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Experimen.al design.of paraffin.methylated melamin.-formaldehyde microen.apsulated composite phase chan.e material an. the application.in.battery thermal man.gemen. system

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Journ.l of Materials Scien.e & Techn.logy 2024年第2期169卷 124-136页

作者： Que Huan. Silon. Wan. Jichun.He Den.ji Xu Safaa n.bdou Mohamed MIbrahim Shiqi Sun.Yan.un.Chen.Han.on. Li ben Bin.Xu Chan.chen. Liu Zein.om M.El-Bahy Zhan.u Guo School of En.iron.en. an. Safety En.in.erin. North University of ChinaTaiyuan 030051China In.titute of Advan.ed En.rgy Materials an. Systems North University of ChinaTaiyuan 030051China School of Resources an. Safety En.in.erin. Central South UniversityChangsha 410010China School of Medical an. BioIn.ormation.En.in.erin. Northeastern UniversityShenyang 110819China Departmen. of Chemistry Khurmah University CollegeTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia Departmen. of Chemistry College of ScienceTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia Mechan.cal an. Con.truction.En.in.erin. Faculty of Engineering and EnvironmentNorthumbria UniversityNewcastle Upon Tyne NE18STUK College of Materials Scien.e an. En.in.erin. Taiyuan University of Science and TechnologyTaiyuan 030024China Departmen. of Chemistry Faculty of ScienceAl-Azhar UniversityNasr City 11884CairoEgypt

In.order to main.ain.the optimal operatin. temperature of the battery surface an. meet the deman. for thermal storage techn.logy,battery thermal man.gemen. system based on.phase chan.e materials has attracted in.reasin. *** this work,a kin. of core-shell structured microcapsule was syn.hesized by an.in.situ polymerization.where paraffin.was used as the core,while methan.l was applied to mod-ify the melamin.-formaldehyde shell to reduce toxicity an. improve thermal ***,three differen. types of heat con.uctive fillers with the same con.en. of 10 wt.%,i.e.,n.n.-Al_(2)O_(3),n.n.-Zn. an. carbon.n.n.tubes were added,gen.ratin. *** microcapsules were un.form,an. were n.t affected by the thermal fillers,which were even.y dispersed *** composite sample with carbon.n.n.tubes(10 wt.%)showed the highest thermal con.uctivity of 0.50 W/(m K)an. laten. heat of 139.64 J/***,accordin. to the leakage testin. an. battery charge/discharge experimen.s,compared with Al_(2)O_(3)an. Zn.,the addition.of carbon.n.n.tubes remarkably en.an.es the heat storage ability as laten. heat from 126.98 J/g for the prepared sample with Al_(2)O_(3)an. 125.86 J/g for the on. with Zn.,then.to 139.64 J/g,as well as dissipation.performan.e as a coolin. effect by decreasin. the sur-face temperature of battery from 2%to 12%of microcapsule,composite sample with carbon.n.n.tubes presen.s a broad application.prospect in.battery thermal man.gemen. system an. en.rgy storage field.

关键词： Microcapsule Phase chan.e material Battery Carbon.n.n.tube Safety

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Stron. metal–support in.eraction.boosts the electrocatalytic hydrogen.evolution.capability of Ru n.n.particles supported on.titan.um n.tride

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Carbon.En.rgy 2024年第1期6卷 245-254页

作者： Xin.Wan. Xiaoli Yan. Guan.xian.Pei Jifa Yan. Jun.he Liu Fen.wan. Zhao Fayi Jin.Wei Jian. Haoxi ben Lixue Zhan. College of Chemistry an. Chemical En.in.erin. Collaborative Innovation Center for Hydrogen Energy Key Materials and Technologies of Shandong ProvinceQingdao UniversityQingdaoShandongChina State Key Laboratory of Bio-fibers an. Eco-Textiles Qingdao UniversityQingdaoShandongChina Qin.dao In.titute of Bioen.rgy an. Bioprocess Techn.logy Chinese Academy of ScienceQingdaoShandongChina

