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Genotypic characteristics of resistant tumors to pre-operative ionizing radiation in rectal cancer

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World Journal of Gastrointestinal Oncology 2014年第7期6卷 194-210页

作者： Zeeshan Ramzan Ammar B Nassri Sergio huerta VA North Texas Healthcare System-Dallas VA Medical Center University of Texas Southwestern Medical Center Dallas TX 75216 United States

Due to a wide range of clinical response in patients un-dergoing neo-adjuvant chemoradiation for rectal cancer it is essential to understand molecular factors that lead to the broad response observed in patients receiving the same form of *** extensive research in this field,the exact mechanisms still remain *** raging from DNA-repair to specific molecules lead-ing to cell survival as well as resistance to apoptosis have been ***,or in combination,there is no single pathway that has become clinically applicable to *** the following review,we describe the current status of various pathways that might lead to resistance to the therapeutic applications of ionizing radiation in rectal cancer.

关键词： Ionizing radiation DNA double-strand break Non-homologous end-joining pathway DNA-PKcs Ku proteins Complete pathological response Radiation therapy Apoptosis Angiogenesis

A domain-independent methodology to analyze IoT data streams in real-time.A proof of concept implementation for anomaly detection from environmental data

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International Journal of Digital Earth 2017年第1期10卷 103-120页

作者： Sergio Trilles Òscar Belmonte Sven Schade Joaquìn huerta Institute of New Imaging Technologies Universitat Jaume ICastellóde la PlanaSpain European Commission–Joint Research Centre Institute for Environment and SustainabilityIspraItaly

Pushed by the Internet of Things(IoT)paradigm modern sensor networks monitor a wide range of phenomena,in areas such as environmental monitoring,health care,industrial processes,and smart *** networks provide a continuous pulse of the almost infinite activities that are happening in the physical space and are thus,key enablers for a Digital Earth Nervous ***,the rapid processing of these sensor data streams still continues to challenge traditional data-handling solutions and new approaches are being *** propose a generic answer to this challenge,which has the potential to support any form of distributed real-time *** neutral methodology follows a brokering approach to work with different kinds of data sources and uses web-based standards to achieve *** a proof of concept,we implemented the methodology to detect anomalies in real-time and applied it to the area of environmental *** developed system is capable of detecting anomalies,generating notifications,and displaying the recent situation to the user.

关键词： Big data real-time analysis data streams sensor networks interoperability brokering approach

Fuzzy Logic for Elimination of Redundant Information of Microarray Data

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Genomics, Proteomics & Bioinformatics 2008年第2期6卷 61-73页

作者： Edmundo Bonilla huerta B'eatrice Duval LERIA Universit'e d'Angers 2 Boulevard Lavoisier 49045 Angers France

Gene subset selection is essential for classification and analysis of microarray data. However, gene selection is known to be a very difficult task since gene expression data not only have high dimensionalities, but also contain redundant information and noises. To cope with these difficulties, this paper introduces a fuzzy logic based pre-processing approach composed of two main steps. First, we use fuzzy inference rules to transform the gene expression levels of a given dataset into fuzzy values. Then we apply a similarity relation to these fuzzy values to define fuzzy equiva- lence groups, each group containing strongly similar genes. Dimension reduction is achieved by considering for each group of similar genes a single representative based on mutual information. To assess the usefulness of this approach, exten- sive experimentations were carried out on three well-known public datasets with a combined classification model using three statistic filters and three classifiers.

关键词： fuzzy processing gene selection dimension reduction classification

Recent progress on bimetallic NiCo and CoFe based electrocatalysts for alkaline oxygen evolution reaction: A review

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Journal of Energy Chemistry 2022年第4期31卷 101-137页

作者： Gebrehiwet Abrham Gebreslase Maria Victoria Martínez-huerta Maria Jesus Lázaro Instituto de Carboquímica CSIC.Miguel LuesmaCastán 450018ZaragozaSpain Instituto de Catálisis y Petroleoquímica CSIC.Marie Curie 228049MadridSpain

The deployment of hydrogen as an energy carrier is found to be a vital alternative fuel for the future. It is expected that water electrolysis, powered by renewable energy sources, be able to scale-up hydrogen production. However, the reaction kinetic of oxygen evolution reaction(OER) is a sluggish process, which predominantly limits the efficiency of water electrolysis. This review recapitulates the recent progress and efforts made in the design and development of two selected earth-abundant bimetallic electrocatalysts(Ni Co and Co Fe) for alkaline OER. Each bimetal electrocatalyst is thoroughly outlined and discussed in five sub-sections, including bimetal(oxy) hydroxides, Layered double hydroxides(LDHs) structures,oxides, composites, alloy and nanostructured electrocatalysts, and assembled with ***, a brief introduction to an in situ/operando characterization techniques and advantages for monitoring the structure of the electrocatalysts is provided. Finally, a summary outlining the challenges and conceivable approaches to advance OER performance is highlighted and discussed.

