检索结果-南通市图书馆

Factors affecting thrombolysis in myocardial infarction myocardial perfusion frame count： insights of myocardial tissue-level reperfusion from a novel index for assessing myocardial perfusion

引用

Chinese Medical Journal 2011年第6期124卷 873-878页

作者： PU Jun SHAN Pei-ren DING Song QIAO Zhi-qin JIANG Li-sheng SONG Wei DU Yong-ping SheN Jie-yan SheN Lin-hong JIN Shu-xuan he ben Department of Cardiology Shanghai Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200127 China Department of Cardiology First Affiliated Hospital of Wenzhou Medical College Wenzhou Zhejiang 325000 China

Background Myocardial tissue-level perfusion failure is associated with adverse outcomes following ST-elevation myocardial infarction （STEMI） despite successful epicardial recanalization. We have developed a new quantitative index-thrombolysis in myocardial infarction （TIMI） myocardial perfusion frame count （TMPFC）-for assessing myocardial tissue level perfusion. However, factors affecting this novel index of myocardial perfusion are currently *** A total of 255 consecutive STEMI patients undergoing primary angioplasty were enrolled. Myocardial tissue level perfusion was assessed by TMPFC, which measures the filling and clearance of contrast in the myocardium using cine-angiographic frame counting. We differentiate three groups with two cut off values for TMPFC： a TMPFC of 90frames was the upper boundary of the 95% confidence interval （CI） for the TMPFC observed in normal arteries, and a TMPFC of 130 was the 75th percentile of *** STEMI patients with TMPFC 〉130 frames （68 patients, 26.7%） had higher clinical and angiographic risk factor profiles as well as a higher 30-day MACE rate compared with those with TMPFC ≤90 frames and those with TMPFC 〉90and ≤130 frames. Multivariable analysis identified that the independent predictors of TMPFC 〉130 frames were age ≥75years （OR 2.08, 95% CI 1.21 to 3.58, P=0.007）, diabetes （OR 1.37, 95% CI 1.01 to 1.86, P=0.042）, Killip class ≥2 （OR1.52, 95% CI 1.05 to 2.21, P=0.027）, and prolonged pain-to-balloon time （OR 1.73, 95% CI 1.07 to 2.79, P=0.013）.TMPFC 〉130 frames was identified as the strongest independent predictor of 30-day major adverse cardiac event （MACE）（OR 2.77, 95% CI 1.21 to 6.31, P=0.008）, along with age ≥75 years （OR 2.19, 95% CI 1.11 to 4.33, P=0.016）,female gender （OR 1.67, 95% CI 1.03 to 2.70, P=0.038）, and Killip class ≥2 （OR 1.83, 95% CI 1.07 to 3.14, P=0.021）.Conclusions STEMI patients with poor myocardial perfusion assessed by TMPFC had higher risk factor *** age, diabetes,

关键词： myocardial infarction perfusion angioplasty outcome

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

筒形基础对浅层气运移的影响及其对基础稳定性的影响

引用

太阳能学报 2023年第3期44卷 218-224页

作者：程章何奔潘华林朱建才洪义赵俞成浙江大学建筑工程学院杭州310058 浙江大学平衡建筑研究中心杭州310028 中国电建集团华东勘测设计研究院有限公司杭州310058 浙江省能源集团有限公司杭州310007 浙江大学建筑设计研究院有限公司杭州310027

海上风电机组附近的浅层气突涌运移可能会诱发基础的失稳破坏,为了解决该潜在工程问题,通过开展模型试验和数值模拟,研究不同静荷载作用下,软黏土中气体运移路径的演化规律以及其对基础稳定性的影响。研究结果表明:静荷载的形式和基础... 详细信息

海上风电机组附近的浅层气突涌运移可能会诱发基础的失稳破坏,为了解决该潜在工程问题,通过开展模型试验和数值模拟,研究不同静荷载作用下,软黏土中气体运移路径的演化规律以及其对基础稳定性的影响。研究结果表明:静荷载的形式和基础与注气点的相对位置影响气体运移路径。当基础作用下压荷载时,气体朝靠近基础的方向运移,可能诱发基础失稳;而当作用上拔荷载时,气体朝远离基础的方向运移,从而不会威胁到基础的安全,且基础与注气点的相对位置越近,这种效应越显著。开展扩展有限元和Cohesive黏聚力单元相结合的应力-渗流耦合分析,进一步研究此种效应,以期为海上风电机组基础选址和设计提供参考依据。

关键词：海上风电机组数值模拟气体运移筒形基础扩展有限元最大主应力准则

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Light-driven sextuple theranostics:nanomedicine involving second near-infrared AIE-active Ir(Ⅲ)complex for prominent cancer treatment

