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小鼠10号染色体上致聋突变基因hml的精确定位(英文)

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西安交通大学学报（医学版） 2004年第3期25卷 209-212,260页

作者： belinda s Harris patricia F Ward-Bailey Heping Yu Roderick T Bronson Muriel T Davisson Kenneth R Johnson The Jackson Laboratory The Jackson LaboratoryThe Jackson LaboratoryThe Jackson LaboratoryThe Jackson LaboratoryThe Jackson LaboratoryThe Jackson Laboratory Bar Harbor Maine 04609 USA Bar Harbor Maine 04609 USA Bar Harbor Maine 04609 USA Bar Harbor Maine 04609 USA Bar Harbor Maine 04609 USA Bar Harbor Maine 04609 USA Bar Harbor Maine 04609 USA

目的　定位小鼠致聋基因 ,识别决定其性状的有关突变 ,为人类耳聋基因研究提供动物模型。方法　利用全基因组扫描来定位名为hml可致小鼠听力丧失突变基因。结果　①hml基因定位在小鼠 10号染色体上 ,距中心粒约4 3cM处。根据已知的鼠 ... 详细信息

目的　定位小鼠致聋基因 ,识别决定其性状的有关突变 ,为人类耳聋基因研究提供动物模型。方法　利用全基因组扫描来定位名为hml可致小鼠听力丧失突变基因。结果　①hml基因定位在小鼠 10号染色体上 ,距中心粒约4 3cM处。根据已知的鼠人同源同线性特点 ,提示人的同源基因位于 12 q2 2 -q2 4 ;②获得了 2 5个多态性微卫星标记 ,通过高分辨的小鼠图谱将 3个已知人类基因进行了正确排列 ,并将hml侯选基因限定在一个 5 0 0kb的区域内。

关键词：小鼠耳聋突变

physical activity and amyloid beta in middle-aged and older adults:A systematic review and meta-analysis

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Journal of sport and Health science 2024年第2期13卷 133-144页

作者： María Rodriguez-Ayllon patricio solis-Urra Cristina Arroyo-ávila Miriam álvarez-Ortega pablo Molina-García Cristina Molina-Hidalgo Manuel Gómez-Río belinda Brown Kirk I.Erickson Irene Esteban-Cornejo Department of Epidemiology Erasmus University Medical Center RotterdamRotterdamGD 3015the Netherlands Department of physical Education and sports Faculty of Sport SciencesSport and Health University Research Institute(iMUDS)University of GranadaGranada 18071Spain Faculty of Education and social sciences Universidad Andres BelloVina del Mar 2531015Chile Department of Nuclear Medicine Virgen de las Nieves University HospitalInstitute of Biosanitary Research of Granada(IBS)Granada 18014Spain physical Medicine and Rehabilitation service Virgen de las Nieves University HospitalInstitute of Biosanitary Research of Granada(IBS)Granada 18014Spain Department of psychology University of PittsburghPittsburghPA 15260USA Centre for Healthy Ageing Health Futures InstituteMurdoch UniversityMurdochWA 6150Australia school of Medical and Health sciences Edith Cowan UniversityJoondalupWA 6027Australia Advent Health Research Institute Neuroscience Institute OrlandoOrlandoFL 32803USA physiopathology of Obesity and Nutrition Research Center(CIBERobn) Institute of Health Carlos Ⅲ(ISCⅢ)Madrid 28029Spain

