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Foundations of Programmable Process Structures for the unified modeling and simulation of agricultural and aquacultural systems

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Information Processing in Agriculture 2024年第1期11卷 91-108页

作者： Monika Varga bela csukas Hungarian University of Agriculture and Life Sciences Kaposvar Campus40 Guba S7400 KaposvarHungary

This research paper defines the theoretical foundations and computational implementation of a non-conventional modeling and simulation methodology,inspired by the needs of problem solving for biological,agricultural,aquacultural and environmental *** challenging practical problem is to develop a framework for automatic generation of causally right and balance-based,unified models that can also be applied for the effective coupling amongst the various(sophisticated field-specific,sensor data processing-based,upper level optimization-driven,etc.)*** scientific problem addressed in this innovation is to develop Programmable Process Structures(PPS)by combining functional basis of systems theory,structural approach of net theory and computational principles of agent based *** offers a novel framework for the automatic generation of easily extensible and connectible,unified models for the underlying complex *** models can be generated from one state and one transition meta-prototypes and from the transition oriented description of process *** models consist of unified state and transition *** local program containing prototype elements,derived also from the meta-prototypes,are responsible for the case-specific *** integrity and consistency of PPS architecture are based on the meta-prototypes,prepared to distinguish between the conservation-laws-based measures and the *** simulation is based on data flows amongst the state and transition elements,as well as on the unification based data transfer between these elements and their calculating *** architecture and its AI language-based(Prolog)implementation support the integration of various field-and task-specific models,*** better understanding is helped by a simple *** capabilities of the recently consolidated general methodology are discussed on the basis of some preliminary applications,focusing on the recently studied

关键词： Unified process model Meta-prototype-based architecture Transition-based structure representation Locally programmable functionality prototypes Agricultural systems Aquacultural systems

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Larval feeding status regulates the transcript levels of genes encoding PTTH and allatoregulatory peptides in silkworm Bombyx mori

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Insect Science 2021年第3期28卷 680-691页

作者： Sanathoibi D.Kh bela Keshan Department of Zoology North-Eastern Hill UniversityShillongMeghalayaIndia

In Bombyx mori,two dorsolateral neurosecretory cells(NSCs)in each of thetwo brain lobes have been identified as prothoracicotropic hormone(PTTH)*** neuropeptide in insects stimulates the prothoracic gland for the synthesis andrelease of ecdysone,responsible for the molting ***(AT)and allatostatin(AST)are allatoregulatory neuropeptides that regulate juvenile hormone ***,by using RT-qPCR,we showed that in ***,nutritional stress modulates themRNA expression of AT and AST-C(allatostain type C)in the central nervous systemconsisting of the brain lobes and all the associated *** whole-mount in situhybridization,we showed that the feeding status of Bombyx larvae also influences the ex-pression of PTTH in the NSCs of the *** deprivation significantly decreased themRNA expression levels of PTTH in larvae at active or terminal growth ***,we showed that insulin modulates the expression level of ***,its action wasdependent on the feeding status of the *** feeding,the insulin decreased the PTTHexpression level,while at food deprivation,the insulin increased the PTTH *** data thus indicates that larval feeding status plays an important role in alteringthe mRNA expression levels of allatoregulatory peptide genes and PTTH.

关键词： allatotropin allatostatin feeding food deprivation prothoracicotropic hor-mone silkworm

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A Stochastic Variational Approach to Viscous Burgers Equations

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Acta Mathematica Sinica,English Series 2016年第9期32卷 1027-1034页

作者： Ana bela CRUZEIRO Guo Ping LIU GFMUL and Dep. de Matematica Instituto Superior Tecnico (Universidade de Lisboa) Av. Rovisco Pais 1049-001 Lisboa Portugal GFMUL and Dep. de Matematica Instituto Superior Tecnico (Universidade de Lisboa) Av. Rovisco Pais 1049-001 Lisboa Portugal Academy of Mathematics and Systems Science Chinese Academy of Sciences 100190 Beijing P. R. China

We consider viscous Burgers equations in one dimension of space and derive their solutions from stochastic variational principles on the corresponding group of homeomorphisms. The metrics considered on this group are Lp metrics. The velocity corresponds to the drift of some stochastic Lagrangian processes. Existence of minima is proved in some cases by direct methods. We also give a representation of the solutions of viscous Burgers equations in terms of stochastic forward-backward systems.

