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Communications in Theoretical Physics 2020年第11期72卷 65-73页

作者： Xiao-Bing Zhang Fu-Ping Peng Yun-ben wu Yi Zhang School of Physics Nankai UniversityTianjin 300071China Department of Physics Shanghai Normal UniversityShanghai 200230China

In this paper,we study the influences of magnetic fields on the coexistence of diquark and chiral condensates in an extended Nambu-Jona-Lasinio model with QCD axial anomaly,as it relates to color-flavor-locked quark *** to the coupling of rotated-charged quarks to magneticfields,diquark condensates become split,and the coexistence region is thus superseded in favor of a specific diquark Bose-Einstein condensation(BEC),denoted as the *** strong magnetic fields,we find that the BECItransition is pushed to larger quark chemical *** effect of magnetic catalysis tends to disrupt the BEC-BCS(Bardeen-Cooper-Schrieffer)crossover predicted in previous *** intermediate fields,the effect of inverse magnetic catalysis is observed,and the axial-anomaly-induced phase structure is essentially unchanged.

关键词： Nambu-Jona-Lasinio model diquark Bose-Einstein condensation magnetic catalysis inverse magnetic catalysis axial-anomaly coexistence of diquark and chiral condensates magnetic field

Association patterns reveal dispersalaggregation dynamics among cattle in a South Texas Rangeland,USA

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Ecological Processes 2018年第1期7卷 323-332页

作者： Christopher Cheleuitte-Nieves Humberto L.Perotto-Baldivieso X.ben wu Susan M.Cooper Department of Ecosystem Science and Management Texas A&M University2120 TAMU320 WFES BuildingCollege StationTX 77843-2138USA Present Address:Center of Comparative Medicine and Pathology Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center1300 York Ave.E-703ENew YorkNY 10065USA Caesar Kleberg Wildlife Research Institute Texas A&M University-Kingsville700 University Blvd.MSC 218KingsvilleTX 78363USA Texas A&M AgriLife Research 1619 Garner Field RoadUvaldeTX 78801USA

Introduction:The spatial association dynamics of free-ranging cattle herds are not fully understood;however,they can have a direct influence on the spatial patterns of resource *** aim of our study was to examine new analytical methods of identifying the spatio-temporal patterns of behavioral dynamics that determine cattle herd dispersal in the semi-arid rangelands of South *** fitted 10 free-ranging cows with global positioning system collars and obtained positions every 5 min for each animal for 21-day trials,twice during the summer and winter *** used an association pattern recognition software(ASSOC1)and the herd center of gravity to identify the spatial and temporal thresholds that defined dispersion-aggregation patterns and individual position to determine their relation to social ***:The association pattern defining herd membership was that animals spent 70%of their time within 200 m of each *** ranking did not appear to influence association membership or position within the *** cattle showed a more dispersed distribution during summer,but in winter,herd members behaved in a more aggregated *** distribution is contrary to patterns described in more northerly and mountainous ***:The spatial thresholds of the cattle herd and the overall distance of all members to the center of the herd were smaller during winter and larger during summer,indicating that this study herd congregated during the winter and dispersed during the *** this study uses a herd of 10 individuals in a 100 ha pasture to evaluate spatio-temporal dynamics,our results provide evidence of the ability of current tracking and spatial association tools to detect and quantify seasonal changes in cattle herd dispersion-aggregation *** use of these data collection and analysis methods could prove useful in larger cattle herds,increase our understanding of herd spatiotemporal behavior,and subsequently he

关键词： Bos taurus Global positioning system(GPS) GPS collar Herd dispersal Social dominance Sub-herd Spatiotemporal pattern of resource use

Oxymatrine liposome attenuates hepatic fibrosis via targeting hepatic stellate cells

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World Journal of Gastroenterology 2012年第31期18卷 4199-4206页

作者： Ning-Li Chai Qiang Fu Hui Shi Chang-Hao Cai Jun Wan Shi-Ping Xu ben-Yan wu Department of Gastroenterology South Build-ing of Chinese People's Liberation Army General Hospital Bei-jing 100853 China Department of Gastroenterology Xi'an Children'sHospital Xi'an 710002 Shaanxi Province China

