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A mitochondria-targeted AIE photosensitizer for enhancing specificity and efficacy of ferroptosis inducer

Science china chemistry 2022年第5期65卷 870-876页

作者： Shan Wang chao chen Jianmin Wu Jianyu Zhang Jacky W.Y.Lam Hongyang Wang Lei chen ben Zhong Tang Fudan University Shanghai cancer center Shanghai Medical CollegeFudan UniversityShanghai 200032China Department of chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and ReconstructionInstitute for Advanced StudyState Key Laboratory of Molecular NanoscienceDivision of Life Scienceand Department of Chemical and Biological EngineeringThe Hong Kong University of Science and TechnologyHong Kong 999077China Institute of Metabolism and Integrative Biology Fudan UniversityShanghai 200433China The International cooperation Laboratory on Signal Transduction Eastern Hepatobiliary Surgery HospitalSecond Military Medical UniversityShanghai 200438China National center for Liver cancer Shanghai 200441China Shenzhen Institute of Aggregate Science and Technology School of Science and EngineeringThe Chinese University of Hong KongShenzhen 518172China AIE Institute Guangzhou Development DistrictGuangzhou 510530China

Ferroptosis is a form of regulated cell death characterized by iron-dependent accumulation of lipid peroxidation and lethal reactive oxygen species(ROS).To date,misregulated ferroptosis has been implicated in several types of cancers,and ferroptosis inducers can be used to promote ferroptosis in tumor cells and play an anti-tumor ***,the specificity and efficacy of ferroptosis inducers remain ***,a new mitochondria-targeted photosensitizer(PS)with aggregation-induced emission(AIE)characteristic named TcSVP was designed,which efficiently generates ROS in mitochondria after light *** administration significantly sensitizes tumor cells to ferroptosis inducer(RSL3)-mediated cell death by specifically and light-dependently triggering a moderate ROS generation in vitro and in ***,the expression levels of ferroptosis related proteins Acyl-coA synthetase long-chain family member 4(FAcL4/AcSL4)and cyclooxygenase-2(cOX2)were increased in TcSVP/RSL3-treated cells after light exposure,coupled with decreased Glutathione peroxidase 4(GPX4)activity and excessive malondialdehyde(MDA)*** study declared that light-induced moderate ROS generation within mitochondria in cancer cells by AIE-PS can be used to enhance the specificity and efficacy of ferroptosis inducers,bringing a new synergistic strategy for tumor intervention.

关键词： controlling ROS generation high-performance AIE-PS lipid peroxidation ferroptosis

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Advancing pressure sensors performance through a flexible MXene embedded interlocking structure in a microlens array

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Nano Research 2023年第7期16卷 10493-10499页

作者： Tong Li Zhenzong Xu ben Bin Xu Zhanhu Guo Yunhong Jiang Xuehua Zhang Maryam Bayati Terence Xiaoteng Liu Yan-Hua Liu School of Optoelectronic Science and Engineering Key Lab of Advanced Optical Manufacturing Technologies of Jiangsu Province&Key Lab of Modern Optical Technologies of Education Ministry of ChinaSoochow UniversitySuzhou 215006China Department of Mechanical and construction Engineering Faculty of Engineering and EnvironmentNorthumbria UniversityNewcastle upon TyneNE18STUK Hub for Biotechnology in the Built Environment Department of Applied SciencesNorthumbria University at NewcastleNE18STUK Department of chemical and Materials Engineering University of AlbertaEdmontonAlberta T6G 1H9Canada