Ruthen.um(Ru)has been.regarded as on. of the most promisin. altern.tives to substitute Pt for catalyzin. alkalin. hydrogen.evolution.reaction.HER),owin. to its in.eren. high activity an. bein. the cheapest platin.m-group ***,based on.the idea of stron. metal–support in.eraction.SMSI)regulation.Ru/Tin.catalysts with differen. degrees of Tin.overlayer over Ru n.n.particles were fabricated,which were applied to the alkalin. electrolytic *** reveal that the Tin.overlayer would gradually en.apsulate the Ru n.n.particles an. in.uce more electron.tran.fer from Ru n.n.particles to Tin.support by the Ru–n.Ti bon. as the SMSI degree *** study shows that the exposed Ru–Tin.in.erfaces greatly promote the H_(2) desorption.***,the Ru/Tin.300 with a moderate SMSI degree exhibits excellen. HER performan.e,with an.overpoten.ial of 38 mV at 10 mA cm^(−2).Also,due to the en.apsulation.role of Tin.overlayer on.Ru n.n.particles,it displays super lon.-term stability with a very slight poten.ial chan.e after 24 *** study provides a deep in.ight in.o the in.luen.e of the SMSI effect between.Ru an. Tin.on.HER an. offers a n.vel approach for preparin. efficien. an. stable HER electrocatalysts through SMSI en.in.erin..

关键词： electron.c structure hydrogen.evolution.reaction ruthen.um stron. metal-support in.eraction titan.um n.tride

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First-prin.iples calculation. to in.estigate structural,electron.c,magn.tic,optical an. thermodyn.mic properties of RE_(2)Rh_(3)Ge(RE=Pr,Sm)

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Journ.l of Rare Earths 2024年第7期42卷 1385-1393,I0007页

作者： A.Ezaier R.Masrour M.Hamedoun.J.Kharbach A.Rezzouk A.Hourmatallah n.benzakour K.Bouslykhan. Laboratory of Solid Physics Faculty of Sciences Dhar El MehrazSidi Mohamed Ben Abdellah UniversityBP 1796FezMorocco Equipe de Physique du Solide LaboratoiresLIPIEcole Normale SupérieureBensoudaFèsMorocco

In.this paper,we an.lyzed the physical characteristics of the tern.ry alloys RE_(2)Rh_(3)Ge(RE=Pr an. Sm)usin. the first prin.iples calculation.based on.fun.tion.l den.ity theory in.egrated in.the Wien.k *** calculated formation.en.rgies of Pr_(2)Rh_(3)Ge an. Sm_(2)Rh_(3)Ge are−5.3827 an.−5.2782 eV/atom,respectively,showin. that these alloys may exist *** results of the ban. structure an. den.ity of states in.icate that all of the compoun.s tested are magn.tic metals,an. their magn.tism is mostly related to the con.ribution.of Pr an. Sm *** total magn.tic momen.s of Pr_(2)Rh_(3)Ge an. Sm_(2)Rh_(3)Ge are 4.07245 an. 11.16161μB/f.u,*** parameters such as heat capacity at con.tan. pressure,en.ropy,Debye temperature,lattice volume,compressibility coefficien.s,an. Grün.isen.parameter alloys were calculated usin. the Gibbs algorithm an. studied in.depth over a large temperature ran.e of 0-900 *** Debye temperature in.reases with in.reasin. pressure an. decreases with decreasin. ***,the Debye temperatures calculated at p=0 GPa an. T=300 K are equal to be 342 an. 322 K for Pr_(2)Rh_(3)Ge an. Sm_(2)Rh_(3)Ge,*** optical characteristics such as the real an. imagin.ry portion. of the dielectric fun.tion.the absorption.coefficien.,the en.rgy-loss fun.tion.an. the refractive in.ex were in.estigated an. discussed in.more depth.

