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Insect Science 2013年第5期20卷 637-642页

作者： Mdellel Lassaad David Martinez-Torres ben ha.ima.ka.el monia Hight Institute of Agronomy Chott Mariem 4042 Sousse Tunisia Institut Cavanilles de Biodiversitat i Biologia Evolutiva Universitat de Valencia Apdo. Correos 22085 46071 Valencia Spain

Pterochloroides persicae （Cholodkovsky） is an aphid species belonging to the subfamily Lachninae that uses different members of Rosaceae （specially Prunus spp.） as hosts. Partial sequences from the mitochondrial cytochrome c oxidase 1 （COI） and the nuclear long-wave opsin genes were obtained for approximately 100 P. persicae aphid individuals sampled from 34 colonies collected mainly in Tunisia and other Mediterranean locations. The variability found at the mitochondrial locus revealed the presence of two maternal haplotypes in the studied area that differed in a single nucleotide. The nuclear gene analyzed, however, failed to reveal any variability in this species. The variability found at the COI locus was related to the season of aphid sampling and with the site of feeding, with haplotype I mostly detected in samples collected in spring and summer on trunks and branches and haplotype II only detected in aphids collected in autumn on roots. The observed pattern of molecular variation suggests the presence of two clonal races of P. persicae coexisting in the studied area differentially adapted to conditions prevalent in the alternative seasons and/or to different feeding sites.

关键词： aphids COI Lachninae life cycle Pterochloroides variability

Physiological, histopathological and cellular immune effects of Pergularia tomentosa extract on Locusta migratoria nymphs

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Journal of Integrative Agriculture 2019年第12期18卷 2823-2834页

作者： Meriam Miladi Khemais Abdellaoui Amel ben hamouda Iteb Boughattas Mouna Mhafdhi Fatma Acheuk monia ben ha.ima.ka.el Higher Agronomic Institute of Chott Mariem Sousse UniversityChott Mariem 4042Tunisia General Directorate of Plant Health and Agricultural Inputs Control Ministry of AgricultureTunis 1002Tunisia Laboratory of Valorization and Conservation of Biological Resources Department of BiologyFaculty of SciencesUniversity of BoumerdesBoumerdes 35000Algeria

The migratory locust Locusta migratoria(Orthoptera,Acrididae)is one of the most important pests due to its extensive and severe damage to crops in large parts of Africa and *** and ecologically natural products such as bota nical insecticides are emergi ng can didates for replaceme nt of usually applied chemical *** crude methanolic extract of Pergularia tomentosa(PME)was investigated for their toxicity and physiological aspects on *** *** showed that treatment of newly emerged fourth and fifth instar nymphs resulted in significant mortality and significant repellent activity with an LC50 value of 0.18 and 0.38%,respectively,after seven days of *** PME toxicity was also dem on strated by histopathological cha nges in the alime ntary canal resulting in con siderable disorganization and severe damage of the caeca and proventriculus *** extract induced cellular immune reactions which manifested by a significant decrease in the number of the differential haemocyte counts(prohemocytes and plasmatocytes)and important cell *** of biochemical analyses showed that the PME reduced the activity of acetylcholinesterase and induced the glutathione *** neurotoxic effect was confirmed by the histological alterations in the brain structure,particularly in the neurosecretory cells showing typical signs of cell necrosis.

关键词： Locusta migratoria Pergularia tomentosa toxicity histopathology haemocytes enzymes

Three siblings with gyrate atrophy of the choroid and retina:a case report

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International Journal of Ophthalmology(English edition) 2023年第12期16卷 2133-2135页

作者： Maamouri Rym Ferchichi Molka ben Chehida Amel hadj-Taieb Sameh Cheour monia Department of Ophthalmology Habib Thameur HospitalTunis 1069Tunisia Department of Pediatrics Rabta HospitalTunis 1007Tunisia Laboratory of Biochemistry Rabta HospitalTunis 1007Tunisia University of Tunis el Manar Faculty of Medicine of Tunis 1068Tunisia

Dear Editor,We report the cases of three siblings with gyrate atrophy(GA)of the choroid and retina with foveoschisis,anterior subcapsular cataracts,and capsular bag *** is a rare autosomal recessive degenerative disorder of the choroid and *** one-third of all reported cases are from Finland where the incidence is estimated to be around 1:50000 whereas the theoretical global incidence is only 1:1500000[1].

