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符合收缩压干预试验标准的美国成人强化收缩压治疗的人群健康获益估计

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中华高血压杂志(中英文) 2024年第8期 800-800页

作者： Derington CG Bress PA Berchie RO Herrick JS Shen JC Ying J Greene T Tajeu GS Sakhuja S Ruiz-Negrón N Zhang YY Howard G Levitan EB Muntner P Safford MM Whelton PK Weintraub WS Moran AE bellows bk 袁源练桂丽

收缩压干预试验(systolic blood pressure inter-vention trial,SPRINT)表明,与标准目标收缩压(<140 mm Hg)相比,强化收缩压目标(<120 mm Hg)可降低心血管疾病(cardiovascular disease,CVD)风险。对最有可能获益的符合SPRINT标准的成年患者进行强化降压效果的评估可用于指导临床实践。方法:研究者评估SPRINT参与者及在脑卒中的地理和种族差异原因(reasons for geographic and racial differ-ences in stroke,REGARDS)研究及美国国家健康和营养调查(national health and nutrition examination surveys,NHANES)中符合SPRINT标准的参与者。

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解决预防高血压的社会决定因素(RESTORE)网络:预防高血压的健康公平研究网络概述

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中华高血压杂志(中英文) 2024年第1期32卷 100-100页

作者： Spruill TM Muntner P Popp CJ Shimbo D Cooper LA Moran AE Penko J Bibbins-Domingo K Ibe C Nnodim OI Howard G bellows bk Spoer BR Ravenell J Cherrington AL Levy P Commodore-Mensah Y Juraschek SP Molello N Dietz KB Brown D Bartelloni A Ogedegbe G 刘青

美国心脏协会资助了一个预防高血压的健康公平研究网络(addressing social determinants to prevent hypertension,RESTORE Network),作为其在所有社区实现健康公平的一部分,本文将概述RESTORE网络。方法:RESTORE网络包括五项独立的随...

美国心脏协会资助了一个预防高血压的健康公平研究网络(addressing social determinants to prevent hypertension,RESTORE Network),作为其在所有社区实现健康公平的一部分,本文将概述RESTORE网络。方法:RESTORE网络包括五项独立的随机试验,测试实施非药物干预措施的方法,这些干预措施已被证实可以降低血压。这些试验以社区为基础,地点包括阿拉巴马州农村的教堂、密歇根州的流动医疗中心、

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中华高血压杂志（中英文） 2024年第8期32卷 800-800页

符合收缩压干预试验标准的美国成人强化收缩压治疗的人群健康获益估计。收缩压干预试验(systolic blood pressure inter-vention trial,SPRINT)表明,与标准目标收缩压(<140 mm Hg)相比,强化收缩压目标(<120 mm Hg)可降低心血管疾病(card... 详细信息

符合收缩压干预试验标准的美国成人强化收缩压治疗的人群健康获益估计。收缩压干预试验(systolic blood pressure inter-vention trial,SPRINT)表明,与标准目标收缩压(<140 mm Hg)相比,强化收缩压目标(<120 mm Hg)可降低心血管疾病(cardiovascular disease,CVD)风险。对最有可能获益的符合SPRINT标准的成年患者进行强化降压效果的评估可用于指导临床实践。方法:研究者评估SPRINT参与者及在脑卒中的地理和种族差异原因(reasons for geographic and racial differ-ences in stroke,REGARDS)研究及美国国家健康和营养调查(national health and nutrition examination surveys,NHANES)中符合SPRINT标准的参与者。

关键词：美国成人心血管疾病种族差异人群健康营养调查临床实践收缩压

Social-ecological correlates of fundamental movement skills in young children

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Journal of Sport and Health Science 2019年第2期8卷 122-129页

作者： Nan Zeng Susan L.Johnson Richard E.Boles Laura L.bellows Department of Food Science and Human Nutrition Colorado State University Department of Pediatrics University of Colorado Anschutz Medical Campus