关键词： Magn.tic metals Fun.tion.l den.ity theory Den.ity of states Magn.tic momen. Optical an. thermodyn.mic properties Rare earths

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n.oadjuvan. n.volumab with or without platin.m-doublet chemotherapy based on.PD-L1 expression.in.resectable n.CLC(CTOn.1804):a multicen.er open.label phase II study

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Sign.l Tran.duction.an. Targeted Therapy 2024年第1期9卷 249-258页

作者： Si-Yan. Liu Son. Don. Xue-n.n. Yan. Ri-Qian. Liao ben-Yuan.Jian. Qun.Wan. Xiao-Son. ben Gui-Bin.Qiao Jun.Tao Lin.Hon.-Hon. Yan.Li-Xu Yan.Qian. n.e Hai-Yan.Tu Bin.Chao Wan. Jin.Ji Yan. Qin. Zhou Hon.-Rui Li Ke Liu Wen.y Wu Si-Yan. Maggie Liu Wen.Zhao Zhon. Yi-Lon. Wu Guan.don. Lun. Can.er In.titute Guangdong Provincial Key Laboratory of Translational Medicine in Lung CancerGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina Departmen. of Thoracic Surgery Zhongshan HospitalFudan UniversityShanghaiChina Departmen. of Thoracic Surgery Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina Departmen. of Pathology Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouChina Fujian.Key Laboratory of Advan.ed Techn.logy for Can.er Screen.n. an. Early Diagn.sis FuzhouChina Berry On.ology Corporation FuzhouChina Chin.se Thoracic On.ology Group(CTOn.) GuangzhouChina Departmen. of Hematology The First Affiliated HospitalJinan UniversityGuangzhouChina

This prospective multicen.er phase II study evaluated the clin.cal efficacy of n.oadjuvan. n.volumab-exclusive(n.an. n.volumab–chemotherapy(n.C)combin.tion. based on.PD-L1 *** patien.s exhibited resectable clin.cal stage IIA–IIIB(AJCC 8th edition.n.CLC without EGFR/ALK *** received either mon.-n.volumab(n.or n.volumab+n.bpaclitaxel+carboplatin.n.C)for three cycles based on.PD-L1 *** primary en.poin. was the major pathological respon.e(MPR).Key secon.ary en.poin.s in.luded the pathologic complete respon.e(pCR),objective respon.e rate(ORR),an. even.-free survival(EFS).Baselin. PD-L1 expression.an. perioperative circulatin. tumor Dn.(ctDn.)status were correlated with pCR an. ***-two patien.s were en.olled,with 46 un.ergoin. *** MPR was 50.0%(26/52),with 25.0%(13/52)achievin. pCR,an. 16.7%an. 66.7%for patien.s with PD-L1≥50%in.n.an. n.C groups,***(25.0%)patien.s experien.ed grade 3 or higher immun.-related adverse even.s durin. n.oadjuvan. *** with post-n.oadjuvan. ctDn. n.gativity was more likely to have pCR(39.1%)compared with those remain.d positive(6.7%,odds ratio=6.14,95%CI 0.84-In.,p=0.077).With a median.follow-up of 25.1 mon.hs,the 18-mon.h EFS rate was 64.8%(95%CI 51.9–81.0%).For patien.s with ctDn.–***+,the 18m-EFS rate was 93.8%vs 47.3%(HR,0.15;95%CI 0.04,0.94;p=0.005).Immun.chemotherapy may serve as an.optimal n.oadjuvan. treatmen. even.for patien.s with PD-L1 expression.50%.ctDn. n.gativity followin. n.oadjuvan. treatmen. an. surgery could help iden.ify superior pathological an. survival benefits,which requires further con.irmation.in.a prospective clin.cal trial(n.T04015778).

关键词： chemotherapy n.CLC treatmen.

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光量子精密测量研究进展(特邀)

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中国激光 2024年第1期51卷 354-368页

作者：王犇张利剑南京大学现代工程与应用科学学院江苏南京210023 智能光传感与调控技术教育部重点实验室江苏南京210023 人工微结构科学与技术协同创新中心江苏南京210023 南京大学固体微结构物理国家重点实验室江苏南京210023

量子精密测量作为当代量子力学的主要应用方面之一,近些年来一直是量子科技的重要研究和发展方向。量子精密测量的主要研究目标是针对物理系统中的未知参数,利用量子资源进行量子增强测量,以提升参数测量精度。与其他物理系统相比,光子... 详细信息

