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Significance of low level infliximab in the absence of anti-infliximab antibodies

World Journal of Gastroenterology 2015年第6期21卷 1907-1914页

作者： bella ungar Adi Anafy Henit Yanai Yulia Ron Miri Yavzori Orit Picard Ella Fudim Ronen Loebstein Uri Kopylov Yehuda Chowers Iris Dotan Rami Eliakim Shomron Ben-Horin Department of Gastroenterology Sheba Medical Center Tel Hashomer and Sack-ler School of Medicine Tel-Aviv University IBD Center Department of Gastroenterology Tel-Aviv Sourasky Medical Center and Sackler School of Medicine Tel-Aviv University Institute of Clinical Pharmacology Sheba Medical Center Tel Hashomer and Sackler School of Medicine Tel-Aviv University Rambam Health Care Campus and Bruce Rappaport School of Medicine Technion Institute of Technology

AIM:To evaluate the prevalence of double negative(DN)sera and the mechanisms responsible for DN ***:Sera of inflammatory bowel disease patients treated with infliximab(IFX)were tested for drug/antibodies to infliximab(ATI)trough levels and the proportion of DN results was compared between a commercially available double antigen ELISA(with labeled IFX as the detection antibody)and an antilambda ELISA(with anti-human lambda chain detection antibody).Repeat testing with lower than customary serum dilution(1:10)was *** with DN status were matched with IFX+/ATI-controls and were followed-up for subsequent development of nontransient ATI to investigate if DN status precedes ***:Of 67 sera obtained at time of loss of response,only 6/67(9%)were DN by anti-lambda ELISA compared to 27/67(40%)with double antigen ELISA(P<0.001,Fisher’s Exact test).Of the latter27 sera,22%were also DN by anti-lambda ELISA,whereas 44%were actually IFX positive(IFX+ATI-),30%were ATI positive(IFX-ATI+)and 4%were double positive(IFX+ATI+).Re-testing using a 1:10 dilution converted most DN results into IFX+and/or ATI+*** with DN status had shorter survival free of non-transient ATI compared with matched controls(log rank test,P<0.001).In 9/30(30%)of these patients,non transient ATI occurred before and after the event at which the DN serum was obtained,supporting the view that a DN result may represent aparticular time-point along the two curves of ATI titer rise and infliximab drug level ***:DN status may result from false negative detection of IFX or ATI by double antigen ELISA,suggesting a transitional state of low-level immunogenicity,rather than non-immunological clearance.

关键词： Inflammatory bowel disease Biological therapy Infl

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Global optimum of microstructure parameters in the CMWP line-profile-analysis method by combining Marquardt-Levenberg and Monte-Carlo procedures

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Journal of Materials Science & Technology 2019年第7期35卷 1508-1514页

作者： Gabor Ribarik Bertalan Joni Tamas ungar Department of Materials Physics Edtvos University BudapestPO Box 32H-15J8Hungary School of Materials The University of ManchesterM139PLUK

Line profile analysis of X-ray and neutron diffraction patterns is a powerful tool for determining the microstructure of crystalline materials. The Convolutional-Multiple-Whole-Profile (CMWP) procedure is based on physical profile functions for dislocations, domain size, stacking faults and twin boundaries. Order dependence, strain anisotropy, hkl dependent broadening of planar defects and peak shape are used to separate the effect of different lattice defect types. The Marquardt-Levenberg (ML) numerical optimiza-tion procedure has been used successfully to determine crystal defect types and densities. However, in more complex cases like hexagonal materials or multiple phases the ML procedure alone reveals uncer-tainties. In a new approach the ML and a Monte-Carlo statistical method are combined in an alternative manner. The new CMWP procedure eliminates uncertainties and provides globally optimized parameters.

