... 详细信息

为了减少渤海油田完井作业过程中完井液的漏失,缩短返排时间,保障渤海油田大斜度、大位移井作业安全,降低压力亏空地层射孔作业卡枪的风险,此文分析了封堵机理及其特点,研发了无固相弱凝胶射孔液体系,并通过室内实验评价其剪切稀释、触变、封堵、抗温、抑制和返排等性能。实验表明,该体系既可通过形成弱凝胶封堵射孔产生的射孔孔眼,阻止完井液漏失,减少对地层的污染;同时也可提高压力亏空地层的地层承压能力,能有效悬浮地层出砂,防止射孔枪卡钻,还具有易返排的特性。该体系在渤海油田大斜度、大位移井的成功应用,有效满足了大斜度、大位移井射孔作业的需求。应用表明,该体系能大幅减少亏空地层作业过程中完井液的漏失量,缩短油井的返排时间,储层保护效果明显,具有很强的推广意义。

关键词：无固相弱凝胶射孔液大位移井储层保护完井工程渤海油田

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采购过程风险管理

系统工程理论与实践 2000年第6期20卷 54-58,74页

作者：陈武杨家本清华大学自动化系北京100084

首先分析了企业采购过程中的主要风险因素 ,在此基础上提出了使用 Va R( Value at Risk,风险值 )方法分析其中由价格波动引起的采购风险 ,为进行有效的风险决策提供了量化的决策依据 .并且以石油化工企业为例。

关键词：原料采购风险分析风险管理石油化工企业

Nonvolatile and reconfigurable two-terminal electro-optic duplex memristor based on Ⅲ-nitride semiconductors

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Light(Science & Applications) 2024年第4期13卷 706-716页

作者： Zhiwei Xie Ke jiang Shanli Zhang jianwei ben Mingrui Liu Shunpeng Lv Yang Chen Yuping jia Xiaojuan Sun Dabing Li State Key Laboratory of Luminescence and Applications Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesDongnanhu Road No.3888Changchun 130033China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesYuquan Road No.19100049 BeijingChina

With the fast development of artificial intelligence(AI),Internet of things(IOT),etc,there is an urgent need for the technology that can efficiently recognize,store and process a staggering amount of *** AlScN material has unique advantages including immense remnant polarization,superior temperature stability and good latticematch to other III-nitrides,making it easy to integrate with the existing advanced III-nitrides material and device ***,due to the large band-gap,strong coercive field,and low photo-generated carrier generation and separation efficiency,it is difficult for AlScN itself to accumulate enough photo-generated carriers at the surface/interface to induce polarization inversion,limiting its application in in-memory sensing and *** this work,an electro-optic duplex memristor on a GaN/AlScN hetero-structure based Schottky diode has been *** twoterminal memristor shows good electrical and opto-electrical nonvolatility and *** both electrical and opto-electrical modes,the current on/off ratio can reach the magnitude of 104,and the resistance states can be effectively reset,written and long-termly *** on this device,the“IMP”truth table and the logic“False”can be successfully reproduced,indicating the huge potential of the device in the field of in-memory sensing and computing.

关键词： polarization duplex limiting

DBLiPro:A Database for Lipids and Proteins in Human Lipid Metabolism

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Phenomics 2023年第4期3卷 350-359页

作者： Qian Wu Yuanyuan Huang Xiangya Kong ben jia Xiaoting Lu Yunqin Chen Zechi Huang Yuan‑Yuan Li Wentao Dai NHC Key Laboratory of Reproduction Regulation&Shanghai‑MOST Key Laboratory of Health and Disease Genomics Shanghai Institute for Biomedical and Pharmaceutical Technologies(SIBPT)Fudan UniversityNo.779Old Hu Min RoadShanghai 200237China Beijing Cloudna Technology Co. Ltd.No.53Yanqi StreetBeijing 100101China Shanghai Key Laboratory of Gastric Neoplasms Department of General SurgeryShanghai Institute of Digestive SurgeryRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Engineering Research Center of Pharmaceutical Translation Shanghai 201203China

To help researchers in the field of biology,medicine,chemistry,and materials science to use lipidomic data conveniently,there is an urgent need to develop a platform that provides a systematic knowledgebase of human lipid metabolism and lipidome-centric omics analysis *** is a user-friendly webserver allowing for access to human metabolism-related lipids and proteins knowledge database and an interactive bioinformatics integrative analysis workflow for lipidomics,transcriptomics,and proteomics *** DBLiPro,there are 3109 lipid-associated proteins(LAPs)and 2098 lipid metabolites in the knowledge base section,which were obtained from Uniprot,Kyoto Encyclopedia of Genes and Genomes(KEGG)and were further annotated by information from other public resources in the knowledge base section,such as RaftProt and *** offers a step-by-step interactive analysis workflow for lipidomics,transcriptomics,proteomics,and their integrating multi-omics analysis focusing on the human lipid *** summary,DBLiPro is capable of helping users discover key molecules(lipids and proteins)in human lipid metabolism and investigate lipid–protein functions underlying mechanisms based on their own omics *** DBLiPro is freely available at http://*** ***/home.

关键词： Lipid-associated proteins Lipid Human lipid metabolism Database Omics

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敏捷供需链中供需协作模式的研究

系统工程理论与实践 2000年第3期20卷 28-32页

作者：柴跃廷杨家本清华大学自动化系北京100084

确定实体 (或企业 )之间的供需协作模式是建立敏捷供需链管理系统的基础 .基于实体之间协作的密切程度不同及供需项目特征的差异 ,将订单划分为确定型和预测型两种类型 ,为设计实体之间的供需协作模式奠定了基础 .给出了连续补给型、紧... 详细信息

确定实体 (或企业 )之间的供需协作模式是建立敏捷供需链管理系统的基础 .基于实体之间协作的密切程度不同及供需项目特征的差异 ,将订单划分为确定型和预测型两种类型 ,为设计实体之间的供需协作模式奠定了基础 .给出了连续补给型、紧密协作型、协作型、一般型四种基本供需协作模式的概念。

关键词：敏捷供链订单预测协作模式企业