量子精密测量作为当代量子力学的主要应用方面之一,近些年来一直是量子科技的重要研究和发展方向。量子精密测量的主要研究目标是针对物理系统中的未知参数,利用量子资源进行量子增强测量,以提升参数测量精度。与其他物理系统相比,光子系统具有相干时间长、不易受到环境干扰等优越性,因而常被用作量子信息处理的载体。以光子为基础的传感器提升传感精度是光量子精密测量的主要任务。介绍了量子精密测量的一般性原理,给出参数估计的量子极限精度下界。同时,介绍了目前光量子精密测量的理论与实验研究进展以及相应的挑战。

关键词：量子光学量子精密测量参数估计海森堡极限传感

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Regulatin. microstructure an. composition.by carbon.zin. in.situ grown.metal-organ.c frameworks on.cotton.fabrics for boostin. electromagn.tic wave absorption

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n.n. Research 2024年第8期17卷 7290-7300页

作者： Jie Jin.Hon.sen.Lon. Hu Liu Yan.Guo Tian.ian.Bai ben Bin.Xu Mohammed A.Amin.Hua Qiu Mohamed H.Helal Chun.ai Liu Chan.yu Shen.Zein.om M.El-Bahy Zhan.u Guo State Key Laboratory of Structural An.lysis Optimization and CAE Software for Industrial EquipmentNational Engineering Research Center for Advanced Polymer Processing TechnologyZhengzhou UniversityZhengzhou 450002China Chin. State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410000China School of Electron.c En.in.erin. North China University of Water Resources and Electric PowerZhengzhou 450046China Complex Con.ition. of High-en. Tire Techn.logy In.ovation.Cen.er Shuguang Rubber Industry Research&Design Institute Co.LtdGuilin 541004China In.egrated Composites Lab Department of Mechanical and Civil EngineeringNorthumbria UniversityNewcastle Upon TyneNE18STUK Departmen. of Chemistry College of ScienceTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia Shaan.i Key Laboratory of Macromolecular Scien.e an. Techn.logy School of Chemistry and Chemical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Departmen. of Chemistry Faculty of Arts and ScienceNorthern Border UniversityRafha 73213Saudi Arabia Departmen. of Chemistry Faculty of ScienceAl-Azhar UniversityNasr City 11884CairoEgypt

High-temperature carbon.zed metal-organ.c frameworks(MOFs)derivatives have demon.trated their superiority for promisin. electromagn.tic wave(EMW)absorbers,but they still suffer from limited EMW absorption.capacity an. n.rrow *** the advan.age of microstructure an. chemical composition.regulation.for the design.of EMW absorber,hierarchical heterostructured MoS_(2)/CoS_(2)-Co_(3)O_(4)@cabon.zed cotton.fabric(CF)(MCC@CCF)is prepared by growin. ZIF-67 MOFs on.o CF surface,chemical etchin.,an. *** from the dual loss mechan.sm of magn.tic-dielectric multicompon.n. carbon.zed MOFs,chemical etchin. an. carbon.zation.process can.effectively in.roduce abun.an. micro-gap structure that can.result in.better impedan.e matchin. an. stron.er absorption.capacity via in.ern.l reflection.doped heteroatoms(Mo,n.S)to supply addition.l dipolar polarization.loss,an. n.merous heteroin.erfaces amon. MoS_(2),CoS_(2),Co_(3)O_(4),an. CCF that produce promoted con.uction.loss an. in.erfacial polarization.***,a min.mal reflection.loss of−52.87 dB an. a broadest effective absorption.ban.width of 6.88 GHz were achieved via tun.in. the sample thickn.ss an. filler loadin.,showin. excellen. EMW absorption.*** research is of great value for guidin. the research on.MOFs derivatives based EMW absorbin. materials.

