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Foodborne toxin Aflatoxin B_(1)induced glomerular podocyte inflammation through proteolysis of RelA,downregulation of miR-9 and CXCR4/TXNIP/NLRP3 pathway

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Food Science and Human Wellness 2024年第4期13卷 2289-2309页

作者： Jie Zhang Shuang Yang Baocai Xu Zihui Qin Xinyi Guo ben Wei Qinghua Wu Kamil Kuca Tushuai Li Wenda Wu School of Biology and Food Engineering Changshu Institute of TechnologySuzhou 215500China Center for Clinical Mass Spectrometry School of Pharmaceutical SciencesSoochow UniversitySuzhou 215123China School of Food and Biological Engineering Hefei University of TechnologyHefei 230009China MOE Joint International Research Laboratory of Animal Health and Food Safety College of Veterinary MedicineNanjing Agricultural UniversityNanjing 210095China Department of Chemistry Faculty of ScienceUniversity of Hradec KraloveHradec Kralove 50003Czech Republic College of Life Science Yangtze UniversityJingzhou 434025China Wuxi Medical College Jiangnan UniversityWuxi 214122China Wuxi Translational Medicine Research Center and Jiangsu Translational Medicine Research Institute Wuxi Branch Wuxi 214013China

Aflatoxin B_(1)(AFB_(1))is a naturally-occurring mycotoxin and recognized as the most toxic foodborne toxin,particularly causing damages to *** podocytes are terminally differentiated epithelial ***_(1)induces podocyte inflammation,proteinuria and renal *** the mechanism of AFB_(1)-induced podocyte inflammation and murine kidney dysfunction,we detected that AFB_(1)increased ubiquitindependent degradation of the transcription factor RelA through enhanced interaction of RelA with E3 ubiquitin ligase tripartite motif containing 7(TRIM7)in mouse podocyte clone-5(MPC-5)and mouse *** of RelA resulted in decreasing microRNA-9(miR-9)and activating the chemokine receptor 4(CXCR4),thioredoxin interacting protein(TXNIP),and NOD-like receptor pyrin domain-containing 3(NLRP3)signaling axis(CXCR4/TXNIP/NLRP3 pathway),leading to podocyte *** also determined that downregulation of miR-9 led to CXCR4 expression and the downstream TXNIP/NLRP3 pathway *** of miR-9 or deletion of CXCR4 suppressed AFB_(1)-induced CXCR4/TXNIP/NLRP3 pathway,resulting in alleviating podocyte inflammation and kidney *** findings indicated that ubiquitin-dependent proteolysis of RelA,downregulation of miR-9,and activation of CXCR4/TXNIP/NLRP3 pathway played an essential role in AFB_(1)-induced glomerular podocyte *** study revealed a novel mechanism,via RelA,for the control of AFB_(1)’s nephrotoxicity,leading to an effective protection of food safety and public health.

关键词： Aflatoxin B_(1) Podocyte inflammation miRNA-9 Chemokine(C-X-C motif)receptor 4 RelA ubiquitin-dependent degradation

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碱激发矿渣混凝土密实性超声无损检测法及其影响因素

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材料导报 2024年第11期38卷 166-172页

作者：李静张灵王昊陈犇陈东彬黄莹陈正广西大学土木建筑工程学院工程防灾与结构安全教育部重点实验室南宁530004

研究了碱激发矿渣混凝土水胶比、模数、碱当量及粗骨料含量对其抗压强度、超声波速的影响,并通过分析混凝土配合比参数与密度、弹性模量、孔隙率之间的关系来揭示超声波速的变化机理。结果表明:不同配合比参数的碱激发矿渣混凝土超声波... 详细信息

研究了碱激发矿渣混凝土水胶比、模数、碱当量及粗骨料含量对其抗压强度、超声波速的影响,并通过分析混凝土配合比参数与密度、弹性模量、孔隙率之间的关系来揭示超声波速的变化机理。结果表明:不同配合比参数的碱激发矿渣混凝土超声波速与弹性模量成正比,与密度、孔隙率成反比,在超声无损检测过程中可将碱激发矿渣混凝土近似作为均质性实体材料进行建模计算,发现其超声波速与抗压强度呈线性关系。基于理论分析与试验结果建立了碱激发矿渣混凝土的密实性计算模型,可以为检测碱激发矿渣混凝土密实性作参考。