关键词： Water electrolysis Oxygen evolution reaction Bimetallic electrocatalyst Nickel Cobalt and iron

Soil-vegetation relationships in Mediterranean forests after fire

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Forest Ecosystems 2021年第2期8卷 240-252页

作者： Víctor Fernández-García Elena Marcos Sara huerta Leonor Calvo Area of Ecology Department of Biodiversity and Environmental ManagementFaculty of Biological and Environmental SciencesUniversidad de León24071 LeónSpain

Background:Wildfires are one of the major environmental concerns in Mediterranean ***,many studies have addressed wildfire impacts on soil and vegetation in Mediterranean forests,but the linkages between these ecosystem compartments after fire are not well *** aim of this work is to analyze soil-vegetation relationships in Mediterranean burned forests as well as the consistency of these relationships among forests with different environmental conditions,at different times after fire,and among vegetation with different functional ***:Our results indicate that study site conditions play an important role in mediating soil-vegetation ***,we found that the nature of soil-vegetation relationships may vary over time as fire effects are less dominant in both ecosystem *** this,we detected several common soil-vegetation relationships among study sites and times after *** instance,our results revealed that available P content and stoichiometry(C:P and N:P)were closely linked to vegetation growth,and particularly to the growth of *** found that enzymatic activities and microbial biomass were inversely related to vegetation growth rates,whereas the specific activities of soil enzymes were higher in the areas with more vegetation height and ***,our results suggest that resprouters may influence soil properties more than seeders,the growth of seeders being more dependent on soil ***:We provide pioneer insights into how vegetation is influenced by soil,and vice-versa,in Mediterranean burned *** results reflect variability in soil-vegetation relationships among study sites and time after fire,but consistent patterns between soil properties and vegetation were also *** research is highly relevant to advance in forest science and could be useful to achieve efficient post-fire management.

关键词： Wildfires Soil nutrients Enzymatic activities Microbial biomass Growth forms Regenerative strategies

Canopy Roughness:A New Phenotypic Trait to Estimate Aboveground Biomass from Unmanned Aerial System

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Plant Phenomics 2020年第1期2卷 419-428页

作者： Monica Herrero-huerta Alexander Bucksch Eetu Puttonen Katy M.Rainey Department of Agronomy Purdue UniversityWest LafayetteINUSA Department of Cartographic and Land Engineering Higher Polytechnic School of AvilaUniversity of SalamancaAvilaSpain Institute for Plant Sciences College of AgriculturePurdue UniversityWest LafayetteINUSA Department of Plant Biology University of GeorgiaAthensGAUSA Warnell School of Forestry and Natural Resources University of GeorgiaAthensGAUSA Institute of Bioinformatics University of GeorgiaAthensGAUSA Finnish Geospatial Research Institute National Land Survey of FinlandMasalaFinland

Cost-effective phenotyping methods are urgently needed to advance crop genetics in order to meet the food,fuel,and fiber demands of the coming ***,characterizing plot level traits in fields is of particular *** developments in highresolution imaging sensors for UAS(unmanned aerial systems)focused on collecting detailed phenotypic measurements are a potential *** introduce canopy roughness as a new plant plot-level *** tested its usability with soybean by optical data collected from UAS to estimate *** validate canopy roughness on a panel of 108 soybean[Glycine max(L.)Merr.]recombinant inbred lines in a multienvironment trial during the R^(2) growth stage.A senseFly eBee UAS platform obtained aerial images with a senseFly *** digital *** a structure from motion(SfM)technique,we reconstructed 3D point clouds of the soybean experiment.A novel pipeline for feature extraction was developed to compute canopy roughness from point *** used regression analysis to correlate canopy roughness with field-measured aboveground biomass(AGB)with a leave-one-out ***,our models achieved a coefficient of determination(R^(2))greater than 0.5 in all ***,we found that canopy roughness has the ability to discern AGB variations among different *** test trials demonstrate the potential of canopy roughness as a reliable trait for high-throughput phenotyping to estimate *** such,canopy roughness provides practical information to breeders in order to select phenotypes on the basis of UAS data.

关键词： soybean Biomass roughness

Photoelectrochemical activity of ZnO:Ag/rGO photo-anodes synthesized by two-steps sol-gel method

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Chinese Physics B 2022年第5期31卷 691-702页

作者： D Ben Jemia M Karyaoui M A Wederni A Bardaoui M V Martinez-huerta M Amlouk R Chtourou Laboratory of Nanomaterials and Renewable Energy Systems LANSER Research and Technology Center of EnergyBorj-Cedria Science and Technology ParkBP 952050 Hammam-LifTunisia Faculty of Science of Tunis University of Tunis El ManarTunisia Laboratory of Physics of Materials and Nanomaterials Applied to the Environment(LaPhyMNE) Faculty of Sciences of GabesCite ErriadhUniversity of Gabes6079 GabesTunisia lnstitute of Catalysis and Petrochemistry CSICin MadridSpain Laboratory of Nanomaterials Nanotechnology and Energy(L2NE)University of Tunis El ManarTunisia