关键词： X-ray line profile analysis Neutron line profile analysis CMWP Global optimum Dislocation densities Grain size Planar defects Monte-Carlo method

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A hybrid method for extraction of protein-protein interactions from literature

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High Technology Letters 2011年第1期17卷 32-38页

作者：钱伟中 ungar Lyle Qin Zhiguang Fu Chong Computer Science and Technology School University of Electronic Science and Technology of China Chengdu 610054 P.R. China Computer Information Science Department University of Pennsylvania PA 19104 USA

In this work, a hybrid method is proposed to eliminate the limitations of traditional protein-protein interactions （PPIs） extraction methods, such as pattern learning and machine learning. Each sentence from the biomedical literature containing a protein pair describes a PPI which is predicted by first learning syntax patterns typical of PPIs from training corpus and then using their presence as features, along with bag-of-word features in a maximum entropy model. Tested on the BioCreAtIve corpus, the PPIs extraction method, which achieved a precision rate of 64%, recall rate of 60%, improved the performance in terms of F1 value by 11% compared with the component pure pattern- based and bag-of-word methods. The results on this test set were also compared with other three extraction methods and found to improve the performance remarkably.

关键词： protein-protein interaction ( PPI) machine learning pattern learning maximum entropy part of speech

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Ecogeomorphic Feedbacks in Semiarid Rangelands:A Review

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Pedosphere 2009年第2期19卷 217-229页

作者： I.STAVI H.LAVEE E.D.ungar P.SARAH Laboratory of Soil and Geomorphology Department of Geography and EnvironmentBar Ilan UniversityRamat Gan 52900(Israel) Department of Agronomy and Natural Resources Institute of Plant SciencesAgricultural Research Organizationthe Volcani CenterBet Dagan 50250(Israel)

The ecogeomorphic processes occurring on semiarid rangelands are reviewed, with emphasis on the source-sink relations and positive feedback loops that existed between shrub patches and intershrub areas, and the way livestock presence affected these interactions. Compared with intershrub areas, the shrub patches had a higher soil porosity, infiltration capacity, water-holding capacity, hydraulic conductivity, structural stability, and organic matter content, and lower bulk density. These differences derived from a host of processes whose intensity was less in the shrub patches, including raindrop impact, mechanical crust formation, overland water flow, soil erosion, evaporative moisture loss, and flock trampling. There was also greater shading of the soil surface; soil and litter deposition; water accumulation; microbial, fungal, and mesofaunal activities in the shrub patches. The overland flow of water carried soil and litter from the intershrub areas to the shrub patches and resulted in microtopographic modifications that tended to strengthen these source-sink relations. Grazing had an impact on these processes, not only at the shrub-intershrub scale but also within the intershrub areas, through the creation of highly compacted trampling routes. The combined role of the above ecogeomorphic processes was to maintain the rangeland＇s functionality. Without these inter-relationships, water loss, soil erosion, and nutrient depletion would occur at the hillside scale, causing degradation of the landscape.

关键词： intershrub areas shrubs soil resources trampling routes

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Two Na^＋ and Cl^- Hyperaccumulators of the Chenopodiaceae

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Journal of Integrative Plant Biology 2005年第3期47卷 311-318页

作者： Ke-FuZHAO HaiFAN JieSONG Ming-XiaSUN Bao-ZengWANG Sheng-QiangZHANG I.A.ungar InstituteofPlantStress ShandongNormalUniversityJinan250014China DepartmentofEnvironmentandPlantEcology OhioUniversityAthensOhio45701USA

Abstract: The authors found five sodium (Na+) and chloride (Cl-.) hyperaccumulating halophytes in the Temperate Desert of Xinjiang, China and studied two of them (Suaeda salsa (L.) Pall. and Kalidium folium (Pall.) Moq.). K. folium and S. salsa had a NaCl content of 32.1% and 29.8%, respectively, on a dry weight basis. X-ray microanalysis of the Na+ in the vacuole, apoplasts and cytoplasm of the two plants indicated a ratio of 7.3:5.6:1.0 in K. folium and 7.3:6.6:1.0 in S. salsa. These data show that K. folium and S. salsa both have a high Na+ and Cl- accumulating capacity, which is related to high activity of tonoplast H+-ATPase and H+-PPase.

