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Immunoregulatory and Anti-cancer Activities of Combination Treatment of Novel Four-Herb Formula and Doxorubicin in 4T1-Breast Cancer Bearing Mice

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Chinese Journal of Integrative Medicine 2024年第4期30卷 311-321页

作者： Lea Ling-Yu Kan ben chung-lap chan Grace Gar-Lee Yue LI Pei-ting Sharon Sze-Man Hon HUANG Dan-qi Miranda Sin-Man Tsang Clara Bik-San Lau Ping-chung Leung Chun-Kwok Wong Institute of Chinese Medicine The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants The Chinese University of Hong KongHong KongChina Department of Chemical Pathology The Chinese University of Hong KongHong Kong SARChina China-Australia International Research Centre for Chinese Medicine School of Health and Biomedical SciencesSTEM CollegeRMIT UniversityBundooraVictoriaAustralia Li Dak Sum Yip Yio Chin R&D Centre for Chinese Medicine The Chinese University of Hong Kong SARHong KongChina

Objective To investigate the in vivo immunomodulatory and anti-tumor mechanisms of the combined treatment of novel Four-Herb formula(4HF)and doxorubicin in triple-negative breast cancer(TNBC).Methods Murine-derived triple-negative mammary carcinoma cell line,4T1 cells,was cultured and inoculated into mouse mammary ***-six mice were randomly assigned into 6 groups(n=11 in ench):naive,control,LD 4HF(low dose 4HF),HD 4HF(high dose 4HF),LD 4HF+D(low dose and doxorubicin),and D(doxorubicin).Apart from the naive group,each mouse received subcutaneous inoculation with 5×10^(5)4T1 cells resuspended in 100µL of normal saline in the mammary fat *** from the day of tumor cell inoculation,tumors were grown for 6 *** LD and HD groups received daily oral gavage of 658 and 2,630 mg/kg 4HF,*** LD 4HF+D group received daily oral gavage of 658 mg/kg 4HF and weekly intraperitoneal injection of doxorubicin(5 mg/kg).The D group received weekly intraperitoneal injections of doxorubicin(5 mg/kg).The treatment naive mice received daily oral gavage of 0.2 mL double distilled water and 0.1 mL normal saline via intraperitoneal injection once a *** control group received daily oral gavage of 0.2 mL double-distilled *** treatment period was 30 *** the end of treatment,mice organs were harvested to analyze immunological activities via immunophenotyping,gene and multiplex analysis,histological staining,and gut microbiota *** Mice treated with the combination of 4HF and doxorubicin resulted in significantly reduced tumor and spleen burdens(P<0.05),altered the hypoxia and overall immune lymphocyte landscape,and manipulated gut microbiota to favor the anti-tumor immunological ***,immunosuppressive genes,cytokines,and chemokines such as C-C motif chemokine 2 and interleukin-10 of tumors were significantly downregulated(P<0.05).4HF-doxorubicin combination treatment demonstrated synergetic activities and was most effective

关键词： adjunctivetherapy breast cancer cytokines Chinese medicine tumor microenvironment

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Meteorin-β/Meteorin like/IL-41 attenuates airway inflammation in house dust mite-induced allergic asthma

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Cellular & Molecular Immunology 2022年第2期19卷 245-259页

作者： Xun Gao Ting-Fan Leung Gary Wing-Kin Wong Wing-Hung Ko Mengyun Cai Ellie Jiayi He Ida Miu-Ting Chu Miranda Sin-Man Tsang ben chung-lap chan Jiawei Ling Xiao Fan Liwei Lu Christopher Wai-Kei Lam Chun-Kwok Wong Department of Chemical Pathology The Chinese University of Hong KongHong KongChina Department of Paediatrics The Chinese University of Hong KongHong KongChina School of Biomedical Sciences The Chinese University of Hong KongHong KongChina Emory College of Arts and Sciences Emory UniversityAtlantaGAUSA Institute of Chinese Medicine and State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants The Chinese University of Hong KongHong KongChina Department of Pathology and Shenzhen Institute of Research and Innovation The University of Hong KongHong KongChina Faculty of Medicine and State Key Laboratory of Quality Research in Chinese Medicines Macao University of Science and TechnologyMacaoChina Li Dak Sum Yip Yio Chin R&D Centre for Chinese Medicine The Chinese University of Hong KongHong KongChina