Purpose: To identify the social-ecological correlates associated with fundamental movement skills at the child, family, and environment levels in young ***: Preschool children from 4 Colorado Head Start/preschool centers were recruited from 2010 to 2012. Two hundred twenty-eight children(128 girls; age = 56.08 § 4.09 months; body mass index(BMI) z-score = 0.53 § 1.12(mean § SD); 42.1% Hispanic/Latino) and 159 families were included in the final analysis. Children's perceived competence and fundamental movement skills were assessed via the Pictorial Scale of Perceived Competence and Social Acceptance and the Bruininks-Oseretsky Test of Motor Proficiency, 2 nd edition. Data on the number of children in the family, parent age, BMI, education, employment status, family income, perception of child coordination, and home physical activity environment were collected via a questionnaire. Linear regressions adjusted for child BMI, age, sex, and school site were performed at each ***: Child perceived cognitive competence was positively associated with locomotor skills(p = 0.04; adjusted R2= 0.035) and object-control skills(p = 0.003; adjusted R2= 0.083) at the child level. Parent education, BMI, and perception of child coordination were positively associated with locomotor skills and explained 8.8% of variance, but only parent education was significant(p = 0.04) at the family level. In addition, physical environment was positively associated with locomotor skills(p = 0.02) and explained 5.5% of variance at the environment ***: Social-ecological correlates associated with young children's fundamental movement skills are multidimensional and differ according to skill category at the child, family, and environment levels.

关键词： Activity environment Fundamental movement skills Parent education Perceived cognitive competence Preschool children

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Doublecortin-like kinase 1 exhibits cancer stem cell-like characteristics in a human colon cancer cell line

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Chinese Journal of Cancer Research 2013年第2期25卷 134-142页

作者： Lianna Li Charles F. bellows Department of Surgery Tulane University University of Mississippi Cancer Institute

Objective： Colon cancer stem cells （CSCs） are implicated in colorectal cancer carcinogenesis, metastasis, and therapeutic resistance. The identification of these cells could help to develop novel therapeutic strategies. Doublecortin-like kinase 1 （DCLK1） has been viewed as a marker for gastrointestinal stem cells that fuel the self-renewal process, however others view them as a marker of Tuft cells or as an enteroendocrine subtype. The purpose of this study was to use a colon cancer cell line to identify and characterize the stem-like characteristics of the DCLKI＋ cell population. Methods： To enrich stem-like cells, HCT116 cells （derived from colon adenocarcinomas） were cultured using serum-free media to form spheres under both normal oxygen and hypoxia condition. DCLK1 transcript expression in the adherent parental cells and spheroids was quantified using quantitative real time reverse transcription- polymerase chain reaction [（q）RT-PCR]. DCLK1 protein expression was determined using flow cytometry. Self-renewal capability from adherent parental cells and spheroids was determined using extreme limiting dilution analysis （ELDA）. Results： Under both normal oxygen and hypoxia condition, the adherent parental cells were composed of cells that express low levels of DCLK1. However, spheroids exhibited an increased frequency of cells expressing DCLK1 on both mRNA and protein levels. Cells derived from spheroids also possess stronger self-renewal capability. Conclusions： The higher fraction of DCLK1 ＋ cells exhibited by spheroids and hypoxia reflects the stem- like characteristics of these cells. DCLK1 may represent an ideal marker to study and develop effective strategies to overcome chemo-resistance and relapse of colon cancer.

关键词： Doublecortin-like kinase 1 (DCLK1) colorectal cancer cancer stem cells stem cell marker spheroids

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Quantitative imaging reveals the role of MpARF proteasomal degradation during gemma germination

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Plant Communications 2024年第11期5卷 116-127页

作者： Shubhajit Das Martijn de Roij Simon bellows Melissa Dipp Alvarez Sumanth Mutte Wouter Kohlen Etienne Farcot Dolf Weijers Jan Willem Borst Laboratory of Biochemistry Wageningen University and ResearchStippeneng 46708WE Wageningenthe Netherlands School of Mathematical Sciences University of NottinghamUniversity ParkNG72RD NottinghamUK Laboratory of Molecular Biology Wageningen University and ResearchDroevendaalsesteeg 16708PB Wageningenthe Netherlands Present address:Institute of Science and Technology 3400 KlosterneuburgAustria

The auxin signaling molecule controls a variety of growth and developmental processes in land plants. Auxin regulates gene expression through a nuclear auxin signaling pathway (NAP) consisting of the ubiquitin ligase auxin receptor TIR1/AFB, its Aux/IAA degradation substrate, and DNA-binding ARF transcription factors. Although extensive qualitative understanding of the pathway and its interactions has been obtained, mostly by studying the flowering plant Arabidopsis thaliana, it remains unknown how these translate to quantitative system behavior in vivo, a problem that is confounded by the large NAP gene families in most species. Here, we used the minimal NAP of the liverwort Marchantia polymorpha to quantitatively map NAP protein accumulation and dynamics in vivo through the use of knockin fluorescent fusion proteins. Beyond revealing the dynamic native accumulation profile of the entire NAP protein network, we discovered that the two central ARFs, MpARF1 and MpARF2, are proteasomally degraded. This auxin-independent degradation tunes ARF protein stoichiometry to favor gene activation, thereby reprogramming auxin response during the developmental progression. Thus, quantitative analysis of the entire NAP has enabled us to identify ARF degradation and the stoichiometries of activator and repressor ARFs as a potential mechanism for controlling gemma germination.

