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Severe hemorrhagic colitis in a patient with chronic myeloid leukemia in the blastic phase after dasatinib use

World Journal of Gastrointestinal Pathophysiology 2013年第3期4卷 59-62页

作者： Zahra Kmira ben Sayed Nesrine Zaghouani Houneida ben fredj wafa Slama Aida ben Youssef Yosra Zaier Monia Badreddine Sriha Khelif Abderrahim Department of Clinical Hematology University Hospital Farhat Hached Sousse 4000 Tunisia Department of Radiology University Hospital Farhat Hached Sousse 4000 Tunisia Department of Gastroenterology University Hospital Sahloul Sousse 4000 Tunisia Department of Anatomopathology University Hospital Farhat Hached Sousse 4000 Tunisia

Dasatinib is a second-line tyrosine kinase inhibitor used in patients with imatinib resistant or intolerant chronic myeloid leukemia (CML) and Philadelphia chromosomepositive acute leukemia. Gastrointestinal bleeding may occur in up to 7% of patients using dasatinib, although, severe dasatinib-related acute colitis had rarely been reported. Here, we present the case of a 36-year-old female who progressed to acute myeloid leukemia after fourteen months of receiving imatinib for CML in the chronic phase and was treated with a dasatinib-containing chemotherapy regimen. On day 34 of treatment, the patient developed moderate abdominal pain and bloody diarrhea with mucous. Analyses of stool specimens were negative for parasites, Clostridium difficile , and other pathogenic bacteria. The cytomegalovirus pp65 antigen was negative in her blood leukocytes. A colonoscopy revealed acute colitis, and a mucosal biopsy showed nonspecific colitis. The patient was treated with broad-spectrum antibiotics, bowel rest and hydration, and dasatinib treatment was stopped. Her bloody diarrhea improved within 72 h. After confirming cytological remission, the patient received initial course of consolidation, and dasatinib treatment was reinstated. However, hemorrhagic colitis recurred. After discontinuing dasatinib, herhemorrhagic colitis drastically improved and did not recur following the administration of nilotinib. The characteristics of our patient suggest that dasatinib treatment can lead to hemorrhagic colitis, which typically resolves after discontinuation of the drug.

关键词： Philadelphia chromosome Chronic myeloid leukemia Dasatinib Colitis

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A Challenging Approach to Improve the Low Affinity of Acrylic Fibres to Be Successfully Dyed with a Bio-Colorant Extracted from Grape Marc

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Journal of Renewable Materials 2019年第3期7卷 289-300页

作者： Noureddine Baaka Manel ben Ticha wafa Haddar Mohamed Farouk Mhenni University of Monastir Faculty of Sciences of MonastirResearch Unity of Applied Chemistry and Environment5000 MonastirTunisia National Engineering School of Monastir 5019 MonastirTunisia Higher Institute of Technological Studies 5070Ksar HellalMonastirTunisia

Acrylic fibres are highly crystalline and non-polar polymers,which makes their dyeing a very difficult step that poses real technical *** order to overcome this concern,it is intended in this paper to modify acrylic fibers by different methods namely cationisation using the Crosscolor DRT then amidoximation using hydroxylamine hydrochloride and ammonium *** resulted samples were dyed then with the bio-colorant extracted from grape *** effect of the pretreatment on fibers fine structure using X-ray diffraction and the scanning electron microscope(SEM)images and its correlation with the colour strength of the dyed fabrics was *** dyeing parameters,such as dye bath pH and temperature on the performances of this dyeing process were *** dyeing qualities and new shades varying from brown to grey and dark green have been obtained following process optimization,mordanting and modification of acrylic fibers by the technique of cationisation.

关键词： Modified acrylic fibers grape marc bio-colorant mordant.

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Vogt-Koyanagi-Harada syndrome and Crohn’s disease:an exceptional association

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Gastroenterology Report 2018年第1期6卷 65-67,I0003页

作者： Ahlem Souguir Aya Hammami wafa Dahmeni Hanene Jaziri Imed ben Mansour Ahlem Zayene Aida ben Slama Mehdi Ksiaa Ahlem Brahem Salem Ajmi Ali Jmaa Department of Gastroenterology University Hospital SahloulSousseTunisia

Vogt-Koyanagi-Harada disease(VKH)is a rare,multisystem disease of melanocyte-containing *** is characterized by diffuse,granulomatous inflammation involving various *** has been reported to occur in association with other autoimmune *** report the case of a female patient who was diagnosed with VKH at the age of 4 years and who was treated with corticosteroids until the age of *** years later,Crohn’s disease was diagnosed,with a severe *** cases of VKH associated with ulcerative colitis have previously been reported anecdotally but,to our knowledge,this is the first case occurring in association to Crohn’s disease.