关键词：碱激发矿渣混凝土抗压强度超声波速无损检测密实性

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用于骨组织再生的电活性高分子材料研究进展

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中国塑料 2024年第8期38卷 113-117页

作者：郑天宜张犇郭敏王颖中国石化北京化工研究院医用卫生材料研究与应用重点实验室北京100013

天然骨组织具有压电特性,重建缺损部位的局部电微环境是刺激骨再生的有效策略。电活性高分子材料能够仿生骨组织压电特性,修复缺损处生理学电微环境,进而促进骨组织再生修复。本文分类介绍了几种类型的电活性高分子材料,包括导电高分子... 详细信息

天然骨组织具有压电特性,重建缺损部位的局部电微环境是刺激骨再生的有效策略。电活性高分子材料能够仿生骨组织压电特性,修复缺损处生理学电微环境,进而促进骨组织再生修复。本文分类介绍了几种类型的电活性高分子材料,包括导电高分子、压电高分子和驻极体高分子材料,概述了其在骨组织修复领域的研究进展,并分析了不同材料的优势与挑战。

关键词：电活性高分子材料骨组织再生导电高分子压电高分子驻极体高分子

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Stochastic PDEs for large portfolios with general mean-reverting volatility processes

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Probability, Uncertainty and Quantitative Risk 2024年第3期9卷 263-300页

作者： ben Hambly Nikolaos Kolliopoulos Mathematical Institute University of OafordRadcliff Observatory QuarterWoodstock RoadOrfordOX26GGUK Department of Mathematics University of Michigan2074 East Hall530 Church StreetAnn ArborMI 48109-1043USA

We consider a structural stochastic volatility model for the loss from a large portfolio of credit risky *** the asset value and the volatility processes are correlated through systemic Brownian motions,with default determined by the asset value reaching a lower *** prove that if our volatility models are picked from a class of mean-reverting diffusions,the system converges as the portfolio becomes large and,when the vol-of-vol function satisfies certain regularity and boundedness conditions,the limit of the empirical measure process has a density given in terms of a solution to a stochastic initial-boundary value problem on a *** problem is defined in a special weighted Sobolev *** results are established for solutions to this problem,and then we show that there exists a unique *** contrast to the CIR volatility setting covered by the existing literature,our results hold even when the systemic Brownian motions are taken to be correlated.

关键词： Stochastic PDEs Large portfolios General mean-reverting volatility processes Stochastic volatility model Credit risk

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AI-Based Helmet Violation Detection for Traffic Management System

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Computer Modeling in Engineering & Sciences 2024年第10期141卷 733-749页

作者： Yahia Said YahyaAlassaf Refka Ghodhbani Yazan Ahmad Alsariera Taoufik Saidani Olfa ben Rhaiem Mohamad Khaled Makhdoum Manel Hleili Department of Electrical Engineering College of EngineeringNorthern Border UniversityArar91431Saudi Arabia Department of Civil Engineering College of EngineeringNorthern Border UniversityArar91431Saudi Arabia Faculty of Computing and Information Technology Northern Border UniversityRafha91911Saudi Arabia College of Science Northern Border UniversityArar91431Saudi Arabia Department of Mathematics Faculty of Sciences of TabukUniversity of TabukTabuk71491Saudi Arabia

Enhancing road safety globally is imperative,especially given the significant portion of traffic-related fatalities attributed to motorcycle accidents resulting from non-compliance with helmet *** the critical role of helmets in rider protection,this paper presents an innovative approach to helmet violation detection using deep learning *** primary innovation involves the adaptation of the PerspectiveNet architecture,transitioning from the original Res2Net to the more efficient EfficientNet v2 backbone,aimed at bolstering detection *** rigorous optimization techniques and extensive experimentation utilizing the India driving dataset(IDD)for training and validation,the system demonstrates exceptional performance,achieving an impressive detection accuracy of 95.2%,surpassing existing ***,the optimized PerspectiveNet model showcases reduced computational complexity,marking a significant stride in real-time helmet violation detection for enhanced traffic management and road safety measures.