引用

Science China Chemistry 2024年第7期67卷 2314-2324页

作者： Xue Liu Jiangao Li Fei Zhang Dingyuan Yan Lei Wang Dong Wang ben Zhong Tang Center for AIE Research Shenzhen Key Laboratory of Polymer Science and TechnologyGuangdong Research Center for Interfacial Engineering of Functional MaterialsCollege of Material Science and EngineeringShenzhen UniversityShenzhen 518060China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Shenzhen 518172China

Light-driven cancer theranostics has shown inexhaustible and vigorous vitality by virtue of its high efficacy,prominent controllability and *** of an all-round theranostic material simultaneously affording both multimodal diagnosis imaging and synergistic phototherapy would be an appealing yet significantly challenging ***,a novel nanomedicine Ir@PPEG-MeEPO was ingeniously constructed by integrating beforehand1O2-charged amphiphilic polymer and well-tailored Ir(Ⅲ)complex IrDPTP,which was featured by second near-infrared(NIR-Ⅱ)aggregation-induced emission(AIE)tendency,efficient reactive oxygen species(ROS)generation,good photothermal conversion efficiency and high-performance hydrogen gas *** the best of our knowledge,IrDPTP held the longest emission wavelength among all reported AIE Ir(Ⅲ)***,Ir@PPEG-MeEPO was capable of controllably releasing ROS via triggered photothermal effect upon NIR irradiation,making it well-adapted to hypoxic environment of *** distinctive characteristics of Ir@PPEG-MeEPO endowed it with unprecedented performance on sextuple theranostics comprised of NIR-Ⅱfluorescence-photoacoustic-photothermal trimodal imaging and photodynamic-photothermal-hydrogen trimodal therapy,witnessed by the precise tumor diagnosis and complete tumor *** study would open up new perspectives for the exploration of superior nanomedicine for practical cancer theranostics.

关键词： aggregation-induced emission NIR-II emission cancer theranostics multimodal diagnosis imaging multimodal therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

RPL-Based IoT Networks under Decreased Rank Attack:Performance Analysis in Static and Mobile Environments

引用

Computers, Materials & Continua 2024年第1期78卷 227-247页

作者： Amal Hkiri Mouna Karmani Omar ben Bahri Ahmed Mohammed Murayr Fawaz Hassan Alasmari Mohsen Machhout Physic Department Electronics and Micro-Electronics LaboratoryFaculty of Sciences of MonastirMonastir5000Tunisia Department of Science and Technology College of RanyahTaif UniversityP.O.Box 11099Taif21944Saudi Arabia

The RPL(IPv6 Routing Protocol for Low-Power and Lossy Networks)protocol is essential for efficient communi-cation within the Internet of Things(IoT)*** its significance,RPL’s susceptibility to attacks remains a *** paper presents a comprehensive simulation-based analysis of the RPL protocol’s vulnerability to the decreased rank attack in both static andmobilenetwork *** employ the Random Direction Mobility Model(RDM)for mobile scenarios within the Cooja *** systematic evaluation focuses on critical performance metrics,including Packet Delivery Ratio(PDR),Average End to End Delay(AE2ED),throughput,Expected Transmission Count(ETX),and Average Power Consumption(APC).Our findings illuminate the disruptive impact of this attack on the routing hierarchy,resulting in decreased PDR and throughput,increased AE2ED,ETX,and *** results underscore the urgent need for robust security measures to protect RPL-based IoT ***,our study emphasizes the exacerbated impact of the attack in mobile scenarios,highlighting the evolving security requirements of IoT networks.

关键词： RPL decreased rank attacks mobility random direction model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于阻抗轨迹估计的自适应相间距离继电器

引用

中国电机工程学报 2007年第31期27卷 71-76页

作者：沈冰何奔腾浙江大学电气工程学院浙江省杭州市310027

在双电源系统中,由于对侧系统助增电流的影响,保护测量到的阻抗会偏离故障线路的实际值,从而引起距离保护发生超越或缩短保护距离。正向经过渡电阻故障时,距离保护测量阻抗随着过渡电阻变化的轨迹可以利用故障前保护测量到的电压、电流... 详细信息

在双电源系统中,由于对侧系统助增电流的影响,保护测量到的阻抗会偏离故障线路的实际值,从而引起距离保护发生超越或缩短保护距离。正向经过渡电阻故障时,距离保护测量阻抗随着过渡电阻变化的轨迹可以利用故障前保护测量到的电压、电流,经过估算得到。通过对阻抗变化轨迹公式的推导和分析,提出一种基于阻抗轨迹估计的自适应四边形距离继电器的原理及实施方案。该继电器利用故障前系统正常运行时电压和电流的测量值,实时估计出阻抗变化轨迹,并自动调整继电器的动作特性。理论分析和仿真计算表明,提出的自适应距离继电器可应用于相间距离保护,可有效防止区外经过渡电阻故障时发生超越,同时在区内故障时提高耐受过渡电阻能力。

