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Asian Pacific Journal of tropical Biomedicine 2024年第6期14卷 245-252页

作者： ben Ye Ji-Zhe Wang Department of Otorhinolaryngology Second Hospital of Dalian Medical UniversityDalian116000China Department of Otorhinolaryngology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan250000China

Objective:to evaluate the anti-allergic effect of boeravinone B against ovalbumin-induced allergic rhinitis in mice and explore its possible ***:For the induction of allergic rhinitis,mice were intraperitoneally sensitized and intranasally challenged with ovalbumin,as well as orally received various concentrations of boeravinone *** mucosal inflammation,and the levels of nitric oxide,β-hexosaminidase,IFN-γ,Ltc-4,myeloperoxidase,Nrf2,HO-1,GAtA-3,ROR-γ,t-bet,antioxidant parameters,and allergen-specific cytokines were ***:Boeravinone B markedly reduced ovalbumin-induced increase in the number of episodes of nasal sneezing,rubbing,and discharge,as well as the levels of IgE,IgG1,andβ-hexosaminidase(Pt also significantly reduced differential cell count,myeloperoxidase,oxide-nitrosative stress,and the levels of IL-1β,IL-4,IL-5,IL-6,IL-13,IL-17,tumor necrosis factor-α,GAtA-3,and ROR-γwhile enhancing the level of ***:Boeravinone B is a potential therapeutic agent for allergic rhinitis by modulating various inflammatory mediators and immune responses.

关键词： Allergic reaction Boeravinone B Oxidative stress Inflammation Ovalbumin

Design of double negativity elastic metamaterial

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International Journal of Smart and Nano Materials 2015年第1期6卷 61-72页

作者： Y.c.Su c.t.Sun School of Aeronautics and Astronautics Purdue UniversityWest Lafay

A metamaterial model that possesses simultaneously negative effective mass density and negative effective Young’s modulus is proposed in this *** curves and dynamic responses of the model are *** the double negative frequency region,it is demonstrated that the phase velocity is *** addition,it was found that the band gap region of the metamaterial can be predicted accurately by taking parts of single-unit cell to analyze the steady-state *** design is also fabricated by a 3D printer.

关键词： acoustic metamaterial double negativity local resonance negative mass negative modulus

Special topic on aggregation-induced emission

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Science china chemistry 2018年第8期61卷 879-881页

作者： Anjun Qin ben Zhong tang State Key Laboratory of Luminescent Materials and Devices Center for Aggregation-Induced Emission Guangzhou International CampusSouth China University of Technology Department of chemistry Hong Kong Branch of National Engineering Research Center for Tissue Restoration and Reconstruction Institute for Advanced Study and Department of Chemical and Biological Engineering The Hong Kong University of Science & Technology

Aggregation-induced emission（AIE）,conceptually termed in 2001 by our group at the Hong Kong University of Science＆technology,refers to a unique phenomenon that a kind of nonemissive or weakly emissive molecules in ... 详细信息

关键词： AIE In BODIPY Special topic on aggregation-induced emission

Lab-in-cell based on spontaneous amino-yne click polymerization

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Science china chemistry 2019年第9期62卷 1198-1203页

作者： Rong Hu Xu chen taotao Zhou Han Si benzhao He Ryan t. K. Kwok Anjun Qin ben Zhong tang State Key Laboratory of Luminescent Materials and Devices Center for Aggregation-Induced Emission South China University of Technology Guangzhou 510640 China Department of chemistry Hong Kong Branch of Chinese National Engineering Research Centre for Tissue Restoration and Reconstruction Institute for Advanced Study Department of Chemical and Biological Engineering The Hong Kong University of Science & Technology Hong Kong China

Unnatural reaction in the living cells is a powerful tool for biological research. However, the polymerization inside cells is rarely reported. In this work, a lab-in-cell is illustrated based on our developed spontaneous amino-yne click polymerization. carbonyl group activated terminal diyne can spontaneously polymerize with tetraphenylethene(tPE)-containing primary diamine inside cells, and polymer with weight-average molecular weight of 7,300 was yielded. By utilizing this in vivo amino-yne click polymerization and taking advantage of the aggregation-induced emission feature of tPE, a "turn-on" cell imaging was realized,and in-situ killing of cells was also acquired by destroying the structures of actin and tubulin, which cannot be realized by preprepared polymer. this strategy provides a useful platform and holds great promise in biochemistry and therapy applications.