关键词： apoplast Cl- cytoplasm hyperaccumulator Kalidium folium (Pall.) Moq Na+ Suaeda salsa (L.) Pall vacuole

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Dental microwear of sympatric rodent species sampled across habitats in southern Africa: Implications for environmental influence

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Integrative Zoology 2016年第2期11卷 111-127页

作者： Jenny H.E.BURGMAN Jennifer LEICHLITER Nico L.AVENANT Peter S.ungar Environmental Dynamics Program University of ArkansasFayettevilleArkansasUSA Department of Anthropology University of Colorado BoulderBoulderColoradoUSA National Museum and University of the Free State BloemfonteinSouth Africa Department of Anthropology University of ArkansasFayettevilleArkansasUSA

Dental microwear textures have proven to be a valuable tool for reconstructing the diets of a wide assortment of fossil ***,some studies have recently questioned the efficacy of this approach,suggesting that aspects of habitat unrelated to food preference,especially environmental grit load,might have a confounding effect on microwear patterning that obscures the diet *** we evaluate this hypothesis by examining microwear textures of 3 extant sympatric rodent species that vary in diet breadth and are found in a variety of habitat types:Mastomys coucha,Micaelamys namaquensis and Rhabdomys *** sample each of these species from 3 distinct environmental settings in southern Africa that differ in rainfall and vegetative cover:Nama-Karoo shrublands(semi-desert)and Dry Highveld grasslands in the Free State Province of South Africa,and Afromontane(wet)grasslands in the highlands of *** differences between habitat types are evident for some of the species,inconsistency in the pattern suggests that the microwear signal is driven by variation in foods eaten rather than grit-level per *** is clear that,at least for species and habitats sampled in the current study,environmental grit load does not swamp diet-related microwear signatures.

关键词： diet grit tooth wear

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Associations between cardiac arrhythmia,incident disability in activities of daily living and physical performance:the ILSA study

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Journal of Geriatric Cardiology 2020年第3期17卷 127-132,I0002-I0004页

作者： Marianna Noale Nicola Veronese Lee Smith Andrea ungar Stefano Fumagalli Stefania Maggi the Italian Longitudinal Study on Aging Working Group National Research Council(CNR) Neuroscience InstituteAging BranchVia Giustiniani 235128 PaduaItaly Azienda ULSS 3 Serenissima Primary Care DepartmentDistrict 3VeniceItaly The Cambridge Centre for Sport and Exercise Sciences Department of Life SciencesAnglia Ruskin UniversityCambridge CB11PTUK Geriatrics and Intensive Care Unit Department of Experimental and Clinical MedicineUniversity of Florence and AOU CareggiFlorenceItaly 不详

Background Cardiac arrhythmias are common conditions in older ***,there is limited literature on associations between cardiac arrhythmias and physical performance or *** therefore aimed to prospectively investigate associations between cardiac arrhythmias and changes in disability and physical performance during 8 years of follow-up,using data from the Italian Longitudinal Study on Aging(ILSA).Methods Cardiac arrhythmias diagnosis was posed through a screening phase,confirmed by a *** onset of disability in activities of daily living(ADL)and the changes in several physical performance tests during follow-up were considered as ***-adjusted and propensity-score Cox Proportional Hazard models and mixed models were used for exploring associations between cardiac arrhythmia and the outcomes of *** The prevalence of cardiac arrhythmia at baseline was 23.3%.People reporting cardiac arrhythmia at the baseline were significantly older,more frequently male,smokers and reported a higher presence of all medical conditions investigated(hypertension,heart failure,angina,myocardial infarction,diabetes,stroke),but no difference in dementia,Parkinsonism,cognitive or mood *** arrhythmia at baseline was significantly associated with the incidence of disability in ADL(HR=1.23;95%:CI:1.01–1.50;P=0.0478 in propensity score analyses;HR=1.28;95%CI:1.01–1.61;P=0.0401 in fully adjusted models).Cardiac arrhythmia at baseline was also associated with a significant worsening in balance test(P=0.0436).Conclusions The presence of cardiac arrhythmia at baseline was associated with a significant higher risk of disability and of worsening in some physical performance tests,particularly those relating to *** and frequently assessing physical performance in older people affected by cardiac arrhythmia can be important to prevent a loss of physical performance,with further,potential,complications of medical managemen