Background:One of the pathological hallmarks distinguishing Alzheimer’s disease from other dementias is the accumulation of amyloid beta(Aβ).Higher physical activity is associated with decreased dementia risk,and one potential path could be through Aβlevels *** aimed to explore the relationship between physical activity and Aβin middle-aged and older ***:A systematic search of pubMed,Web of science,psycINFO,Cochrane Central Register of Controlled Trials,and spORTDiscus was performed from inception to April 28,*** were eligible if they included physical activity and Aβdata in adults aged 45 years or ***-level metaanalyses of intervention and observational studies were performed to examine the role of physical activity in modulating Aβ***:In total,37 articles were included(8 randomized controlled trials,3 non-randomized controlled trials,4 prospective longitudinal studies,and 22 cross-sectional studies).The overall effect size of physical activity interventions on changes in blood Aβwas medium(pooled standardized mean difference=-0.69,95%confidence interval(95%CI):-1.41 to 0.03;I^(2)=74.6%).However,these results were not statistically significant,and there were not enough studies to explore the effects of physical activity on cerebrospinal fluid(CsF)and brain Aβ.Data from observational studies were examined based on measurements of Aβin the brain using positron emission tomography scans,CsF,and *** physical activity was positively associated with Aβonly in the CsF(Estimate r=0.12;95%CI:0.05-0.18;I^(2)=38.00%).Conclusion:physical activity might moderately reduce blood Aβin middle-aged and older ***,results were only near statistical significance and might be interpreted with caution given the methodological limitations observed in some of the included *** observational studies,higher levels of physical activity were positively associated with Aβonly in ***,further research is needed t

关键词： Aging Cognitive impairment Dementia Exercise pET

Neuroinflammation and α-synuclein Dysfunction potentiate Each Other Driving Chronic progression of parkinson's Disease

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Neuroinflammation and α-Synuclein Dysfunction Potentiate Ea...

Decreasing recurrent bowel obstructions,improving quality of life with physiotherapy:Controlled study

Neurotoxicity and Neurodegeneration:Local Effect and Global Impact--13th International Neurotoxicology Association Meeting & 11th International symposium on Neurobehavioral Methods and Effects in Occupational and Environmental Health

作者： Wayneho Kam belinda Wilson Jau-shyong Hong Laboratory of Toxicology and pharmacology National Institute of Environmental Health Sciences/National Institutes of HealthResearch Triangle ParkNC27709

Background: Both genetic and environmental risk factors have been implicated in parkinson's disease(pD),the second most common neurodegenerative ***,mechanisms whereby gene-environment interactions mediate chronic,pro... 详细信息

关键词： Neuroinflammation and synuclein Dysfunction potentiate Each Other Driving Chronic progression of parkinson's Disease

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World Journal of Gastroenterology 2018年第19期24卷 2108-2119页

作者： Amanda D Rice Kimberley patterson Evette D Reed belinda F Wurn Kristen Robles Bernhard Klingenberg Leonard B Weinstock Janey sA pratt C Richard King III Lawrence J Wurn Department of Internal Medicine College of Medicine-PhoenixUniversity of ArizonaPhoenixAZ 85004United States Clear passage Therapies GainesvilleFL 32606United States Department of Mathematics and statistics Williams CollegeWilliamstownMA 01267United States Clinical Medicine and surgery Washington University School of MedicineSpecialists in GastroenterologyLLCSt.LouisMO 63141United States Department of surgery Stanford University School of MedicinePalo AltoCA 94035United States College of Medicine University of FloridaGainesvilleFL 32607United States

AIM To compare(1) quality of life and(2) rate of recurrent small bowel obstructions(sBO) for patients treated with novel manual physiotherapy vs no treatment. METHODs One hundred and three subjects(age 19-89) with a history of recurrent adhesive sBO were treated with a manual physiotherapy called the Clear passage Approach(CpA) which focused on decreasing adhesive crosslinking in abdominopelvic viscera. pre-and post-therapy data measured recurring obstructions and quality of life, using a validated test sent 90 d after therapy. Results were compared to 136 untreated control subjects who underwent the same measurements for subjects who did not receive any therapy, which is the normal course for patients with recurring sBO. Comparison of the groups allowed us to assess changes when the physiotherapy was added as an adjunct treatment for patients with recurring *** Despite histories of more prior hospitalizations, obstructions, surgeries, and years impacted by bowel issues, the 103 CpA-treated subjects reported a significantly lower rate of repeat sBO than 136 untreated controls(total obstructions p = 0.0003; partial obstructions p = 0.0076). subjects treated with the therapy demonstrated significant improvements in five of six total domains in the validated small Bowel Obstruction Questionnaire(sBO-Q). Domains of diet, pain, gastrointestinal symptoms, quality of life(QOL) and pain severity when compared to post CpA treatment were significantly improved(p s not changed in the CpA treated group(p = 0.176).CONCLUsION CpA physical therapy was effective for patients with adhesive sBO with significantly lower recurrence rate, improvement in reported symptoms and overall quality of life of subjects.