AIM： To investigate the potential mechanism of Arg- Gly-Asp （RGD） peptide-labeled liposome loading oxy- matrine （OM） therapy in CCI4-induced hepatic fibrosis in rats. METHODS： We constructed a rat model of CCh- induced hepatic fibrosis and treated the rats with dif- ferent formulations of OM. To evaluate the antifibrotic effect of OM, we detected levels of alkaline phospha- tase, hepatic histopathology （hematoxylin and eosin stain and Masson staining） and fibrosis-related gene expression of matrix metallopeptidase （MMP）-2, tis- sue inhibitor of metalloproteinase （TIMP）-I as well as type I procollagen via quantitative real-time poly- merase chain reaction. To detect cell viability and apop- tosis of hepatic stellate cells （HSCs）, we performed 3-（4,5）-dimethylthiahiazo（-z-yl）-3,5-diphenytetrazoli- umromide assay and flow cytometry. To reinforce the combination of oxymatrine with HSCs, we constructed fluorescein-isothiocyanate-conjugated Arg-Gly-Asp peptide-labeled liposomes loading OM, and its targeting of HSCs was examined by fluorescent microscopy. RESULTS： OM attenuated CCh-induced hepatic fibro- sis, as defined by reducing serum alkaline phosphatase （344.47± 27.52 U/L vs 550.69 ± 43.78 U/L, P 〈 0.05）, attenuating liver injury and improving collagen deposits （2.36% ± 0.09% vs 7.70% ±0.60%, P 〈 0.05） and downregulating fibrosis-related gene expression, that is, MMP-2, TIMP-1 and type I procollagen （P 〈 0.05）. OM inhibited cell viability and induced apoptosis of HSCs in vitro. RGD promoted OM targeting of HSCs and en- hanced the therapeutic effect of OM in terms of serum alkaline phosphatase （272.51 ± 19.55 U/L vs 344.47 ± 27.52 U/L, P 〈 0.05）, liver injury, collagen deposits （0.26%± 0.09% vs 2.36% ± 0.09%, P 〈 0.05） and downregulating fibrosis-related gene expression, that is, MMP-2, TIMP-1 and type I procollagen （P 〈 0.05）. Moreover, in vitro assay demonstrated that RGD en- hanced the effect of OM on HSC viability and apoptosis. CONCLUSION： OM attenuated hepatic fi

关键词： Oxymatrine Arg-Gly-Asp peptide Hepaticstellate cell Hepatic fibrosis Target therapy

Magnifying endoscopy in upper gastroenterology for assessing lesions before completing endoscopic removal

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World Journal of Gastroenterology 2012年第12期18卷 1295-1307页

作者： Ning-Li Chai En-Qiang Ling-Hu Yoshinori Morita Daisuke Obata Takashi Toyonaqa Takeshi Azuma ben-Yan wu Department of Gastroenterology Division of South Building Chinese People's Liberation ArmyGeneral Hospital Beijing 100853 China Department of Gastroenterology ChinesePeople's Liberation Army General Hospital Beijing 100853China TakeshiAzuma Department of gastroenterology and endoscopy KobeUniversity Graduate School of Medicine Kobe 650-0017 Japan

Any prognosis of gastrointestinal (GI) cancer is closely related to the stage of the disease at *** submucosal dissection (ESD) and en bloc endoscopic mucosal resection (EMR) have been performed as curative treatments for many early-stage GI lesions in recent *** technologies have been widely accepted in many Asian countries because they are minimally invasive and supply thorough histopathologic evaluation of the ***,before engaging in endoscopic therapy,an accurate diagnosis is a precondition to effecting the complete cure of the underlying malignancy or carcinoma in *** the past few years,many new types of endoscopic techniques,including magnifying endoscopy with narrow-band imaging (MENBI),have emerged in many countries because these methods provide a strong indication of early lesions and are very useful in determining treatment options before ESD or ***,to date,there is no comparable classification equivalent to "Kudo's Pit Pattern Classification in the colon",for the upper GI,there is still no clear internationally accepted classification system of magnifying ***,in order to help unify some viewpoints,here we will review the defining optical imaging characteristics and the current representative classifications of microvascular and microsurface patterns in the upper GI tract under ME-NBI,describe the accurate relationship between them and the pathological diagnosis,and their clinical applications prior to ESD or en bloc *** will also discuss assessing the differentiation and depth of invasion,defying the lateral spread of involvement and targeting biopsy in real time.

关键词： Magnifying endoscopy with narrow-band im-aging Upper gastroenterology Assessment Endoscopicsubmucosal dissection Endoscopic mucosal resection

LINE-1 family member GCRG123 gene is up-regulated in human gastric signet-ring cell carcinoma

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World Journal of Gastroenterology 2008年第5期14卷 758-763页

作者： Gang-Shi Wang Meng-Wei Wang ben-Yan wu Xin-Yan Yang Wei-Hua Wang Wei-Di You Department of Gerontal Gastroenterology General Hospital of Chinese PLA Beijing 100853 China