关键词： Non-helmet use detection traffic violation safety deep learning optimized PerspectiveNet

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Dark Matter Search in Dwarf Irregular Galaxies with Ten Years of Data from the Ice Cube Neutrino Observatory

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Research in Astronomy and Astrophysics 2024年第3期24卷 75-82页

作者： Yi-Fei Lü ben-Yang Zhu Rong-Lan Li Xue-Kang Guo Tian-Ci Liu Yong-Bo Huang Yun-Feng Liang Guangxi Key Laboratory for Relativistic AstrophysicsSchool of Physical Science and TechnologyGuangxi University Nanning 530004China

Dwarf irregular galaxies(dIrrs),as rotationally supported systems,have more reliable J-factor measurements than dwarf spheroidal galaxies and have received attention as targets for dark matter detection in recent *** this paper,we use 10 yr of IceCube muon-track data and an unbinned maximum-likelihood-ratio method to search for neutrino signals beyond the background from the directions of seven dIrrs,aiming to detect neutrinos produced by heavy annihilation dark *** do not detect any significant *** on such null results,we calculate the upper limits on the velocity-averaged annihilation cross section for 1 TeV–10 PeV dark *** limits,although weaker than the strictest constraints in the literature in this mass range,are also a good complement to the existing results considering the more reliable J-factor measurements of dIrrs.

关键词： (cosmology) dark matter-cosmology theory-galaxies dwarf

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Pancreatic giant malignancy simulating a gastrointestinal stromal tumor

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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 431-433页

作者： ben-Jie Liu Chen-Hui Jin Yan-Lun Guo Zhi-Gang Ke Jun-Jun Huang Lin-Ping Cao Department of Hepatobiliary Surgery Department of General SurgeryPujiang Branch of the First Affiliated HospitalZhejiang University School of MedicineJinhua 322200China Department of Pathology Pujiang Branch of the First Affiliated HospitalZhejiang University School of MedicineJinhua 322200China Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Pancreatic acinar cell carcinoma(PACC)is a rare malignant tumor of pancreatic epithelial cells,which produces pancreatic exocrine *** originates from acinar cells and terminal branches of the pancreatic ducts in the exocrine tissue of the *** accounts for 1%−2%of pancreatic exocrine tumors[1].Herein,we present an elderly woman with PACC who recovered after effective laparoscopic *** tumor was located on the left side of the abdomen;imaging suggested that it was a gastrointestinal stromal tumor of the gastric wall origin,infiltrating the tail of the pancreas and omentum,while postoperative pathology suggested PACC.

关键词： Pancreatic gastrointestinal pancreas

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Monogenic features of urolithiasis: A comprehensive review

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Asian Journal of Urology 2024年第2期11卷 169-179页

作者： Kyo Chul Koo Abdulghafour Halawani Victor K.F.Wong Dirk Lange ben H.Chew Department of Urology Yonsei University College of MedicineSeoulRepublic of Korea Department of Urology King Abdulaziz UniversityJeddahSaudi Arabia Department of Urological Sciences University of British ColumbiaStone Centre at Vancouver General HospitalVancouverBritish ColumbiaCanada

Objective: Urolithiasis formation has been attributed to environmental and dietary factors. However, evidence is accumulating that genetic background can contribute to urolithiasis formation. Advancements in the identification of monogenic causes using high-throughput sequencing technologies have shown that urolithiasis has a strong heritable ***: This review describes monogenic factors implicated in a genetic predisposition to urolithiasis. Peer-reviewed journals were evaluated by a PubMed search until July 2023 to summarize disorders associated with monogenic traits, and discuss clinical implications of identification of patients genetically susceptible to urolithiasis ***: Given that more than 80% of urolithiases cases are associated with calcium accumulation, studies have focused mainly on monogenetic contributors to hypercalciuric urolithiases, leading to the identification of receptors, channels, and transporters involved in the regulation of calcium renal tubular reabsorption. Nevertheless, available candidate genes and linkage methods have a low resolution for evaluation of the effects of genetic components versus those of environmental, dietary, and hormonal factors, and genotypes remain undetermined in the majority of urolithiasis ***: The pathophysiology underlying urolithiasis formation is complex and multifactorial, but evidence strongly suggests the existence of numerous monogenic causes of urolithiasis in humans.