Piezoresistive composite elastomers have shown great potentials for wearable and flexible electronic applications due to their high sensitivity,excellent frequency response,and easy signal detection.A composition membrane sensor with an interlocked structure has been developed and demonstrated outstanding pressure sensitivity,fast response time,and low temperature drift *** with a flexible MXene-based flat sensor(Ti_(3)c_(2)),the interlocked sensor exhibits a significantly improved pressure sensitivity of two magnitudes higher(21.04 kPa^(-1)),a fast reaction speed of 31 ms,and an excellent cycle life of 5000 test *** viability of sensor in responding to various external stimuli with high deformation capacity has been confirmed by calculating the force distribution of a polydimethylsiloxane(PDMS)film model with a microlens structure using the solid mechanics module in *** conventional process,we utilized three-dimensional(3D)laser-direct writing lithography equipment to directly transform high-precision 3D data into a micro-nano structure morphology through variable exposure doses,which reduces the hot melting ***,the flexible pressure device is capable of detecting and distinguishing signals ranging from finger movements to human pulses,even for speech *** simple,convenient,and large-format lithographic method offers new opportunities for developing novel human-computer interaction devices.

关键词： three-dimensional(3D)lithography microlens array flexible electronics pizoresistive pressure sensors MXene

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高脂高热量饮食对中国健康受试者口服甲硝唑片药代动力学的影响

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中国临床药理学杂志 2024年第1期40卷 102-106页

作者：赵娜郭彩会刘亚丽宋浩静史犇胡义亭贾彩云董占军河北省人民医院Ⅰ期临床研究室河北石家庄050051 石家庄四药有限公司河北石家庄050051 苏州国辰生物科技股份有限公司江苏苏州215104

目的评价在空腹和高脂高热量饮食情况下甲硝唑片在中国健康受试者中的药代动力学特征。方法本方案按单中心、随机、开放、单剂量的试验设计。空腹和高脂高热量饮食条件下共入组47例中国健康受试者,单次口服甲硝唑片200 mg,给药前后按规... 详细信息

目的评价在空腹和高脂高热量饮食情况下甲硝唑片在中国健康受试者中的药代动力学特征。方法本方案按单中心、随机、开放、单剂量的试验设计。空腹和高脂高热量饮食条件下共入组47例中国健康受试者,单次口服甲硝唑片200 mg,给药前后按规定时间点采集静脉血样。用高效液相色谱串联质谱法测定血浆中甲硝唑的浓度并计算药代动力学参数。结果甲硝唑片空腹和高脂高热量饮食后的主要药代动力学参数如下:c_(max)分别为(4799.13±1195.32)和(4044.17±773.98)ng·mL^(-1),t_(max)分别为1.00和2.25 h,t1/2分别为(9.11±1.73)和(9.37±1.79)h,AUc_(0-t)分别为(5.59±1.19)×10^(4)和(5.51±1.18)×10^(4) ng·mL^(-1)·h,AUc_(0-∞)分别为(5.79±1.33)×10^(4)和(5.74±1.32)×10^(4) ng·mL^(-1)·h;高脂饮食后服药较空腹条件下服药,t_(max)延迟1.25 h(Pc_(max)、AUc_(0-t)、AUc_(0-∞)虽有不同程度的较少或降低,但影响较小(均P>0.05)。结论高脂餐饮食对甲硝唑的药代动力学参数影响较小,虽然不会显著改变药物的吸收程度,但是会使达峰时间明显延迟。

关键词：甲硝唑片高脂饮食药代动力学食物效应

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Trends in ophthalmology journals： a five-year bibliometric analysis （2009-2013）

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International Journal of Ophthalmology(English edition) 2016年第11期9卷 1669-1675页

作者： christopher B.Schulz Alasdair Kennedy ben c.Rymer Eye Unit Royal Bournemouth Hospital Bournemouth BH77DW 15I( Department of Ophthalmology Conquest Hospital St.Leonards-on-Sea TN37 7RD UK Department of Plastic Surgery Queen Elizabeth HospitalBirmingham B15 2TH UK