AIM： To analyze the expression profiles of a human gastriccancer-related gene, GCRG123, in human gastric signetring cell carcinoma tissues, and to perform bioinformatics analysis on GCRG123.METHODS： In situ hybridization was used to explore the GCRG123 expression pattern in paraffin-embedded gastric tissues, including 15 cases of signet-ring cell carcinoma, 15 of intestinal-type adenocarcinoma, and 15 of normal gastric mucosa. Northern blotting was used to analyze the differences in GCRG123 expression between stomach signet-ring cell carcinoma and intestinal-type adenocarcinoma tissues. Online software, including BLAST, Multalin and BLAT, were applied for bioinformatics analysis. National Center for Biotechnology Information （NCBI） and the University of California Santa Cruz （UCSC） databases were used for the analyses.RESULTS： The in situ hybridization signal appeared as blue precipitates restricted to the cytoplasm. Ten out of 15 cases of gastric signet ring cell carcinoma, normal gastric mucosal epithelium and pyloric glands showed high GCRG123 expression. Low GCRG123 expression was observed in gastric intestinal-type adenocarcinoma and normal gastric glands. Northern blotting revealed that GCRG123 was up-regulated in signet-ring cell carcinoma tissue but down-regulated in intestinal-type adenocarcinoma tissue. BLAST and Multalin analyses revealed that the GCRG123 sequence had 92% similarity with the ORF2 sequence of human long interspersed nuclear element retrotransposons （LINE-1, L1）. BLAT analysis indicated that GCRG123 mapped to all chromosomes. GCRG123 was found to integrate in the intron-17 and -23 of Rb, 5＇ flanking region of IL-2 and clotting factor Ⅸ genes.CONCLUSION： GCRG123, an active member of the Lt family, was up-regulated in human gastric signet-ring cell carcinoma.

关键词： Stomach Signet-ring cell carcinoma GCRG123 LINE-1 In situ hybridization Bioinformatics

Classification,clinicopathologic features and treatment of gastric neuroendocrine tumors

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World Journal of Gastroenterology 2014年第1期20卷 118-125页

作者： Ting-Ting Li Feng Qiu Zhi Rong Qian Jun Wan Xiao-Kun Qi ben-Yan wu Department of Geriatric Gastroenterology Chinese People’s Liberation Army General Hospital Department of Neurology Chinese Navy General Hospital Department of Medical Oncology Dana-Farber Cancer InstituteBostonMA 02215United States

Gastric neuroendocrine tumors (GNETs) are rare lesions characterized by hypergastrinemia that arise from enterochromaffin-like cells of the stomach. GNETs consist of a heterogeneous group of neoplasms comprising tumor types of varying pathogenesis, histomorphologic characteristics, and biological behavior. A classification system has been proposed that distinguishes four types of GNETs; the clinicopathological features of the tumor, its prognosis, and the patient’s survival strictly depend on this classification. Thus, correct management of patients with GNETs can only be proposed when the tumor has been classified by an accurate pathological and clinical evaluation of the patient. Recently developed cancer therapies such as inhibition of angiogenesis or molecular targeting of growth factor receptors have been used to treat GNETs, but the only definitive therapy is the complete resection of the tumor. Here we review the literature on GNETs, and summarize the classification, clinicopathological features (especially prognosis), clinical presentations and current practice of management of GNETs. We also present the latest findings on new gene markers for GNETs, and discuss the effective drugs developed for the diagnosis, prognosis and treatment of GNETs.

关键词： Gastric neuroendocrine tumor Classification Clinicopathological significance Diagnosis Prognosis Treatment

Protective effect of bone marrow mesenchymal stem cells in intestinal barrier permeability after heterotopic intestinal transplantation

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World Journal of Gastroenterology 2014年第23期20卷 7442-7451页

作者： Wen Zhang Zhong-Yang Shen Hong-Li Song Yang Yang ben-Juan wu Nan-Nan Fu Tao Liu Department of Organ Transplantation Tianjin First Central Hospital Key Laboratory of Emergency Care Medicine of Ministry of Health Tianjin First Central Hospital

AIM: To explore the protective effect of bone marrow mesenchymal stem cells (BM MSCs) in the small intestinal mucosal barrier following heterotopic intestinal transplantation (HIT) in a rat model.

关键词： Bone marrow mesenchymal stem cells Small intestinal transplantation Intestinal mucosal barrier Occludin Zona occludens-1

Metastatic infection caused by hypervirulent Klebsiella pneumonia and co-infection with Cryptococcus meningitis: A case report

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World Journal of Clinical Cases 2019年第22期7卷 3812-3820页

作者： Yun-Feng Shi Yu-Kai Wang Yan-Hong Wang Hui Liu Xiao-Han Shi Xiao-Jie Li ben-Quan wu Medical Intensive Care Unit Department of Respiratory and Critical Care MedicineThird Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630Guangdong ProvinceChina Institute of Respiratory Diseases Sun Yat-Sen UniversityGuangzhou 510630Guangdong ProvinceChina Department of Laboratory Medicine Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630Guangdong ProvinceChina