We sought to examine the regulatory effect of Meteorin-β(Metrnβ)/Meteorin like(Metrnl)/IL-41 on lung inflammation in allergic *** found that Metrnβwas elevated significantly in asthmatic patients and in mice with allergic asthma induced by house dust mite(HDM)*** exposure to HDM,Metrnβwas secreted predominantly by airway epithelial cells and inflammatory cells,including macrophages and *** increased Metrnβeffectively blocked the development of airway hyperreactivity(AHR)and decreased inflammatory cell airway infiltration and type 2 cytokine production,which was associated with downregulated DC-mediated adaptive immune ***,Metrnβimpaired the maturation and function of bone marrow-derived dendritic cells in *** mice adoptively transferred with dendritic cells isolated from Metrnβ-treated allergic mice displayed decreased AHR,airway inflammation,and lung ***βalso displayed anti-inflammatory properties in immunodeficient SCID mice with allergic asthma and in in vitro 3D ALI airway ***,blockade of Metrnβby anti-Metrnβantibody treatment promoted the development of allergic *** results revealed the unappreciated protective roles of Metrnβin alleviating DC-mediated Th2 inflammation in allergic asthma,providing the novel treatment strategy of therapeutic targeting of Metrnβin allergic asthma.

关键词： Metrnβ Eosinophils Dendritic cells Allergic asthma Air-liquid interface

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Multicomponent polymerization of elemental sulfur,difluoromethylene phosphobetaine and aryl silyl ethers toward aromatic poly(O,O′-monothiocarbonate)s

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Science China Chemistry 2025年

作者： Yongjiang Yu Rongrong Hu ben Zhong Tang State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates South China University of Technology School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong Kong AIE Institute

Polythiocarbonates with similar structures to polycarbonates, have emerged as a group of promising sulfur-containing polymers with a range of practical applications, taking advantages of their excellent optical properties, good thermal stability and filmforming ability, and so on. However, the synthesis of polythiocarbonates generally suffered from mixed isomeric structures of repeating units, and hazardous sulfur-containing reagents. In this work, an efficient multicomponent reaction of elemental sulfur,difluoromethylene phosphobetaine（PDFA）, and aryl silyl ethers was designed with the assistance of organic base 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene（MTBD） to produce 12 kinds of O,O′-monothiocarbonate compounds in up to 93% yields,taking advantages of the unique chemical property of difluorocarbene, and the deprotection of silyl group by F-generated from PDFA. Most importantly, the MTBD-assisted multicomponent polymerization of bis（aryl silyl ether）s, elemental sulfur, and PDFA was developed, affording 12 kinds of poly（O,O′-monothiocarbonate）s with well-defined structures, high Mws of up to16900 g/mol and high yields（up to 99%）. These poly（O,O′-monothiocarbonate）s possessed good film-forming properties and thermal stability, high light refractive indices and transmittance. The facile synthesis of these polymonothiocarbonates might pave the way for the development of promising sulfur-containing polymer materials.