关键词： Clear passage approach Manual therapy physical therapy small bowel obstructions Adhesions physiotherapy Alternative therapy

不同温度下绿僵菌对东亚飞蝗3龄蝗蝻的致病力影响

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中国生物防治学报 2019年第4期35卷 642-647页

作者：刘银民程雨蒙李红梅农向群 belinda LUKE 中国农业科学院植物保护研究所/农业农村部-CABI生物联合实验室北京100193 淮北师范大学生命科学学院淮北235000 CABI东亚中心北京100081 中国农业科学院植物保护研究所/植物病虫害生物学国家重点实验室北京100193 CABI英国埃格姆 TW209TY

采用体表接菌法测定了商品生物农药金龟子绿僵菌油悬浮剂pD20080671在15、20、25、30、35和40℃等6个不同温度条件下对东亚飞蝗3龄蝗蝻的致病力的影响。结果表明:东亚飞蝗3龄蝗蝻的累积死亡率在接菌后19 d内均随天数的增加而升高。35℃... 详细信息

采用体表接菌法测定了商品生物农药金龟子绿僵菌油悬浮剂pD20080671在15、20、25、30、35和40℃等6个不同温度条件下对东亚飞蝗3龄蝗蝻的致病力的影响。结果表明:东亚飞蝗3龄蝗蝻的累积死亡率在接菌后19 d内均随天数的增加而升高。35℃的累积死亡率最高(82.50%),显著高于其他处理;40℃的累积死亡率最低,为55.00%。死亡个体的湿度培养结果显示绿僵菌在高温条件下萌发的时间较短,40℃为4.26 d,15℃为19.36 d。结果表明环境温度低于15℃或高于35℃都不利于绿僵菌杀死蝗虫。因此,在田间施用金龟子绿僵菌防治东亚飞蝗时应尽量避免高温天气,建议在上午低温时进行防治。

关键词：商品生物农药金龟子绿僵菌东亚飞蝗蝗蝻

Recurrent Bilateral Orbital Infiltration as primary Manifestation of Rosai Dorfman Disease

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Open Journal of Ophthalmology 2017年第3期7卷 225-229页

作者： belinda pustina Naser salihu Arben Rroji Gentian Kaloshi Mentor petrela Department of Ophthalmology University Clinical Center of Kosovo Prishtina Kosovo Department of Neurosurgery University Hospital Center “Mother Theresa” Tirana Albania

Rosai Dorfman disease, also known as histiocytosis with massive lymphadenopathy, is a very rare idiopathic disease. It is characterized by over production and accumulation of non Langerhans sinus histiocyte most often in lymph nodes, but may occur in other areas leading to organ damage. Based on the research, it can be caused by an infectious agent, immunodeficiency or autoimmunity and genetic causes. Extranodal manifestation is uncommon, however extranodal sites include liver, kidney, respiratory organs, orbit and eyeball. We present a case report of a 44-year-old female with recurrent bilateral orbital infiltration as first location of Rosai Dorfman disease.