关键词： Vogt-Koyanagi-Harada disease granulomatous inflammation Crohn’s disease

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Effectiveness of plant growth-promoting rhizobacterium Pantoea sp. BRM17 in enhancing canola growth on phosphogypsum-amended soil

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Pedosphere 2020年第4期30卷 570-576页

作者： Houda TRIFI Issam benSALEM Naima KOLSI benZINA Amine FOURATI Maria Clara COSTA wafa ACHOUAK Haitham SGHAIER Mouldi SAIDI Laboratory of Biotechnology and Nuclear Technology(LR16CNSTN01) National Center for Nuclear Sciences and Technology(CNSTN)Sidi Thabet Technopark 2020(Tunisia) Faculty of Sciences of Bizerte Carthage UniversityJarzouna 7021(Tunisia) Soil Sciences and Environment Laboratory National Institute of Agronomy of TunisiaTunis Mahrajene 1082(Tunisia) Tunisian Chemical Group Route de Gabes Km 3.5Sfax 3018(Tunisia) Centro de Ciencias do Mar Universidade do AlgarveCampus de GambelasFaro 8005-139(Portugal) Laboratory of Microbial Ecology of the Rhizosphere and Extreme Environment CEA CadaracheSaint Paul Lez Durance 13108(France) Laboratory of Energy and Matter for Development of Nuclear Sciences(LRJ6CNSTN02) National Center for Nuclear Sciences and Technology(CNSTN)Sidi Thabet Technopark 2020(Tunisia) Laboratory of Biotechnology and Bio-Georesources Valorization(LR1IES31) National Center for Nuclear Sciences and Technology(CNSTN)Sidi Thabet Technopark 2020(Tunisia)

Dear Editor,Phosphogypsum(PG)is the main by-product generated during phosphoric acid production from mineral *** contains mainly calcium sulfate dehydrate(CaSO4:2H2O),phosphate,fuoride,heavy metals,and radionuclides(Elloumi et al.,2015).Around 170×10^6 t PG is produced annually worldwide,although PG management is an environ-mental concern in several countries.

关键词： annually soil metals

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Seasonal and daily lfuctuation of diatoms during spring tide periods in Kerkennah Islands

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Journal of Coastal Life Medicine 2015年第6期 446-452页

作者： Mounir ben brahim wafa Feki-Sahnouna Morsi Feki Mabrouka Mahfoudi Asma Hamza Faculty of Sciences of Sfax.Road of Soukra km 4BP 802-3038 SfaxTunisia National Institute of Sciences and Technology of the Sea Center of SfaxBP-1035-CP.3018.SfaxTunisia

Objective:To study seasonal and the daily distribution of diatoms in the three tidal periods(flood,slack and ebb period)during the spring ***:Water samples were taken and environmental variables were measured three times in each tidal period during 10 days of spring *** was done in 2007 in Cercina station located in the western coast of Kerkennah(34°41'27''N;11°07'45''E)(Southern Tunisia).Results:Nutrients showed significant variation between seasons,increasing in spring and decreasing noticeably in autumn and *** 36 diatom species were *** revealed a remarkable abundance increase in spring and *** differences in diatom abundances were revealed over the tidal periods,with the highest rates being detected during the flood and the ebb period,while the abundance rate was lowest during the slack *** could presumably be attributed to the increase of nutrient supply of suspended particulate matter during water *** results revealed a correlation between diatom abundance and temperature,NO_(2)^(-),NO_(3)^(-),Si(OH)_(4) and PO_(4)^(3).Temperature seemed to be the most important factors which may influence the distribution and diatom ***:Tide has various effects on the nutrients status and diatoms community(in terms of species composition,succession and abundance)between different tidal *** of diatoms was correlated with changes in the circulation of water bodies and changes in nutrient regime.