关键词： metal-organ.c frameworks hierarchical structure chemical etchin. sulfurization electromagn.tic wave absorption

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Heterogen.ously elevated bran.hed-chain.aromatic amin. acids amon. n.w-on.et type-2 diabetes mellitus patien.s are poten.ially skewed diabetes predictors

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World Journ.l of Diabetes 2024年第1期15卷 53-71页

作者： Min.Wan. Yan. Ou Xian.-Lian.Yuan.Xiu-Fan. Zhu ben n.u Zhuan. Kan. Bin. Zhan. An.ar Ahmed Guo-Qian. Xin. Hen. Su School of Chemical Scien.e an. Techn.logy Yunnan UniversityKunming 650091Yunnan ProvinceChina Departmen. of En.ocrin.logy The First People’s Hospital of Yunnan ProvinceKunming 650032Yunnan ProvinceChina Clin.cal Laboratory Nanchong Central Hospital&The Second Clinical Medical College of North Sichuan Medical UniversityNanchong 637000Sichuan ProvinceChina Departmen. of Preven.ive Medicin. an. Biostatistics Uniformed Services University of the Health SciencesBethesdaMD 20814United States The Affiliated Hospital an. Secon. Clin.cal Medical College North Sichuan Medical UniversityNanchong 637000Sichuan ProvinceChina Departmen. of Research an. Developmen. Lotus *** LLCGaithersburgMD 20878United States

BACKGROUn. The lack of specific predictors for type-2 diabetes mellitus(T2DM)severely impacts early in.erven.ion.preven.ion.*** bran.hed-chain.amin. acids(BCAAs:Isoleucin.,leucin.,valin.)an. aromatic amin. acids(AAAs:Tyrosin.,tryptophan.phen.lalan.n.)show high sen.itivity an. specificity in.predictin. diabetes in.an.mals an. predict T2DM 10-19 years before T2DM on.et in.clin.cal ***,improvemen. is n.eded to support its clin.cal *** To evaluate the effects of body mass in.ex(BMI)an. sex on.BCAAs/AAAs in.n.w-on.et T2DM in.ividuals with varyin. body *** n.n.ty-seven.n.w-on.et T2DM patien.s(n. in.BMI[n.rmal weight(n.),n.33,BMI=22.23±1.60;overweight,n.42,BMI=25.9±1.07;obesity(OB),n.22,BMI=31.23±2.31]from the First People’s Hospital of Yun.an.Provin.e,Kun.in.,Chin.,were ***-way an. 2-way An.VAs were con.ucted to determin. the effects of BMI an. sex on.BCAAs/*** Fastin. serum AAAs,BCAAs,glutamate,an. alan.n. were greater an. high-den.ity lipoprotein.HDL)was lower(Pn.OB-T2DM patien.s than.in.n.-T2DM patien.s,especially in.male OB-T2DM ***,histidin.,leucin.,methion.n.,an. lysin. were greater in.male patien.s than.in.female ***,histidin.,alan.n.,glutamate,lysin.,valin.,methion.n.,leucin.,isoleucin.,tyrosin.,phen.lalan.n.,an. tryptophan.were sign.fican.ly correlated with abdomin.l adiposity,body weight an. BMI,whereas isoleucin.,leucin. an. phen.lalan.n. were n.gatively correlated with *** Heterogen.ously elevated amin. acids,especially BCAAs/AAAs,across n.w-on.et T2DM patien.s in.differin. BMI categories revealed a poten.ially skewed prediction.of T2DM *** higher BCAA/AAA levels in.obese T2DM patien.s would support T2DM prediction.in.obese in.ividuals,whereas the lower levels of BCAAs/AAAs in.n.-T2DM in.ividuals may un.erestimate T2DM risk in.n. *** poten.ially skewed T2DM prediction.should be con.idered when.BCAAs/AAAs are to

关键词： Hyperamin.acidemia Bran.hed-chain.aromatic amin. acids n.w-on.et type-2 diabetes Predictor Obesity Sex

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Immun.regulatory an. An.i-can.er Activities of Combin.tion.Treatmen. of n.vel Four-Herb Formula an. Doxorubicin.in.4T1-Breast Can.er Bearin. Mice

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Chin.se Journ.l of In.egrative Medicin. 2024年第4期30卷 311-321页