关键词： Burgers equations stochastic variational principles Lagrangian diffusions

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Preparation and Structural Characterization of Rapidly Solidified Al-Cu Alloys

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Journal of Materials Science & Technology 2014年第4期30卷 394-400页

作者： Iuliana Lichioiu Ildiko Peter bela Varga Mario Rosso Department of Materials Science Transilvania University of Brasov Department of Applied Science and Technology Institute of Science & Engineering of Materials for the Innovative Technologies

Rapidly solidified Al100-x-Cux alloys （x = 5, 10, 15, 25, 35 wt%） were prepared and analyzed. High cooling rate increased the Cu solubility in α-AI matrix. The influence of the cooling rate on Cu solubility extension in AI was experimentally simulated. Thus the pouring was performed in metallic die and by melt spinning-low pressure （MS- LP） technique. Melt processing by liquid quenching was performed using a self-designed melt spinning set-up which combined the cooling technology of a melt jet on the spinning disc with the principle of the mold feeding from low pressure casting technology. The thickness of the melt-spun ribbons was in the range of 30-70 μm. The cooling rate provided by MS-LP was within 105-106 K/s after the device calibration. The obtained alloys were characterized from structural, thermal and mechanical point of view. Optical microscopy and scanning electron microscopy were employed for the microstructural characterization which was followed by X-ray analysis. The thermal properties were evaluated by dilatometric and differential scanning calorimetric measurements. Vickers microhardness measurements were performed in the study. In the case of the hypereutectic alloy with 35 wt% Cu obtained by MS-LP method, the microhardness value increased by 45% compared to the same alloy obtained by gravity casting method. This was due to the extended solubility of the alloying element in the α-AI solid solution.

关键词： AI-Cu alloy Melt spinning Fractographs Extended solubility

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L^p-gradient Estimates of Symmetric Markov Semigroups for 1 〈 p ≤ 2

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Acta Mathematica Sinica,English Series 2006年第1期22卷 101-104页

作者： Ana bela CRUZEIRO Xi Cheng ZHANG Department Matemdtica I.S.T. Av. Rovisco Pais 1099-01 Lisboa Portugal and Grupo de Fisica-Matemdtica U.L. Lisboa Portugal Department of Mathematics Huazhong University of Science and Technology Wuahan 430074 P. R. China

For 1 〈 p ≤2, an L^p-gradient estimate for a symmetric Markov semigroup is derived in a general framework, i.e. ‖Γ^/2（Ttf）‖p≤Cp/√t‖p, where F is a carre du champ operator. As a simple application we prove that F1/2（（I- L） ^-α） is a bounded operator from L^p to L^v provided that 1 〈 p 〈 2 and 1/2〈α〈1. For any 1 〈 p 〈 2, q 〉 2 and 1/2 〈α 〈 1, there exist two positive constants cq,α,Cp,α such that ‖Df‖p≤ Cp,α‖（I - L）^αf‖p,Cq,α（I-L）^（1-α）‖Df‖q＋‖f‖q, where D is the Malliavin gradient （[2]） and L the Ornstein-Uhlenbeck operator.