关键词： Diatoms Tidal periods Seasonal variability Kerkennah

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Variability in patterns of macro-epiphytic leaf community of Posidonia oceanica in the Islands of Kuriate:Western coast of Tunisia

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Journal of Coastal Life Medicine 2016年第3期4卷 211-216页

作者： ben Brahim Mounir Abdennahder Moufida Feki-Sahnoun wafa Mahfoudi Mabrouka Hamza Asma Faculty of Sciences of Sfax Road of Soukra km 4BP 802-3038 SfaxTunisia National Institut of Sciences and Technology of the Sea Center of SfaxBP 1035-CP 3018 SfaxTunisia

Objective:To test the response of the epiphyte community structure and biomass of the Posidonia oceanica(***)leaves to natural ***:Sampling of *** was carried in winter and summer on three sites in Kuriate Islands(western coast of Tunisia)subject to different environments *** of *** were preserved in seawater-formalin(5%)solution for macro-epiphytes species identification in the *** samples were examined for leaf surface per shoot and the coverage(expressed as a percentage of leaf surface)of each morphological group,then carefully scraped with a razor *** and scraped leaves were oven-dried at 60℃for 48 *** was expressed as g dry weight/***:The biomass and the percentage cover of macro-epiphytic leaves showed seasonal *** highest values of epiphytic leaves were detected in summer whereas the lowest values were registered during *** showed that Kuriate Islands functioned as a single ecosystem in terms assemblage of macro-epiphytic leaves since no significant variation was detected for biomass and percentage cover at the scale *** study showed that natural disturbance had no effect on the assemblage distribution and the biomass of macro-epiphyte on the leaves of *** between the scales of site,whereas variability at the smallest scale was *** showed that exposure to wind and current had no effect on the biomass of macro-epiphytes ***:Biomass and assemblages of macro-epiphytic leaves of *** were high in summer and homogenous between all sites *** disturbances such as exposure to wind have no effect on the distribution and the biomass of epiphytes on the shallow meadow.

关键词： Macro-epiphyte Assemblage Variability Posidonia oceanica Tunisia

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Factor driving heterotrophic dinoflagellate in relation to environment conditions in Kerkennah Islands(eastern coast of Tunisa)

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Journal of Coastal Life Medicine 2015年第9期 686-690页

作者： Mounir ben Brahim Morsi Feki wafa Feki-Sahnoun Mabrouka Mahfoudi Asma Hamza Faculty of Sciences of Sfax Road of Soukra km 4BP 802-3038 SfaxTunisia National Institute of Sciences and Technologies of the Sea Center of Sfax-BP 1035-CP.3018.SfaxTunisia

Objective:To study the seasonal variability of heterotrophic dinoflagellate in the station of Cercina(southern coast of Tunisia).Methods:Sampling was done in 2007 in Cercina station located in the western coast of Kerkennah(34°41'27''N;11°07'45''E)(Southern Tunisia).Three replicates of water samples were taken during 10 days of each *** variables and nutrients were measured in ***:A significant seasonal difference was observed for temperature and water *** highest values were observed in spring and *** significant seasonal difference was,however,detected for nitrite,nitrate,ammonia,silica and ***-five species of dinoflagellate were identified in the station of *** of dinoflagellates fluctuated between seasons with values showing a significant seasonal and monthly *** highest mean abundance was recorded in spring in April,while the lowest abundance was detected in December in *** granii was the main species contributing to the dissimilarity between spring and winter with 13.98%followed by Peridinium *** 12.5%of dissimilarity and by Polykrikos *** 10.58%.Conclusions:Heterotrophic dinoflagellates proliferate in spring and *** increase was justified by the nutrient *** granii and Polykrikos kofoidii were the main heterotrophic dinoflagellate making difference between seasons and their densities were positively correlated with both temperature and salinity.

关键词： Heterotrophic dinoflagellate Variability Seasonal Kerkennah Tunisia

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A Rare Entity of Accelerated Chronic Lymphocytic Leukemia: A Report of Two Cases and Review of Literature

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Health 2023年第8期15卷 861-870页

作者： Zahra Kmira ben Yahya Noura Chembah wafa ben Sayed Nesrine Chiba Dorra Bouteraa Walid Zaier Monia ben Youssef Yosra Haifa Regaieg Khelif Abderrahim Department of Clinical Hematology Farhat Hached University Hospital Sousse Tunisia Department of Pathology Farhat Hached University Hospital Sousse Tunisia