AIM： To explore the trends in the ophthalmic literature over a 5-year period in relation to country, research expenditure and demographics. METHODS： Articles published between 2009 and 2013 by the 20 highest-contributing countries in the 20 top- ranked ophthalmology journals were identified by their country of affiliation. The number of articles published and mean impact factor were measured per country for each year and trends explored using regression analysis with 5-year and 10-year forecasts calculated. Data on research expenditure was collected and tested for correlation with the number of articles and mean impact factor. RESULTS： The analysis included 19 338 articles. The USA, UK and Europe accounted for 60.2% of articles published, with the USA contributing 7388 articles （34.0%）. The USA also demonstrated the highest mean impact factor （3.5）. Research expenditure was significantly correlated with both research output （r=0,86, P〈0.001） and scholarly impact （r=0.42, P〈0.001）. china （P〈0.01）, Korea （P〈0.01） and India （P〈0.02） demonstrated a significant growth in research output over the study period. The research contribution of these three countries combined is forecasted to overtake that of Europe within ten years, with china expected to be the second-largest contributor within five years. These countries were also among those demonstrating the greatest growth in research expenditure. cONcLUSION： While the USA and European countries are major contributors of ophthalmic research, the productivity of some Asian countries is growing impressively. The contribution of china, Korea and Indiais forecasted to outweigh that of Europe by 2023. Research expenditure is highly correlated with research productivity and these trends reflect the differing economic priorities across the world.

关键词： bibliometrics ophthalmology journalimpact factor

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N^(6)-methyladenosine modification of cENPK mRNA by Zc3H13 promotes cervical cancer stemness and chemoresistance

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Military Medical Research 2022年第5期9卷 576-591页

作者： Xian Lin Feng Wang Jian chen Jing Liu Yi-Bin Lin Li Li chuan-ben chen Qin Xu Departments of Gynecology Fujian Cancer Hospital and Fujian Medical University Cancer HospitalFujian Medical UniversityFuzhou 350014China Department of Radiation Oncology Fujian Cancer Hospital and Fujian Medical University Cancer HospitalFujian Medical UniversityFuzhou 350014China Shenzhen Key Laboratory of Immunity and Inflammatory Diseases Peking University Shenzhen HospitalShenzhen Peking University?the Hong Kong University of Science and Technology Medical CenterShenzhen 518036GuangdongChina Outpatient Department Fujian Hospital of People's Armed PoliceFujian Medical UniversityFuzhou 350014China

Background:Stemness and chemoresistance contribute to cervical cancer recurrence and *** the current study,we determined the relevant players and role of N^(6)-methyladenine(m^(6)A)RNA methylation in cervical cancer ***:The roles of m^(6)A RNA methylation and centromere protein K(cENPK)in cervical cancer were analyzed using bioinformatics *** RNA immunoprecipitation was adopted to detect m^(6)A modification of cENPK *** cervical cancer clinical samples,cell lines,and xenografts were used for analyzing gene expression and *** staining and the tumorsphere formation,clonogenic,MTT,and EdU assays were performed to determine cell stemness,chemoresistance,migration,invasion,and proliferation in HeLa and SiHa cells,*** blot analysis,co-immunoprecipitation,chromatin immunoprecipitation,and luciferase reporter,cycloheximide chase,and cell fractionation assays were performed to elucidate the underlying ***:Bioinformatics analysis of public cancer datasets revealed firm links between m^(6)A modification patterns and cervical cancer prognosis,especially through Zc3H13-mediated m^(6)A modification of cENPK *** expression was elevated in cervical cancer,associated with cancer recurrence,and independently predicts poor patient prognosis[hazard ratio=1.413,95%confidence interval=1.078−1.853,P=0.012].Silencing of cENPK prolonged the overall survival time of cervical cancer-bearing mice and improved the response of cervical cancer tumors to chemotherapy in vivo(PcENPK was directly bound to SOX6 and disrupted the interactions of cENPK withβ-catenin,which promotedβ-catenin expression and nuclear translocation,facilitated p53 ubiquitination,and led to activation of Wnt/β-catenin signaling,but suppression of the p53 *** dysregulation ultimately enhanced the tumorigenic pathways required for cell stemness,DNA damage repair pathways necessary f