关键词： Symmetric Markov semigroup Carre du champ Path space

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Long-term omeprazole and esomeprazole treatment does not significantly increase gastric epithelial cell proliferation and epithelial growth factor receptor expression and has no effect on apoptosis and p53 expression

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World Journal of Gastroenterology 2005年第30期11卷 4721-4726页

作者： Istvan Hritz Laszlo Herszenyi bela Molnar Zsolt Tulassay Laszlo Pronai 2nd Department of Medicine

AIM： To study the effect of proton pump inhibitor （PPI） treatment on patients with reflux esophagitis and its in vivo effect on apoptosis, p53- and epidermal growth factor receptor （EGFR） expression. METHODS： After informed consent was obtained, gastric biopsies of the antrum were taken from patients with reflux oesophagitis prior to and after 6 mo of 20 mg omeprazole （n = 24） or 40 mg esomeprazole （n = 22） therapy. Patients did not take any other medications known to affect the gastric mucosa. All patients were Helicobacter pylori negative as confirmed by rapid urease test and histology, respectively. Cell proliferation, apoptosis, EGFR, and p53 expression were measured by immunohistochemical techniques. At least 600 glandular epithelial cells were encountered and results were expressed as percentage of total cells counted. Was considered statistically significant. RESULTS： Although there was a trend towards increase of cell proliferation and EGFR expression both in omeprazole and esomeprazole treated group, the difference was not statistically significant. Neither apoptosis nor p53 expression was affected. CONCLUSION： Long-term PPI treatment does not significantly increase gastric epithelial cell proliferation and EGFR expression and has no effect on apoptosis and p53 expression.

关键词： Proton pump inhibibor Omeprazole Esomeprazole Cell proliferation Apoptosis p53 expression Epidermal growth factor receptor

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Minimally invasive image-guided therapy of primary and metastatic pancreatic cancer

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World Journal of Gastroenterology 2021年第27期27卷 4322-4341页

作者： Andras Bibok Dae Won Kim Mokenge Malafa bela Kis Department of Diagnostic Imaging and Interventional Radiology H.Lee Moffitt Cancer CenterTampaFL 33612United States Department of Transplantation&Surgery Radiology UnitSemmelweis UniversityBudapest 1085Hungary Department of Gastrointestinal Oncology H.Lee Moffitt Cancer CenterTampaFL 33612United States

Pancreatic cancer is a challenging malignancy with limited treatment options and poor life *** only curative option is surgical resection,but only 15%-20%of patients are resectable at presentation because more than 50%of patients has distant metastasis at diagnosis and the rest of them has locally advanced pancreatic cancer(LAPC).The standard of care first line treatment for LAPC patients is chemotherapy with or without radiation *** developments in minimally invasive ablative techniques may add to the treatment armamentarium of *** are increasing number of studies evaluating these novel ablative techniques,including radiofrequency ablation,microwave ablation,cryoablation and irreversible *** studies which included pancreatic tumor ablation,demonstrated improved overall survival in LAPC ***,the exact protocols are yet to set up to which stage of the treatment algorithm ablative techniques can be added and in what kind of treatment *** with metastatic pancreatic cancer has dismal prognosis with 5-year survival is only 3%.The most common metastatic site is the liver as 90%of pancreatic cancer patients develop liver *** is the primary treatment option for patients with metastatic pancreatic ***,when the tumor is not responding to chemotherapy or severe drug toxicity develops,locoregional liver-directed therapies can provide an opportunity to control intrahepatic disease progression and improve survival in selected *** the last decade new therapeutic options arose with the advancement of minimally invasive technologies to treat pancreatic cancer *** new therapies have been a topic of increasing interest due to the severe prognostic implications of locally advanced and metastatic pancreatic cancer and the low comorbid risk of these *** review summarizes new ablative options for patients with LAPC and percutaneous liver-directed th

关键词： Pancreatic neoplasms Interventional radiology Ablation techniques Electroporation Radiofrequency ablation Therapeutic embolization

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《前哥伦布时期中国人的全球探索:一幅古世界地图的证据》书评

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青海师范大学学报（社会科学版） 2024年第2期46卷 160-164页