Background: Accelerated-chronic lymphocytic leukemia (A-CLL) is a rare disease entity as it represents less than 1% of all reported cases of chronic lymphoid leukemia (CLL). Moreover, it is most likely an under diagnosed entity due to its rarity and the non-standardized practice of lymph node biopsy in CLL. Purpose: The aims of our work are to establish the diagnosis of A-CLL and to study the prognosis and treatment of this rare entity. Method: here, we report the clinical presentation and the follow up of two cases of A-CLL. Results: Distinguishing Richter transformation (RT) from A-CLL is important as it may result in a major change in disease management. The prognosis of A-CLL is intermediate between CLL and RT. The prognosis is mainly poor due to a predominance of poor prognostic markers including an increasing number of p53-positive cases. Conclusion: To this date, no prospective study has been led to define the best treatment for A-CLL. The shorter survival of A-CLL when compared to typical CLL implies the need of a more aggressive treatment.

关键词： Accelerated Chronic Lymphocytic Leukemia Richter Transformation Prognosis Treatment

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Challenges to associate early onset epilepsy with COVID-19 autoimmune encephalitis:A case

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World Journal of Immunology 2023年第1期13卷 1-10页

作者： Salma Zouari Mallouli Olfa Jallouli wafa Bouchaala Sihem ben Nsir Fatma Kamoun Feki Chahnez Charfi Triki Department of Child Neurology Hedi Chaker Sfax University Hospital and Research Laboratory LR19ES15-University of SfaxTunisiaSfax 3029Tunisia

BACKGROUND Diagnosis of coronavirus disease 2019(COVID-19)-related neurological events in the pediatric population is *** clinical picture of children with altered neurological state and inborn errors of metabolism,in addition to the frequency of asymptomatic COVID-19 cases,pose the main challenges for *** approaches to the onset post-COVID 19 subacute encephalopathy are still troublesome as seronegative autoimmune encephalitis(AIE)is *** SUMMARY A 27-mo-old boy was admitted for stormy refractory seizure of polymorphic semiology and altered mental status followed by various neuropsychiatric features that were suggestive of *** magnetic resonance imaging and cerebrospinal fluid analysis were *** the immunological assessment,including viral serologies,antinuclear antibodies,autoimmune antibodies(NMDA,AMPA,CASPR2,LG11,GABARB,Hu,Yo,Ri,CV2,PNMA2,SOX1,Titin,amphiphysin,Recoverin),nor the metabolic assessment for lactate and pyruvate showed significant *** positive history of COVID-19 infection and the findings of characteristic repetitive extreme delta brush played a key role in the diagnosis of COVID-19-related AIE.A remarkable improvement in the state of the child was noted after two pulse doses of intravenous Veinoglobulin and high dose of intravenous *** Diagnostic biomarkers for AIE might aid effective treatment.

关键词： Post-COVID-19 Auto-immune encephalitis Diagnosis biomarkers Pediatric population Delta brush sign Autoimmune antibodies

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Primary Lymphoma of the Larynx: A Case Report and Literature Review

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Open Journal of Clinical Diagnostics 2015年第2期5卷 81-85页

作者： Khaled Khamassi Madiha Mahfoudhi Habib Jaafoura Khaoula Ouertani wafa Kaabachi Lobna Bougacha Rim Lahiani Mamia ben Salah Department of Otorhinolaryngology—Head and Neck Surgery Charles Nicolle Hospital Tunis Tunisia Department of Internal Medicine A Charles Nicolle Hospital Tunis Tunisia

Background: Primary non-hodgkin lymphoma of the larynx is a rare entity accounting for 1% of laryngeal tumors. Fewer than 100 cases have been reported in the literature. Case presentation: A 52-year-old man, presented with a two-month history of dysphonia. Nasofibroscopy showed left submucosal bulging of the laryngeal supraglottic floor. Cervical computed tomography showed extensive left supraglottic mass, with partial lysis of the thyroid cartilage. Direct laryngoscopy showed left submucosal bulging of the supraglottic floor. Transmucosal biopsies were performed. Histological study concluded to the presence of a diffuse large-cell B lymphoma. The patient was treated with chemotherapy followed by external radiotherapy. Evolution was favourable. Conclusion: Although primary laryngeal non-hodgkin lymphoma is rare, it should be considered in the differential diagnosis of a mass in the neck region, especially in the supraglottic area. Direct laryngoscopy with biopsy makes the diagnosis. Treatment and prognosis depend on the stage and the grade of the lymphoma.

关键词： Larynx Lymphoma Laryngoscopy Chemotherapy Radiotherapy

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