关键词： N^(6)-methyladenosine centromere protein K cervical cancer Stemness chemoresistance

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原花青素B2通过miR⁃499⁃5p促进骨骼肌慢肌纤维基因的表达

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西南民族大学学报（自然科学版） 2024年第3期50卷 259-267页

作者：龙青焘王文静陈本莉徐孟刁慧西南民族大学青藏高原动物遗传资源保护与利用教育部重点实验室四川成都610041 西南民族大学动物科学国家民委重点实验室四川成都610041 四川省畜牧科学研究院动物遗传育种四川省重点实验室四川成都610066 四川省畜科集团有限公司畜禽生物制品四川省重点实验室四川成都610066

旨在探究原花青素B2(Proanthocyanidins B2,PB2)是否通过miR⁃499⁃5p调控骨骼肌慢肌纤维基因的表达.在小鼠c2c12细胞和猪骨骼肌卫星细胞诱导分化形成肌管后,分别向肌管中添加0μg/mL、2.5μg/mL、5μg/mL和10μg/mL的PB2,探究不同浓度PB... 详细信息

旨在探究原花青素B2(Proanthocyanidins B2,PB2)是否通过miR⁃499⁃5p调控骨骼肌慢肌纤维基因的表达.在小鼠c2c12细胞和猪骨骼肌卫星细胞诱导分化形成肌管后,分别向肌管中添加0μg/mL、2.5μg/mL、5μg/mL和10μg/mL的PB2,探究不同浓度PB2对慢肌纤维基因表达的影响.在机制研究试验中,分别向c2c12肌管和猪肌管中添加10μg/mL的PB2,同时转染200 nM的miR⁃499⁃5p inhibitor抑制miR⁃499⁃5p的表达.结果表明,不同添加剂量的PB2均可促进c2c12肌管MyHc I基因的表达(Pc I基因的表达(Pc2c12肌管和猪肌管miR⁃499⁃5p的表达水平(Pc I mRNA和慢型MyHc蛋白表达的促进作用.以上研究表明,PB2可以通过miR⁃499⁃5p促进骨骼肌慢肌纤维基因的表达.

关键词：慢肌纤维基因原花青素B2 miR⁃499⁃5p

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Tunable piezoelectric and ferroelectric responses of Al1-xScxN:The role of atomic arrangement

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Science china(Physics,Mechanics & Astronomy) 2023年第7期66卷 142-148页

作者： Hang Zang Zhiming Shi Mingrui Liu Yuping Jia Ke Jiang Jianwei ben Yang chen Shunpeng Lv Xiaojuan Sun Dabing Li State Key Laboratory of Luminescence and Applications Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

In this study,we present first-principles investigations of the atomic structure of Al_(1-x)Sc_(x)N and its influence on its piezoelectric and ferroelectric *** unbiased structure searching revealed that Al_(1-x)Sc_(x)N with phase separation feature,where Al N and Sc N form a layered structure with different symmetries,is more stable than the corresponding wurtzite *** piezoelectric response of Al_(1-x)Sc_(x)N is strongly dependent on the atomic arrangements;in particular,Al_(0.5)Sc_(0.5)N with a wurtzite structure exhibits a large positive e33of 4.79 c/m^(2),whereas Al_(0.5)Sc_(0.5)N with a phase separation structure exhibits a negative e33of-0.67 c/m^(2).Moreover,the ferroelectric switching of Al_(1-x)Sc_(x)N demonstrated two distinct pathways for the wurtzite and phase separation structures,and the spontaneous polarization thus calculated exhibits entirely different ***,we demonstrated that Al_(1-x)Sc_(x)N with a phase separation structure exhibits a low polarization switching barrier of 0.15 e V/*** a large spontaneous polarization of-0.77 c/m^(2);thus,it can serve as a novel Al_(1-x)Sc_(x)N-based ferroelectric *** the dipoles in Al_(1-x)Sc_(x)N with a phase separation structure are localized in the AlN region,they are individually switchable at no domain wall energy cost and are stable against extrinsic effects.