作者： [美]维多利亚·贝拉 [美]王胜炜(译) 《南华早报》中国香港美国南加州大学

学者王胜炜所著的《前哥伦布时期中国人的全球探索:一幅古世界地图的证据》(1)是一本有关中国历史的新书,书中指出,明朝的宝船队曾远航至美洲、澳洲,作者通过分析1602年出版的中文世界地图《坤舆万国全图》来主张她的观点。这篇书评分... 详细信息

学者王胜炜所著的《前哥伦布时期中国人的全球探索:一幅古世界地图的证据》(1)是一本有关中国历史的新书,书中指出,明朝的宝船队曾远航至美洲、澳洲,作者通过分析1602年出版的中文世界地图《坤舆万国全图》来主张她的观点。这篇书评分为两部分,在书评第一部分中,中国香港《南华早报》的科学作家维多利亚·贝拉(Victoria bela),考查了来自东方的古代水手先于哥伦布踏上美洲海岸的问题。

关键词：世界地图书评《坤舆万国全图》《南华早报》哥伦布维多利亚

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Regulation of cancer stem cells in triple negative breast cancer

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Cancer Drug Resistance 2021年第2期4卷 321-342页

作者： Norman Fultang Madhuparna Chakraborty bela Peethambaran Department of Pathology and Laboratory Medicine University of PennsylvaniaPhiladelphiaPA 19140USA Department of Biological Sciences The University of the SciencesPhiladelphiaPA 19140USA.

Triple Negative Breast Cancer(TNBC)is the most lethal subtype of breast *** the successes of emerging targeted therapies,relapse,recurrence,and therapy failure rates in TNBC significantly outpace other subtypes of breast *** evidence suggests accumulation of therapy resistant Cancer Stem Cell(CSC)populations within TNBCs contributes to poor clinical *** CSCs are enriched in TNBC compared to non-TNBC breast *** mechanisms underlying CSC accumulation have been well-characterized and discussed in other *** this review,we focus on TNBC-specific mechanisms that allow the expansion and activity of self-renewing *** highlight cellular signaling pathways and transcription factors,specifically enriched in TNBC over non-TNBC breast cancer,contributing to *** also analyze publicly available single-cell RNA-seq data from basal breast cancer tumors to highlight the potential of emerging bioinformatic approaches in identifying novel drivers of stemness in TNBC and other cancers.

关键词： Cancer stem cells TNBC transcriptional regulation breast cancer

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Interleukin and interleukin receptor gene polymorphisms in inflammatory bowel diseases susceptibility

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World Journal of Gastroenterology 2014年第12期20卷 3208-3222页

作者： Lili Magyari Erzsebet Kovesdi Patricia Sarlos Andras Javorhazy Katalin Sumegi bela Melegh Department of Medical Genetics University of Pecs Szentagothai Research Centre 1~(st) Department of Internal Medicine University of Pecs Department of Urology University of Pecs

Inflammatory bowel disease (IBD), which includes Crohn’s disease (CD) and ulcerative colitis (UC), represents a group of chronic inflammatory disorders caused by dysregulated immune responses in genetically predisposed individuals. Genetic markers are associated with disease phenotype and long-term evolution, but their value in everyday clinical practice is limited at the moment. IBD has a clear immunological background and interleukins play key role in the process. Almost 130 original papers were revised including meta-analysis. It is clear these data are very important for understanding the base of the disease, especially in terms of clinical utility and validity, but text often do not available for the doctors use these in the clinical practice nowadays. We conducted a systematic review of the current literature on interleukin and interleukin receptor gene polymorphisms associated with IBD, performing an electronic search of PubMed Database from publications of the last 10 years, and used the following medical subject heading terms and/or text words: IBD, CD, UC, interleukins and polymorphisms.

关键词： Inflammatory bowel disease, Crohn’ s disease, Ulcerative colitis, Interleukin, Interleukin receptor, Polymorphisms

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