关键词： atrophy cases cataract

Anti-inflammatory and analgesic activities with gastroprotective effect of semi-purified fractions and isolation of pure compounds from Mediterranean gorgonian Eunicella singularis

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Asian Pacific Journal of Tropical Medicine 2015年第8期8卷 598-603页

作者： monia Deghrigue Carmen Festa Lotfi Ghribi Maria Valeria D’Auria Simona De Marino Hichem ben Jannet Abderrahman Bouraoui Laboratoire de développement chimique galénique et pharmacologique des médicaments (LR12ES09).Equipe de Pharmacologie marineFaculté de pharmacie de MonastirUniversité de Monastir Department of Pharmacy University of Naples "Federico II" Laboratoire de chimie hétérocyclique produits naturels et réactivité. Equipe de chimie médicinale et produits naturels (LR11ES39)Faculté des sciences de MonastirUniversité de Monastir Laboratoire de chimie hétérocyclique produits naturels et réactivité.Equipe de chimie médicinale et produits naturels (LR11ES39)Faculté des sciences de MonastirUniversité de Monastir

Objective: To explore anti-inflammatory activities of organic extract and its semi-purified fractions(ethanol, acetone, methanol/dichloromethane) from the Mediterranean gorgonian Eunicella singularis. Methods: The anti-inflammatory and analgesic activities were evaluated, using the carrageenan-induced rat paw edema model and the acetic acid writhing test in mice. The gastroprotective activity was determined using HCl/Et OH induced gastric ulcers in rats. The purification and structure elucidation of compound(s) from the more effective fraction were determined by chromatographic and spectroscopic methods and in comparison with data reported in the literature. Results: The fraction F-Et OH showed an important antiinflammatory activity associated with significant analgesic and gastroprotective properties. The purification and structure elucidation of compound(s) from this fraction lead to the identification of one diterpenoid and four sterols. Conclusions: These results suggested that components from the active fraction can be used to treat various anti-inflammatory diseases.

关键词： Eunicella singularis Anti-inflammatory activity Analgesic activity Gastroprotective effect Diterpenoid Sterols

Left intracardiac thrombosis: An exceptional complication revealing BehCet’s disease

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Open Journal of Internal Medicine 2013年第1期3卷 15-18页

作者： Mounira el Euch ben Fredj Ismail Fatma Rezgui Amel karmani monia Derbali Fatma Amri Raja Laouani Kechrid Chedia Department of Internal Medicine Sahloul University Hospital Sousa Tunisia

Although cardiac involvement during Behcet syndrome is uncommon and intracardiac thrombosis is exceptional, it concerns the right ventricle much more than the left one. We report an illustrative case of left intracard... 详细信息

关键词： Behcet’s Disease Cardiac Involvement Thrombosis

Sea-blue histiocytes syndrome: Case report and review of literature

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Open Journal of Internal Medicine 2013年第1期3卷 19-21页

作者： Mounira el Euch Fatma ben Fredj Ismail Amel Rezgui monia karmani Belgacen Mrad hassen Hosi Mhiri Chedia Laouani Kechrid Department of Internal Medicine Sahloul Hospital Soussa Tunisia

A 57-year-old female was admitted with pancytopenia, and mild splenomegaly. The multiple myeloma diagnosis was wrongly made since the discovery of monoclonal peak to the protein electrophoresis. Further microscopic examination of bone marrow revealed the accumulation of sea-blue histiocytes. The evolution was stable and the patient did not receive any treatment due to the lack of nervous symptoms.