关键词： auxin signaling ARF degradation Marchantia polymorpha live cell imaging

Adipose tissue-derived progenitor cells and cancer

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World Journal of Stem Cells 2010年第5期2卷 103-113页

作者： Charles F bellows Mikhail G Kolonin General Surgery and Minimally Invasive Surgery Tulane University Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases University of Texas Health Science Center at Houston

Recruitment of stem cells and partially differentiated progenitor cells is a process which accompanies and facilitates the progression of *** of the factors complicating the clinical course of cancer is obesity,a progressively widespread medical condition resulting from overgrowth of white adipose tissue(WAT),com-monly known as white *** mechanisms by which obesity in uences cancer risk and progression are not completely *** of WAT secret soluble molecules(adipokines) that could stimulate tumor growth,although there is no consensus on which cell populations and which adipokines are *** reports suggest that WAT-derived mesenchymal stem(stromal) cells,termed adipose stem cells(ASC),may represent a cell population linking obesity and *** in animal models demonstrate that adipokines secreted by ASC can promote tumor growth by assisting in formation of new blood vessels,a process necessary for expansion of tumor ***,migration of ASC from WAT to tumors has been demonstrated,indicating that the tumor microenvironment in cancer may be modulated by ASC-derived trophic factors in a paracrine rather than in an endocrine ***,we review possible positive and adverse implications of progenitor cell recruitment into the diseased sites with a particular emphasis on the role in cancer progression of progenitors that are expanded in obesity.

关键词： Progenitor Stromal Cell mobilization Obesity Adipose tissue Cancer Tumor

Clinical significance of magnetic resonance imaging findings in rectal cancer

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World Journal of Radiology 2011年第4期3卷 92-104页

作者： Charles F bellows Bernard Jaffe Lorenzo Bacigalupo Salvatore Pucciarelli Guiseppe Gagliardi Department of Surgery Tulane UniversityNew Orleans Department of Radiology Galliera Hospital Department of Surgery University of Padua

Staging of rectal cancer is essential to help guide clini-cians to decide upon the correct type of surgery and determine whether or not neoadjuvant therapy is indicated. Magnetic resonance imaging (MRI) is currently one of the most accurate modalities on which to base treatment decisions for patients with rectal cancer. MRI can accurately detect the mesorectal fascia, assess the invasion of the mesorectum or surrounding organs and predict the circumferential resection margin. Although nodal disease remains a difficult radiological diagnosis, new lymphographic agents and diffusion weighted imaging may allow identification of metastatic nodes by criteria other then size. In light of this, we have reviewed the literature on the accuracy of specific MRI findings for staging the local extent of primary rectal cancer. The aim of this review is to establish a correlation between MRI findings, prognosis, and available treatment options.

关键词： Magnetic resonance imaging Preoperative staging Prognostic factors Rectal cancer

Waste-to-Hope: Measuring Sustainability Benefits of Product Philanthropy Partnership

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Journal of Environmental Protection 2017年第10期8卷 1219-1242页

作者： Oral S. Saulters Brijesh Krishnan Mary Beth Harris Hani Bashour Laura bellows Evan J. Ringquist Diane Henshel School of Public and Environmental Affairs Indiana University Bloomington IN USA

This study investigates the sustainability-related impacts of the Framing Hope program, an innovative private and nonprofit sector partnership between the nonprofit Good360 and The Home Depot. Specifically, this paper estimates the energy savings, landfill space not filled, and the energy- and landfill-related cost savings associated with the Good360 product philanthropy program with The Home Depot, illustrating that benefits accrue to both company and communities by linkages between environmental, socioeconomic, and energy dimensions. Findings suggest that by redirecting products from the waste stream into usable community resources, considerable landfill space, costs, and energy savings were realized. Product donations can serve as an important platform for sustainable community development and capacity building. This research adds to the growing body of knowledge on environmental performance, corporate giving, and cross-sector partnerships in sustainable and social entrepreneurship.

关键词： Sustainability Product Philanthropy Corporate Social Responsibility