检索结果-南通市图书馆

Gemcitabine and cisplatin treatment over a 3-week versus a 4-week dosing schedule： a randomized trial coducted in Chinese patients with nonsmall cell lung cancer

引用

Chinese Medical Journal 2008年第10期121卷 892-897页

作者： LIAO Mei-lin ZHU Yun-zhong LI Long-yun WAN Huan-ying YU Shi-ying belinda hall Teena WEST WANG Li Clinical Medical Centre of Lung Tumour Shanghai ChestHospital Shanghai 200030 China Department of Oncology Beijing Chest Tumour Hospital Beijing 101149 China Department of Pulmonary Medicine Peking Union HospitalBeijing 100730 China Department of Pulmonary Medicine Shanghai Ruijin HospitalShanghai 20025 China Center of Oncology Tongji Hospital Wuhan 430030 China Intercontinental Information Sciences Eli Lilly Australia PtyLimited Australia Eli Lilly Asia Shanghai Office Shanghai 200021 China

Background Gemcitabine plus cisplatin is a standard treatment for stages IIIB and IV nonsmall cell lung cancer （NSCLC）. This randomized phase Ⅱ study evaluated a 3-week versus a 4-week schedule of gemcitabine-cisplatin as first line treatment for Chinese patients with advanced NSCLC. Methods Patients were randomized to receive cisplatin 75 mg/m^2 on day 1 plus either gemcitabine 1250 mg/m^2 on days 1 and 8 of a 21-day cycle （3-week group） or gemcitabine 1000 mg/m2 on days 1,8 and 15 of a 28-day cycle （4-week group）. Results One hundred patients were enrolled in this study. The response rate was 24% （12/51 patients） in the 3-week group and 27% （13/49 patients） in the 4-week group. There were no statistically significant differences between the two treatment groups in survival （hazard ratio： 1.19; 95% CI： 0.68-2.09） with a median survival of 12.1 months and 13.8 months in the 3-week group and the 4-week group respectively. The rate of grade 3/4 toxicity in the 3-week group was 55% compared with 86% in the 4-week group （P=0.001）. The difference in the incidence of grade 3/4 haematological toxicities did not reach statistical significance （3-week： 37%, 4-week： 57%）, however grade 3/4 drug related neutropenia （3-week： 27%, 4-week： 51%） and thrombocytopenia （3-week： 8%, 4-week： 31%） were significantly lower in the 3-week group. Grade 3/4 nonhaematological toxicities were less in the 3-week group （33% cf 63%; P=0.005）. Conclusions The differences in the efficacy endpoints were all in favour of the 4-week schedule of gemcitabine plus cisplatin, however these differences did not reach statistical significance. Fewer grade 3/4 toxicities were observed in the 3-week group compared with the 4-week group.

关键词： chemotherapy gemcitabine cisplatin carcinoma, nonsmall cell lung

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mapping wetlands in Indonesia using Landsat and PALSAR data-sets and derived topographical indices

引用

Geo-Spatial Information Science 2014年第1期17卷 60-71页

作者： belinda A.MARGONO Jean-Robert B.BWANGOY Peter V.POTAPOV Matthew C.HANSEN Department of Geographical Sciences University of Maryland4321 Hartwick Bld.College ParkMD 20742USA GIS Center of Excellence South Dakota State University1021 Medary Ave.Wecota HallBrookingsSD 57007USA The Ministry of Forestry(MoF)of Indonesia Manggala Wanabhkati Bld.Jakarta 10270Indonesia

Wetlands play an important role in the provision of ecosystem services,ranging from the regulation of hydrological systems to carbon sequestration and biodiversity *** paper reports the mapping of Indonesia’s wetland cover as a single thematic class,including peatlands,freshwater wetlands,and ***-interpreted training data were used to identify wetland formations including areas of likely past wetland extent that have been converted to other land *** indices(Shuttle Radar Topography Mission-derived)and optical(Landsat)and radar(PALSAR)image inputs were used to build a bagged classification tree model based on training data in order to generate a national-scale map of wetland extent at a 60 m spatial *** resulting wetland map covers 21.0%(39.6 Mha)of Indonesia’s land,including 25.2% of Sumatra(11.9 Mha),22.9% of Kalimantan(12.2 Mha),and 28.9% of Papua(11.8 Mha).Results agree with existing image-interpreted products from Indonesia’s Ministries of Forestry and Agriculture and Wetlands International(89% overall agreement),and with the Ministry of Forestry forest inventory data for Sumatra and Kalimantan(91% overall agreement).An internally consistent algorithm-derived national wetland extent map can be used to quantify changing rates of land conversion inside and outside of ***,wetlands extent can be used to efficiently allocate field resources in national assessments of wetland sub-types such as peatlands,which are a current focus of policies aiming to reduce carbon emissions from land use change.

关键词： wetlands Indonesia remote sensing Landsat digital elevation model(DEM) PALSAR Shuttle Radar Topography Mission(SRTM)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

建网站、开博客——欧美业主卖房有新招

引用

住宅与房地产（中） 2006年第12期 19-20页

作者： belinda Archer 张征（译）

艾弗·雅各布斯（Ivor Jacobs）决定卖掉位于英国德比郡价值600万英镑的Hopwell hall豪宅时，建立了自己的专属网站帮助推销。

关键词：网站卖房业主欧美博客英镑豪宅推销

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：