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A multi-objective pigeon inspired optimization algorithm for fuzzy production scheduling problem considering mould maintenance

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Science China(Information Sciences) 2019年第7期62卷 15-32页

作者： Xiaoyue FU Felix T.S.chan ben NIU Nick S.H.chung Ting QU Department of Industrial and Systems Engineering The Hong Kong Polytechnic University College of Management Shenzhen University School of Electrical and Information Engineering Jinan University

The fuzzy production scheduling problem considering mould maintenance(FPSP-MM) is studied. The processing time and the maintenance time are represented by triangular fuzzy numbers. When tasks are executed based on the sequence provided by the fuzzy schedule, the real duration of each task needs to be known so the posteriori solution with deterministic processing times can be obtained. Therefore, the concept of the schedule robustness needs to be considered for the fuzzy problem. The robustness is considered as the optimization objective except for the fuzzy makespan in this research. To optimize these two objective functions, a multi-objective pigeon inspired optimization(MOPIO) algorithm is developed. To extend the pigeon inspired optimization(PIO) algorithm from the single-objective case to the multi-objective case, nondominated solutions are used as candidates for the leader pigeon designation and a special crowding distance is used to ensure a good distribution of solutions in both the objective space and the corresponding decision space. Furthermore, an index-based ring topology is used to manage the convergence speed. Numerical experiments on a variety of simulated scenarios show the excellent efficiency and effectiveness of the proposed MOPIO algorithm by comparing it with other algorithms.

关键词： fuzzy production scheduling mould maintenance pigeon inspired optimization multi-objective

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Trimetallic mesoporous PdCuRu for efficient formate electrosynthesis from polyethylene terephthalate recycling

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Science China Chemistry 2025年

作者： Yuting Li Huiqin Yao Lizhi Sun Shu Han Xiaoxiang Xu Guangyin Fan ben Liu College of Chemistry and Materials Science Sichuan Normal University Key Laboratory of Green Chemistry and Technology of Ministry of Education College of Chemistry Sichuan University School of Basic Medical Sciences Ningxia Medical University Department of Otorhinolaryngology-Head and Neck Surgery Zhongnan Hospital of Wuhan University

Electrochemical recycling of waste polyethylene terephthalate（PET） plastics represents a green and sustainable route to produce valuable fuels and address serious environmental issues. Despite some encouraged achievements, their progress is still slower because of the lack of highly active and selective electrocatalysts. Here, we reported an efficient PET recycling route with trimetallic PdCuRu mesoporous nanospheres（MSs） as a high-performance electrocatalyst that achieved selective electrosynthesis of valuable formate from PET hydrolysate（PETH） electrooxidation. Penetrated metal mesopores and trimetallic compositions of PdCuRu MSs synergistically optimized electronic structures of Pd sites and changed chemisorption properties of intermediates, which disclosed a high formate Faradic efficiency of 97% and impressive yield rate of 0.49 mmol h-1cm-2in an alkaline solution. Meanwhile, this electrocatalyst held good electrocatalytic stability, retaining high formate Faradic efficiency and yield rate even being performed for 10 cycles, which highlighted its potential applications for practical PET recycling. Our study provides a powerful strategy for designing high-performance electrocatalysts toward selective electro-synthesis of valuable fuels from various waste plastics.

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Specific staining and precise killing of cancer cells through fusion of pharmaceutical chemistry and π-bridge effect design philosophy

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Science China Chemistry 2025年

作者： Qiong Liu Qiyun Deng changxu Zhu Kongqi Chen Lidan Chen Zhaohui Sun ben Zhong Tang Zhiming Wang AIE Institute Center for Aggregation-Induced Emission State Key Laboratory of Luminescent Materials and Devices Key Laboratory of Luminescence from Molecular Aggregates of Guangdong Province South China University of Technology Department of Laboratory Medicine General Hospital of Southern Theater Command School of Life Sciences The Chinese University of Hong Kong Shenzhen Institute of Aggregate Science and Technology School of Science and Engineering The Chinese University of Hong Kong HKUST-Shenzhen Research Institute

The development of an advanced phototheranostic platform that combines imaging and therapy in a single agent is an appealing yet challenging *** this study,we successfully constructed three novel fluorescent probes by leveraging pharmaceutical chemistry and the design philosophy of theπ-bridge *** a systematic comparative analysis of their fluorescence properties,water solubility,molecular conformation,and electrostatic potential,we revealed the fundamental principles governing the optical behavior and biological selectivity of these ***,the probe TPhIQ-CNTh demonstrated extended fluorescence in the near-infrared region,a significant aggregation-induced emission (AIE) effect,and the ability to distinguish tumor cells from normal ***,it efficiently generated reactive oxygen species (ROS) and specifically labeled lipid droplets,enabling the precise staining and killing of cancer *** study presents a practical strategy for designing precise tumor treatments that integrate efficient imaging-guided photodynamic therapy (PDT) by harnessing the unique properties of AIE materials.