关键词： Extranodal Rosai Dorfman Genetic Immunodeficiency Histiocytosis with Massive Lymphadenopathy Orbit Kidney

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“国家地理”网络观

知识就是力量 1999年第7期 20-21页

作者： belinda

美国的“国家地理”是世界上最大的非赢利性的综合科学和教育研究机构,始建于1888年1月13日。而国人对她的了解多数只是《廊桥遗梦》里罗伯特·金凯摄影照片发表的那么一个杂志,仅此而已。我偶然在朋友那里看到几本过时的《国家地理》。

关键词：国家地理图书馆网络《廊桥遗梦》网页网站教育研究机构主要内容文字说明综合科学

Risk factors and classifications of hilar cholangiocarcinoma

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World Journal of Gastrointestinal Oncology 2013年第7期5卷 132-138页

作者： Miguel Angel suarez-Munoz Jose Luis Fernandez-Aguilar belinda sanchez-perez Jose Antonio perez-Daga Beatriz Garcia-Albiach Ysabel pulido-Roa Naiara Marin-Camero Julio santoyo-santoyo General Digestive and Transplantation surgery service HPB and Liver Transplant UnitUniversity Hospital Carlos Haya29010 MalagaSpain

Cholangiocarcinoma is the second most common primary malignant tumor of the *** cholangiocarcinoma or Klatskin tumor represents more than 50% of all biliary tract cholangiocarcinomas.A wide range of risk factors have been identified among patients with perihilar cholangiocarcinoma including advanced age,male gender,primary sclerosing cholangitis,choledochal cysts,cholelithiasis,cholecystitis,parasitic infection(Opisthorchis viverrini and Clonorchis sinensis),inflammatory bowel disease,alcoholic cirrhosis,nonalcoholic cirrhosis,chronic pancreatitis and metabolic *** classifications have been used to describe the pathologic and radiologic appearance of *** three systems most commonly used to evaluate perihilar cholangiocarcinoma are the Bismuth-Corlette(BC) system,the Memorial sloan-Kettering Cancer Center and the TNM *** BC classification provides preoperative assessment of local *** Memorial sloan-Kettering cancer center proposes a staging system according to three factors related to local tumor extent:the location and extent of bile duct involvement,the presence or absence of portal venous invasion,and the presence or absence of hepatic lobar *** TNM classification,besides the usual descriptors,tumor,node and metastases,provides additional information concerning the possibility for the residual tumor(R) and the histological grade(G).Recently,in 2011,a new consensus classification for the perihilar cholangiocarcinoma had been *** consensus was organised by the European Hepato-pancreatoBiliary Association which identified the need for a new staging system for this type of *** classification includes information concerning biliary or vascular(portal or arterial) involvement,lymph node status or metastases,but also other essential aspects related to the surgical risk,such as remnant hepatic volume or the possibility of underlying disease.

关键词： Hilar cholangiocarcinoma Klatskin tumor perihilar cholangiocarcinoma Bile duct cancer

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访谈:何镜堂的建筑与变化的中国

建筑学报 2018年第1期 18-25页

作者：冯江彼得.罗黄全乐陈轲李俊何婧 belinda Lausier 华南理工大学建筑学院哈佛大学华南理工大学建筑设计研究院

讨论了岭南派的“现代建筑”与“地域建筑”两种交织在一起的混成印象，通过对气候、庭园、线条和体积4个关键词的剖析，认为新中国以来岭南建筑的理念内核实际上更多源自于对现代性的追寻；分析了何镜堂的话语选择和作品引用源，揭示... 详细信息

讨论了岭南派的“现代建筑”与“地域建筑”两种交织在一起的混成印象，通过对气候、庭园、线条和体积4个关键词的剖析，认为新中国以来岭南建筑的理念内核实际上更多源自于对现代性的追寻；分析了何镜堂的话语选择和作品引用源，揭示了其建筑理念中蕴含的将建筑作为一种修辞的理解，这一理解正好在走出岭南的过程中与各个地域和国家对主体身份认同的渴求相契合。在现代建筑与地域主义的辨析中阐释了从夏昌世到何镜堂的建筑理念的嬗递。

关键词：地域主义意识形态修辞引用源现代性岭南派

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