关键词：过渡电阻距离保护电力系统自适应算法

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

水底隧道饱水地层衬砌作用荷载研究

引用

岩土力学 2010年第8期31卷 2465-2470页

作者：张志强何本国何川西南交通大学土木工程学院地下工程系成都610031

与山岭隧道所不同,采用矿山法修建水底隧道,二次衬砌将承受很大外水压力,特别是穿越饱水破碎地层时,具有很大的施工风险。以厦门翔安海底隧道为工程背景,针对F4风化深槽地层,研究不同水位条件下,衬砌荷载与排放流量及排放方式之间相关... 详细信息

与山岭隧道所不同,采用矿山法修建水底隧道,二次衬砌将承受很大外水压力,特别是穿越饱水破碎地层时,具有很大的施工风险。以厦门翔安海底隧道为工程背景,针对F4风化深槽地层,研究不同水位条件下,衬砌荷载与排放流量及排放方式之间相关关系。研究得出:当控制排放量为全排条件流量1/3左右时,可卸掉80%外水压力;从环境和经济角度考虑,可将出现拐点折减系数0.2作为水底隧道限量排放的设计基准值;从支护结构体系组成考虑,对于F4强风化深槽破碎围岩,必须施作注浆圈,才可以保证在水压、土压共同作用下衬砌结构安全,结果显示施作注浆圈能够减少衬砌作用荷载30%～40%,提高安全系数几乎一倍;从主体结构受力特征看,水底隧道最不利受力位置在墙脚和仰拱,因此,无论是防水型还是排水型隧道,均应对仰拱形式及支护参数加强设计。

关键词：水底隧道饱水地层衬砌作用荷载限量排放

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Unidirectional movement behavior of underwater bubbles on the wettability gradient mesh via asymmetrical bounce

引用

Science China Chemistry 2024年第8期67卷 2606-2613页

作者： Yuzhen Ning Zhihong Zhao Shuang ben Qiang Li Cunming Yu Xudong Zhang Huawei Chen Kesong Liu Lei Jiang School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology School of ChemistryBeihang UniversityBeijing 100191China Research Institute of Aero-Engine Beihang UniversityBeijing 100191China School of Materials Science and Engineering Shenyang Ligong UniversityShenyang 110159China Tianmushan Laboratory Hangzhou 310023China The Analysis Testing CenterBeihang UniversityBeijing 100191China

The impact of underwater bubbles on solid surfaces with a gradient wettability is important for fundamental science and technological applications. Despite progress in the translational motion of underwater bubbles on asymmetric surface, a fundamental dynamic understanding of asymmetrical bounce behavior of the underwater bubble needs to be further ***, we investigate asymmetrical bounce of underwater bubbles after impacting the wettability gradient copper mesh *** bounce of the underwater bubble on the wettability gradient mesh(WGM) surface is composed by asymmetrical spread in the spread process and asymmetrical recoil in the recoil process, which induce the unidirectional movement ***, effective bubble-size manipulation can be easily implemented due to different volumes of bubbles remaining at different locations of WGM surface. We envision that this work will provide a new understanding of asymmetrical bounce behavior of the underwater bubble on the wettability gradient surface, and propose a novel and feasible strategy for constructing the underwater bubble manipulation system.

关键词： asymmetrical bounce unidirectional movement behavior gradient wettability

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Two-color emissive AIEgens with anti-Kasha property for dual-organelle imaging and phototherapy

引用

Science China Chemistry 2024年第5期67卷 1740-1752页

作者： Pu Chen Guogang Shan Qingli Nie Yuting Yan Pengfei Zhang Zujin Zhao Hai-Tao Feng ben Zhong Tang AIE Research Center Shaanxi Key Laboratory of PhytochemistryCollege of Chemistry and Chemical EngineeringBaoji University of Arts and SciencesBaoji 721013China Institute of Functional Material Chemistry and National&Local United Engineering Lab for Power Battery Faculty of ChemistryNortheast Normal UniversityChangchun 130024China College of Chemistry&Materials Science Northwest UniversityXi’an 710127China Guangdong Key Laboratory of Nanomedicine CAS-HK Joint Lab of BiomaterialsCAS Key Laboratory of Biomedical Imaging Science and SystemShenzhen Engineering Laboratory of Nanomedicine and NanoformulationsCAS Key Lab for Health InformaticsShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China State Key Laboratory of Luminescent Materials and Devices Key Laboratory of Luminescence from Molecular Aggregates of Guangdong ProvinceSouth China University of TechnologyGuangzhou 510640China School of Science and Engineering Shenzhen Institute of Aggregate Science and TechnologyThe Chinese University of Hong KongShenzhen(CUHK-Shenzhen)Shenzhen 518172China