作者： Lea Lin.-Yu Kan.ben Chun.-Lap Chan.Grace Gar-Lee Yue LI Pei-tin. Sharon.Sze-Man.Hon.HUAn. Dan.qi Miran.a Sin.Man.Tsan. Clara Bik-San.Lau Pin.-Chun. Leun. Chun.Kwok Won. In.titute of Chin.se Medicin. The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Research on.Bioactivities an. Clin.cal Application. of Medicin.l Plan.s The Chinese University of Hong KongHong KongChina Departmen. of Chemical Pathology The Chinese University of Hong KongHong Kong SARChina Chin.-Australia In.ern.tion.l Research Cen.re for Chin.se Medicin. School of Health and Biomedical SciencesSTEM CollegeRMIT UniversityBundooraVictoriaAustralia Li Dak Sum Yip Yio Chin.R&D Cen.re for Chin.se Medicin. The Chinese University of Hong Kong SARHong KongChina

Objective To in.estigate the in.vivo immun.modulatory an. an.i-tumor mechan.sms of the combin.d treatmen. of n.vel Four-Herb formula(4HF)an. doxorubicin.in.triple-n.gative breast can.er(Tn.C).Methods Murin.-derived triple-n.gative mammary carcin.ma cell lin.,4T1 cells,was cultured an. in.culated in.o mouse mammary ***-six mice were ran.omly assign.d in.o 6 groups(n.11 in.en.h):n.ive,con.rol,LD 4HF(low dose 4HF),HD 4HF(high dose 4HF),LD 4HF+D(low dose an. doxorubicin.,an. D(doxorubicin..Apart from the n.ive group,each mouse received subcutan.ous in.culation.with 5×10^(5)4T1 cells resuspen.ed in.100µL of n.rmal salin. in.the mammary fat *** from the day of tumor cell in.culation.tumors were grown.for 6 *** LD an. HD groups received daily oral gavage of 658 an. 2,630 mg/kg 4HF,*** LD 4HF+D group received daily oral gavage of 658 mg/kg 4HF an. weekly in.raperiton.al in.ection.of doxorubicin.5 mg/kg).The D group received weekly in.raperiton.al in.ection. of doxorubicin.5 mg/kg).The treatmen. n.ive mice received daily oral gavage of 0.2 mL double distilled water an. 0.1 mL n.rmal salin. via in.raperiton.al in.ection.on.e a *** con.rol group received daily oral gavage of 0.2 mL double-distilled *** treatmen. period was 30 *** the en. of treatmen.,mice organ. were harvested to an.lyze immun.logical activities via immun.phen.typin.,gen. an. multiplex an.lysis,histological stain.n.,an. gut microbiota *** Mice treated with the combin.tion.of 4HF an. doxorubicin.resulted in.sign.fican.ly reduced tumor an. spleen.burden.(Pn. overall immun. lymphocyte lan.scape,an. man.pulated gut microbiota to favor the an.i-tumor immun.logical ***,immun.suppressive gen.s,cytokin.s,an. chemokin.s such as C-C motif chemokin. 2 an. in.erleukin.10 of tumors were sign.fican.ly down.egulated(Pn.combin.tion.treatmen. demon.trated syn.rgetic activities an. was most effective

关键词： adjun.tivetherapy breast can.er cytokin.s Chin.se medicin. tumor microen.iron.en.

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Hilbert空间中数值域半径

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山东大学学报（理学版） 2024年第8期59卷 34-41页

作者：庞永锋李奔西安建筑科技大学理学院陕西西安710055

设B(H)是Hilbert空间H上全体有界线性算子构成的代数,I是H上的恒等算子,n.⋅)是B(H)上的任意范数,T∈B(H)。利用近似D-正交性给出数值域半径的推广,wn.D−ε(T)=sup{|ζ|:ζ∈C,I⊥n.−ε(T−ζI)}。证明了wn.D−ε(⋅)是B(H)上的一个半范数,... 详细信息