BACKGROUND Klebsiella pneumoniae(***)used to affect mainly people with compromised immunity or weakened by other infections,but recent emergence of hypervirulent strains has increased infections even in healthy *** infections include liver abscess,pneumonia,bacteremia,meningitis,necrotizing fasciitis,and *** metastatic infection by hypervirulent ***(hvKP)is increasingly recognized,co-infection with Cryptococcus neoformans(***)meningitis in immunocompetent hosts is rare but ***,it is necessary to determine the risk factors,complications,and comorbidity of this *** SUMMARY This report describes a 58-year-old man with hvKP pulmonary abscess,bacteremia,and meningitis,accompanied by fatal Cryptococcus *** patient presented with fever for 1 wk and drowsiness for 3 *** findings revealed pulmonary abscess and bacteremia of *** was given intravenous antibiotic therapy,and the infection was under control for about 1 ***,his condition deteriorated rapidly because of metastatic purulent *** hvKP and *** were isolated and confirmed,the patient died of spontaneous respiratory and cardiac arrest caused by cerebral *** HvKP has emerged as a cause of metastatic infections in immunocompetent *** co-infections should be taken into consideration when metastatic infection is present.

关键词： Hypervirulent Klebsiella pneumoniae Metastatic infection Cryptococcusneoformans meningitis Comorbidity Case report

Formation of a three-dimensional bispyridyl based metal-organic architecture containing unique Ag...Ag （d^10-d^10） interactions

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Chinese Chemical Letters 2008年第5期19卷 604-606页

作者： Xiao Ling Guo Yun Yin Niu Qing Li Wang ben Lai wu Hong Yun Zhang Hong Wei Hou Yi Han Ling Fang Wang Department of Chemistry Zhengzhou University Henan 450052 China

A novel co-ordination polymer based on IB metal thiocyanates, [Ag2（NCS）2（4,4＇-bipy）]. （1）（4,4＇-bipy = 4,4＇-bispyridine）, has been synthesized by the pre-assembly method and characterized by X-ray crystallography. The complex exists as a three- dimensional network consisting of （AgSCN）. undulating layers linked by 4,4＇-bipy bridges.

关键词： d^10-d^10 interaction Metal thiocyanates Crystal structure Supramolecular structure Molecular structure

A novel gene,GCRG224,is differentially expressed in human gastric mucosa

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World Journal of Gastroenterology 2003年第1期9卷 30-34页

作者： Gang-Shi Wang Meng-Wei Wang ben-Yan wu Wei-Di You Xin-Yan Yang Department of Gastroenterology,General Hospital of Chinese PLA,Beijing 100853,China Department of Gastroenterology General Hospital of Chinese PLA Beijing 100853 China. wanggangshi@***

AIM: To clone genes that may predispose us to humangastric cancer and to analyze it's expression in gastric ***: Specimens of paired tumor, paratumor andnormal gastric mucosa tissues collected from fifteen patientswho suffered from stomach antrum adenocarcinoma wereused for analysis. Seven out of the fifteen cases were firststudied by fluorescent differential display reversetranscription polymerase chain reaction (DDTR-PCR) *** differentially expressed bands of interest were cloned,analyzed by Northern blot, sequencing and RT-PCR. ThroughBLAST, the sequencing results were compared with GenBankdatabase for homology analysis. In situ hybridization withDIG-labeled cRNA probes was used to analyze the expressionof interesting cDNA bands in paraffin embedded pairednormal gastric mucosa and cancer tissues isolated from 30gastric adenocarcinoma ***: DDRT-PCR showed that one of the interestingcDNA bands, which was named W2, expressed much higherin all seven tested tumor and paratumor samples than intheir normal counterparts, it was sub-cloned into a pGEM-TEasy vector. Two subclones were subsequently *** of the subclone, GCRG224, was studied further. Thesequencing result showed that GCRG224 consisted of 1 159base pairs and had one open reading frame (ORF). It locatedat human chromosome 11q14. No homologue was found inGenBank database with GCRG224-ORF. This nucleotidesequence data were submitted to GenBank with accessionNo. AF438406. RT-PCR showed that GCRG224 expressedhigher in 11/15 gastric cancer tissues than in non-tumortissues. However, the result of Northern blot analysis showeda higher GCRG224 expression in the non-tumor tissue thanin the tumor one. Human multiple tissue Northern blot analysisrevealed that GCRG224 also expressed in human normal colontissue, and peripheral blood leukocyte. In situ hybridizationanalysis showed that only 5/30 adenocarcinoma, 3/18dysplasia and 6/18 intestinal metaplasia showed higherGCRG224 express

关键词： GCRG224基因胃癌胃粘膜聚合酶链反应克隆肿瘤病理学