关键词： Atrial fibrillation Cardiac arrhythmia Disability Physical activity Physical performance

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牙齿微痕研究在古食性重建中应用的简述

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人类学学报 2021年第2期40卷 292-306页

作者：华李成 Peter S ungar 浙江宁波大学机械工程与力学学院宁波315211 Department of Anthropology University of ArkansasFayettevilleAR 72701USA

在古食性研究中,牙齿微痕是指动物在咀嚼食物的过程中在牙齿咬合面上产生的微观磨损痕迹。不同食性的动物具有不同的牙齿微痕特征,因此可以通过研究牙齿微痕特征来重建灭绝动物的古食性,为探讨动物演化和古生态环境变化提供重要信息。... 详细信息

在古食性研究中,牙齿微痕是指动物在咀嚼食物的过程中在牙齿咬合面上产生的微观磨损痕迹。不同食性的动物具有不同的牙齿微痕特征,因此可以通过研究牙齿微痕特征来重建灭绝动物的古食性,为探讨动物演化和古生态环境变化提供重要信息。本文主要介绍牙齿微痕作为一种简单而高效的古食性重建方法在古生物领域中的应用。本文主要内容包括牙齿微痕的发展历史,形成机理与应用,以及近年来被广泛应用的牙齿微痕定量化分析——表面纹理分析法,并在最后浅谈了牙齿微痕研究未来可能研究的方向。

关键词：牙齿微痕表面纹理饮食结构分析方法

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Dynamic Pressures on Tunnel Roofs due to Vehicle Passages

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Sound & Vibration 2018年第4期52卷 6-8页

作者： James D.Barnes Ethan R.Brush Mark S.Newmark Eric E.ungar Acentech Inc.33 Moulton StreetCambridgeMA02138USA

Pressure and proximity measurements made in a tunnel indicate that a typical vehicle passage produced on the tunnel roof an initial pressure increase of small magnitude,followed by a sharp and more substantial drop in pressure below *** magnitude of the pressure drop was found to increase with smaller clearances between the vehicle top and the tunnel roof,consistent with the Bernoulli relation and the vehicle *** dynamic pressures potentially may have significant effects on the vibration and noise environments on the lower floors of“air rights construction”buildings that span highways.

关键词： Pressure pulses vehicle passages tunnel roofs

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抗逆力的跨文化研究

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首都师范大学学报（社会科学版） 2015年第2期 120-130页

作者： Michael ungar 王然田国秀加拿大Dalhousie大学社会工作学院首都师范大学政法学院首都师范大学社会学与社会工作系

文章通过对全球范围内14个研究基地、1500多名青少年的混合研究,验证了在文化和环境基础上人们对抗逆力涵义理解的四种命题:(1)除了全球性,青少年身处的文化性、环境性因素都会对其抗逆力的形成产生影响;(2)抗逆力对青少年产生怎样的影... 详细信息

文章通过对全球范围内14个研究基地、1500多名青少年的混合研究,验证了在文化和环境基础上人们对抗逆力涵义理解的四种命题:(1)除了全球性,青少年身处的文化性、环境性因素都会对其抗逆力的形成产生影响;(2)抗逆力对青少年产生怎样的影响取决于形成该抗逆力的具体文化和环境;(3)影响青少年抗逆力形成的因素与能够反映青少年的文化背景显著相关;(4)个人与其所处文化环境之间张力(tension)的解决方法,很大程度上反映出个体与抗逆力之间的联系。

关键词：抗逆力跨文化研究跨文化实践文化生态理论

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