关键词： AIS_(c)N piezoelectric ferroelectric density functional theory

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Effects of Medicines and Supplements on Spontaneous Pregnancy and Semen Parameters in Male Infertility:A Systematic Review Update and Network Meta-Analysis

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Engineering 2022年第9期16卷 198-209页

作者： Jian Li Qi Wu Ernest Hung Yu Ng ben Willem J.Mol Xiao Ke Wu chi chiu Wang Department of Obstetrics and Gynecology First Affiliated HospitalHeilongjiang University of Chinese MedicineHarbin 150040China Department of Obstetrics and Gynecology The Affiliated Hospital of Gui Zhou Medical UniversityGuiyang 550004China Department of Obstetrics and Gynaecology Prince of Wales HospitalThe Chinese University of Hong KongHong Kong 999077China Department of Obstetrics and Gynecology Obstetrics and Gynecology HospitalFudan UniversityShanghai 30009China Department of Obstetrics and Gynaecology Queen Mary HospitalThe University of Hong KongHong Kong 999077China Department of Obstetrics and Gynaecology Monash UniversityClaytonVIC 3168Australia Heilongjiang Provincial Hospital Harbin Institute of TechnologyHarbin 150036China Reproduction and Development Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong Kong 999077China i School of Biomedical SciencesThe Chinese University of Hong KongHong Kong 999077China The chinese University of Hong Kong–Sichuan University Joint Laboratory of Reproductive Medicine Hong Kong 999077China

In this study,we used a network meta-analysis(NMA)to compare the effectiveness of medicines and supplements for idiopathic male infertility and to identify the best ***,Excerpta Medica Database(EMBASE),Ovid,and china National Knowledge Infrastructure(cNKI),were searched for the period from January 1990 to June 2021 using the keywords"male infertility,""medical therapy,""supplement/nutrient therapy,"and related *** controlled trials(RcTs)investigating medicines(mainly follicle-stimulating hormone(FSH),androgen,and clomiphene/tamoxifen)or supplements(mainly zinc,selenium,vitamin c or E,carnitine,coenzyme Q10(coQ10),or combined treatment)for idiopathic infertile men were selected for *** reporting items for systematic reviews and meta-analysis(PRISMA)was used for data extraction,and a risk-of-bias tool and grades of recommendation,assessment,development,and evaluation(GRADE)system adapted to the NMA were employed to assess the quality of the *** primary outcomes were live birth and spontaneous pregnancy rate(SPR).The secondary outcomes were sperm parameters(including concentration,progressive motility,and morphology)and side *** total,65 RcTs involving 7541 men with sperm abnormalities but normal hormone levels were included.A total of 36 studies reported SPR but only three reported live birth *** quality of the included studies was found to be moderate to *** with a placebo or being untreated,carnitine plus vitamins significantly improved SPR(relative risk(RR)=3.7,95%confidence interval(95%cI),1.6-8.5);fatty acids significantly increased sperm concentrations(mean difference(MD)=12.5×10^(6)mL-1,95%cI,3.1×10^(6)-22.0×10^(6));and selective estrogen receptor modulator(SERM)plus coQ10 significantly improved sperm progressive motility(MD=11.0%,95%cI,0.1%-21.9%)and normal sperm morphology(MD=11.0%,95%cI,4.6%-17.4%).The most optimal intervention was carnitine plus vitamins and fatty acids for SPR a

关键词： Male infertility Medicine Supplement Spontaneous pregnancy rate Sperm parameters

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Radiolarian and Planktic Foraminifera Biostratigraphy of the Early Albian Organic Rich Beds of Fahdene Formation,Northern Tunisia

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Journal of Earth Science 2014年第1期25卷 45-63页

作者： M ben Fadhel T Zouaghi A Amri M ben Youssef Département de Géologie Faculté des Sciences de Gafsa-Campus Universitaire Sidi Ahmed Zarrouk–2112 Département des Géoressources CERTE–Technopole de Borj Cédria