关键词： Syndrome of the Sea-Blue Histiocyte Pancytopenia Splenomegaly

Interstitial Lung Diseases Associated with Connective Tissue Pathologies: Radiologic Features

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Open Journal of Respiratory Diseases 2019年第4期9卷 112-122页

作者： Houda Gharsalli monia Attia Sawssen hantous-Zannad Imen Sahnoun Sonia Maalej Leila Douik el Gharbi Henda Neji Khaoula ben Miled-Mrad Department of Pulmonology Abderrahmane Mami Hospital Ariana Tunisia University of Tunis el Manar Tunis Tunisia Department of Radiology Abderrahmane Mami Hospital Ariana Tunisia

Introduction: The high resolution computed tomography (HRCT) is an important part in the diagnostic approach of interstitial lung disease (ILD) associated with connective tissue diseases (CTD) by providing detailed information on the elementary lesion and the radiological pattern of ILD. Aim: to point out the role of HRCT in the diagnosis of ILD associated with CTD (ILD-CTD). Methods: A Retrospective descriptive study was conducted between 2008 and 2017. Data of 24 patients presenting ILD-CTD were collected. A review of HRCT was performed by a radiologist without knowledge of the CTD. Results: Predominant elementary lesion of ILD associated with dermatomyositis (9 cases) was ground glass opacity (n = 9) followed by consolidation (n = 6). Non Specific Interstitial Pneumonia (NSIP) was the most reported pattern (5 cases). Ground glass opacity was also the predominant elementary lesion for the 2 cases of scleroderma and in Sjögren’s syndrome (4 cases/5). NSIP was the predominant radiological presentation in these two CTD. Lymphoid interstitial pneumonia revealed Sjögren’s syndrome in one case. In rheumatoid arthritis (6 cases), the elementary HRCT lesions were irregular interlobular septal thickening (n = 4) and honeycombing (n = 4) consistent with Usual Interstitial Pneumonia (UIP) in 2 cases. Similarly UIP has been described for the 2 patients with lupus and mixed connective tissue disease. Conclusion: HRCT plays an important role in the management of ILD-CTD. Description of the HRCT elementary lesions and the radiological pattern of ILD can be helpful for CTD’s diagnosis.

关键词： Interstitial Lung Diseases Connective Tissue Diseases Computed Tomography imaging Diagnosis

A seropositive nodular rheumatoid polyarthritis without arthritis, does it exist?

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Open Journal of Internal Medicine 2013年第2期3卷 70-72页

作者： ben Fredj Ismail Fatma Rezgui Amel karmani monia ben Abdallah Olfa Azzebi Samira Laouani Kechrid Chedia Department of Internal Medicine Sahloul Hospital Sousse Tunisia

Introduction: The rheumatoid polyarthritis is the most frequent chronic polyarthritis. It affects essentially woman between 40 and 60 years old. Rheumatic subcutaneous nodules and tenosynovitis are usually associated with seropositive symptomatic rheumatoid polyarthritis. However, it is rare that they constitute the essential clinical expression of the disease. Case report: A 60-year-old woman was hospitalized for tumefaction of the dorsal face of the right hand evolved two months before. The clinical examination was found isolated subcutaneous nodules. The anatomopathological exam of one nodule ended in its rheumatoid origin and the MRI of a second one confirmed a tenosynovitis. Anti-CCP antibodies were positive. The patient has never suffered from arthralgias. The evolution was favourable under corticosteroid therapy, methotrexate and colchicine. Discussion: Rheumatic subcutaneous nodules and tenosynovitis are usually associated with seropositive symptomatic rheumatoid polyarthritis. It is rare that they constitute the essential clinical expression of the disease. Conclusion: The extra-articular appearances of the rheumatoid polyarthritis must not be underestimated especially since they can constitute—even rarely—the essential clinical expression of the disease.