关键词： lab in cell intracellular polymerization aggregation-induced emission cell imaging

Epo/EpoR signaling in osteoprogenitor cells is essential for bone homeostasis and Epo-induced bone loss

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Bone Research 2021年第4期9卷 549-556页

作者： Martina Rauner Marta Murray Sylvia thiele Deepika Watts Drorit Neumann Yankel Gabet Lorenz c.Hofbauer ben Wielockx Department of Medicine III&center for Healthy Aging Technische Universitat DresdenDresdenGermany lnstitute for clinical chemistry and Laboratory Medicine Technische Universitat DresdenDresdenGermany Department of cell and Developmental Biology Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Department of Anatomy&Anthropology Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael

High erythropoietin(Epo)levels are detrimental to bone health in adult *** mice receiving high doses of Epo lose bone mass due to suppressed bone formation and increased bone *** humans,high serum Epo levels are linked to fractures in elderly *** earlier studies indicated that Epo modulates osteoblast activity;however,direct evidence that Epo acts via its receptor(EpoR)on osteoblasts in vivo is still ***,we created mice lacking EpoR in osteoprogenitor cells to specifically address this *** of EpoR in osteoprogenitors(EpoR:Osx-cre,cKO)starting at 5 weeks of age did not alter red blood cell parameters but increased vertebral bone volume by 25%in 12-week-old female *** was associated with low bone ***(osteoblast number,bone formation rate)and serum(P1NP,osteocalcin)bone formation parameters were all reduced,as were the number of osteoclasts and tRAP serum *** of osteoblast precursors isolated from cKO versus control mice resulted in lower expression of osteoblast marker genes including Runx2,Alp,and col1a1 on day 21,whereas the mineralization capacity was ***,the RANKL70PG ratio,which determines the osteoclast-supporting potential of osteoblasts,was substantially decreased by 50%.Similarly,coculturing cKO osteoblasts with control or cKO osteoclast precursors produced significantly fewer osteoclasts than coculture with control ***,exposing female mice to Epo pumps(10 U-d_1)for 4 weeks resulted in trabecular bone loss(-25%)and increased osteoclast numbers(1.7-fold)in control mice only,not in cKO *** data show that EpoR in osteoprogenitors is essential in regulating osteoblast function and osteoblast-mediated osteoclastogenesis via the RANKI70PG ***,osteogenic Epo/EpoR signaling controls bone mass maintenance and contributes to Epo-induced bone loss.

关键词： progenitor homeostasis doses

On Douglas General(α,β)-metrics

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Acta Mathematica Sinica,English Series 2017年第7期33卷 951-968页

作者： Xiao Ming WANG ben Ling LI Department of Mathematics Ningbo UniversityNingbo 315211P.R.China

Douglas metrics are metrics with vanishing Douglas curvature which is an important projective invariant in Finsler geometry. to find more Douglas metrics, in this paper we consider a class of Finsler metrics called general （α, β）-metrics, which are defined by a Riemannian metric and a . We obtain the differential equations that characterizes these metrics with vanishing Douglas curvature. By solving the equivalent PDEs, the metrics in this class are totally determined. then many new Douglas metrics are constructed.

关键词： Finsler metric general (α β)-metrics Douglas metric Douglas curvature

comparison of Flux-Switching Machines With and Without Permanent Magnets

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chinese Journal of Electrical Engineering 2015年第1期1卷 78-84页

作者： christopher H.t.Lee K.t.chau c.c.chan Department of Electrical and Electronic Engineering The University of Hong KongHong KongChina

In this paper,three advanced flux-switching(FS)machines,namely the radial-field flux-switching permanent-magnet(RF-FSPM)machine,the radial-field flux-switching Dc-field(RF-FSDc)machine,and the axial-field FSDc(AF-FSDc)machine are quantitatively *** the installation of the high-energy-density PM materials,the RF-FSPM machine can definitely provide the superior torque performances as compared to its magnetless ***,the PM machines suffer from two major fundamental problems,namely the high material costs,and the uncontrollable flux *** utilizing the concept of axial-field structure,the AF-FSDc machine can offer comparable torque performance as the RF-FSPM ***,with the consideration of the cost-effectiveness and the control flexibility,the magnetless AF-FSDc machine has exhibited promising potential in various applications.