关键词： Gene Genetic expression Inheritance pattern Urolithiasis

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Genetic variation of circHIBADH enhances prostate cancer risk through regulating HNRNPA1-related RNA splicing

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Journal of Biomedical Research 2024年第4期38卷 358-368页

作者： Yifei Cheng Rongjie Shi Shuai ben Silu Chen Shuwei Li Junyi Xin Meilin Wang Gong Cheng Department of Environmental Genomics Jiangsu Key Laboratory of Cancer BiomarkersPrevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingJiangsu 211166China Department of Urology the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Bioinformatics School of Biomedical Engineering and InformaticsNanjing Medical UniversityNanjingJiangsu 211166China Jiangsu Cancer Hospital Jiangsu Institute of Cancer Researchthe Affiliated Cancer Hospital of Nanjing Medical UniversityNanjingJiangsu 210009China The Affiliated Suzhou Hospital of Nanjing Medical University Suzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhouJiangsu 215002China

The current study aimed to investigate associations of circRNAs and related genetic variants with the risk of prostate cancer(PCa)as well as to elucidate biological mechanisms underlying the *** first compared expression levels of circRNAs between 25 paired PCa and adjacent normal tissues to identify riskassociated circRNAs by using the MiOncoCirc *** then used logistic regression models to evaluate associations between genetic variants in candidate circRNAs and PCa risk among 4662 prostate cancer patients and 3114 healthy controls,and identified circHIBADH rs11973492 T>C as a significant risk-associated variant(odds ratio=1.20,95%confidence interval:1.08-1.34,P=7.06×10^(-4))in a dominant genetic model,which altered the secondary structure of the corresponding RNA *** the in silico analysis,we found that circHIBADH sponged and silenced 21 RNA-binding proteins(RBPs)enriched in the RNA splicing pathway,among which HNRNPA1 was identified and validated as a hub RBP using an external RNA-sequencing data as well as the in-house(four tissue samples)and publicly available single-cell ***,we demonstrated that HNRNPA1 influenced hallmarks including MYC target,DNA repair,and E2F target signaling pathways,thereby promoting *** conclusion,genetic variants in circHIBADH may act as sponges and inhibitors of RNA splicing-associated RBPs including HNRNPA1,playing an oncogenic role in PCa.

关键词： genetic variants prostate cancer circRNA RNA-binding protein RNA splicing sing-cell RNA sequencing

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Observation on the Clinical Effect of Applying Venetoclax Combined with Demethylation Drug Therapy in Patients with Acute Myeloid Leukemia

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Journal of Clinical and Nursing Research 2024年第4期8卷 248-252页

作者： ben Niu Limin Hou Department of Hematology Shaanxi Provincial People’s HospitalXi’an 710068Shaanxi ProvinceChina

Objective: To investigate the therapeutic effect of applying venetoclax combined with demethylating drugs in treating patients with acute myeloid leukemia (AML). Methods: Eighty cases of AML patients treated with venetoclax combined with demethylating drugs in our hospital were selected from March 2021 to March 2024, including 40 cases of primary treatment patients and 40 cases of relapsed and refractory patients. The efficacy and safety of the combined drug therapy was analyzed. Results: The primary treatment group was presented with a complete remission (CR) rate of 40.5%, partial remission (PR) rate of 47.50%, no response (NR) rate of 12.50%, and a remission rate of 87.50%. The relapsed- refractory group was presented with a CR rate of 37.50%, PR rate of 42.50%, NR rate of 17.50%, and a remission rate of 87.50%. There was no statistical significance between the groups (P > 0.05). The hematological adverse reactions of the combined treatment for AML were leukopenia and the non-hematological adverse reactions were mainly infections, with an incidence rate of 87.50%. Conclusion: The efficacy of venetoclax combined with demethylating drugs in AML was remarkable and the treatment regimen can be adjusted according to the treatment-resistant response.

关键词： Acute myeloid leukemia Venetoclax Demethylating drugs Combination therapy Efficacy

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