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Redistributing Cu species in Cu-SSZ-13 zeolite as NH3-SCR catalyst via a simple ion-exchange

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Chinese Journal of Chemical Engineering 2022年第1期35卷 329-341页

作者： ben Liu Nangui Lv chan Wang Hongwei Zhang Yuanyuan Yue Jingdong Xu Xiaotao Bi Xiaojun Bao National Engineering Research Center of Chemical Fertilizer Catalyst College of Chemical EngineeringFuzhou UniversityFuzhou 350002China Qingyuan Innovation Laboratory Quanzhou 362801China Sinochem Quanzhou Energy Technology Co LtdQuanzhou 362000China Department of Chemical&Biological Engineering University of British Columbia2360 East MallVancouverBC V6T 1Z3Canada State Key Laboratory of Photocatalysis on Energy&Environment College of ChemistryFuzhou UniversityFuzhou 350116China

The nature and distribution of Cu species in Cu-SSZ-13 play a vital role in selective catalytic reduction of NO by NH3(NH3-SCR),but existing methods for adjusting the Cu distribution are complex and difficult to ***,we report a simple and effective ion-exchange approach to regulate the Cu distribution in the one-pot synthesized Cu-SSZ-13 that possesses sufficient initial Cu species and thus provides a“natural environment”for adjusting Cu distribution *** using this proposed strategy,a series of Cu-SSZ-13x zeolites with different Cu contents and distributions were *** is shown that the dealumination of the as-synthesized Cu-SSZ-13 during the ion-exchange generates abundant vacant sites in the double six-membered-rings of the SSZ-13 zeolite for relocating Cu2+species and thus allows the redistribution of the Cu *** catalytic results showed that the ion-exchanged Cu-SSZ-13 zeolites exhibit quite different catalytic performance in NH3-SCR reaction but superior to the parent *** structure–activity relationship analysis indicates that the redistribution of Cu species rather than other factors(e.g.,crystallinity,chemical composition,and porous structure)is responsible for the improved NH3-SCR performance and SO_(2) and H_(2)O *** work offers an effective method to precisely adjust the Cu distribution in preparing the industrial SCR catalysts.

关键词： Catalyst Zeolite Cu-SSZ-13 Ion-exchange Redistribution of Cu species Selective catalytic reduction(SCR)

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Effect of irradiation on temperature performance of dispersioncompensation no-core cascade optical-fiber sensor coated with polydimethylsiloxane film

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Nuclear Science and Techniques 2022年第9期33卷 10-20页

作者： Fang Wang Qiu-Feng Wu Yu-Rong Jiang chan Jin Xiao-Hui Wang ben-Shang Zhang Chun-Wang Ma College of Electronic and Electrical Engineering Henan Normal UniversityXinxiang 453007China Key Laboratory of Optoelectronic Sensing Integrated Application of Henan Province Xinxiang 453007China School of Physics Henan Normal UniversityXinxiang 453007China Engineering Laboratory of Intelligent Additive Manufacturing of Henan Province Xinxiang 453007China Key Laboratory of Interfacial Physics Technology Project Chinese Academy of SciencesShanghai 201800China Institute of Isotope Research Henan Academy of SciencesZhengzhou 450000China