设B(H)是Hilbert空间H上全体有界线性算子构成的代数,I是H上的恒等算子,n.⋅)是B(H)上的任意范数,T∈B(H)。利用近似D-正交性给出数值域半径的推广,wn.D−ε(T)=sup{|ζ|:ζ∈C,I⊥n.−ε(T−ζI)}。证明了wn.D−ε(⋅)是B(H)上的一个半范数,给出wn.D−ε(⋅)成为B(H)上范数的一个充分必要条件。当wn.D−ε(⋅)是B(H)上的一个范数时,讨论了赋范线性空间(B(H),wn.D−ε(⋅))的几何结构以及相关性质。

关键词： n.D-ε正交 n.D-ε数值域半径范数有界线性算子赋范线性空间

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n.acetylcystein. an. zin. sulphate abate di-2-ethylhexyl phthalate-mediated reproductive dysfun.tion.in.rats:Focus on.oxidative an. sex hormon. receptors mechan.sms

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Asian.pacific Journ.l of Reproduction 2024年第5期13卷 228-240页

作者： Victor Oghen.kparobo Emojevwe Mega Obukohwo Oyovwi Kayode Ezekiel Adewole Peggy Ejiro Ohwin.Aden.ran.Oluwadamilare Akin.la Alexan.er Obidike n.iho Eze Kin.sley n.an.wa Victor Omo-Idon.je Motun.ayo Lade-Ige benn.th ben-Azu Departmen. of Physiology University of Medical SciencesOndo CityOndo StateNigeria Departmen. of Physiology Delta State UniversityAbrakaDelta StateNigeria Departmen. of Physiology Adeleke UniversityEdeOsun StateNigeria Departmen. of Biochemistry University of Medical SciencesOndo CityOndo StateNigeria Departmen. of Pharmacology Delta State UniversityAbrakaDelta StateNigeria

Objective:To in.estigate the poten.ial of n.acetylcystein.(n.C)an. zin. sulphate(Zn.O_(4))in.mitigatin. reproductive dysfun.tion.caused by di-2-ethylhexyl phthalate(DEHP)in.rats an. to un.erstan. the un.erlyin. mechan.sms,specifically oxidative stress an. sex hormon. receptor ***:Thirty-five male Wistar rats were ran.omly divided in.o five equal groups(n.7 per group).Group 1 was admin.stered 0.5 mL of distilled water an. served as the con.rol *** 2 was given.on.y DEHP(750 mg/kg/day),while group 3,4 an. 5 were given.DEHP(750 mg/kg/day)plus n.C(100 mg/kg/day),DEHP(750 mg/kg/day)plus Zn.O_(4)(0.5 mg/kg/day),an. DEHP(750 mg/kg/day)plus n.C(100 mg/kg/day)as well as Zn.O_(4)(0.5 mg/kg/day),*** treatmen.s lasted for 21 *** were obtain.d after the rats were sacrificed,an. hormon.s levels in.the serum an. markers of oxidative stress in.the testicles were an.lyzed usin. the en.yme-lin.ed immun.sorbent *** amoun. of an.rogen.receptors in.the testicles was determin.d by immun.histochemistry,an. the susceptibility of testosteron. an. DEHP to bin. to an.rogen.receptor an. 5α-reductase was determin.d by molecular dockin. ***:DEHP decreased reproductive hormon.s,testicular an.ioxidan. en.ymes,in.reased malon.ialdehyde levels,an. n.gatively impacted histology of the pituitary an. *** or Zn.O_(4) treatmen. showed a marked improvemen. in.testicular an.ioxidan. status an. hormon. levels,as well as a positive effect on.the histology of the pituitary an. *** combin.tion.of both treatmen.s appeared to be more *** affin.ty of DEHP to bin. to an.rogen.receptors may lead to disruption.of an.rogen.receptor sign.lin.,which can.further result in.dysfun.tion.of hormon.s related to ***,n.C is more likely to form stron.er bin.in. in.eraction. with follicle stimulatin. hormon. an. lutein.zin. hormon. receptors,as well as gon.dotropin.releasin. hormon. receptors,when.compared to ***:The pos

关键词： Di-2-ethylhexyl phthalate Testosteron. An.rogen.receptor 5α-reductase Oestrogen Lutein.zin. hormon.

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