The lower part of Fahdene Formation outcropping in northeastern Tunisia is repre- sented by pelagic sequences and characterized by an important siliciclastic fraction that includes ra- diolarian and organic-rich beds of Allam Member. Litho-biostratigraphic analysis based on planktic foraminifera and radiolaria shows that deposition of organic-rich beds of Allam Member is confined to the Microhedbergella rischi Zone through the lower part of Ticinella primula Zone. Age diagnostic radiolaria recovered from these beds has been identified to constrain a direct age of black shale depo- sition. The assemblages can be correlated with the radiolarian biochronozone U.A.10-11 indicating an Early Albian to early Middle Albian in age. Radiolarian assemblages composed of species characteris- tic of U.A.10 biochronozone （A. montisserei, D. gracilis） are associated with radiolarian taxa belonging to costata Zone （U.A.9 Pseudoeucyrtis hanni and Thanarla pseudodecora）, which can be correlated with Dercourt Member in the Ionian Zone and Paquier level of the Vocontian Basin （southeast of France）. Biostratigraphic and abundance curves analysis has demonstrated significant diversification of cryptocephalic Nassellaria and Archaeodictyomitrae, probably adapted to eutrophic conditions that characterized the Aptian-Albian transition. Ecological conditions may have governed the stratigraphic range of many cosmopolitan taxa （i.e., Pseudodictyomitrae lodogaensis） compared with stratigraphic distributions schemes reported from other domains. The timing of black shales deposition was dia- chronic due to local geodynamic conditions and upwelling currents distribution. The Allam black shales are correlative with the oceanic anoxic event OAElb which is characterized by the widespread of supraregionnally organic-rich beds in the Mediterranean Tethys basins across the Aptian-Albian transition.

关键词： northeastern Tunisia Albian Allam Member black shale radiolaria planktic foraminifera.

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细颗粒等静压石墨结构调控及性能研究

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炭素技术 2024年第3期43卷 41-46页

作者：连鹏飞赵俊通张俊鹏宋金亮刘犇赵红超刘占军中国科学院山西煤炭化学研究所山西太原030001 五星新材科技有限公司河南平顶山467000 中国科学院上海应用物理研究所上海201800 中国科学院大学北京100049

分别采用骨料/黏结剂二元法和中间相炭微球单相自烧结法制备了细颗粒等静压石墨。以煤沥青为黏结剂,平均粒径分别为10μm和5μm的沥青焦为骨料制备等静压石墨,标记为G1和G2;以平均粒径为5μm的中间相炭微球为原料,制备等静压石墨,标记... 详细信息

分别采用骨料/黏结剂二元法和中间相炭微球单相自烧结法制备了细颗粒等静压石墨。以煤沥青为黏结剂,平均粒径分别为10μm和5μm的沥青焦为骨料制备等静压石墨,标记为G1和G2;以平均粒径为5μm的中间相炭微球为原料,制备等静压石墨,标记为G3。研究了原料种类和颗粒尺寸对石墨材料微观结构、孔隙结构、晶体参数和热力学性能等的影响。骨料的粒径减小,能够有效地降低石墨材料结构内部的孔隙/缺陷尺寸,并提高材料的力学强度;G2石墨的平均孔径为0.527μm,远低于G1石墨的1.620μm,其抗折和抗压强度分别达到84MPa和142MPa。然而,较小的骨料粒径会降低石墨的结晶程度和晶粒尺寸,从而不利于其热性能的提升。采用平均粒径5μm的中间相炭微球试制的G3石墨具有非常优异的机械性能,抗折强度高达96MPa,平均孔径仅为0.071μm,而石墨化度和晶粒尺寸L_(a)分别为71.5%和38.8nm,石墨的常温热导率仅有47W/(m·K)。

关键词：细颗粒等静压石墨孔径分布微观结构热力学性能

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