A temperature measurement device can produce data deviations and can even be damaged in a high-dose radiation *** reduce the radiation damage to such a device and improve the temperature measurement accuracy in a radiation environment,a temperature sensor based on optical-fiber sensing technology is *** sensor has a cascade structure composed of a single-mode fiber(SMF),a dispersion-compensation fiber(DCF),a nocore fiber(NCF),and another SMF(SDNS).The DCF and NCF are coated with a polydimethylsiloxane(PDMS)film,which is a heat-sensitive material with high thermal optical and thermal expansion *** experiments,PDMS was found to produce an irradiation crosslinking effect after irradiation,which improved the temperature sensitivity of the SDNS *** experimental results showed that within a range of 30–100℃,the maximum temperature sensitivity after irradiation was 62.86 pm/℃,and the maximum transmission sensitivity after irradiation was 3.353×10^(-2)dB/℃,which were 1.22 times and 2.267 times the values before irradiation,*** addition,repeated temperature experiments verified that the SDNS sensor coated with the PDMS film had excellent temperature ***,it was found that with an increase in the irradiation intensity,the irradiation crosslinking degree of PDMS increased,and the temperature sensitivity of the sensor was *** proposed sensor could potentially be applied to temperature measurement in a nuclear-radiation environment.

关键词： ^(60)Co-γirradiation Optical-fiber sensor Temperature performance PDMS Radiation crosslinking

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SYNTHESIS AND CHARACTERIZATION OF NOVEL REACTIVE POLYORGANOSILOXANE CONTAINING NITRO GROUPS

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Chinese Journal of Polymer Science 2001年第1期19卷 1-6页

作者： Chun-qing Liu Yang Liu Ping Xie Rong-ben Zhang Chao-bin He Neal Tai-shung chung PCLCC Center for Molecular Science Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China PCLCCCenter for Molecular Science Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China PCLCCCenter for Molecular Science Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China PCLCCCenter for Molecular Science Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China Institute of Materials Research and Engineering National University of Singapore Singapore 119260 Institute of Materials Research and Engineering National University of Singapore Singapore 119260

A novel reactive polyorganosiloxane containing nitro groups was first prepared by acid-catalyzed equilibration polymerization. The monomer, 3-(4-nitrophenoxy)propylmethyldichlorosilane (NPPMS), was synthesized by hydrosilylation reaction with dicyciopentadienylplatinum(II) chloride (Cp2PtCl2) catalyst in high yield. The synthesized polynitroorganosiloxane, which has potential application as a precursor for synthesizing advanced functional polymers, was characterized by FTIR, H-1-NMR, C-13-NMR, Si-29-NMR, vapor pressure osmometry (VPO) and gel permeation chromatography(GPC).

关键词： polyorganosiloxane equilibration polymerization hydrosilylation characterization

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SYNTHESIS AND CHARACTERIZATION OF A NOVEL ALCOHOL-SOLUBLE POLYORGANOSILOXANE CONTAINING AMINO SIDE GROUPS

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Chinese Journal of Polymer Science 2001年第1期19卷 97-102页

作者： Chun-qing Liu Yang Liu Zhong-rong Shen Ping Xie Rong-ben Zhang Chao-bin He Tai-shung chung PCLCC Center for Molecular Science Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China PCLCCCenter for Molecular Science Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China PCLCCCenter for Molecular Science Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China PCLCCCenter for Molecular Science Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China PCLCCCenter for Molecular Science Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China Institute of Materials Research and Engineering National University of Singapore Singapore 119260 Institute of Materials Research and Engineering National University of Singapore Singapore 119260

A novel alcohol-soluble polyorganosiroxane containing amino side groups, poly[3-(4-aminophenoxy)-aminophenoxy) propylmethylsiloxane] (2), was first prepared by the reduction of nitro groups on 4-nitrophenoxypropyl side chains of poly[3-(4-nitrophenoxy)propylmethylsiloxane] (1). The reaction proceeded easily with nearly 100% conversion. The synthesized alcohol-soluble polymer 2, which has potential application as a precursor for preparing advanced functional polymers, was characterized by FTIR, H-1-NMR, C-13-NMR, Si-29-NMR, VPO and GPC, respectively.

关键词： alcohol-soluble polyorganosiloxane reduction characterization

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