This work investigated the influence of silver plasmon and reduced graphene oxide(r GO)on the photoelectrochemical performance(PEC)of Zn O thin films synthesized by the sol-gel *** physicochemical properties of the obtained photo-anodes were systematically studied by using several characterization *** x-ray diffraction analysis showed that all samples presented hexagonal wurtzite structure with a polycrystalline *** and energy dispersive x-ray(EDX)studies confirmed the existence of both Ag and r GO in Zn O:Ag/r GO thin *** estimated grain size obtained from scanning electron microscopy(SEM)analysis decreased with Ag doping,then increased to a maximum value after r GO *** UV-vis transmission spectra of the as-prepared Zn O:Ag and Zn O:Ag/r GO thin films have shown a reduction in the visible range with a redshift at the absorption *** bandgaps were estimated to be around 3.17 e V,2.7 e V,and 2.52 e V for Zn O,Zn O:Ag,and Zn O:Ag/r GO,***,the electrical measurements revealed that the charge exchange processes were enhanced at the Zn O:Ag/r GO/electrolyte interface,accompanied by an increase in the(PEC)performance compared to Zn O and Zn O:Ag ***,the photocurrent density of Zn O:Ag/r GO(0.2 m A·cm^(-2)) was around 4 and 2.22 times higher than photo-anodes based on undoped Zn O(0.05 m A·cm^(-2)) and Zn O:Ag(0.09 m A·cm^(-2)),***,from the flat band potential and donor density,deduced from the Mott-Schottky,it was clear that all the samples were n-type semiconductors with the highest carrier density for the Zn O:Ag/r GO photo-anode.

关键词： zinc oxide reduced graphene oxide silver doping sol-gel photoelectrochemical performance

Submicroscopic 11p13 deletion including the elongator acetyltransferase complex subunit 4 gene in a girl with language failure, intellectual disability and congenital malformations: A case report

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World Journal of Clinical Cases 2020年第21期8卷 5296-5303页

作者： Jaime Toral-Lopez Luz María González huerta Olga Messina-Baas Sergio A Cuevas-Covarrubias Departamento de Genética Medica Centro Medico EcatepecISSEMYMEcatepec 55000México Programa de Maestría y Doctorado en Ciencias Médicas Odontológicas y de la Salud/Hospital Infantil de MéxicoUniversidad Nacional Autónoma de MéxicoMéxico 06720México Departamento de Biología Molecular Hospital General de MéxicoCuauhtémoc 06720México Departamento de Oftalmología Hospital General de MéxicoCuauhtémoc 06720México Genetica Hospital General de MéxicoCuauhtémoc 06726Mexico Sergio A Cuevas-CovarrubiasPrograma de Maestría y Doctorado en Ciencias MédicasOdontológicas y de la SaludUniversidad Nacional Autónoma de MéxicoMéxico 06720Mexico

BACKGROUND We described the main features of an infant diagnosed with facial dysmorphic,language failure,intellectual disability and congenital malformations to strengthen our understanding of the ***,treatment is only rehabilitation and surgery for cleft lip and *** SUMMARY The proband was a 2-years-8-months-old *** history was negative for congenital malformations or intellectual *** patient had microcephaly,upward-slanting palpebral fissures,depressed nasal bridge,bulbous nose and bilateral cleft lip and *** magnetic resonance imaging showed cortical atrophy and band *** motor and intellectual development is delayed.A submicroscopic deletion in 11p13 involving the elongator acetyltransferase complex subunit 4 gene(ELP4)and a loss of heterozygosity in Xq25-q26.3 were *** There is no treatment for the ELP4 deletion caused by a submicroscopic 11p3 *** describe a second case of deletion of the ELP4 gene without aniridia,which confirms the association between ELP4 gene with several defects and absence of this ocular *** clinical data in the deletion of the ELP4 gene as cleft palate,facial dysmorphism,and changes at level brain could be associated to this gene or be part of the effect of the recessives genes involved in the loss of heterozygosity region of Xq25-26.3.

关键词： Submicroscopic 11p13 deletion Elongator acetyltransferase complex subunit 4 gene Language failure Intellectual disability Congenital malformations Case report

Cardiopulmonary resuscitation in the elderly: a clinical and ethical perspective

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Journal of Geriatric Cardiology 2007年第2期4卷 117-119页

作者： Ana L. huerta-Alardín Manuel Guerra-Cantú Joseph Varon Dorrington Medical Associates Houston Texas Universidad de Monterrey School of Medicine Monterrey México The University of Texas Health Science Center St. Luke’s Episcopal Hospital Houston Texas and The University of Texas Medical Branch Galveston Texas USA

The daily practice of cardiopulmonary resuscitation (CPR) in elderly patients has brought up the attention of outcome research and resource allocation. Determinants to predict survival have been well identified. There has been empirical evidence that CPR is of doubtful utility in the geriatric population, more studies have showed controversial data. Sometimes situations in which CPR needs to be given in the elderly, causes stress to healthcare providers, due to lack of communication of the patient’s wishes and the belief that it will not be successful. It is of importance to state that we have the duty to identify on time the patients that will most likely benefit from CPR, and find out the preferences of the same. Whenever it is possible to institute these guidelines, we will avoid patient suffering.

关键词： cardiopulmonary resuscitation advanced directives