关键词： Rheumatoid Polyarthritis Rheumatoid nodules Seropositive Tenosynovitis

A Rare Entity of Accelerated Chronic Lymphocytic Leukemia: A Report of Two Cases and Review of Literature

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Health 2023年第8期15卷 861-870页

作者： Zahra Kmira ben Yahya Noura Chembah Wafa ben Sayed Nesrine Chiba Dorra Bouteraa Walid Zaier monia ben Youssef Yosra haifa Regaieg Khelif Abderrahim Department of Clinical Hematology Farhat Hached University Hospital Sousse Tunisia Department of Pathology Farhat Hached University Hospital Sousse Tunisia

Background: Accelerated-chronic lymphocytic leukemia (A-CLL) is a rare disease entity as it represents less than 1% of all reported cases of chronic lymphoid leukemia (CLL). Moreover, it is most likely an under diagnosed entity due to its rarity and the non-standardized practice of lymph node biopsy in CLL. Purpose: The aims of our work are to establish the diagnosis of A-CLL and to study the prognosis and treatment of this rare entity. Method: here, we report the clinical presentation and the follow up of two cases of A-CLL. Results: Distinguishing Richter transformation (RT) from A-CLL is important as it may result in a major change in disease management. The prognosis of A-CLL is intermediate between CLL and RT. The prognosis is mainly poor due to a predominance of poor prognostic markers including an increasing number of p53-positive cases. Conclusion: To this date, no prospective study has been led to define the best treatment for A-CLL. The shorter survival of A-CLL when compared to typical CLL implies the need of a more aggressive treatment.

关键词： Accelerated Chronic Lymphocytic Leukemia Richter Transformation Prognosis Treatment

Severe hemorrhagic colitis in a patient with chronic myeloid leukemia in the blastic phase after dasatinib use

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World Journal of Gastrointestinal Pathophysiology 2013年第3期4卷 59-62页

作者： Zahra Kmira ben Sayed Nesrine Zaghouani Houneida ben Fredj Wafa Slama Aida ben Youssef Yosra Zaier monia Badreddine Sriha Khelif Abderrahim Department of Clinical Hematology University Hospital Farhat Hached Sousse 4000 Tunisia Department of Radiology University Hospital Farhat Hached Sousse 4000 Tunisia Department of Gastroenterology University Hospital Sahloul Sousse 4000 Tunisia Department of Anatomopathology University Hospital Farhat Hached Sousse 4000 Tunisia

Dasatinib is a second-line tyrosine kinase inhibitor used in patients with imatinib resistant or intolerant chronic myeloid leukemia (CML) and Philadelphia chromosomepositive acute leukemia. Gastrointestinal bleeding may occur in up to 7% of patients using dasatinib, although, severe dasatinib-related acute colitis had rarely been reported. Here, we present the case of a 36-year-old female who progressed to acute myeloid leukemia after fourteen months of receiving imatinib for CML in the chronic phase and was treated with a dasatinib-containing chemotherapy regimen. On day 34 of treatment, the patient developed moderate abdominal pain and bloody diarrhea with mucous. Analyses of stool specimens were negative for parasites, Clostridium difficile , and other pathogenic bacteria. The cytomegalovirus pp65 antigen was negative in her blood leukocytes. A colonoscopy revealed acute colitis, and a mucosal biopsy showed nonspecific colitis. The patient was treated with broad-spectrum antibiotics, bowel rest and hydration, and dasatinib treatment was stopped. Her bloody diarrhea improved within 72 h. After confirming cytological remission, the patient received initial course of consolidation, and dasatinib treatment was reinstated. However, hemorrhagic colitis recurred. After discontinuing dasatinib, herhemorrhagic colitis drastically improved and did not recur following the administration of nilotinib. The characteristics of our patient suggest that dasatinib treatment can lead to hemorrhagic colitis, which typically resolves after discontinuation of the drug.

关键词： Philadelphia chromosome Chronic myeloid leukemia Dasatinib Colitis