Despite the rapid development of probes for targeting single organelle, the construction of robust dual-organelle targeting probes with multicolor emission was rarely reported. herein, two dual-emissive aggregation-induced emission luminogens(AIEgens)with donor-π-acceptor structures were designed and synthesized, namely QT-1 and QF-2. Both two AIEgens exhibited excitation wavelength-dependence defying the Kasha's rule, and could stain lipid droplets(LDs) and mitochondria in blue and red fluorescence, respectively. Moreover, thanks to the near-infrared emission and abundant reactive oxygen species(ROS) generation efficiency of QT-1, it was chosen as a photodynamic therapy agent to selectively kill cancer cells from normal cells. Upon light irradiation, an obvious decrease of mitochondrial membrane potential(MMP) and serious change of mitochondrial shape in cells were observed, which corresponded to the efficient inhibition of tumor growth in vivo. This work afforded a promising strategy for the construction of multicolor emission by tuning anti-Kasha behaviors and expanding their application in dualorganelle targeting-based phototheranostics.

关键词： aggregation-induced emission anti-Kasha luminescence fluorescent probe bioimaging photodynamic therapy

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

压剪荷载作用下双隧道围岩的剪切型岩爆:对比分析

引用

Journal of Central South University 2023年第12期30卷 4207-4229页

作者：辛杰江权翟迪丰光亮何本国李邵军 State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China Energy School Xi’an University of Science and TechnologyXi’an 710054China Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines Northeastern UniversityShenyang 110819China

认识剪切型岩爆的触发机理对地下工程科学设计与安全施工具有重要意义。为揭示隧道围岩(DTR)的剪切触发型岩爆机理,进行了砂岩的双矩形隧道和双圆形隧道物理模型剪切试验。在剪切试验过程中,利用高速摄像机和声发射监测仪对DTR的岩爆过... 详细信息

认识剪切型岩爆的触发机理对地下工程科学设计与安全施工具有重要意义。为揭示隧道围岩(DTR)的剪切触发型岩爆机理,进行了砂岩的双矩形隧道和双圆形隧道物理模型剪切试验。在剪切试验过程中,利用高速摄像机和声发射监测仪对DTR的岩爆过程进行监测和记录,揭示了压剪下DTR的宏观和细观断裂特征;进而建立了5种隧道间距数值模型,分析了压剪下含隧洞试样连续-非连续剪切过程及其触发的岩爆机理;提出了一种新的能量冲击指数(S)来评价剪切型岩爆倾向性。试验结果表明,在剪切试验中,DTR的实时剪切特征、内外破裂特征和微裂纹数演化特征可划分为4个典型阶段:整体剪切压缩阶段(Ⅰ阶段)、以裂纹萌生为主的弹性阶段(Ⅱ阶段)、以裂纹扩展-贯通和剪切岩爆为主的剪切破裂阶段(Ⅲ阶段)和剪切摩擦阶段(Ⅳ阶段)。此外,试验结果还表明DTR在剪切型岩爆发生后可形成对称猫耳形缺口;微裂纹演化过程中DTR经历了裂纹预备阶段(Ⅰ阶段)、裂纹初始增长阶段(Ⅱ阶段)、裂纹快速增长阶段(Ⅲ阶段)和裂纹稳定阶段(Ⅳ阶段)。更重要的是,综合分析发现,双矩形隧道和双圆形隧道触发剪切型岩爆机制存在差别的本质是截面形状导致的结构效应,即双矩形隧道和双圆形隧道应力场分布差异导致断裂行为不同。研究结果有利于加深对剪切型岩爆机理的认识,为岩土工程防治提供理论依据。

关键词：剪切岩爆物理模型双隧道围岩离散元法隧道间距应力场

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Notch信号对血管新生调控作用的研究进展

引用

上海交通大学学报（医学版） 2010年第5期30卷 589-591页

作者：姜萌何奔上海交通大学医学院仁济医院心内科上海200001

对Notch信号在血管新生中作用的研究主要集中于内皮细胞的增生、尖细胞与茎细胞比例调节、动静脉分化及周细胞动员等方面。Notch调控血管生成的研究可为组织缺血、创伤和肿瘤等提供合理的治疗方向。该文就Notch信号转导通路的组成、Notc... 详细信息

对Notch信号在血管新生中作用的研究主要集中于内皮细胞的增生、尖细胞与茎细胞比例调节、动静脉分化及周细胞动员等方面。Notch调控血管生成的研究可为组织缺血、创伤和肿瘤等提供合理的治疗方向。该文就Notch信号转导通路的组成、Notch在生理性血管新生中的作用和机制,以及在脐血造血干细胞中的应用研究作一综述。

关键词： Notch 血管新生脐血造血干细胞

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：