关键词： Flux-switching magnetless radial-field axial-field cost-effectiveness

three-space Problems for the Bounded compact Approximation Property

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Acta Mathematica Sinica,English Series 2013年第4期29卷 625-632页

作者： Dong Yang cHEN ben tuo ZHENG School of Mathematical Sciences Xiamen University Department of Mathematical Sciences The University of Memphis

In this paper, the notion of the bounded compact approximation property （BcAP） of a pair [Banach space and its subspace] is used to prove that if X is a closed subspace of Eoo with the BcAP, then L∞/X has the BcAP. We also show that X＊ has the A-BcAP with conjugate operators if and only if the pair （X, Y） has the A-BcAP for each finite codimensional subspace Y c X. Let M be a closed subspace of X such that M~ is complemented in X＊. If X has the （bounded） approximation property of order p, then M has the （bounded） approximation property of order p.

关键词： the bounded compact approximation property a pair the (bounded) approximationproperty of order p

Multivariate adaptive regression splines and neural network models for prediction of pile drivability

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Geoscience Frontiers 2016年第1期7卷 45-52页

作者： Wengang Zhang Anthony t.c.Goh School of civil and Environmental Engineering Nanyang Technological UniversitySingapore 639798Singapore

Piles are long, slender structural elements used to transfer the loads from the superstructure through weak strata onto stiffer soils or rocks. For driven piles, the impact of the piling hammer induces compression and tension stresses in the piles. Hence, an important design consideration is to check that the strength of the pile is sufficient to resist the stresses caused by the impact of the pile hammer. Due to its complexity, pile drivability lacks a precise analytical solution with regard to the phenomena *** situations where measured data or numerical hypothetical results are available, neural networks stand out in mapping the nonlinear interactions and relationships between the system’s predictors and dependent responses. In addition, unlike most computational tools, no mathematical relationship assumption between the dependent and independent variables has to be made. Nevertheless, neural networks have been criticized for their long trial-and-error training process since the optimal configuration is not known a priori. this paper investigates the use of a fairly simple nonparametric regression algorithm known as multivariate adaptive regression splines（MARS）, as an alternative to neural networks, to approximate the relationship between the inputs and dependent response, and to mathematically interpret the relationship between the various parameters. In this paper, the Back propagation neural network（BPNN） and MARS models are developed for assessing pile drivability in relation to the prediction of the Maximum compressive stresses（McS）, Maximum tensile stresses（MtS）, and Blow per foot（BPF）. A database of more than four thousand piles is utilized for model development and comparative performance between BPNN and MARS predictions.

关键词： Back propagation neural network Multivariate adaptive regression splines Pile drivability computational efficiency Nonlinearity

Light-triggered catalytic Performance Enhancement Using Magnetic Nanomotor Ensembles

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Research 2020年第1期2020卷 986-996页

作者： Fengtong Ji ben Wang Li Zhang Department of Mechanical and Automation Engineering The Chinese University of Hong KongShatin N.T.Hong KongChina chow Yuk Ho technology centre for Innovative Medicine The Chinese University of Hong KongShatin N.T.Hong KongChina

Micro/nanomachines have attracted extensive attention in the biomedical and environmental fields for realizing functionalities at small ***,they have been rarely investigated as active *** nanocatalysts have exceptional reusability and recyclability,and integration with magnetic materials enables their recovery with minimum ***,we propose a model active nanocatalyst using magnetic nanomotor ensembles(MNEs)that can degrade contaminants in an aqueous solution with high catalytic *** composed of a magnetite core coated with gold nanoparticles as the nanocatalyst can rotate under the action of a programmable external field and carry out rapid reduction of 4-nitrophenol(4-NP).the hydrogen bubbles generated in the catalytic reaction provide random perturbations for the MNEs to travel in the reaction solution,resulting in uniform *** reduction can be further boosted by irradiation with near-infrared(NIR)*** field induces the rotation of the MNEs and provides microstirring in the *** enhances the catalytic activity via the photothermal *** MNEs are also capable of moving to the targeted region through the application of a programmable magnetic field and then process the contaminant in the targeted *** expect that such magnetic MNEs may help better in applying active heterogeneous nanocatalysts with magnetic field and light-enhanced performance in industrial applications due to their advantages of low material cost and short reaction time.

关键词： effect catalyst stirring